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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 4 No 2 (2006): JIFI" : 8 Documents clear
Ekstraksi Kurkuminoid dari Temulawak (Curcuma xanthorriza Roxb.) secara Perkolasi dengan Pelarut Etanol Imam Paryanto; Bambang Srijanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A study has been carried out to find out the effect of temperature, solvent flow rate and ethanol-water solvent composition on curcuminoid content in the extract produced from the extraction process (percolation) of Curcuma xanthorriza Roxb. Experiment was designed and analysed using complete random analysis with 3 factors and 2 duplications. Observed variables were: (1) varied extraction temperatures of 35°C, 45° C and 55° C; (2) varied solvent flow rates of 40 ml/minute, 60 ml/minute and 80 ml/minute; and (3) various solvent (ethanol 96%-water) compositions of 100:0,75:25 and 50:50, respectively. The measurement of curcuminoid content in the extract was done using spectrophotometer UV-visible light with wavelength setting of 420 nm. The results of analysis statistically explained that temperature and solvent flowrate did not affect significantly on curcuminoid content in the extract, but ethanol-water (solvent) composition did significantly influence on extracted curcuminoid content each shown in F table 0.01. Therefore, the optimum result of the study showed that the higher the ethanol concentration in the solvent was, the higher the curcuminoid content in the extract became. The highest curcuminoid content of 10.7% in extract was resulted at temperature of 35° C, solvent flow rate of 40 ml/minute and ethanol: water (solvent) composition of 100:0.
Formulasi Sediaan Sabun Mandi Cair dari Jus Lidah Buaya (Aloe barbadensis Mill.) Kartiningsih Kartiningsih; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Aloe vera leaf contains hydroxyanthraquinone derivatives, aloin (barbaloin and the distereoismeric 10-C glucosides of aloe-emodin anthracene) and 7-hydroxyaloin isomer and to a lesser extent aloe emodin, chrysophanol, chromone derivative and aloeresin as major glycoside-anthracene derivative. The aloin content varies in different species of aloe. The main constituent of aloin is barbaloin which is a pale yellow crystalline glycoside, soluble in water. Recent studies confirm that aloe has an antibacterial (against Staphylococcus ssp. and Streptococcus ssp.) and a fungicidal activity, so it can be used as antiseptic agent. The main purpose of this research was to obtain a physically stable liquid soap containing aloe vera. The formulation contained sodium lauryl ether sulphate with various concentrations. The obtained liquid bath soaps were evaluated cencernng their stability i.e.: viscosity, surface tension, and pH for eight weeks. Each formula gave a viscosity in the range of 8100 to 10400 cps and showed a pseudoplastic flow.
Uji Aktivitas Enzim Xilanase Ekstraselular dan Intraselular Bakteri Endofitik Tanaman Brucea javanica (L.) Merr. Shirly Kumala; Wibowo Mangunwardoyo; Diah Dethriani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Assay for xylanase enzyme activity of endophytic bacteria from Brucea javanica (L.) Merr. has been carried out. Parts of the plants used in this study were stem, leave and fruit. Samples were collected from Bogor, Cianjur and Tawangmangu. To evaluate the enzyme activity the fungi were shakefermented for 14 days. The supernatant were used to examine the extracellular enzyme and biomass for intracellular enzyme, using DNS methode to test the activity of enzyme. The results showed that from ten isolates only four isolates produced xylanase enzyme. Isolate 2.3.1 and 2.3.6 produced extra and intracellular enzyme, while isolate 2.1.15 and 2.3.13 only produced extracellular xylanase enzyme.
Pengaruh Pemanasan Berulang terhadap Sifat Fisikokimia dan Kandungan Asam Palmitat pada Minyak Goreng Yunahara Farida; Irene Frederika Siregar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Determination of physicochemical properties and contents of its palmitic acid of cooking oil have been done. The treatment of physicochemical properties of cooking oil was carried out after heating on temperature 150, 170, 200 and 225°C for 7 days and then it was stored. The result showed that physicochemical properties from the refractive index, specificic gravity, acid values, peroxide values, total carbonil and thiobarbituric acid, are increased but iodine values is decreased by treated on temperature and time stored. The content of palmitic acid from palm oil which determine by gas chromatography decreased on the third days of storing.
Penetapan Kadar Simultan Deksametason dan Metilprednisolon dengan Metode Kromatografi Gas Spektrometri Massa melalui Derivatisasi Swasono R. Tamat; Ernawati Ernawati; Linda Rosalina; Sonny Pujianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This investigation is intended to find a simultaneous assay method for glucocorticosteroids declared as doping compound by the International Olympic Committee. Experiments were carried out in the determination of dexamethason and methylprednisolon in urine matrix by gas chromatography-mass spectrometry (GC-MS) using various derivatisation reagents, reaction temperature and time. Selection of the best derivatisation reagent was based on the separation of total ion chromatogram (TIC) and appearance of three characteristic ions, m/z 305, 345,680 or m/z 206,456, 662 for dexamethasone; and m/ z 279, 369, 459 or m/z 147, 424, 644 for methylprednisolone. Dexamethasone and methylprednisolone derivates in the GC-MS spectra were identified by characteristic ions of m/z 305 (dexamethasone) and m/ z 279 (methylprednisolone). The best derivatisation yield was achieved by a combination of TMSI - [BSTFA-TMCS (99:1)](2:1) reacted at 90°C for 90 minutes, which produced a linear correlation between concentration (0-150 ng/ml ) and ratio of quantitation-ion abundance of standard compound/ion abundance of D3-testosterone internal standard with r= 0.9937 for dexamethasone and r=0.9823 for methylprednisolone; high precision CV=12.14% (dexamethasone) and CV=13.87%(methylprednisolone); high recovery for both dexamethasone and methylprednisolone, and LOD values of 4,44ng/ml (dexamethasone) and 1.80ng/ml (methylprednisolone). The method can be used for simultaneous quantitative assay of glucocorticosteroids, and has been validated for ten other glucocorticosteroid compounds.
Analisis Cemaran Logam Berat dalam Buah Ananas comosus (L.) Merr. Kaleng secara Spektrofotometri Serapan Atom Setyorini Sugiastuti; Sediarso Sediarso; Wila Lesthia Kharisma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study evaluated heavy metal contamination (lead, copper and cadmium) of canned pineapple. The research was done towards some canned pineapples with different expiry date, one year, two years and three years using wet digestion and atomic absorption spectrophotometry. The result showed that the lead contamination values of 1, 2 and 3 years expiry date canned pineaplles are 0.93 ppm, 0.73 ppm and 0.23 ppm. The copper contamination values are 2.15 ppm, 1.56 ppm, 0.92 ppm while the cadmium contamination values are 0.02 ppm, 0.02 ppm, 0.01 ppm. The closer to the expiry date, the higher values of heavy metal contamination.
Studi Farmakognosi, Penapisan Fitokimia, dan Uji Hayati secara BSLT dari Buah Merah (Pandanus conoideus Lam.) Ratna Djamil; Dian Karina; Wiwi Winarti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Nowadays Buah Merah (Pandanus conoideus Lam.), the Indonesian herb is famous for medicinal treatment. The chemical constituens of the fruit have been examined, and brine shrimp lethality test (BSLT) have been carried out. On phytochemical screening, the fruit showed the existence of: volatile oil, sterol, triterpene, carrotene, higher fatty acid, flavon aglycon, emodols, coumarine, tannin, steroid glycoside, reducing compound, flavonoside, antosianoside and saponine. Brine Shrimp Lethality Test showed that the LCs of the n-hexane fraction of the fruit was 24.17 ppm, the ethyl acetate fraction was 29.24 ppm, while the methanol fraction was 94.01 ppm. It could be concluded that the n-hexane fraction has the highest biological activity.
Gambaran Histopatologi Pankreas Tikus Hiperglikemia setelah Mengkonsumsi K-Karagenan dan í-Karagenan Lestahari Rahayu; Rahma Damayanti; Thamrin Wikanta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Research on the effect of K-carrageen and i-carrageen feeding on the representation of pancreatic B-cell histopathology of hyperglycemic rat has been carried out. Rats were previously damaged by aloxan monohydrat induction. There were 6 groups of rats, each group containing 5 animals. Group I normal control, group II negative control, group III 1st positive control, group IV 2nd positive control, group V K-carrageen treatment, group VI i-carrageen treatment. Group I, II, IV, V, and VI, were given orally, while group III was given subcutaneously. All the treatments were given during 15 days. All the rats were then killed and pancreatic hystopathology were carried out. The results revealed that aloxan monohydrat induction resulting the rat pancreatic weight reduction in all treatment groups. The ratio of rat body weight to the pancreatic weight was not significant difference in all treatment groups. Insulin injection was unable to increase the size of Langerhans islet and unable to support the recovery process of pancreatic damaged due to aloxan induction. On the other hand, chlorpropamide, K-carrageenan, and i-carrageenan were able to increase the size of Langerhans islet because they can support the recovery process of pancreatic organ damaged due to aloxsan induction. Insulin injection was unable to increase the ratio of Langerhans islet diameter to the amount of B-cells. While, chlorpropamide, K-carrageenan, and i-carrageenan were able to increase the ratio of Langerhans islet diameter to the amount of ß-cells. The macroscopic observation revealed that there was a black spot on the rat intestine receiving carrageen.

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