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Majalah Patologi Indonesia
Published by Perhimpunan Ahli Patologi Indonesia
ISSN : 02157284     EISSN : 25279106     DOI : https://doi.org/10.55816/
Core Subject : Health,
Health Professions Public Health
Majalah Patologi Indonesia (MPI) digunakan sebagai wahana publikasi hasil penelitian, tinjauan pustaka, laporan kasus dan ulasan berbagai aspek di bidang patologi manusia. Tujuannya ialah menghadirkan forum bagi permakluman dan pemahaman aneka proses patologik serta evaluasi berbagai penerapan cara diagnostik sejalan dengan kemajuan perkembangan ilmu dan teknologi. Selain itu juga untuk merangsang publikasi barbagai informasi baru/mutakhir.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 8 Documents
 1 
Search results for , issue "Vol. 34 No. 1, Januari 2025" : 8 Documents clear
Thyroid Leiomyosarcoma: A Rare Case Report Juanita; Maulana, Aries; Yamin, Amalia; prihatni, Imeldi; Sungowati, Ni Ketut; Miskad, Upik Anderiani
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.553

Abstract

Background Primary thyroid leiomyosarcoma is a very rare tumor. The incidence is less than 0.01% of all primary thyroid tumors. Thyroid leiomyosarcoma are tumours showing smooth muscle differentiation, originating from thyroid gland vascular smooth muscle. Case Description Female, 47 years old, with lump on the left neck since 1 year ago, getting bigger in the last 3 months, no shortness of breath, no history of previous surgery. Physical examination revealed a mass was 13x6 cm in size, solid, firm.  Cytological features from fine needle aspiration biopsy (FNAB) showed cellular spindle cells with atypical, pleomorphic, hyperchromatic nuclei and  several normal thyroid follicles among them, sugesting  malignant thyroid tumor (Bethesda VI). Total thyroidectomy was performed, followed by histopathological examination. Microscopically showed proliferation of atypical, pleomorphic, hyperchromatic spindle cells with eosinophilic cytoplasm. The spindle cells arranged in fascicular and interlacing pattern. Several follicular thyroid are entrapped within this atypical spindle cells. Based on these finding, this case was diagnosed as anaplastic thyroid carcinoma. To confirm the diagnosis, immunohistochemical examination with cytokeratin, desmin and Ki-67 were performed and the result showed negative for cytokeratin, positive for desmin and Ki-67 was highly positive. Based on these results, a diagnosis of thyroid leiomyosarcoma was made. Discussion and Conclusion Differential diagnosis with other primary mesenchymal thyroid  tumors should be considered in the cases with atypical spindle cells microscopic appearance. The diagnosis of thyroid leiomyosarcoma based on cytology and histopathology is difficult to establish, therefore immunohistochemical staining is required to establish the accurate final diagnosis.
Clinicopathological Characteristics of Cutaneous Melanocytic Lesions for Predicting Biological Behavior: 5 Years Retrospective Study in National Referral Hospital Rosari, Bayu Perkasa; Arisanty, Riesye
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.648

Abstract

Background Cutaneous melanocytic lesions have variety of subtypes ranging from benign (nevus) to malignant lesions (malignant melanoma). Differentiating benign and malignant melanocytic lesions is challening, particularly due to overlapping characteristics. This study was conducted to determine clinicopathological characteristics of cutaneous melanocytic lesions and the prevalence ratio of each characteristic for predicting malignant behavior. Method Cross-sectional study was conducted with data retrieved from Anatomic Pathology Department of Faculty of Medicine Universitas Indonesia and Dr. Cipto Mangunkusumo Hospital. Data of 145 histopathology-confirmed cutaneous melanocytic lesions cases between 2018 – 2022 were sampled and collected. Bivariate analysis was used to determine the prevalence ratio of each characteristic to predict malignant behavior. Result Out of 145 cases, 14.5% were malignant lesions (melanoma) and the rest were benign (nevus). Clinicopathology features and characteristics were correlated with malignant behavior, such as cytological atypia (p <0.01), dermal mitosis (PR=91.5; p<0.01), asymmetry (PR=31.8; p <0.01), suprabasal melanocyte (PR=21.4; p <0.01), lower extremity location (PR=6.5; p <0.01), sized >6 mm (PR=5.2; p <0.01), and male gender (PR=3.3; p <0.01). Conclusion Clinicopathological characteristics of cutaneous melanocytic lesions such as cytological atypia, dermal mitosis, asymmetry, suprabasal melanocyte, lower extremity location, sized >6 mm, dermal lymphocytic infiltrate, and male gender were predictive to predict malignant lesions.
Limfadenitis KronikGranulomatosa Profil Klinikopatologik Limfadenitis Kronik Granulomatosa Tuberkulosis dan non-Tuberkulosis di Departemen Patologi Anatomik FKUI-RSCM Periode Tahun 2018-2022 Nurlia Erdian, Defi; Harahap, Agnes Stephanie; Ham, Maria Francisca
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.609

Abstract

Background Chronic granulomatous lymphadenitis (CGL) is an inflammatory condition associated with lymphoproliferative lesions, infections, and autoimmune diseases. One of the etiologies of CGL is Mycobacterium tuberculosis (MTB). According to WHO data in 2020, Indonesia still ranks third globally for TB cases. To ensure appropriate patients’ treatment, there is a need to accurately diagnose TB lymphadenitis through clinicopathological. Therefore, this research aimed to determine the clinicopathological features that differentiate TB lymphadenitis from other types. Method This research was a retrospective analytical review and data were collected from the Department of Anatomic Pathology archives, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital for 5 years, from 2018 to 2022. Clinical data were obtained from electronic medical records. The histopathological assessment involved evaluating the presence of polymorphonuclear cells (PMN), datia cells, and central necrosis in CGL. Result A total of 156 CGL cases were identified, with 63.8% of TB lymphadenitis patients being female and the highest age group was <45 years. No significant association was found between age, a history of autoimmune diseases, malignancy, and TB lymphadenitis. The most commonly involved lymph node location was in the colic area, with a proportion of 62.2%. There was a significant association between lymph node location and the occurrence of TB lymphadenitis (p<0.003). Other variables assessed included the presence of PNM cells (81.7%), datia cells (94%), and central necrosis (88.8%), with p-values <0.000 for each variable. The results showed a significant association between PMN cells, datia cells, and central necrosis with TB lymphadenitis. Conclusion The characteristics of the female gender, lymph node location, presence of PMN cells, central necrosis, and datia cells could be considered as features to assess for diagnosing CGL caused by MTB.
PROFIL KLINIKOPATOLOGI KARSINOMA LARING DI RSUD DR SOETOMO, SURABAYA 2018-2021 Djuanda, Stephanie Natasha; Kusumastuti, Etty Hary; Ariani, Grace
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.614

Abstract

Introduction Laryngeal carcinoma is the second most common malignancy of the respiratory tract1. Based on 2020 Global Cancer Observatory data, the incidence rate of laryngeal carcinoma is 184,615 cases with a mortality rate > 50%2. There are some prognostic factors that predict the prognosis and 5 year survival rate of the patients. Study of this factor is very important because it will affect the patient's management 1,3.The clinicopathological profile is very important in laryngeal carcinoma because the majority of specimen are received in the small biopsies. Methods This research is observational descriptive study with a retrospective approach. Population of this study are paraffin blocks obtained from biopsy and surgical that had been diagnosed histopathologically as laryngeal carcinoma in the Dr. Soetomo General Academic Hospital from January 2018 - December 2021. Demographic, radiologic and histopathology data were taken from the patient's medical records. Results The majority patients were males (93%). The average age of patients was 59 (±5.91) years, with age range is 27 – 84 years, peak incidence were in 61-70 years (34.1%). The tumor located mostly in glottic (60.2%). Based on the T and N staging, most patient came at T4 and N2 stage. All the tumor were conventional squamous cell carcinoma. Conclusion Clinicopathology profile is very important in determine the prognostic factor in laryngeal carcinoma. Most of patient were males, in age group 61-70 years, located in glottis. Most patient came at advanced stadium. Most tumor were conventional squamous cell carcinoma, and the majority was well differentiated grade.  
KESESUAIAN DIAGNOSIS FINE NEEDLE ASPIRATION BIOPSY DENGAN HISTOPATOLOGI POSTOPERATIF PAPILLARY THYROID CARCINOMA DI RUMAH SAKIT RUJUKAN DALAM 3 TAHUN Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.624

Abstract

Introduction Thyroid carcinoma is the most common malignancy of the endocrine organ, with papillary thyroid carcinoma being the most common variant. Fine needle aspiration biopsy is still one of cost-effective and less invasive preliminary tests for thyroid lesion. The Bethesda System for Reporting Thyroid Cytopathology uses six categories for thyroid reporting. Methods This was an observational descriptive study with retrospective approach. Data of patients with postoperative histopathology diagnosis papillary thyroid carcinoma was obtained. We then retrieved and reviewed all the previous FNAB slides. All was classified based on Bethesda system for reporting thyroid cytopathology. We considered only patients with histopathology proven diagnosis who underwent FNAB in the same institution. Results 56 cases of FNAB with post-operative histopathology diagnosis papillary thyroid carcinoma were obtained, 34 (62%) of them were diagnosed as papillary thyroid carcinoma, 9 (14.8%) cases were non diagnostic, 10 (17.8%) cases were diagnosed as benign, and 3 (5.3%) cases fell into atypia category. Conclusion Pre-operative FNAB had 36% rate of misdiagnosis, with benign criteria being the most common category. Cases with non-diagnostic category should do repeated FNAB with USG guiding to decrease the possibility of misdiagnosis. Nodule with less than 1 cm size cause the most common misdiagnosis in this study. Most malignant FNAB result has more than 6 cm size.
Comparison of Examination Results of Cytocentrifuge Cytology and Cell Block Methods on Pleural Fluid Confirmed with Calretinin Immunohistochemistry as Mesothelial Cell Marker Fitri Desimilani, Fitri Desimilani; Mariedina, Causa Trisna; Betty, Betty; Soekimin, Soekimin; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.627

Abstract

Background Pleural effusion is an abnormal accumulation of fluid in the pleural cavity, which occurs as a result of disturbance in the balance between production and reabsorption. Cytologycal examination is important as diagnosis, determining the stage, guiding further treatment for malignancy. Effusion fluid is often processed using cytocentrifuge cytology or cell block methods which have their advantages and disadvantages. Calretinin as mesothelial cell marker valuable for establishing a more definitive cytopatholgical diagnosis. Methods Analytic observational study with a cross-sectional approach of 49 samples cytologically diagnosed pleural fluid specimens at private hospital in Medan. Examination method cytocentrifuge cytology and cell block followed calretinin immunohistochemistry. Data analysis was tested with Chi-square test. Results The result of pleural effusion examination were confirmed by calretinin immunohistochemistry, which showed positive mesothelial cell in 45 cases (91,8%), while those who did not show or negative mesothelial cell were 4 cases (8,2%). Conclusion There was a significant different between the result of the cytocentrifuge cytology and cell block methods with a p-value < 0,001.
Hubungan Ekspresi Imunohistokimia Matrix Metalloproteinase-9 dengan Tumor Budding Peritumoral dan Subtipe molekuler pada Invasive Breast Carcinoma of No Special Type Indriani Saragih, Septina; Delyuzar, Delyuzar; Intan, T. Kemala
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.642

Abstract

Abstract Background Breast cancer ranks first most often in the world and is a malignant cancer that often occurs in women. Matrix metalloproteinase-9 (MMP-9) has been the focus of attention in several previous studies in the field of breast cancer. MMP-9 plays a role in the degradation of the extracellular matrix. High expression of MMP-9 is associated with tumor aggressiveness, metastatic potential and poor prognosis. The presence of tumor budding and molecular subtypes also indicates tumor aggressiveness, one of which is the potential for metastasis through extracellular matrix degradation. The aim of this study was to analyze the association of MMP-9 mmunohistochemistry expression with peritumoral tumor budding and molecular subtypes in IBC-NST. Methods This study is an analytic study with a cross sectional approach on 41 samples of paraffin block cases of IBC-NST which had been diagnosed histopathologically and then performed with MMP-9 mmunohistochemistry staining. The correlation between the immunohistochemical expression of MMP-9 with peritumoral tumor buds and molecular subtypes in IBC-NST was tested statistically using Somers'd test and Eta test. Results There was a significant relationship between the immunohistochemistry expression of MMP-9 with peritumoral tumor budding and molecular subtypes. Conclusion Reporting the results of MMP-9 expression on IBC-NST can be one of the prognostic criteria that can be applied in routine examinations. However, the relationship with prognosis cannot be concluded from this study because it is not associated with survival rate
The Correlation of Immunohistochemical Expression of Matrix Metalloproteinase-9 with Tumor Budding Index and Histopathological Grading in Endometrial Carcinoma Nafilah Yuzar, Devi; Chrestella, Jessy; Ibnu Alferraly, T.; Soekimin, Soekimin; Trisna Mariedina, Causa; Nadjib Dahlan Lubis, M.
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.643

Abstract

ABSTRACT Background Malignancies of the uterine corpus are the sixth most common malignancy in women, where endometrial carcinoma accounts for the largest number of these cases. Tumor budding has been described as a sign of cancer cell motility and as an early step in the metastatic process. One of the most important aspects of the metastatic process is the correlation between tumor budding and the epithelial mesenchymal transition (EMT), that are characterized by an increase matrix metalloproteinases. One of MMPs is Matrix Metalloproteinase-9 (MMP-9) which plays a role in degrading the extracellular matrix and basement membrane, which is a prerequisite for the process of invasion and metastasis. Method This is an analytic study with a cross sectional approach on 38 surgical samples diagnosed as endometrial carcinoma and then performed with MMP-9 immunohistochemical staining. The statistical analysis was performed to analyze the correlation of immunohistochemical expression of MMP-9 with tumor budding index and histopathological grading in endometrial carcinoma. Results Based on statistical analysis for 38 samples of endometrial carcinoma patients, there was a significant correlation between the immunohistochemical expression of MMP-9 with tumor budding index with p-value: 0.021 and histopathological grading with p-value: 0.005. Conclusion There was a significant correlation between the immunohistochemical expression of MMP-9 with tumor budding index and histopathological grading in endometrial carcinoma, where the immunohistochemical expression of MMP-9 increased at high tumor budding index and histopathological grading as well.

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