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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol 19, No 2 (2013)" : 12 Documents clear
AIR GANDARUSA (Justicia gendarussa Burm. f.) DAN GAMBARAN GEN HYALURONIDASE LEWAT ANALISIS PCR Sri Lestari Utami; Didik P. Restanto; Bambang Prajogo EW
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1059

Abstract

Gandarusa (J. gendarussa Burm. f.) is an etnomedicine which is used as a male contraceptive alternative, known to inhibit the enzymefunction of spermatozoa hyaluronidase during fertilization. One of the ideal contraceptive conditions is the safetyness (among others nonmutagenic), requiring a long research during the verification process. The early research is the gene expression of hyaluronidase mice(M.musculus L.) testis given water fraction of the gandarusa with PCR analysis. The total RNA was isolated from the normal mice testis(as the negative control or no treatment group) and the mice testis from the treatment groups. The treatment groups consisted of group Iand II treated with water fraction of the gandarusa 15 mg/20 gr BW and 7.5 mg/20 gr BW, subsequently, the positive control group wasalso given hesperidins 1 mg/20 gr BW once a day per oral during the 1.5 times of spermatogenesis cycle (for 55 days). The results of thestudy showed that (1) the cDNA fragment confirmed as the gene of hyaluronidase mice testis (with 710 bp length of nucleotide) passedthrough RT-PCR at the total RNA negative control group, sequenced, isolated and alignment in the NCBI gene bank. (2) the same cDNAfragment gene of hyaluronidase mice testis (from the negative control group) did not transcript in the treatment I and positive controlgroups (where there is no band), but this gene will be transcripted in the treatment II group (where the band is emerged).
GAMBARAN KLINIS SEPSIS DAN KADAR NITRIC OXIDE PADA MENCIT YANG DIIMBAS DENGAN LIPOPOLYSACCHARIDE Sotianingsih Sotianingsih; Soeharyo Soeharyo; Lisyani S; Guntur H
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1058

Abstract

Sepsis remains a health problem because of the high related mortality and morbidity. One of the efforts is the improvement of knowledgeabout manifestation and pathophysiology of sepsis at the level of molecular biology. Nitric oxide (NO) levels increased in sepsis and this isrelated to the occurrence of cell apoptosis. The purpose of this study was to know and to see the clinical picture of sepsis and elevated levels ofNO in mice Balb/C which were injected with lipopolysaccharide (LPS). In this research, the mice were divided into three (3) groups, groupA were injected with saline, group B were injected with LPS 0.1 mg per mouse, while group C was injected with 0.2 mg per mouse. Themice were then measured by clinical parameters from day 0 and day 1, and 3,5 to 7. The levels of NO were assessed by blood sampling asmuch as 1 cc from the peri orbital plexus and examined by Griess method on days 1, 3, 5, 7. The results of the study showed that from theweight parameter there was a decrease in body weight on day 1 in group B and C and the weight continued to decline until day 3. From thetemperature parameter it was shown that the temperature decreased both in group B and C on day 1 but on day 3 and so on varies in bothgroups. From the piloerection parameters from day 1 to day 7 showed that there was piloerection in both groups. Related to the discharge byperi orbital parameters and diarrhoea many variations, occurred on day 1 peri orbital discharge and diarrhoea was found, but not uniformlyin all the mice in each group. On day 5 and 7 the peri orbital discharge and diarrhoea were not visible. NO levels increased mainly on day3 and the percentage was higher in group C and on day 5 and day 7 the levels were negative. In conclusion in this study it was shown, thatthe clinical picture is striking, weight loss and increased levels of NO occurs on day 3 of the observation.

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