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Jurnal Jejaring Matematika dan Sains
Published by Universitas Palangka Raya
ISSN : -     EISSN : 26861658     DOI : -
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Physics
Jurnal Jejaring Matematika dan Sains dikelola oleh Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Palangka Raya Dengan e-ISSN 2686-1658, merupakan wadah bagi peneliti yang bergerak dibidang Sains khususnya Fisika, Kimia dan Biologi serta penelitian di bidang Matematika untuk dapat mempublikasikan hasil penelitian yang telah dilakukan. Fokus utama dalam jurnal ini adalah pengelolaan serta pemanfaatan potensi lokal khususnya di daerah Kalimantan untuk berbagai terapan dalam menjawab permasalahan masyarakat serta berkontribusi dalam perkembangan ilmu pengetahuan. Jurnal Jejaring Matematika dan Sains bersifat Open Access terbit setiap 6 bulan sekali dengan 8 artikel setiap terbitannya.
Arjuna Subject : Umum - Umum
Articles 5 Documents
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Search results for , issue "Vol. 4 No. 1 (2022): Vol. 4 No. 1 (2022): Edisi Juni 2022" : 5 Documents clear
Uji In Silico Ellagic Acid sebagai Agen Anti Hiperpimentasi: Uji In Silico Ellagic Acid sebagai Agen Anti Hiperpimentasi Ni Kadek Sita Febriyanti
Jurnal Jejaring Matematika dan Sains Vol. 4 No. 1 (2022): Vol. 4 No. 1 (2022): Edisi Juni 2022
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2021.v4.i1.704

Abstract

Hyperpigmentation is a skin problem that occurs due to excess melanin synthesis. One of the factors that cause hyperpigmentation is continuous exposure to UV rays on the skin. Melanin biosynthesis is catalyzed by the melanogenic enzyme tyrosinase. Melanin synthesis can be inhibited by using anti hyperpigmentation agents, one of which is sourced from natural ingredients. Ellagic acid is a phenolic compound that is widely found in plants and has antioxidant activity so that it can inhibit hyperpigmentation through ROS inhibition mechanism. This study aims to determine the potential of ellagic acid in inhibiting the tyrosinase enzyme which will be compared with its native ligand in silico. The in silico test was carried out by molecular docking with the steps of preparation and optimization of ellagic acid using Hyperchem 8, preparation of the tyrosinase enzyme using Chimera 1.11.1, validation and docking using AutoDockTools 1.5.6 equipped with Autodock 4 and Autogrid 4. Molecular docking methods can be declared valid if the value of RMSD (root mean square distance) obtained is not more than 3 . The results of the molecular docking test showed that ellagic acid had an affinity for the tyrosinase enzyme. The bond energy values ​​obtained indicate that the affinity of ellagic acid is stronger and more stable for tyrosinase compared to native ligands. The bond energy value between ellagic acid and tyrosinase is -5.78 kcal/mol. Meanwhile, the binding energy between tyrosinase and its native ligand is -4.83 kcal/mol, so that ellagic acid has the potential as an anti hyperpigmentation agent through the mechanism of inhibition of tyrosinase enzyme activity.
- REVIEW ARTIKEL : Uji Iritasi Sediaan Topikal dari Tumbuhan Herbal: - Sumarni, Ni Komang
Jurnal Jejaring Matematika dan Sains Vol. 4 No. 1 (2022): Vol. 4 No. 1 (2022): Edisi Juni 2022
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2021.v4.i1.703

Abstract

Irritation is an inflammatory phenomenon that occurs on the skin caused by the presence of foreign compounds on the skin. Factors that can cause irritation include contact time, penetration rate, area, and the level of toxicity of the materials used. Formulas and active substances used in a pharmaceutical preparation with a topical route can trigger side effects such as irritation of the skin. Thus, it is necessary to have a safety test that aims to meet product requirements before being marketed to the wider community. One of the safety tests that can be done is skin irritation test. Irritation testing can be carried out using four methods, namely draize, acute dermal, slug irritation test, and human patch test. The results of the study of 25 articles showed that only 16 preparations with herbal plant active substances had the best irritation index which was indicated by the irritation index (0.00) which means that the preparation did not irritate the skin. These plants are pomegranate peel, binahong leaves, jeruju leaves, red ginger, pinang seed husk, starfruit leaves, banana peel, clove flowers, seeds of papaya, shallot peel, ruruhi rind, sappan wood, pare fruits, eggplant peel, bay leaves, and longan leaves.
- REVIEW ARTIKEL: Penyembuhan Luka Insisi Sediaan Topikal dari Tanaman Herbal: - Agung Fajarningrum, Putu Yunda
Jurnal Jejaring Matematika dan Sains Vol. 4 No. 1 (2022): Vol. 4 No. 1 (2022): Edisi Juni 2022
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2021.v4.i1.705

Abstract

An incision wound is a wound made using a scalpel to open deeper tissues or organs, taking into account the size, location, and purpose of the wound. Many herbal plants have been reported to have wound healing activity and can be used as alternative therapies. This review aims to determine the potential of plants that have wound healing activity which is focused on studying herbal plants that have wound healing activity in vivo. The results of the study from 30 articles that plants that have wound healing activity are Dewa leaves, gotu kola leaves, tiger grass, jatropha, binahong leaves, earrings leaves, red betel leaves, african leaves, aloe vera leaves, jasmine leaves, kecombrang flowers, jengkol leaves, meniran leaves, broken bones, betadine leaves, kenikir leaves, Java wood stems, bitter melon leaves, Indian almond leaves. Herbal plant preparations of ethanol extract gel from red castor leaves (Jatropha gossypifolia Linn) gave the optimum effect in wound healing in rabbits at a concentration of 3%.
Potensi Clitoria ternatea sebagai Upaya Terapi Preventif Penyakit Alzheimer : Kajian Literatur: Potensi Clitoria ternatea sebagai Upaya Terapi Preventif Penyakit Alzheimer Lina Kurniasari; N. P. Ayu Wulandari Dewi
Jurnal Jejaring Matematika dan Sains Vol. 4 No. 1 (2022): Vol. 4 No. 1 (2022): Edisi Juni 2022
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2022.v4.i1.701

Abstract

One of degenerative disease on elderly people is dementia. Dementia is characterized by memory loss. Antioxidant is one of the pharmacological therapies that use to treat Alzheimer’s disease. Clitoria ternatea is one of plant that contains antioxidant. The purpose of writing this article is to provide information about the benefits of Clitoria ternatea in curing and preventing alzheimer’s disease. This method is carried out by studying literature from several related journals. The result showed that Clitoria ternatea is proven to be able to treat and prevent Alzheimer’s disease
Studi In Silico Theaflavin sebagai Agen Anti-Photoaging: Studi In Silico Theaflavin sebagai Agen Anti-Photoaging Febyani, Putu Dewi; I Gede Bayu Krisnayana
Jurnal Jejaring Matematika dan Sains Vol. 4 No. 1 (2022): Vol. 4 No. 1 (2022): Edisi Juni 2022
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36873/jjms.2022.v4.i1.702

Abstract

Photoaging is skin aging due to extrinsic factors. Photoaging occurs due to excessive degradation of collagen caused by excessive exposure to UV radiation. Excessive UV exposure triggers induction of MMP-1 activities that actively degrade collagen in skin. Theaflavin is known to have pharmacological activity related to anti-photoaging. This study aims to determine the mechanism of MMP-1 inhibition by theaflavin, a polyphenol compound with high antioxidant activity, using in silico molecular docking. Molecular docking in silico is carried out in several step such as optimization of the 3D structure of theaflavin compounds, preparation of target protein, method validation, and docking between optimized theaflavin compounds and the MMP-1 enzyme (PDB ID: 966C) which refers to the binding energy parameter where The lower the binding energy value, the stronger and more stable the bond between theaflavin compound and the MMP-1 enzyme will be. The results obtained in the form of an binding energy between theaflavin compound with the MMP-1 enzyme, which is -10,56 kcal/mol, while the binding energy native ligand with the MMP-1 enzyme is -11,03 kcal/mol. This energy indicates that theaflavin compounds have potential as anti-photoaging agents because they are able to inhibit the MMP-1 enzyme.

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