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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 11 Documents
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Search results for , issue "Vol. 8 No.1 (2025)" : 11 Documents clear
Toxicity and Alpha Glucosidase Inhibitory Activity of Roasted Kedawung Seed (Parkia timoriana) Supandi, Supandi; Hadi, Ismanurrahman; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57945

Abstract

Introduction: Kedawung (P. timoriana) seeds are empirically utilised as a traditional medicine; it also contains various phytochemical compounds, antioxidant activities as well as other beneficial pharmacological effects. In some regions in Indonesia, the utilisation of kedawung seeds is usually done by involving the roasting process. Aims: This study aims to investigate the effect of roasting on phytochemical compounds, toxicity and alpha glucosidase inhibitory effects. Method: Kedawung seeds were roasted at 150 ºC (15 minutes); then separated from the skin, powdered and macerated in ethanol. Result: The extract was phytochemically screened with the results obtained showing positive for saponins, flavonoids, alkaloids, and terpenoids. The following test is toxicity test using BSLT (Brine Shrimp Lethality Test) method as well as inhibitory activity on alpha glucosidase enzyme. The test results showed that kedawung extract had an LC50 of 78.18 ppm in the BSLT test, as well as inhibition of alpha glucosidase enzyme at 265.24 ppm. Conclusion: The results obtained show that the ethanol extract of roasted kedawung seeds still has phytochemical metabolite compounds, but is moderately toxic and has weak inhibition on alpha glucosidase

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