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Al-Iqra Medical Journal
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Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran
Published by Universitas Muhammadiyah Makassar
ISSN : -     EISSN : 2549225X     DOI : 10.26618
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Medicine and Health Indonesia is a peer-reviewed journal of medicine and health. This journal is designed as a forum for disseminating information and knowledge which is published twice a year. It publishes original articles, review articles, and case reports. It comprises biomedical science, clinical medicine, public health science, and medical science education. This journal has been established since 2018 (Print ISSN 2085-4145, ISSN Online 2527-2950) which is managed by the Faculty of Medicine, University of Muhammadiyah Makassar.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 2, No 1 (2019): Ophthamology" : 5 Documents clear
POTENSI SEL T MOBIL HER2 SPESIFIK MODIFIKASI CRISPR / CAS9 PD-1 / PD-L1 PEMBLOKIRAN SEBAGAI INOVASI TERAPI UVEAL MELANOMA Muhammad AH Khoiruddin; Yusi Windya Febriyanti; Nafia Amalia
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.2745

Abstract

Uveal Melanoma (UM) is the primary intraocular tumor most commonly found in adults. The combination of therapy, Brachytherapy, surgery, Tranpupillary Thermal Therapy (TTT), Proton Beam Theraphy has not produced satisfactory results. The discovery of HER2 receptors expressed by UM cells can be used as a specific antigen target for the treatment of CAR T-celss. However, the effectiveness of CAR T-cell immunotherapy in tumors results in immunosuppressive T cells caused by an increase in Programmed cell Death Ligand-1 (PD-L1). This literature review demonstrates the success of HER2-specific CART T Cells as UM therapeutic efforts capable of eliminating tumor cells. In addition, CRSPR / Cas9 PD-1 / PD-L1-blocking modified HER2-specific CAR T cells can be a gene innovation in UM sufferers. Further clinical trials are needed to prove the effectiveness of CRISPR / Cas9 PD-1 / PD-L1-Blocking modified HER2-specific CAR T Cells in the treatment of UM patients.Keywords: Uveal melanoma, CAR T cell, reseptor HER
POTENSI TEMPE (RHYZOPUS.SP) SEBAGAI SUMBER PHYTOESTROGENS UNTUK MENGAKTIFKAN DAN MENCAPAI SEL STEM DALAM PERBAIKAN LENSA KATARAK DAN PERBAIKAN METANOLIK DARI EKSTRAK GARLIC (ALLIUM SATIVUM) SEBAGAI TERAPI TERAPI DALAM KATAK DIABETIK Ihsan Otriami; Devin Mahendika; Dio Jainata
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.2746

Abstract

Cataracts are turbidity lenses that are normally transparent and light is passed through to the retina, which is caused by various things resulting in impaired vision. One of the causes of cataract is diabetes mellitus which manifests clinically as hyperglycemia. Various therapies have been developed to deal with cataracts. However, the therapy is a definitive form of surgery which causes long-term complications in the form of blindness. One of the therapeutic modalities developed today is stem cell therapy. Stem cells are undifferentiated cells and have high potential to become other cells. Stem cells can differentiate to repair damaged lentic capsules and the formation of subepithelial lamellar fibers. Stem cells proliferate and migrate will be assisted by estrogen. However, the use of estrogen often causes bad side effects for the body. So, estrogen replacement is needed which has the same effect but does not produce side effects.Tempe is a typical Indonesian food that has isoflavonoid content. Isoflavonoids are able to function as phytoestrogens in the human body and have the same function as 17β-estradiol. In stem cells, phytoestrogens will play a role in activating paracrine actin (Akt) and stromal cell derived-1 (SDF-1) signals. Phytoestrogens will accelerate the rate of mesenchymal stem cell (MSC) / induced pluripotential stem cell (iPSC) and bind to the right receptors, so as to increase the work effectiveness of stem cells. Meanwhile, in diabetic cataract conditions the potential for garlic methanolic has recently been developed in relation to antioxidant effects, effective hypoglycemic and scavenging oxidative stress factors such as H2O2 and decreasing protein fraction in the lens due to protein insolubility. Keywords : Tempe, Stem Cell, Phytoestrogens, Garlic, and Metanolic.
POTENSI 6-AZA-INDAZOLE SEBAGAI TERAPI YANG DAPAT DIPERBAIKI UNTUK PERAWATAN RETINOPATI DIABETIK MELALUI INHIBISI FAKTOR D PENYELESAIAN Dhitta Shabrina; Ihya Fakrurizal; Afid Brilliana P
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.2747

Abstract

Diabetes mellitus is a chronic disease that has a high prevalence in Indonesia. One of diabetes’ complications is Diabetic Retinopathy (DR). DR is one of the highest cause of preventable blindness in the world. The treatment for DR up till then uses intravitreal anti-VEGF injection, intravitreal steroid antiinflammation injection. Intravitreal administration can cause some side effects such as increased intraocular pressure and endophthalmitis. Furthermore, patient’s convenience is also disturbed, for always having to see a medical personnel frequently. One pathogenesis of DR is the activation of the complement system which causes lysis of endothelial cells and results in ischemic damage to the retina. This ischemic effect will stimulate VEGF secretion that manifests in the phase of Proliferative Diabetic Retinopathy (PDR). Inhibitor of D factor, 6-aza indazole is a small size protein, less than 300 Da which has the potential to inhibit progress of DR by interfering with the activation of alternative pathway (AP) of the complement system. This is supported by the in-vivo test result, where there is a significant inhibition of intraocular AP activation continuously for 8 hours after an oral administration of this agent at a dose of 30 mg/kg. But this study is still in a pre-clinical phase that uses mice as the subject. Therefore, there must be a further study and clinical trial to find out the dosage and safety of this agent to be applied to humans. Keywords: 6-aza indazole, alternative pathway, complement factor D inhibitor, diabetic retinopathy
PENGARUH TRANSPLANTASI SEL PUNCA MESENKIMAL TERHADAP PERJALANAN PENYAKIT ALZHEIMER BERBASIS PENELITIAN PADA TIKUS: SEBUAH TINJAUAN SISTEMATIS Naufal Nandita Firsty; Devi Nadilah; Ilman Arif Aritonang
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v2i1.2748

Abstract

Penyakit Alzheimer atau Alzheimer’ s disease (AD) merupakan salah satu penyakit neurodegeneratif yang paling umum didiagnosis pada populasi dunia, terkhusus pada wanita. Beberapa manifestasi patologi yang dapat diobservasi adalah deposisi beta-amyloid (Aβ), hiperfosforilasi protein tau, dan inflamasi yang ketiganya berperan sebagai core-pathology dari AD. Permasalahan terberat dari terapi AD saat ini adalah ketidakmampuan berbagai agen farmakologis saat ini untuk menghentikan progresivitas AD. Oleh karena itu, salah satu ikon terapi medis modern yaitu terapi sel punca atau stem cell (SC), khususnya menggunakan sel punca mesenkimal atau mesenchymal SC (MSCs) pada beberapa tahun terakhir telah dijadikan sebagai salah satu fokus studi terapi kuratif penyakit degeneratif yang selama ini hampir selalu tidak mungkin tercapai. Manuskrip tinjauan sistematis ini bertujuan untuk menjabarkan pengaruh transplantasi MSCs secara xenogenik maupun alogenik pada berbagai spesies tikus yang telah diinduksi dengan Aβ untuk mengalami kondisi AD buatan yang dilaporkan oleh berbagai penelitian orisinal pada beberapa tahun terakhir. Sebanyak 32 penelitian dijadikan sebagai referensi utama yang keseluruhannya menunjukkan perbaikan perihal manifestasi patologis seperti reduksi dari deposisi Aβ, penurunan kondisi inflamasi melalui berbagai biomarka, peningkatan aktivitas neurogenesis pada beberapa regio otak seperti hipokampus, dan efek neuroproteksi yang cukup signifikan. Pengaruh tersebut juga dapat diobservasi pada kondisi tingkah laku (behavior) tikus percobaan seperti perbaikan fungsi kognitif dan memori yang diukur berdasarkan metode observasi tertentu. Oleh karena itu, MSCs diduga memiliki potensi untuk menjadi sebuah terapi kuratif bagi AD yang selama ini tidak mampu menghentikan progresivitasnya.
KARAKTERISASI MICRORNA TRIPLE HELIX MELALUI METODE HYDROGEL SCAFFOLD SPESIFIK TERHADAP MICRORNA-26A DAN HSA-MICRORNA-15A: MODALITAS KURATIF MUTAKHIR PADA PENYAKIT KATARAK Nisrina Hanifa Afnan; Endah Sari R.Kumala; Mochammad Afifuddin
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.2749

Abstract

Cataract is an eye disease that is marked by it decrease in lens transparency. Cataract is a major cause of blindness. Data The World Health Organization (WHO) in 2010 showed that there were 285 million people have visual impairments worldwide, 39 million of them blindness where 33% of them are caused by cataracts. Governance cataracts are currently limited to surgical efforts and administration of eye drops as antioxidant. But both have flaws because of the risk of complications limited ocular and lens penetrating ability. Therefore, the author reviewed the potential for triple helix microRNA characterization through specific Hydrogel Scaffold methods against microRNA-26a and hsa-microRNA-15a as the latest curative modalities on cataract disease. microRNA is a non coding RNA molecule consisting of 22 nucleotide. microRNA is known to have a specific target gene so it will increase the effectiveness of therapy in cataracts. The method used in this writing is a study of literature. The author reviews various sources, the majority come from a global journal. The author enters several keywords such as cataract, microRNA, triplex nanoparticle, and Hydrogel Scaffold. The website is used including nature, sciencedirect, pubmed, and ebsco. After extraction based on the inclusion and exclusion criteria that have been determined, the journal is then analyzed and synthesized whose results are written in this review literature. based on literature obtained, microRNA-26a has decreased expression in cataract cases. So that when microRNA-26a is transfected, there will be an increase in regulation which can increase the positive effect on inhibiting the process of fibrosis oncataract pathomechanism mediated by Notch / Jagged-1. Meanwhile, microRNA- 15a overexpresses, so that when transfected antagomir microRNA-15a, then this microRNA will decrease and give negative feedback so the expression of bcl-2 and mcl-1 as antiapoptotic and antioxidant proteins will be increased. To increase its stability, both microRNA-26a and antagomir microRNA-15a will be formed into a triple helix RNA structure through addition dendrimer with the Hydogel Scaffold method. This allows the microRNA become more stable in circulation and can be released in specific genes. By therefore, through the triple helix RNA characterization specific to microRNA-15a and microRNA-26a, cataract therapy is expected to be more effective and efficient. Keywords : cataracts, triple helix microRNA, microRNA-15a, microRNA-2

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