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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 24 Documents
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Search results for , issue "Vol 8 No 2 (2025)" : 24 Documents clear
Analisis Metode Perencanaan Dan Pengendalian Persediaan Obat Fast Moving Di Apotek Durikulon Negara, Sri Bintang Sahara Mahaputra Kusuma; Khumairo, Lina Nurna; Suryani, Andini
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p1-8

Abstract

Drug availability is a crucial component of pharmaceutical services to ensure optimal patient care. Inadequate inventory planning and control, particularly for fast-moving drugs, often lead to stock shortages or surpluses that disrupt services and increase operational risks. This study aimed to analyze drug inventory planning and control for fast-moving items at Pharmacy X using consumption methods, Economic Order Quantity (EOQ), safety stock, and reorder point (ROP) approaches. This descriptive quantitative research utilized stock cards and observation sheets as instruments. Data on drug usage, stock availability, and procurement patterns from November 2024 to January 2025 were collected and analyzed. The results showed that applying these methods, such as for Renadinac tablets, produced an optimal procurement plan of 539 tablets, EOQ of 416 tablets, safety stock of 490 tablets, and a reorder point of 791 tablets. Proper planning and inventory control effectively ensured drug availability and optimized stock management.
Analisis Tingkat Kepuasan Pasien Rawat Jalan Pada Pelayanan Kefarmasian Di Rumah Sakit Universitas Sebelas Maret Periode Bulan Oktober Tahun 2023 Abadi, Dzithauly Maulidiva; Rejeki, Endang Sri; Purwaningsih, Avianti Eka Dewi Aditya
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p66-71

Abstract

Pharmaceutical health services need to be considered service standards, one of which is about patient satisfaction with pharmaceutical services in hospitals. Patient satisfaction is the patient's assessment of the service delivery received. The purpose of the study was to determine the level of patient satisfaction with pharmaceutical services and determine the relationship between the level of satisfaction with the dimensions of patient satisfaction. This type of research is descriptive non-experimental with cross sectional method. The study used 100 respondents. Data collection using accidental sampling method. Data analysis used univariate tests to obtain frequency distribution of patient satisfaction levels. Simple linear regression bivariate analysis to determine the relationship between patient satisfaction level and satisfaction dimension. The patient satisfaction level of the pharmaceutical installation of Sebelas Maret University Hospital obtained reliability results of 75.25%, responsiveness 70.43%, emphty 69.16%, assurance 77%, tangible 74.87%. The relationship between service quality and the highest level of satisfaction obtained the responsiveness dimension of 0.742
Uji Aktivitas Analgetik Ekstrak Rimpang Bangle (Zingiber purpureum R.) Pada Tikus Putih Jantan Dengan Metode Writhing Test Shahira, Iyem; Ningsih, Dwi; Herowati, Rina
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p72-79

Abstract

Pain is an unpleasant emotional sensation caused by tissue damage. Bangle rhizome is a plant that can be used to treat pain. The purpose of this study was to determine the analgesic activity of a 96% ethanol extract of bangle rhizome in male white Wistar rats and to determine the most effective dose for producing analgesic effects. Bangle rhizome was extracted by maceration method using 96% ethanol solvent. This study used Writhing test method at 25 male divided into five groupes. Group I as negative control was administered 0,1% CMC, group II as positive control was administered acid mefenamic, group III, IV, and V was administered extract of bangle rhizome. The data obtained from this study were the number of wriggles of the test animals and the reaction time of the test animals' responses (minute). The result of the research showed that extract doses 30,843 mg/200 g BB, 61,686 mg/ 200 g BB, and 123,372 mg/ 200 g BB comparable to the positive control and different from the group given the negative control.. Extract dose 123,372 mg/ 200 gB compare with positive control was indicated that extract doses 123,372mg/ 200 g BB showed the highest analgesic activity.
PENGARUH VARIASI KONSENTRASI AVICEL PH 101 DAN LAKTOSA SEBAGAI HOST DALAM PEMBUATAN TABLET CAMPURAN INTERAKTIF GLIMEPIRID MENGGUNAKAN METODE KEMPA LANGSUNG Nugroho, Muhammad Agung; Kuncahyo, Ilham; Harjanti, Reslely
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p80-91

Abstract

Glimepirid is an antidiabetic drug from the sulfonylurea class with low solubility, thus requiring a formulation approach to improve its bioavailability. This study aimed to examine the effect of varying concentrations of avicel pH 101 and lactose as carrier (host) materials on the physical properties and dissolution profile of glimepirid tablets prepared using the direct compression method. Three formulas were developed with avicel pH 101:lactose ratios: F1 (1:0.5), F2 (1:1), and F3 (1.5:1). Quality evaluation included tests of granule flow properties (angle of repose and flow time) and physical tablet tests (content uniformity, hardness, friability, disintegration time, and dissolution) based on the Indonesian Pharmacopoeia. ANOVA statistical analysis showed significant differences between formulas (p < 0.05). The results indicated that variations in avicel pH 101 and lactose concentrations affected the physical quality and dissolution profile of the tablets. Formula 1 had the fastest disintegration time and the highest drug release. Formula 2 demonstrated the best content uniformity, good powder flow, and stable dissolution. Formula 3 produced the hardest tablets with the lowest friability but required longer disintegration time. Formula 2 was considered the most optimal and is recommended for further development of glimepirid tablets.
Studi In Silico : Aktivitas Senyawa Tanaman Kecombrang (Etlingera elatior) Sebagai Kandidat Obat Antihiperurisemia: Studi Awal Pemanfaatan Kecombrang Sebagai Terapi Alternatif Gout Fessolsalmin, Muhammad; Naufalin, Rifda; Wulansari, Putri Dian; Susanti, Susanti; Nurzaman, Moch Herdi; Fadilah, Nitya Nurul; Mardianingrum, Richa
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p126-135

Abstract

Hyperuricemia is a metabolic disorder caused by an increase in uric acid levels, which is at risk of ausing gout. The plant kecombrang (Etlingera elatior) is known to contain bioactive compounds that have the potential to act as xanthine oxidase inhibitors. This study aims to evaluate 50 compounds from kecombrang as antihyperuricemia candidates using an in silico approach. The analysis includes toxicity and pharmacokinetics (ADMET) predictions, Lipinski's rule of five, molecular docking, and molecular dynamics simulations. The docking results of selected compounds Aduncetin E (-8.93 kcal/mol) and Methyllinderatin (-8.78 kcal/mol) show the best affinity for xanthine oxidase enzyme with lower binding energy compared to allopurinol (-6.26 kcal/mol). Molecular simulations support the stability of the ligand-receptor complex the MMGBSA results indicate that Aduncetin E (13.4048 kcal/mol) and Methyllinderatin (-30.3009 kcal/mol) have potential that can be developed as antihyperuricemia drug candidates.
PENGEMBANGAN DAN VALIDASI METODE PENENTUAN RESIDU PELARUT DALAM BAHAN FARMASI AKTIF LAMIVUDIN MENGGUNAKAN KROMATOGRAFI GAS Safitri, Ayu Nadila; Abshar, Irham Fauzi; Herlambang, Aldillah
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pelarut kimia yang digunakan dalam sintesis bahan farmasi aktif dapat tertinggal sebagai residu pelarut yang berdampak negatif bagi kesehatan. Bahan farmasi aktif lamivudin beresiko mengandung residu pelarut berupa etanol, isopropil asetat, metanol dan trietilamina. Sedangkan metode penentuan residu pelarut dalam bahan farmasi aktif lamivudin sulit untuk diimplementasikan dan membutuhkan biaya yang mahal. Penelitian ini bertujuan untuk mengembangkan dan memvalidasi metode penentuan residu pelarut dalam bahan farmasi aktif lamivudin yang sederhana, tepat, dan akurat dengan menggunakan kromatografi gas. Percobaan dilakukan dengan sistem kromatografi gas (Sistem GC Shimadzu) yang dilengkapi dengan detektor ionisasi nyala. Hasil yang diperoleh dibandingkan dengan batas yang ditentukan dari pedoman standar USP. Parameter validasi dilakukan dengan mengevaluasi spesifisitas, linearitas, presisi, akurasi, batas deteksi, batas kuantifikasi, kestabilan larutan dan ketahanan. Tidak adanya interferensi puncak menunjukkan metode tersebut spesifik. Hubungan linear dievaluasi pada rentang 1-150% dan diperoleh koefisien regresi R’ untuk residu pelarut ≥0,9974. Nilai batas deteksi dan kuantifikasi memenuhi syarat dengan penentuan signal-to-noise (S/N). Nilai presisi pada enam kali pengulangan dan akurasi pada level konsentrasi 80%, 100% dan 120% menghasilkan nilai sesuai persyaratan. Pengujian ketahanan dengan modifikasi parameter tidak menunjukkan perbedaan yang signifikan. Semua larutan standar dan sampel menunjukkan kestabilan hingga 12 jam. Metode kromatografi gas yang sederhana, spesifik, akurat, presisi dan tangguh berhasil dikembangkan dan divalidasi.
Uji aktivitas penyembuhan luka sayat menggunakan sediaan patch ektrak etanol daun jambu biji (psidium guajava l.) secara in vivo Hafidz, Mulyadi Dai Muhammad; Rizkulloh, Lina Rahmawati; Nofriyaldi, Ali
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p100-107

Abstract

The ethanol extract of (Psidium guajava L.) leaves, containing key phytocmhemicals such as tannins, flavonoids, and saponins, has demonstrated potential in enhancing wound repair. This research aimed to formulate a transdermal patch and investigate its in vivo wound-healing activity. Extraction was carried out through maceration of the simplicia using 96% ethanol as the solvent. Patches were formulated with HPMC and PVP, containing 2.5%, 5%, and 10% extract (F1, F2, F3). Physical evaluation (homogeneity, pH, thickness, adhesion) was performed. Rabbits (n=5) with a 2 cm dorsal incision were treated daily with patches (F1-F3), A negative control was represented by a (patch without extract) while the positive control used (povidone-iodine). Wound length was measured for 7 days. All evaluations met the physical requirements except pH at (F2: 6,6±0,1; F3: 6,8±0,1). F3 (10% extract) showed the highest wound healing activity, reducing wound length to 2 mm on day 7, significantly better than the control (7 mm) and lower concentrations (F1: 4 mm; F2: 3 mm). Guava leaf extract patches were effective at healing incised wounds, with concentration-dependent efficacy.
PENGARUH KUALITAS PELAYANAN TERHADAP LOYALITAS PASIEN RAWAT JALAN RUMAH SAKIT LUDIRA HUSADA TAMA YOGYAKARTA: - Primantana, Y.B. Arya; Dwiastuti, Rini
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p92-99

Abstract

This study analyzes the effect of service quality on outpatient loyalty through patient satisfaction at RS Ludira Husada Tama Yogyakarta. Using purposive sampling, 150 outpatients completed SERVQUAL-based questionnaires analyzed with SEM-PLS. Results showed that tangible (p=0.017) and assurance (p=0.002) dimensions significantly influenced patient satisfaction, while reliability (p=0.554), responsiveness (p=0.646), and empathy (p=0.902) did not. Patient satisfaction significantly influenced loyalty (p=0.001). The findings indicate that physical facilities and service assurance are critical factors in building patient loyalty through satisfaction in outpatient settings.. Keywords: service quality, patient satisfaction, patient loyalty, outpatient, SERVQUAL
Evaluasi Efek Samping Penggunaan Nsaid Pada Pasien Osteoartritis Di Instalasi Rawat Jalan RSUD R.A. Kartini Jepara Ningrum, Nuzulatul Wahyu Mustika; Etikasari, Ria; Husna, Ulviani Yulia
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p118-125

Abstract

Osteoarthritis (OA) is a common degenerative disease in the elderly and a leading cause of disability. Excessive joint pain results in limited daily activities. In pharmacological therapy, Nonsteroidal Anti-inflammatory Drugs (NSAIDs) are the main choice for OA treatment. Appropriate use of NSAIDs in OA patients is essential to achieve optimal therapeutic outcomes. This study aimed to analyze and evaluate adverse effects of NSAID use in OA patients at the Outpatient Installation of RSUD R.A. Kartini Jepara. The research was conducted using a descriptive observational method with a retrospective design based on secondary data from medical records. Samples were determined through purposive sampling with inclusion criteria: OA patients aged 45–75 years who had at least three visits during January–December 2024. Exclusion criteria were incomplete or unreadable medical records. Data were analyzed descriptively to present patient characteristics, NSAID usage profiles, and adverse effects. The results showed that OA patients were predominantly female (72.9%), aged 65–75 years (46.9%), and had BMI >27 (53.1%). Most patients had disease duration >12 months (38.4%) and received NSAID therapy for more than 3 weeks (70.8%). Hypertension was the most common comorbidity (50%), while the most frequently used concomitant medications were gastrointestinal drugs (23.98%) and antihypertensives (23.17%). Meloxicam was the most frequently prescribed NSAID (51%). The most common adverse effects were gastrointestinal disorders, including dyspepsia (56.10%) and vertigo (17.07%).
Penetapan Kadar Total Fenolik dan Flavonoid Ekstrak dan Fraksi Ekstrak Kulit Buah Pepaya Muda (Carica papaya L.) Saptawati, Tunik; Ardani, Annisa Dea; Rachma, Firstca Aulia; Suwarni, Sri
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p136-143

Abstract

Papaya peel (Carica Papaya L.) is a plant that has several pharmacological activities because it contains secondary metabolites in the form of phenolics and flavonoids. This study aims to determine the total phenolic and flavonoid levels in the extract and fraction of papaya peel using the colorimetric method. The research method for determining total phenolic content with the Folin-Ciocalteu method, using gallic acid as a comparator, and the determination of total flavonoid content using the AlCl3 complex formation method with quercetin as a comparator, both using UV-Visible spectrophotometry. The results of the total phenolic content of the ethanol extract of papaya peel, the water fraction of papaya peel, the ethyl fraction of papaya peel, and the n-hexane fraction of papaya peel were 79.6393%, 65.5173%, 84.5257%, and 48.0085%, respectively. The results of the total flavonoid content of the ethanol extract of papaya fruit peel, the water fraction of papaya fruit peel, the ethyl acetate fraction of papaya fruit peel, and the n-hexane fraction of papaya fruit peel were 55.1744%, 33.2677%, 87.2572%, and 21.1696%, respectively. Based on these results, it can be concluded that the greatest total phenolic and total flavonoid content was in the ethyl acetate fraction of unripe papaya fruit peel extract.

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