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Zulfiayu Sapiun
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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 4, No 1 (2024): February 2024" : 5 Documents clear
Standarisasi Ekstrak Etanol Daun Sirsak (Annona muricata Linn.) Asal Daerah Gowa dan Takalar Amin, Asni; Rasyid, Faradiba Abdul; Syarif, Rezki Amriati; A.M, Sinta Faradilla; Saputri, Dicka; Sukmawati, Sukmawati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.972

Abstract

Tumbuhan sirsak (Annona muricata Linn.) memiliki aktivitas sebagai antikanker dan antiinflamasi. Bahan baku ekstrak daun sirsak yang akan dikembangkan menjadi obat modern Indonesia asli harus terstandardisasi untuk menjaga mutu ekstrak yang dapat dipengaruhi oleh tempat tumbuh. Penelitian ini bertujuan melakukan standarisasi ekstrak daun sirsak asal daerah Gowa dan Takalar. Masing-masing ekstrak daun sirsak dilakukan standarisasi dengan parameter spesifik dan non spesifik. Hasil penelitian diperoleh data untuk pengujian parameter spesifik berupa uji organoleptik ekstrak yaitu bentuk kental, warna coklat kehitaman, dan berbau khas. Kadar senyawa larut air dan etanol  sebesar 7, 560% dan 13,94%untuk Gowa, sedangkan Takalar sebesar 6,64% dan 10,1%. Hasil uji parameter non spesifik untuk daerah Gowa dan Takalar sebagai berikut, susut pengeringan 0,289% dan 0,293%, bobot jenis 0,814 g/mL dan 0,818 g/mL, kadar air 4,488% dan 7,436%, kadar abu total 4,467% dan 6,560%, kadar abu tidak larut asam 0,499% dan 0,248%, cemaran mikroba < 1,0 x 101 koloni/g, cemaran logam berat cadmium < 0,0001 µg/g,  cemaran logam timbal sebesar 0,0390 µg/g dan < 0,0471 μg/g, residu pestisida < 0,001 mg/kg. Penelitian ini menunjukkan ekstrak daun sirsak asal daerah Gowa dapat digunakan menjadi sumber bahan baku daun sirsak.Annona muricata Linn. has anticancer and anti-inflammatory activity. The raw material for soursop leaf extract, which will be developed into authentic modern Indonesian medicine, must be standardized to maintain the quality of the extract, which can be influenced by the place of growth. This research aims to standardize soursop leaf extract from the Gowa and Takalar areas. Each soursop leaf extract was standardized with specific and non-specific parameters. The results of the research obtained data for testing specific parameters in the form of an organoleptic test of the extract, namely thick form, blackish brown color, and distinctive smell. The levels of water-soluble compounds and ethanol were 7,560% and 13.94% for Gowa, while for Takalar they were 6.64% and 10.1%. The results of non-specific parameter tests for the Gowa and Takalar areas are as follows: drying loss 0.289% and 0.293%, specific gravity 0.814 g/mL and 0.818 g/mL, water content 4.488% and 7.436%, total ash content 4.467% and 6.560%, acid insoluble ash content 0.499% and 0.248%, microbial contamination < 1.0 x 101 colonies/g, heavy metal cadmium contamination < 0.0001 µg/g, lead metal contamination 0.0390 µg/g and < 0.0471 μg/g, pesticide residue < 0.001 mg/kg. This research shows that soursop leaf extract from the Gowa area can be used as a source of raw material for soursop leaves.
Potensi Ekstrak Etanol Daun Murbei (Morus alba L.) sebagai Antifungi terhadap Jamur Candida albicans Utami, Yuri Pratiwi; Rante, Herlina; Handayani, Tuti; Jariah, Ainun; Erianto, Fatricia
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.969

Abstract

Senyawa kimia di daun murbei (Morus alba L.), termasuk flavonoid, tanin, steroid, dan saponin. Salah satu golongan senyawa yaitu flavonoid memiliki sifat antioksidan, antibakteri, dan sifat antimikroba yang dapat meningkatkan kontraksi luka. Penelitian dilakukan untuk mengetahui bagaimana potensi daun murbei sebagai antifungi terhadap jamur Candida albicans. Untuk menghasilkan ekstrak yang akan diskrining fitokimia, teknik maserasi menggunakan pelarut etanol 70% digunakan untuk ekstraksi sampel. Uji bebas etanol dan dilanjutkan dengan pengujian antifungi terhadap jamur Candida albicans. Hasil ekstraksi memperoleh persen rendemen ekstrak 3,89%. Pengujian skrining fitokimia mengandung flavonoid, saponin dan tannin. Pengujian ekstrak dengan konsentrasi 1,25%, 2,5%, 5% dan 10% memiliki aktivitas sebagai antifungi terhadap Candida albicans yaitu 9,7 mm ± 0,36, 10,83 mm ± 0,45, 15,8 mm ± 3,31, 26,06 mm ± 3,27 dan ketokonazole sebagai kontrol positif 33,4 mm ± 0,57. Disimpulkan bahwa ekstrak etanol daun murbei memiliki aktivitas sebagai antifungi terhadap Candida albicans. Ekstrak etanol daun murbei dapat menghambat pertumbuhan Candida albicans hingga konsentrasi 1,25%, sehingga dapat dimanfaatkan sebagai antijamur.Chemical compounds in mulberry leaves (Morus alba L.) include flavonoids, tannins, steroids, and saponins. One class of compounds, namely flavonoids, has antioxidant, antibacterial, and antimicrobial properties that can increase wound contraction. Research was conducted to determine the potential of mulberry leaves as an antifungal against the fungus Candida albicans. To produce extracts that will be screened for phytochemicals, a maceration technique using 70% ethanol solvent is used for sample extraction. Ethanol-free test and continued with antifungal testing against Candida albicans fungus. The extraction results obtained an extract yield percentage of 3.89%. Phytochemical screening tests contain flavonoids, saponins, and tannins. Extract testing with concentrations of 1.25%, 2.5%, 5%, and 10% had antifungal activity against Candida albicans, namely 9.7 mm ± 0.36, 10.83 mm ± 0.45, 15.8 mm ± 3.31, 26.06 mm ± 3.27, and ketoconazole as a positive control (33.4 mm ± 0.57). It was concluded that the ethanol extract of mulberry leaves has antifungal activity against Candida albicans. Mulberry leaf ethanol extract can inhibit the growth of Candida albicans up to a concentration of 1.25%, so it can be used as an antifungal.
Efek Ekstrak Etanol 70% Herba Akar Kucing (Acalypha indica L.) dalam Menurunkan Kadar Gula Darah Mencit (Mus musculus) Jantan yang diinduksi Aloksan Nihe, Nur Fauziyah S.; Hartati, Hartati; Nur, Moh. Usman; Husain, Fadli
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.914

Abstract

Tanaman akar kucing (Acalypha indica L.) merupakan tanaman yang biasanya digunakan oleh masyarakat untuk mengatasi penyakit diabetes. Tanaman ini memiliki kandungan senyawa flavonoid dan alkaloid yang diduga memiliki efek terhadap penurunan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui konsentrasi ekstrak etanol herba akar kucing yang efektif dalam menurunkan kadar gula darah pada mencit (Mus musculus) jantan setelah diinduksi aloksan. Penelitian ini merupakan penelitian berjenis eksperimental laboratorium dengan kelompok perlakuan dosis yang berbeda yaitu F1 (5 mg), F2 (10 mg), dan F3 (15 mg) dan sebagai kontrol positif (K+) digunakan obat glibenklamid dan dilakukan pengukuran kadar gula darah menggunakan glukometer terhadap mencit jantan. Hasil penelitian menunjukkan penurunan kadar gula darah terjadi pada mencit yang telah diberikan ekstrak etanol herba akar kucing setelah 7 hari pengamatan dengan selisih penurunan yaitu F1 41 mg/dl (33,06%), F2 57 mg/dl (45,72%), F3 64 mg/dl (57,06%). Hasil uji One Way Anova menggunakan SPSS 25.0 menunjukkan bahwa terdapat perbedaan yang signifikan diantara 4 perlakuan tersebut dengan control positif. Kesimpulannnya bahwa semua konsentrasi ekstrak etanol herba akar kucing memiliki kemampuan dalam menurunkan kadar gula darah pada mencit dengan konsentrasi yang paling efektif adalah kelompok F3 15 mg (57,06%).The Acalypha indica L. is a plant that is usually used by people to treat diabetes. This plant contains flavonoid and alkaloid compounds, which are thought to have an effect on reducing blood glucose levels. This study aims to determine the concentration of the ethanol extract of the Acalypha indica herb that is effective in reducing blood sugar levels in male mice (Mus musculus) after being induced by alloxan. This research is a laboratory experimental type study with different dose treatment groups, namely F1 (5 mg), F2 (10 mg), and F3 (15 mg), and as a positive control (K+), the drug glibenclamide was used, and blood sugar levels were measured using a glucometer against male mice. The results showed that a decrease in blood sugar levels occurred in mice that had been given an ethanol extract of Acalypha indica herb after 7 days of observation, with a difference in the decrease, namely F1 41 mg/dl (33.06%), F2 57 mg/dl (45.72%), and F3 64 mg/dl (57.06%). The results of the one-way ANOVA test using SPSS 25.0 showed that there were significant differences between the four treatments and the positive control. The conclusion was that all concentrations of Acalypha indica herb ethanol extract had the ability to reduce blood sugar levels in mice, with the most effective concentration being the F3 15 mg group (57.06%).
Phytochemical Study of Green Meniran Herb (Phyllanthus niruri L.) and Red Meniran Herb (Phyllanthus urinaria L.) in Jekan Raya Sub-district of Palangka Raya City, Central Kalimantan Province Damiti, Sukmawati; Mashar, Harlyanti Muthma’innah; Yusuf, Baharuddin
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.891

Abstract

Kalimantan is one of the islands in Indonesia that is famous for its rich biodiversity. Knowledge about the use of traditional medicine using plants has been passed down from generation to generation among the ethnic natives of Kalimantan. One of the typical Kalimantan plants that is efficacious as traditional medicine and contains various potential secondary metabolites is meniran. Based on ethnobotanical studies in Central Kalimantan, meniran is boiled to treat fever, dysentery, jaundice, malaria, therefore further research is needed for the chemical content of meniran which is efficacious. This study aims to determine the phytochemical of green meniran herb (Phyllanthus niruri L.) and red meniran herb (Phyllanthus urinaria L.). Determination of plant samples was carried out for both types of meniran. Then processing, extraction and identification of chemical content. The yield values of each extract obtained were 7.40% and 8.76%. As for the results of phytochemical studies, green and red meniran herb both contain alkaloid, tannins and flavanoids, but green meniran is indicated to have steroid content and red meniran contains triterpenes. Secondary metabolites possessed by these two types of meniran plants are beneficial for health, including as antioxidants, antibacterial, antiviral, anticancer and a number of pharmacological activities that are significant in improving one's health and minimizing the risk of infection by pathogens. However, further research is needed to test the activity of the content of these two types of meniran as a basis for the manufacture of traditional medicines.
Anti-Inflammatory Activity Test of Ethanol Extract of Kencur Rhizome (Kaempferia galanga L.) on Male White Mice (Mus musculus L.) Induced Carrageenan Khasanah, Nisfi Lailatul; Riyanta, Aldi Budi; Susiyarti, Susiyarti
Journal of Experimental and Clinical Pharmacy (JECP) Vol 4, No 1 (2024): February 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v4i1.949

Abstract

Inflammation needs to be addressed, considering that inflammation is a local protective response caused by tissue damage. This condition can indeed be overcome by consuming chemical drugs, one of which is in the NSAIDS group, namely diclofenac sodium, but chemical drugs have many negative effects, including nonsteroidal anti-inflammatory drugs and steroids. Therefore, there has been the creation of anti-inflammatory drugs using natural ingredients, especially plants. For generations, Indonesian people have used kencur as an edema medicine. This study aims to examine the anti-inflammatory properties of kencur ethanol extract rhizomes. This study tested anti-inflammatory activity through regeninduced suppression of foot edema in male white mice. In this study, 15 eligible mice aged 2–3 months and weighing 20–30 grams were divided into 5 treatment groups. Three separate doses of galangal rhizome extract—50 mg/kgBW, 150 mg/kgBW, and 250 mg/kgBW—were used in the test. Ethanol extract of kencur rhizomes at a dose of 250 mg/kgBW can reduce edema in male white mice produced by carrageenan by 1% and show possible anti-inflammatory properties, according to the results of studies tested by measuring edema using a digital caliper.

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