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Zulfiayu Sapiun
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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 5, No 1 (2025): February 2025" : 5 Documents clear
The Comparison of Antioxidant Activity of Ethanol Extract of Fruit, Seeds and Leaves of Yellow Pumpkin (Cucurbita moschata D.) using the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method Rahmatillah, Annie; Rohmana, Vivin Marwiyati; Mahendra, Andika Dwi; Puspita Sari, Mawar Dela; 'Arifah, Zainul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1317

Abstract

Yellow pumpkin (Cucurbita moschata D.) has various compounds that can be used as antioxidants, such as tocopherol, carotene, and phenolics. This research aims to determine which parts of the plant have potential as antioxidants by comparing the antioxidant activity of fruit, leaves, and seeds. Antioxidant activity measurements were carried out using the DPPH method by comparing the absorbance of the control and the absorbance of the sample to determine the percentage of antioxidant activity and IC50 value of each sample. From the measurement results, the IC50 values for pumpkin leaves, seeds, and fruit were 182.85 ppm, 57.04 ppm, and 90.88 ppm, respectively. Based on these results, leaves have the highest antioxidant activity compared to seeds and fruit. The results of this study show that pumpkin fruit and seeds have lower antioxidant activity than leaves. The results of this study show that pumpkin leaves had lower antioxidant activity than seeds and flesh.
Analysis of Medicine Use in Disaster Management Wulandari, Tri; Abriani, Nurul Gilang
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1312

Abstract

Medicine is the basic logistics to meet the basic needs in disaster management. The use of medicine in disaster management is adjusted to the needs during a disaster. Different types of medicine on pharmacological effects determine the use of medicine in the disaster emergency category. This research is to analyze the use of medicine based on the types of markers and pharmacological effects needed in disaster management. Data collection used descriptive design and methods based on medicine use in the last five years of disaster management in Karanganyar district collected from medical records and interviews. Medicine was categorized based on the drug packaging labeling as general sales list, pharmacy medicines, prescription-only medicines, and controlled group medicine. Based on the effect of pharmacology, medicine can be used as vaccines, psychotropics, multivitamins, analgesics, antipyretics, antibiotics, antiviruses, corticosteroids, mucolytics, anthelmintics, gastritis, and flu. So it is concluded that based on the type of marker, there are three, and not all medicines that have a pharmacological effect are used in disaster management. The implication of this study is that medication requests should align with the needs of the specific type of disaster.
Potential of Ciplukan Leaf Extract (Physalis angulata L.) Against Streptococcus pneumoniae Growth in Vitro Rakhman, Farizky; Widayati, Ratna; Turnip, Oktaviani Naulita; Fatmaria, Fatmaria; Hanasia, Hanasia
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1314

Abstract

Pneumonia is a disease that infects the lungs, and antibiotics such as tetracycline show a high degree of resistance. Therefore, the use of alternative natural materials, such as ciplukan leaves (Physalis angulata L.), which the Dayak people commonly use to treat lung diseases, is necessary. This study aimed to prove that the extract of ciplukan leaves can inhibit Streptococcus pneumoniae by measuring the diameter of the clear zone and determining the Minimum Inhibitory Concentration (MIC). The extract was obtained by maceration using 96% ethanol, and then concentrations of 5%, 10%, 15%, 20%, and 25% were prepared. The positive control was levofloxacin 5 µg, and the negative control was DMSO 1%. The average inhibition zone diameters of the ciplukan leaf extract were 5% (0 mm), 10% (0.17 mm), 15% (0.45 mm), 20% (1.95 mm), 25% (2.67 mm). Antibacterial test using the disk diffusion method. From the Kruskal-Wallis and Mann-Whitney Post Hoc statistical test, a significance value of <0.05 was obtained. Therefore, There is an effect of ciplukan leaf extract on Streptococcus pneumoniae at concentrations of 15%, 20%, and 25%, with the MIC 15%.
Phytochemical Profile and Antioxidant Activity of Bajakah Kalalawit Leaf Extract Priyadi, Muhammad; Gunawan, Yohanes Edy; Saputra, Rizki Rachmad; Decenly, Decenly; Citrariana, Shesanthi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1321

Abstract

Natural products have long been recognized for their significant role in supporting human health, with natural ingredients playing an essential part in disease treatment and wellness across generations. The bajakah species, particularly bajakah kalalawit (Uncaria gambir Roxb.), has gained attention in recent research due to its potential bioactive compounds. Especially, its antioxidant properties from any part of plant has potential to explore. This study aims to determine the various secondary metabolite compounds possessed by bajakah kalalawit leaves and test their antioxidants. Bajakah kalalawit leaves were extracted using reflux with aqueous solvents, checked for phytochemical profiles using GC-MS, and conducted antioxidant tests using the DPPH method. Based on the phytochemical test, there are 22 predicted compounds in the extract and the antioxidant test results showed an IC50 value of 14.44 ppm. In conclusion, bajakah kalalawit leaf aqueous extract has antioxidant activity and is supported by bioactive compounds.
Formula Optimization of Rosemary (Rosmarinus officinalis L.) Extract-loaded Film-forming Spray using Box-Behnken Design Aulia, Ridha Nurul; Akmal, Tubagus
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1325

Abstract

Film-forming sprays are practical and effective in creating a protective film on wounds that evenly distributes active ingredients. Rosmarinic acid in rosemary has antioxidant and anti-inflammatory properties, helping to accelerate wound healing by enhancing macrophage and lymphocyte proliferation and reducing inflammation. This study aims to determine the optimal formulation of a film-forming spray using xanthan gum as a film-forming agent, propylene glycol as a plasticizer, and ethanol as a penetration enhancer. Optimization was carried out using the Box-Behnken design in Design Expert-13, focusing on viscosity, spray diameter, spray angle, area, density, and theoretical film thickness. The optimal base and extract formulas were evaluated for stability over 28 days at room temperature using GraphPad Prism-10. The ideal formula contained 0.1% xanthan gum, 3.6% propylene glycol, and 40% ethanol, with a desirability score of 0.943. The confirmation results showed no significant difference between actual and predicted values, validating the model. The optimal formula had a viscosity of 100 ± 0.00 cps, a spray diameter of 4.52 ± 0.06 cm, a spray angle of 65.70 ± 0.31°, an area of 16.02 ± 0.43 cm², a density of 0.908 ± 0.00 g/ml, and a theoretical film thickness of 0.007 ± 0.00 cm. This formula was then used as the base for the rosemary extract FFS. Stability tests showed that the addition of extracts significantly affected viscosity, spray diameter, spray angle, area, and theoretical film thickness (p<0.05), while density was unaffected (p>0.05). The study’s limitation is the lack of in vivo testing to confirm the formulation's effectiveness in promoting wound healing and its antimicrobial properties.

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