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Zulfiayu Sapiun
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Gedung Jurusan Farmasi Politeknik Kesehatan Kementerian Kesehatan Gorontalo Jln, Taman Pendidikan, Kecamatan Kota Timur, Kota Gorontalo, Gorontalo 96113
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Journal of Experimental and Clinical Pharmacy (JECP)
Published by Politeknik Kesehatan Kementerian Kesehatan Gorontalo
ISSN : -     EISSN : 27751368     DOI : https://doi.org/10.52365/JECP
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health
Journal of Experimental and Clinical Pharmacy (JECP) merupakan jurnal yang issue tiap 6 bulan sekali (Februari-Agustus) dalam bidang farmasi eksperimen dan farmasi klinik secara nasional. Penelitian eksperimental dalam jurnal ini mencakup penelitian pengembangan obat dan makanan secara in vivo, in vitro, in silico, dan formulasi serta pemeriksaan mutu makanan. Sementara itu, penelitian klinis mencakup uji klinik, case report, case series, cohort, dan crossectional dari penggunaan obat obatan dan kosmetika. Kami juga menerima artikel penelitian mengenai farmasi komunitas dan entreprenuer pharmacy (Pharmaprenuer). Selain artikel penelitian, kami juga menerima karya dalam bentuk review artikel, mini review dan Short Communication. Jurnal ini adalah jurnal akses terbuka Jurnal ini adalah jurnal akses terbukadan tidak memungut biaya publikasi untuk berlangganan, pengiriman, dan penerbitan jurnal.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol 5, No 2 (2025): August 2025" : 7 Documents clear
Application of Natural Deep Eutectic Solvents (NADES) in the Natural Product of Antioxidant Activity Hidayah, Andi Nurul Annisa; Ahmad, Aktsar Roskiana; Rasyid, Faradiba Abdul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1345

Abstract

The extraction of bioactive compounds from plant-based materials poses significant challenges due to the limitations of traditional organic solvents, including toxicity and environmental impact. Natural Deep Eutectic Solvents (NADES), formed from natural components at defined molar ratios, have emerged as green, sustainable alternatives for efficient extraction. This literature review aims to investigate the applications, compositions, and effectiveness of NADES in extracting antioxidant-rich compounds from natural sources. Relevant peer-reviewed articles published within the last ten years were retrieved from Google Scholar and PubMed using keywords such as “NADES,” “natural product,” and “antioxidant activity.” Studies included using NADES to extract phytochemicals, pharmaceuticals, or food compounds and address their toxicity, safety, and physicochemical properties. Non-peer-reviewed articles, unrelated solvent systems, and duplicate studies were excluded. The review identified compelling NADES compositions, including choline chloride: lactic acid (1:2), choline chloride: oxalic acid (1:1), and citric acid: glycerol (1:1), which demonstrated high extraction efficiency and antioxidant activity. The tunability of hydrogen bond donor and acceptor ratios allows NADES to be optimized for specific bioactive compounds. In conclusion, NADES offers a promising and eco-friendly approach for future applications in natural product extraction.
Identification of Hydroquinone in Cosmetics Circulating in Kotamobagu City Using Chromatography Method Bahi, Rizky Resvita R; Mappa, Moh Rivaldi; Hasan, Firja; Mokoginta, Warningsih
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1513

Abstract

The use of hazardous materials in facial whitening creams can endanger the health of users. Excessive use of hydroquinone can cause ochronosis, where the skin feels like it is burning and itching. Creams containing hydroquinone are widely circulated in the community and often cause undesirable effects. This study aims to analyze hydroquinone in cosmetics circulating in Kotamobagu City qualitatively using the Thin Layer Chromatography method. The results showed that the Rf value of the hydroquinone standard was 0.87 with a blackish brown stain color. Meanwhile, the Rf value and stain color of samples A, B, C, D and E were respectively 0.37 brownish yellow, 0.62 purple, 0.87 blackish brown, 0.75 blackish brown and 0.80 blackish brown. Based on the results of qualitative analysis using TLC, facial whitening cream cosmetics circulating in Kotamobagu City with samples A, B, C, D and E were positive for containing hydroquinone.
Efficacy and Safety Assessment of Emulgel Containing SnakeheadFish (Ophiocephalus striatus) Dry Extract for Burn Wound Treatment in Rabbit Model Tungadi, Robert; Njotowidjojo, Dyah Muliawati; Ruswandi, Edy; Akhyar, Akhyar; Magfirah, Rima
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1351

Abstract

Burn injuries are a significant health concern requiring effective treatment to accelerate healing and reduce complications. Conventional topical therapies often have limitations, prompting the development of alternative treatments. Snakehead fish extract, rich in bioactive compounds, has been traditionally used for wound healing. This study aimed to evaluate the efficacy and safety of an emulgel containing snakehead fish dry extract at different concentrations for burn wound treatment in rabbits. Three emulgels were formulated with extract concentrations of 0.25%, 0.5%, and 1%, then characterized for physicochemical properties, including pH, viscosity, spreadability, and adhesion. Protein content was determined using the Bradford method. An in vivo study was performed on rabbits with second-degree burn wounds, divided into five groups: negative control (emulgel base), positive control (Burnazine cream), and treatment groups receiving 0.25%, 0.5%, and 1% extract emulgel. Wound healing was assessed by measuring wound contraction for 16 days. Organoleptic tests showed no changes in color, odor, or homogeneity during four weeks of storage. The emulgel formulations showed stable physicochemical properties, with pH 6.0–6.5, viscosity 8000–10000 cPs, spreadability 6.8–6.9 cm, and adhesion time over 4 seconds, suitable for skin application. Protein content increased proportionally with extract concentration. The in vivo study showed that 1% extract emulgel significantly accelerated wound healing, with greater wound contraction compared to both controls (p < 0.05). No irritation, erythema, or edema were observed, indicating safety. The 1% snakehead fish dry extract emulgel achieved the most effective burn wound healing in rabbits. The formulation is stable, safe, and has strong potential as a natural alternative for burn treatment.
Effect of Leuhang Therapy on Lung Histopathology, Leukocytes, and Bronchoalveolar Lavage Fluid (BALF) in Asthma Rat Model Imanulhaq, Hasbi; Septiani, Tria; Parwoko, Nasywa Asy Syaffa'; Ramadhan, Harry Rachman; Laksono, Bambang Tri
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1419

Abstract

The prevalence of asthma is increasing, especially in developing countries due to lifestyle and air pollution. In addition, asthma medications can cause serious side effects, such as the use of the asthma medication LABA, which causes the side effects of tachycardia, tremor, and epicardial elevation, which is considered quite dangerous for the elderly. Sundanese people from West Java have a traditional therapy called Leuhang therapy. This therapy is believed to have various properties, including anti-asthma. In addition, this therapy is also safer and has minimal side effects. This study aims to obtain an optimal Leuhang therapy formula for preventing asthma recurrence and determine the relationship between plant extract vapor in Leuhang and its effects on the organs of asthma-induced mice. The study was conducted by dividing the mice into several groups, namely normal control, positive control, comparison, test I, and test II. Each mouse was given treatment according to its respective group. Based on the results obtained from this study, leuhang therapy with a combination of formulas focusing on anti-asthmatic properties showed anti-asthmatic activity against OVA-induced allergic asthma. The combination treatment decreased the total and differential cell counts in blood and BALF and affected the thickness of mouse lung mucosa and muscle, thus demonstrating its anti-inflammatory properties. Leuhang therapy also reduced the infiltration of neutrophils, lymphocytes, and plasma, showing its immunomodulatory properties. Statistical tests using One-Way ANOVA showed a p-value of <0.05, meaning that the four groups' mean lung histopathology scores were significantly different. Thus, Leuhang therapy has been shown to have promising potential in the alternative treatment of asthma.
Comparative Analysis of Cost Effectiveness of Ceftriaxone and Cefotaxime Antibiotic Therapy in Inpatients with Typhoid Fever in Aulia Pandeglang Regional Hospital in 2023 Yusransyah, Yusransyah; Rustiyani, Risa; Nurani, Agnes Wieanita; Stiani, Sofi Nurmay; Udin, Baha; Halimatusyadiah, Leni
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1436

Abstract

Typhoid fever is still a significant health problem for children in developing countries, including Indonesia. This disease is caused by infection with Salmonella Typhi bacteria, which is a Gram-negative bacteria and requires treatment with antibiotics. The use of antibiotics usually takes up a large portion of the hospital treatment budget. This study aims to compare the cost-effectiveness between two types of antibiotics, namely ceftriaxone and cefotaxime, in typhoid fever patients at Aulia Pandeglang Hospital, and to find the most cost-efficient treatment. This study is descriptive and observational, with retrospective data collection. The data used came from medical records and cost records of inpatients with typhoid fever in children aged 1 to 11 years at Aulia Pandeglang Hospital in 2023. A total of 20 patients met the study criteria. The outcomes measured in this study were the average length of stay in the hospital. The cost components calculated consisted of direct medical costs, such as drug costs, action costs, inpatient costs, medical device costs, and laboratory fees. The analysis was conducted from the payer's perspective. The results showed that the cost for the effectiveness of using ceftriaxone and cefotaxime was IDR 15,264 and IDR 18,265, with an ICER of IDR 257.9 to increase the effectiveness of cefotaxime. The conclusion of this study is that ceftriaxone is a more cost-effective antibiotic.
Overview of Pneumonia Treatment in Hospitalized Geriatric Patients at One of the Gorontalo Provincial Hospitals: Case Report Papeo, ⁠Dizky Ramadani Putri; Kai, Mohamad Nur Fadjri; Isa, Moh. Arya Avrilio; Sumaga, Nabila Natasya; Mursidi, Sitti Rahmawaty Sisilia; Canon, Afifah Aliya
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1445

Abstract

Pneumonia is a common respiratory infection affecting all age groups, particularly the elderly, who are more susceptible due to comorbidities and age-related decline in immune function. This case report aims to evaluate the role of clinical pharmacy in the management of community-acquired pneumonia (CAP) in a geriatric patient. A descriptive qualitative method was conducted through retrospective analysis of medical records, including clinical presentation, diagnostic findings, pharmacological and non-pharmacological interventions, and patient outcomes. The pharmacological therapy included ceftriaxone and azithromycin as antibiotics, mucolytics, bronchodilators, antipyretics, gastrointestinal protection, and vitamin supplementation, with clinical pharmacy involvement in therapy optimization and monitoring. Non-pharmacological strategies involved oxygen therapy, semi-Fowler positioning, effective coughing techniques, and hydration support. The patient showed marked clinical improvement with increased SpO₂ from 95% to 98%, a reduction in respiratory rate from 30 to 22 breaths/minute, and symptom resolution by day four. This report highlights that the integration of clinical pharmacy interventions significantly contributes to effective and safer management of CAP in elderly patients
Overview of Antipsychotic Use in Schizophrenia Patients at the East City Health Center in 2024 Tuloli, Teti Sutriyati; Makkulawu, Andi; Sumaga, Khairunnisa Alya; Madania, Madania; Manno, Mohamad Reski
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1388

Abstract

Schizophrenia is a severe mental disorder that affects individuals and greatly impacts their families and society, with symptoms like hallucinations, delusions, and emotional or thought disturbances that disrupt daily life and well-being. Treatment for schizophrenia usually involves a combination of antipsychotic drug therapy, psychotherapy, and social support. This study aims to determine the description of antipsychotic use, including the type of drug, rules of use, drug dosage, and duration of use in schizophrenia patients at the Kota Timur Health Center. This study used a descriptive observational research design with data collection using a retrospective method. The research data were obtained from secondary data in the form of medical record data from as many as 25 patients with mental illness. The data were processed with Excel and analyzed using SPSS version 26. The results showed that schizophrenia was predominantly suffered by male patients (56%), and more were in the age range of 34-46 years (as many as 48%). The most widely used antipsychotic drugs were a combination of typical and atypical, as many as 92%. The most frequently used type of drug is clozapine with a dose of 25 mg, and the rules of use are 2 x 1/2 as much as 46%. The longest duration of treatment is already in the maintenance phase, which is 96%. Additional drug trihexyphenidyl 2 mg (2 x 1) is used as much as 92%. The most widely used type of therapy is 3-combination therapy, namely Risperidone + THP + Clozapine, as much as 56%. This study was conducted at the East City Health Center, Gorontalo, which is one of the largest primary healthcare facilities in the region and manages a considerable number of schizophrenia patients with limited psychiatric resources. Therefore, the study setting provides important insights into the real-world use of antipsychotic medications in a community-based healthcare center.

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