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Contact Name
Hanif Amrulloh
Contact Email
jmans@pandawainstitute.com
Phone
+6285664335022
Journal Mail Official
jmans@pandawainstitute.com
Editorial Address
Pratama Praja Street No. 17 Mulyojati West Metro, Metro City, Lampung. 34111
Location
Kota metro,
Lampung
INDONESIA
Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 1 Documents
Search results for , issue "Vol. 5 No. 3 (2025): Journal of Multidisciplinary Applied Natural Science" : 1 Documents clear
Synthesis, Characterization and Biological Activity of Some New Pyrimidine Derivatives Abdul-Bary, Mariam; Haddad, Batool; Al Ameri, Jenan
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 3 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.277

Abstract

In this study, four derivatives of pyrimidine-2(1H)-thione were synthesized via the reaction between the compounds of α,β-unsaturated ketone and thiourea. The first step included a reaction between 1 mol of four different derivatives of primary amines and 1 mol of benzil. In the second step, the resulting compound was interacted with acetone to prepare α,β-unsaturated ketone. In the third step, the resulting compound was then interacted with thiourea to form the following compounds: 5,6-dihydropyrimidin-2(1H)-thione. The IR, (1H and 13C) NMR and MS spectroscopies were used to confirm the structures of the prepared compounds and examine their antibacterial activities against (Staphylococcus aureus and Escherichia coli) by well diffusion method. It was found that the synthesized compounds have high activity against these two types of bacteria, especially compound P2 had the most inhibitory activity.

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