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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 2, No 3 (2022): September-Desember 2022" : 9 Documents clear
Gambaran Interaksi Obat Pada Pasien Gagal Ginjal Kronik Dalam Proses Hemodialisis Siti Alfanda Makmur; Madania Madania; Nur Rasdianah
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13333

Abstract

Chronic Kidney Disease (CKD) is a condition in which there is a decrease in kidney function due to the presence of chronic and irreversible renal parenchyma. Patients with chronic disease often require a combination of several drugs. The administration of drugs combination is generally expected to have a beneficial effect. However, in some cases, drug interactions resulted in ineffective treatment and the emergence of unexpected events. This research aimed to determine drug interactions in patients with chronic kidney disease who are undergoing hemodialysis in the Inpatient Installation of Dr. M.M Dunda Limboto Hospital. This research was observational using a cross-sectional design and retrospective data collection. The sampling technique used was a purposive sampling technique with a total of 51 patient who met the inclusion criteria during the July-Desember 2020 period. Drug interaction data analysis was based on the Drug Interaction Checker and Drug Interaction Facts. The results showed that the most widely used drugs in patients with chronic kidney disease at Dr. M.M Dunda Limboto Hospital were anti-hypertensi drugs (17%), vitamins and minerals (13.30%), and gastrointestinal (11.32%). Drugs interactions with pharmacodynamic mechanisms were 31 cases (53.45%), pharmacokinetics were 21 cases (36.21%), and 6 cases were unknown (10.34%). The level of clinical significance in patients with chronic kidney disease was 75.86% moderate, 13.80% minor, and 10.34% major.
The Formulation and Stability Test of The Balm Emprit Ginger (Zingiber officinale var. amarum) Essential Oil Ferna Indrayani; Nurul Hikma
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15863

Abstract

Emprit ginger (Zingiber officinale var. amarum) is a rhizome plant that is much of the time tracked down in the locale. Tanasitolo, Kab. Wajo. Its utilization is most generally utilized as a cooking zest, defeating joint inflammation, muscle torment, treating colds, treating hacks, as a characteristic cell reinforcement and warming the body. The compound parts contained in emprit ginger (Zingiber officinale var. amarum) are zingiberene, shagaol, sap, and gingerol which are adequate as cancer prevention agents and mitigating or then again reflexology. This study aims to decided how to of ginger emprit (Zingiber officinale var. amarum) as a salve form of a natural balm. This type of research is a direct observation in the laboratory using the distillation method to obtain the essential oil in ginger emprit (Zingiber officinale var. amarum) was then made in the form of a balm with different concentrations of essential oils, namely F1 (0 g), F2 (1.5 g), and F3 (2 g) using accelerated stability testing on the balm preparation, stored for 6 days with 3 cycles (40C and 400C) the observations included organoleptic tests (shape, smell, and colour), homogeneity test, pH test, spreadability test, adhesion test, and specific gravity.. This study indicate that a stable balm preparation that meets the standard requirements based on SNI with accelerated stability testing is formula F3 with a concentration of 2 grams of ginger essential oil. Emprit ginger (Zingiber officinale var. amarum) can be formed in a balm preparation.
Formulating Oil Emulgel of Nyamplung (Calophyllum inophyllum L) with Variations of HPMC and Activity Testing for Incision in Rabbit New Zealand Erinda Risma Puspita Cahya; Dewi Ekowati; Dwi Ningsih
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15455

Abstract

Emulgel is an emulsion of both O/W and W/O which is made into a gel by mixing it with a gelling agent. One of the gelling agents that is often used is HPMC because it can produce a clear gel, easily soluble in water, and has low toxicity. Nyamplung oil has wound healing activity by stimulating cell proliferation and the production of collagen and GAG (glycosaminoglycans). The purpose of this study was to find out that nyamplung (Calophyllum inophyllum L) oil can be made into a good emulgel preparation, has the effect of healing cuts, to determine the effect of variations in HPMC concentration on the physical quality and stability of the emulgel, and in accelerating the healing of cuts. This study used three formulas containing 1%, 2%, and 3% HPMC plus one control formula. Emulgel is made by mixing emulsion with gel and contains 1% nyamplung oil, then physical quality tests are carried out : organoleptic, homogeneity, pH, adhesion, dispersibility, viscosity test, emulgel type test, stability test. The wound healing activity test was carried out on the back of New Zealand rabbits. The percentage of treatment results were statistically analyzed. The results showed that all nyamplung oil emulgel formulas could be made ini emulgel preparations, had good physical quality and stability and had the effect of wound healing. The effect of gelling agent concentration affects the speed of wound healing. The result of the most optimal wound healing activity test is the formula 2.
Formulation and Antibacterial Potential Activity Test of Antiseptic Transparent Soap Preparations Srikaya Leaf (Annona squamosa L.) Ari Dwidayati; Muhammad Asri; Adinda Putri; Nurfitria Junita
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15658

Abstract

Srikaya leaf (Annona squamosa L.) is a plant that contains several active compounds including flavonoids, saponins, alkaloids and tannins which have antibacterial properties. Transparent antiseptic extract of srikaya leaf (Annona squamosa L.) has antibacterial activity against Staphylococcus aureus. This research method is an experimental study with physical and chemical evaluation of the preparation as well as testing of antibacterial activity using the paper disc technique diffusion method at concentrations of 1%, 2%, 3%, negative control and positive control. The results of the study at concentrations of 1%, 2% and 3% met the physical and chemical requirements as well as the antibacterial activity test with a concentration of 1% inhibition zone 15.6 mm (Strong), 2% inhibition zone 19.6 mm (Strong) and 3% zone of inhibition 21.2 mm (Very strong). It was concluded that for a concentration of 3% with an inhibition zone diameter of 21.2 mm (Very strong) the most effective.
Antipyretic Activity Test of Combination of Peperomia pellucida Extract and Andrographis paniculata in Mice (Mus musculus) Khairil Pahmi; Muhammad Ricky Ramadhian; Gabena Indrayani Dalimunthe
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15654

Abstract

Pepper elder (Peperomia pellucida) and green chiretta (Andrographis paniculata) are plants that have been used empirically to reduce fever. Fever is a symptom of a disease characterized by a significant increase in body temperature. This study aimed to determine the antipyretic effect of the combination of pepper elder herbal extract (P. pellucida) and green chiretta herbal extract (A. paniculata) (80:20) in the male house mice (Mus musculus). Extraction was conducted through maceration using ethyl acetate solvent. The total of 25 male mice were divided into 5 groups, namely a negative control group (Na-CMC 1%), a positive control group (paracetamol), and a treatment group induced by a combination of pepper elder herbal extracts and green chiretta herbal extract at the dose of (80 + 20), (40 +10), and (20 + 5) mg/kg BW. DPT vaccine 0.2 ml was used intramuscularly as a fever inducer. The observation was carried out at 30, 60, 90, and 120 minutes after treatment. The data obtained were analyzed using one-way ANOVA followed by the LSD test to determine the differences between groups. The results showed that variations in the dose of the combination of pepper elder and green chiretta herbal extracts had an antipyretic effect where the most effective dose was (80 + 20) mg/kg BW due to its stable temperature reduction power and effectiveness that are equivalent to paracetamol. The combination of suruhan herb extract (P. pellucida) and sambiloto herb (A. paniculata) has potential as an antipyretic
Effect of HEC (Hydroxyethyl Cellulose) Polymer on Nanoemulsion-Based Curcumin Transdermal Patch Release Rahmatia Is. Kaluku; Robert Tungadi; Nur Ain Thomas
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.12025

Abstract

Curcumin a hydrophobic polyphenolic compound and water-insoluble that creates low systemic bioavailability inside the body, has broad pharmacological activity, including anti-inflammation. This study aims to formulate, characterize and evaluate the nanoemulsion based on curcumin through an in vitro transdermal patch preparation. This study starts from formulating a curcumin nanoemulsion solution and characterizing the particle size of curcumin through PSA (Particle Size Analyzer). Further, it formulates the transdermal patch preparation with the smallest curcumin particles within three concentrations (HEC 0,625%, 1,25%, and 2,5%) combined with HPMC 2,5% as polymer. Those formulations are evaluated through organoleptic, thickness, weight uniformity, humidity, and folding resistance tests. In the next step, this study examines the penetration through an in vitro by using a franz diffusion cell within 72 hours. The result shows increasing penetration on each formula where the best penetrations occur in the 15th and 24th hours. It also discovers that the formula containing HEC 2,5% (2c) creates the highest cumulative drug penetration (15,83%). Therefore, it deduces that curcumin nanoemulsion in the transdermal patch has good characteristics and is compatible between drug and polymer.
Sintesis Khalkon dan Uji Aktivitas Tabir Surya Secara In Vitro Dewi Darmiyani Napu
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.19326

Abstract

Synthesis of 2’,4’-dihydroxy-3,4-dimethoxychalcone and in vitro test of its sunscreen activity have been carried out. Chalcone was synthesized from 3,4-dimethoxybenzaldehyde and 2,4-dihydroxyacetophenone through Claisen-Schmidt condensation. The synthesis was performed by using KOH 40% under stirring at room temperature for 48 h. The synthesized compounds was characterized using FTIR, GC-MS and 1H NMR spectrometers. Further, the chalcone were screened for its in vitro sunscreen activity by using UV-Vis spectrophotometer. The result showed that the chalcone has been succesfully synthesized in 36.94% Yield. The activity of invitro test showed the chalcone has SPF values with maximal protection category at the consentration 15 µ/mL produce SPF 9.749
Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan Muhamad Handoyo Sahumena; Suryani Suryani
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.20405

Abstract

Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when it encounters the aqueous phase in the digestive tract. Parameters for the success of the SNEDDS formula include emulsification time, stability, and droplet size using a particle size analyzer (PSA). The SNEDDS formulation was carried out by mixing span 80 and tween 20, PEG 400 and VCO as the oil phase. The characteristics of SNEDDS ibuprofen include homogeneity of SNEDDS, clarity, transmittance, emulsification time, and droplet size. The composition of the optimum formula for SNEDDS ibuprofen is 1 mL of VCO; 1 mL PEG; 7 mL tween 20; 1 mL span 80. The formula shows good homogeneity, is clear with emulsification time of 15 seconds, transmittance is 92.69%, and droplet size is 221.9 nm.
Pengaruh Waktu Ekskresi terhadap Residu Kafein pada Urine Responden Pengkonsumsi Teh Celup Hitam menggunakan Pereaksi Parry Anik Eko Novitasari; Nia Nadia Alfatika
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.22162

Abstract

Addictive substance is NAPZA component. Caffeine is one of addictive substance that has psychoactive properties, induce addicted, and as drug for eleminating drowsiness, mood enhancer, performance, and vigilance. This aim study is identification residual of caffeine in urine and urine effect excretion time after consumed a tea to caffeine visible in urine. Black tea is one of caffeine source. Caffeine reabsorbed in tubules kidney and excretion through urine . This study use 10 urine of human as sample examination. Each of them get instruction to consuming of 250 ml tea and record the time after consuming tea till urination. The urine extracted by eter using separating funnel. The urine extract is identified by Parry Reaction in qualitative method. This study has been shown that all of urine sample have contained caffeine residual after consuming tea with green complex colour marked due to Parry Reaction and it visible from 10 minutes until 3 hours after consuming tea. But, this study need some developments about comparing other reaction to identification caffeine in qualitative method, quantitative method to show level of caffeine in and out from body, and special treatment for subjects.

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