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Journal of Science and Technology Research for Pharmacy
Published by Universitas Negeri Semarang
ISSN : -     EISSN : 27760685     DOI : https://doi.org/10.15294/jstrp.v1i2
Core Subject : Science,
Chemistry
Journal of Science and Technology Research for Pharmacy is open access, peer-reviewed journal published by Pharmaceutical Science Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Indonesia. The journal publishes only papers describing original findings and review articles of all aspects in developing the field of pharmaceutical science and technology.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 2 No 2 (2022)" : 5 Documents clear
Evaluation of Antibiotics Appropriateness in the Treatment of Typhoid Fever in Pediatric Outpatient at Gondosari Gebog Kudus Health Center Firda Tryana Yulistina
Journal of Science and Technology Research for Pharmacy Vol 2 No 2 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i2.68492

Abstract

Background : Typhoid fever is an acute bacterial infection in the human digestive tract caused by Salmonella typhi bacteria. Typhoid fever is treated with antibiotics. However, inappropriate use of antibiotics can lead to resistance. Aim : To evaluate the appropriateness of using antibiotics in outpatient pediatric typhoid fever at the Gondosari Gebog Kudus Health Center in 2021-2022. Methods : Non-experimental research with retrospective data collection and descriptive analysis. Parameters in this study for evaluating the antibiotics appropriateness are 7 parameters (right diagnosis, right patient, right indication, right drug, right dose, right way of administration, and right duration) based on the Rational Drug Use module according to Indonesian Ministry of Health (2011). Results : The samples obtained in this study were 40 patients. The results of evaluating the appropriate use of antibiotics in pediatric typhoid fever in this study were 100% right diagnosis, 100% right patient, 100% right indication, 100% right drug according to WHO (2011), 100% right drug according to Indonesian Ministry of Health (2006), 85% right dose according to WHO (2011), 100% right dose according to Indonesian Ministry of Health (2006), 100% right method of administration, 20% right duration according to WHO (2011), and 80% right duration according to Indonesian Ministry of Health (2006). Conclusion : The results of the evaluation of the appropriate use of antibiotics at the Gondosari Health Center are appropriate based on 7 parameters (right diagnosis, right patient, right indication, right drug, right dose, right way of administration, and right duration). Keywords : Typhoid fever, Antibiotics, Appropriateness of treatment
A Review of Continuous Manufacturing in Pharmaceutical Process Monitoring Pradip Iramdhan Aliyansah
Journal of Science and Technology Research for Pharmacy Vol 2 No 2 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i2.68836

Abstract

This review explores continuous manufacturing (CM) process monitoring in the pharmaceutical industry and its advantages over batch processes. The case study focuses on CM production of solid dosage forms, using a water-based wet granulation method. The research proposes a monitoring strategy through in-process control (IPC), process analytical technology (PAT), and critical process parameters (CPPs). The study demonstrates that the CM process is robust and provides satisfying results, with critical quality attributes (CQAs) meeting target specifications. The role of IPC and PAT in ensuring product quality is highlighted, with IPC used to monitor and adjust processing operations, while PAT enables real-time monitoring of drug content. The advantages of CM include improved product quality, agility in drug development, elimination of scaling-up challenges, and reduced environmental exposure. However, implementing CM requires a systematic approach and significant capital investment. The review concludes that CM offers benefits despite the challenges and presents a promising approach to modernizing pharmaceutical manufacturing.
Phenytoin: Clinical Use, Pharmacokinetics, Pharmacodynamics, Toxicology, Side Effects, Contraindication, and Drug Interactions Gavriel Fauzan Faturachman; Lolita Tiara Sari; Naura Artanti; Shakira Shakira; Tsabita Nafla Zalikha
Journal of Science and Technology Research for Pharmacy Vol 2 No 2 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i2.69275

Abstract

Phenytoin is an antiepileptic drug derived from an organic compound called hydantoin. Phenytoin is an antiepileptic drug primarily used to treat seizures in people with epilepsy. Phenytoin works by targeting and blocking voltage-gated sodium channels in the nervous system, which helps reduce abnormal electrical activity in the brain that leads to seizures. Phenytoin can also be used to treat trigeminal neuralgia and ventricular tachycardia. Absorption of phenytoin depends on the mode of administration either peroral or parenteral. The distribution of phenytoin is affected by plasma protein binding. Phenytoin is metabolized primarily by liver enzymes, especially the cytochrome P450 enzyme system. Phenytoin excretion is influenced by the pH in the urine. Side effects of phenytoin use that can occur are sedation, hallucinations, fever, sedation, confusion, hallucinations, peripheral neuropathy, stevens-johnson syndrome, cardiovascular collapse, hypotension, purple glove syndrome, nystagmus, ataxia, nausea, coma, seizures, vomiting, hyperactivity, lethargy, fetal hydantoin syndrome (FHS), and megaloblastic anemia. Contraindications to the use of phenytoin are in someone with hypersensitivity to phenytoin or other hyndatoin, pregnant women, and lactating women. Oral phenytoin overdose causes neurotoxicity and parenteral phenytoin overdose causes cardiovascular toxicity. There is no specific antidote for phenytoin toxicity and the usual treatment is supportive care. There are various drugs that can interact with phenytoin to decrease or increase phenytoin levels.
Determination Of Polyphenol Levels And Antioxidant Activity Extract Combination Instant Powder Preparation Katuk Leaf (Sauropus androgynus (L.) Merr.) And Cacacao Beans (Theobroma cacao L.) Youstiana Dwi Rusita
Journal of Science and Technology Research for Pharmacy Vol 2 No 2 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i2.69406

Abstract

Natural immunomodulators are obtained from herbal plants with natural antioxidant content.The content of polyphenol compounds as natural antioxidants in katuk leaves and cocoa beansis utilized in the form of instant powder preparations.This study aimed to determine the levels of polyphenols and the antioxidant activity of instantpowder combination of katuk leaves and cocoa beans.Material dan Methods : this study used a quantitative descriptive method with test parametersincluding organoleptic, moisture content, ash content, polyphenol qualitative, polyphenolcontent and antioxidant activity.The results of the instant powder moisture content test were 1.71 ± 0.04%; 1.68 ± 0.03%; and1.59 ± 0.03%. The results of the instant powder ash content test were 1.16 ± 0.03%; 1.18 ±0.04%; and 1.11 ± 0.03%. The positive instant powder qualitative test results containedpolyphenols as indicated by the formation of blackish-brown color. Polyphenol levels in instantpowder were 43.83 ± 1.76 mg GAE/g; 34.40 ± 0.71 mg GAE/g; and 29.50 ± 0.76 mg GAE/g.The instant powder is classified as a medium antioxidant category with an IC50 value of 119.25ppm respectively; 129.25 ppm; and 146,40 ppm.The Conclusion Formula 1 is a formula that has a large polyphenol content and strongantioxidant activity.
Utilization of Avocado (Persea americana Mill.) Seeds and Cinnamon (Cinnamomum burmannii) as A Functional Powder Drinks Arum Dwi Agustin
Journal of Science and Technology Research for Pharmacy Vol 2 No 2 (2022)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v2i2.69408

Abstract

Functional powder drinks are drinks that if consumed can have a positive influence on the health of the body. Avocado seeds and cinnamon have bioactive compounds where these compounds have antioxidant properties that are good for our bodies. This research aims to find out the physical quality and antioxidant activity of functional powder drinks from avocado seeds and cinnamon. Methods and types of research conducted are quantitative research using descriptive design. Testing parameters include tests of physical quality, qualitative and quantitative flavonoid tests as well as antioxidant activity tests using UV-Vis Spectrophotometers. The results of physical quality tests showed functional beverage powder has a smooth texture, a whitish brown color, a distinctive smell of spices, and a distinctive sweetness of spices with a pH of 6,569. Qualitative tests of flavonoids showed the results of functional powder drinks positive containing flavonoid compounds due to the presence of red color formed, then continued with quantitative tests flavonoids obtained flavonoid levels of 12.201%. Antioxidant test results in functional powder drinks showed IC50 value of 128,422 mg/L which belongs to the category of moderate-level antioxidants.

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