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PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Published by Transpublika Publisher
ISSN : -     EISSN : 28099745     DOI : https://doi.org/10.55047/comorbid
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Nursing
About the Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) is an international, modern, general medical publication that publishes research on all aspects of medicine, from fundamental research to significant clinical trials and cost-effectiveness analyses. We generally publish human research that contribute to our understanding of medical epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; clinical trials that evaluate the efficacy of particular therapies and comparative trials; and systematic reviews. We want to encourage the conversion of fundamental research into clinical trials and clinical evidence into therapeutic practice. When studies in animal models produce remarkable research findings that are extremely clinically relevant, we publish them on occasion. The international medical community, as well as educators, policymakers, patient advocacy groups, and other interested parties, are among our target audiences. The online edition of COMORBID is updated on a regular basis. Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Articles from all branches of medicine and associated subjects are published in PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 3 No. 3 (2024): JULY" : 5 Documents clear
ESSENTIALS OF PRE- AND POST-OPERATIVE EVALUATION OF TOTAL HIP ARTHROPLASTY Ahmed, Ahmed Faydhullah; Abdulkareem, Makwan Mohammed
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1340

Abstract

Total Hip Arthroplasty is one of the most successful surgical interventions in the history of orthopedic surgery. Multiple factors affect Total Hip Arthroplasty stability such as soft tissue tension, component position, surgical approach and patient compliance. Most common indication of Total Hip Arthroplasty is end-stage, symptomatic osteoarthritis. This study aimed at defining detailed evaluation of total hip joint Arthroplasty before and after surgery. This review article was conducted by using deferent previously published articles considering effective preoperative and postoperative assessment of total hip Arthroplasty. Preoperative detailed history, examination along with preoperative radiographic assessments and postoperative CT and/or plain radiographic assessments are mandatory for successful outcome. Total Hip Arthroplasty could be performed by different surgical approaches with the posterior one being the most commonly applied.
THE FACTORS RELATED TO H. PYLORI INFECTION RESISTANCE AFTER ERADICATION OR ITS RECURRENCE IN SULAIMANI CITY Ahmad, Hazhan Nawzad; Abdulkareem, Makwan Mohammed; Alshekhani, Muhamad Abdularahman Muhamad
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1414

Abstract

Helicobacter pylori (H. pylori) infection can lead to peptic ulcers, chronic gastritis, lymphoma and gastric cancer. This study aimed to assess the factors related to H. pylori resistance after eradication and its recurrence after 6 months. 574 patients tested for H. pylori and those who positive has been assessed for recurrence after 6 months or resistance to treatment and factors related to recurrence in correlation with demographic data. 51% of men and 49% of women were still testing positive for H. pylori after receiving treatment.   The majority of patients who tested positive again for H. pylori were taking clarithromycin-based triple therapy, with only a small percentage being treated with levofloxacin, rate of resistance and recurrence were 23.54% and 8.7%, respectively. Most common symptoms after recurrence were epigastric pain and nausea (62.96%) and dyspepsia (55.55%). The highest rate of recurrence is related to O+ blood group, which is 47.82%. Recurrence rate after H. pylori eradication by standard therapy (clarithromycin triple treatment) or levofloxacin-based therapy is 8.7%. Poor sanitation, low income, and treatments regimens are independent risk factors for recurrence of H. pylori. Reducing the frequency of eating outdoors and treating family members may reduce H. pylori infection recurrence.
NARRATIVE REVIEW OF ADJUSTMENT DISORDERS AMONG FRESHMEN Edward, Sara Nabeel; Amin, Nazar Mohammad Mohammad; Abdulkareem, Makwan
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1445

Abstract

Adjustment disorders refer to the psychological reactions to adapt to new circumstances, including situations such as divorce, major work change, transition from school to university, or migration. This study aimed at summarizing adjustment disorders in a single short paper by using different recent sources and references. This review article was conducted by using deferent recently published articles considering adjustment disorders generally and its occurrence among first year student of colleges specifically. Adjustment disorders are very common mental health issues that arise in response to significant changes in life style and warrant proper assessment and evaluation in order to maximize daily functioning.
GENE EXPRESSIONS IN THE INCIDENCE OF NON-SYNDROMIC CLEFT LIP AND PALATE Al Hafiz, Al Hafiz; Supriyadi, Fauzia Latifah; Raymond, Benni
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1656

Abstract

The cleft lip and aisle (CL/P) are a craniofacial malformation caused by genetic mutations, environmental factors, or an interaction between the two. The development of the lip and auricle involves morphogenesis, molecular signaling pathways, mesenchymal-epithelial interactions, and auricle fusion. CL/P events involve initiation, growth, morphogenesis, and auctioning fusion. The Genome-Wide Association Study (GWAS) identified genes and loci associated with non-syndromic CL/P into 43 types significantly associated with single nucleotide polymorphism (SNP) near the gene. This systematic review aims to explore the genetic underpinnings of CL/P by analyzing findings from Genome-Wide Association Studies (GWAS) and identifying key genes and molecular pathways involved in palatogenesis. The most significant genes and loci in non-syndromic CL/P were Interferon regulatory factor 6 (IRF6), MAF bZIP transcription factor B (MAFB), Paired Box 7 (PAX7), Forkhead Box E1 (FOXE1), Msh Homeobox 1 (MSX1), T-box transcription factor 22 (TBX22), and Methylenetetrahydrofolate reductase (MTHFR). Genetic factors play an essential role in the pathogenesis of non-syndromic CL/P, including disruption of signaling pathways. IRF6, MAFB, PAX7, FOXE1, MSX1, TBX22, and MTHFR are genes that play a role in palatogenesis. Mutations in these genes have an impact on orofacial development.
DE-ESCALATING INTENSITY AND PRESERVING OUTCOMES: A BAYESIAN-ML NETWORK META-ANALYSIS OF MULTIMODAL TREATMENT STRATEGIES IN HPV-POSITIVE OROPHARYNGEAL CANCER Rafi, Muhammad Allam
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 3 (2024): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i3.1699

Abstract

The study presents the first integrative Bayesian-machine learning (ML) network meta-analysis, enhanced by machine learning algorithms, to evaluate and rank de-escalation treatment strategies for HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). A total of 2,298 patients from 10 multicenter studies and randomized controlled trials were included, comprising randomized controlled trials, observational studies, and phase II investigations. Twelve distinct treatment strategies were analyzed, including TORS with de-escalated adjuvant RT, reduced-dose chemoradiotherapy, adaptive radiotherapy, and immunotherapy-based regimens. The SUCRA (Surface Under the Cumulative Ranking) scores indicated TORS + de-escalated RT as the top-ranked strategy (SUCRA = 0.91), followed by reduced-dose CRT (0.88) and adaptive RT (0.84). SHAP (SHapley Additive exPlanations) analysis from a Random Forest classifier confirmed that toxicity reduction (impact = 0.34) and quality of life (QOL) improvement (0.28) were the most critical factors driving high SUCRA rankings, with overall survival (OS) rates consistently above 90% in the top three strategies. Funnel plots suggested low publication bias, while cluster heatmaps demonstrated clear stratification of treatment profiles. The t-SNE visualization validated strong feature convergence among top-performing modalities. This analysis highlights the potential of machine learning-guided evidence synthesis to enhance clinical decision-making in personalized OPSCC therapy by balancing oncologic efficacy with functional outcomes.

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