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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 21 Documents
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Search results for , issue "Vol 4 No 2 (2019): JIIS" : 21 Documents clear
STUDI PEMBERIAN INFORMASI TENTANG TEKNIK PENGGUNAAN METERED DOSE INHALER OLEH APOTEKER DAN TENAGA TEKNIS KEFARMASIAN DI APOTEK KECAMATAN MERTOYUDAN, KABUPATEN MAGELANG Heni Lutfiyati; Tiara Mega Kusuma; Septi Wardani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.84 KB) | DOI: 10.36387/jiis.v4i2.258

Abstract

Asthma is a serious health problem and can attack all age groups. Inhalation of drugs is the most important route in the management of asthma. The purpose of this study was to find out the description of the provision of information about the technique of using Metered Dose Inhalers by pharmacists and pharmacy technician at the Mertoyudan District pharmacy, Magelang District. This research is a descriptive study using the investigation research approach that is gathering information related to the provision of information on the use of Metered Dose Inhaler techniques by pharmacists and pharmacy technicians by means of investigation. The data obtained is then analyzed and made conclusions. The variables in this study are providing information about the use of Metered Dose Inhalers by pharmacists and pharmacy technicians. Data collection was carried out in February 2018. The population in this study were all pharmacists and pharmacy technicians in the Mertoyudan District, Magelang District. The sample in this study is Pharmacists and Pharmacy technicians who practice in the pharmacy of the Mertoyudan District Region, Magelang District. Observations made by researchers in Mertoyudan District with a total of 15 pharmacies, obtained 40% of pharmacies available inhaler drugs and 60% of pharmacies are not available because rarely patients buy and the price of drugs is expensive. The results showed that from 9 stages of using Metered Dose Inhalers, all respondents demonstrated the opening and closing stage of the inhaler and press the canister and only 6.67% gave information slowly exhaling until there was no remaining air to be exhaled. The conclusion of the pharmacist who provided complete information about the technique of using inhalers was 6.67%.
KADAR TOTAL ALKALOID, FENOLAT, DAN FLAVONOID DARI EKSTRAK ETIL ASETAT HERBA SURUHAN (Peperomia pellucida [L] Kunth) Islamudin Ahmad; Maryono Maryono; Abdul Mun'im
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.745 KB) | DOI: 10.36387/jiis.v4i2.261

Abstract

The study aimed to determine the total alkaloid, phenolic, and flavonoid content of ethyl acetate extract of Peperomia pellucida (L.) Kunth herbs, especially the herb was obtained from oil palm plantations in Baras, Nort Mamuju District, West Sulawesi Province. The sample was macerated using n-hexane then was followed with ethyl acetate. Determination of total phenolic content was performed using Folin-Ciocalteu reagent, and its absorbance was measured at 750 nm wavelength with gallic acid as a standard. Determination of total flavonoid content was conducted using AlCl3 reagent, and the absorbance was calculated at 415 nm wavelength using quercetin as a standard. Determination of total alkaloid content was calculated against the equal piperine at a wavelength of 435 nm using Dragendorff reagent. Based on the results of determination on ethyl acetate extract of Suruhan herbs was obtained the total phenolic content of 178.768+10.63139 mg/gram, total flavonoid content of 1.397+0.004509 mg/gram, and total alkaloid content of 0.615+0.155885 mg/gram. These results are preliminary data of further studies to the isolation of the targeted compounds and the utilization purposes as a raw material of herbal medicine.
FORMULASI KRIM EKSTRAK ETANOL BETATAS UNGU (Ipomoea batatas L.) Sulistianingsih Sulistianingsih; Ravika Ramli; Herlando Sinaga
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.226 KB) | DOI: 10.36387/jiis.v4i2.262

Abstract

This research aims to determine the best formulation from the cream of a purple sweet potato (Ipomoea batatas L.) ethanol extract. This type of research is descriptive with a laboratory experimental approach. Samples of purple sweet potato (Ipomoea batatas L.) used were from Arso 3 Keerom Regency. The extraction method used is the maceration method using 70% ethanol solvent. In this research, ethanol extract of purple sweet potato was made a cream with three formulas using variations of stearate acid concentration, namely: F1-6%, F2-12%, and F3-18%. The cream will be evaluated including the organoleptic test, pH test, a homogeneity test, irritation test, accelerated stability test. The results showed that the best cream formulation for ethanol extract of purple sweet potato was F3 with variations in stearate acid concentration (18%). Cream F3 has a purplish red color, has a distinctive odor, thick, homogeneous consistency, pH 7, and does not change after storage for ± 3 weeks.
MIKROENKAPSULASI EKSTRAK BUAH BUNI (Antidesma bunius L.) MENGGUNAKAN MALTODEKSTRIN DENGAN METODE SPRAY DRYING Michrun Nisa; Agustina Ma'tang Parinding; Abdul Halim Umar; Nur Khairi; Astuti Amin; Maulita Indrisari; Wahyu Hendrarti; Andi Nur Aisyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.314 KB) | DOI: 10.36387/jiis.v4i2.270

Abstract

Buni fruits (Antidesma bunius L.) is one of the plants that contain anthocyanin dyes. This study aims to create and characterize buni fruit extract microcapsules containing anthocyanin using spray drying method. The coating materials used were 5%, 7%, 5%, 5%, and 5% of the maltodextrin. Buni fruit was determined by the total content of anthocyanin and microcapsules obtained by organoleptic characterization, microencapsulation efficiency, particle morphology, and particle size distribution. The total content of anthocyanin from buni fruit extract is 18.14 mg/100g. Microcapsules obtained by variation concentration of pink maltodextrin typical of buni fruit weighing 2.7 g, 3.3 g, 2.3 g, obtained the value of EEC (%) 50, 55, and 59, respectively, on the appearance of SEM form spheries and on PSA particle size distribution 2.5 μm, 2.1 μm, 2.6 μm.
POTENSI EKSTRAK KULIT LIMAU BANJAR (Citrus reticulata) DENGAN METODE DPPH SEBAGAI ANTIOKSIDAN Bela Ghonim Nashucha; Rakhmadhan Niah; Lutfi Anggraini; Winola Exliscia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.313 KB) | DOI: 10.36387/jiis.v4i2.323

Abstract

Free radicals are a factor that causes various degenerative diseases to occur. Degenerative diseases have become the biggest cause of death in Indonesia, such as cancer, diabetes, heart disease and premature aging. The body needs an important substance to help protect against attacks by free radicals that work by reducing the negative effects of these compounds, namely antioxidants. Natural antioxidants can be obtained through the consumption of herbal plants that contain secondary metabolites of antioxidants, such as banjar orange peel (Citrus reticulata). The aim of this study was to determine the antioxidant activity of banjar orange peel extract which was expressed by inhibitors Consentration 50 (IC50). The banjar orange peel was extracted by maceration method using aquadest solvent and antioxidant activity was tested using the DPPH (1,1-diphenyl-2-picrylhydrazly) method by UV-Vis spectrophotometry at a wavelength of 517 nm. The results showed that the banjar orange peel contained antioxidants which were 10 ppm (29,814%), 20 ppm (35,182%), 30 ppm (43,482%), 40 ppm (50,022%), 50 ppm (58,682%) with IC50 values ​​of 39,041 ppm which is included in the range of very strong antioxidant activity. The conclusion of the study is that the banjar orange peel extract has the potential to be developed as a source of natural antioxidants for humans.
UJI VALIDITAS DAN RELIABILITAS KUESIONER KEPATUHAN MGLS (MORISKY, GREEN, LEVINE ADHERENCE SCALE) VERSI BAHASA INDONESIA TERHADAP PASIEN EPILEPSI Iin Ernawati; Wardah Rahmatul Islamiyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.407 KB) | DOI: 10.36387/jiis.v4i2.330

Abstract

Epilepsy is a chronic brain disease that is characterized by seizures spontaneously, recurs and there is no improvement in each seizure. One measure of therapy epilepsy is decreased or loss of seizures. One of the things that still causes the uncontrolled seizure is adherence. Measurement of adherence in epilepsy patients is one of the tool for know related to the type of therapy and intervention provided. One of the adherence questionnaires that can be used is MGLS (Morisky, Green, Levine Scale Adherence Scale). The MGLS questionnaire is a adherence questionnaire with 4 items of questions, where the questionnaire questions can describe the level of patient adherence in drug consumption. The purpose of this study is to test the validity and reliability of the MGLS questionnaire with the intention that the questionnaire can be applied to patients.This study was a descriptive observational study conducted on epilepsy patients at Airlangga University Hospital. Sampling was done through consecutive sampling method, obtained 42 epilepsy patients between May-July 2018. Validity test was carried out using the Pearson correlation method (correction value ≥0.3) and the reliability test using internal cronbach alpha coefficient ≥0.6. Based on the results of the validity test it is known that the correlation score of each question with the total score is known to correlate more than r table (N = 42) 0.3496. These results indicate that all questions on the Indonesian version of the MGLS questionnaire are valid. Reliability test showed cronbach alpha coefficient 0.634> 0.6 (p <0.05). The conclusion of this study is the valid and reliable MGLS Indonesian version of the questionnaire instrument to determine the level of adherence in epilepsy patients.
IDENTIFIKASI DAN MOLECULAR DOCKING KOMPONEN UTAMA MINYAK KULIT BUAH JERUK NIPIS SEBAGAI AGEN ANTIKANKER Indah Hairunisa; Normaidah Normaidah; Sylvan Septian Ressandy; Fhirda Azhari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.306 KB) | DOI: 10.36387/jiis.v4i2.338

Abstract

Cancer is the highest cause of death in the world. This disease is known to have different regulations from other diseases. The development of drugs today is to target anticancer drugs on cancer regulation sites at Hallmark of Cancer. Lime (Citrus aurantifolia) is one type of Citrus (orange) which contains beneficial chemical compounds and active as anticancer agents. Lime peel is known to have bioactive content in the form of essential oils and flavonoids such as hesperidin and hesperitin. The content of this compound is closely related to anticancer activity. This study aims to identify the content of compounds in lime peel oil and the study of molecular docking silico in these compounds in protein that play a role in the regulation of cancer cells. Lime peel oil is obtained using the steam distillation method then analyzed using GC-MS to determine its constituent components to be analyzed in silico then using YASARA 10.1.8, MarvinSketch 15.4.20, and PLANTS software. The results showed that the main components of lime peel oil were d-limonen and beta-pinen with a percentage of 59.71% and 36.81%. In silico analysis shows that each of these compounds has an affinity greater than the native ligand on caspase-8 proteins (protein regulation of apoptosis). Based on these results it can be concluded, that the lime peel oil has the potential to be developed as an anticancer agent.
POTENSI KOMBINASI KAPUR SIRIH DAN DAUN KUMPAI MAHUNG (Eupatorium inulifolium H.B&K.) SEBAGAI ALTERNATIF SALEP ANTI INFLAMASI ALAMI Dwi Rizki Febrianti; Siska Musiam
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.251 KB) | DOI: 10.36387/jiis.v4i2.339

Abstract

Kumpai Mahung (Eupathorium inulifolium H.B & K) is one of an endemic plant in South Kalimantan. Hereditary used as traditional medicine. kapur sirih (calcium carbonate) is also used by the community as a food additive (BTP), especially in the manufacture of chips and fruit ice. Traditionally these two ingredients are combined to treat swollen (oedema) mastitis in nursing mothers. This research method using raw test pad oedema in legs male rats. simple ointment dosage form, induction carrageenan 3% and hydrocortisone as a positive control anti-inflammatory calculated the value and the value AUC (area under the curve). the results expressed Ointment combination Kumpai Mahung leaf extract and calcium carbonate have anti-inflammatory power of 14.91% greater than the positive control 9.95%.
ANALISIS KANDUNGAN FORMALIN PADA CABE MERAH GILING YANG DIJUAL DI PASAR TRADISIONAL KOTA JAMBI Havizur Rahman; Dika Zamri Yanni; Putri Maya Sari; Mia Prajuwita; Intan Lestari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.065 KB) | DOI: 10.36387/jiis.v4i2.341

Abstract

Research has been conducted to analyze the presence of formaldehyde content in ground red chili which is sold in the traditional markets of Jambi city. The milled red chili samples were obtained from 5 markets and each market was chosen by 5 milled red chili traders. Stages in this study include sample preparation, a qualitative test of formaldehyde content using chromatophenic acid reagents, and quantitative analysis of formalin using UV-Vis spectrophotometer at a wavelength of 566 nm. The results of this study showed 6 of the 25 samples identified to contain formalin. Qualitative analysis with chromatophenic acid reagents showed a change in color to brown. Formalin levels for positive samples included A2 samples at 0.54 g / kg, B4 at 0.74 g / kg, C2 at 0.56 g / kg, D3 at 0.65 g / kg, E3 at 0.53 g / kg, and E4 of 0.65 g / kg. It can be concluded that the discovery of formaldehyde content in ground red chili at several points in the traditional markets of the city of Jambi.
EFEKTIVITAS DAUN RAMANIA ASAL KALIMANTAN SELATAN UNTUK MENURUNKAN KADAR GULA DARAH Saftia Aryzki; Yugo Susanto
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.866 KB) | DOI: 10.36387/jiis.v4i2.342

Abstract

Ramania or Gandaria is a swamp plant in the area of South Kalimantan from one of the mango families that is not cultivated by the community, the types are diverse, including fruit size, flavor, and color. Ramania leaves have properties to reduce blood sugar levels. High blood sugar levels are a manifestation of diabetes mellitus. The purpose of this study was to determine the effectiveness of ramania leaf extract as a decrease in blood sugar levels with the oral glucose tolerance test (TTGO) method. This study was a true experimental with a pre-post test design with randomized control group design. The stages of the research method were carried out with a preliminary stage and an antidiabetic activity test stage with an oral glucose tolerance test (TTGO) method with Sprague Dawley strain male rats. The results of the research that have been done can be concluded that the extract of ramania leaf (Bouea macrophylla Griffith) can reduce the blood sugar levels of white mice (Mus muscullus) which are induced by alloxan. The dose used in this study was the lowest dose 0.455 mg / 200 kg body weight, treatment group 2 (P2) with moderate dose (usual use dose) 0.91 mg / 200 g body weight, and treatment group 3 (P3) with high dose 1, 82 mg / 200 g BW. Of the three groups approaching positive control, P3 with blood sugar levels after 14 days of treatment was 77.08 mg / dL and 77.79 mg / dL, respectively.

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