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Jurnal Farmanesia

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Published by Universitas Sari Mutiara Indonesia

ISSN : """" EISSN : 25282484 DOI : https://doi.org/10.51544/jf.v8i2

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 19 Documents

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Search results for , issue "Vol 4 No 2 (2017): Jurnal Farmanesia" : 19 Documents clear

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli, Shigella dysentriae, DAN Salmonella typhi Yosy Cinthya Eriwaty Silalahi; Realisni Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

One of the medicinal plants is the areca nut (Areca catechu L.) from the Arecae family which has the potential as an anticancer having antioxidant and antimutagenic, astringent, and anthelmintic effects. Areca nut seeds contain alkaloids, such as arekoline, arekolidine, arekain, guvakolin, guvasine and isoguvasine. This study aims to determine the characteristics of the betel nut (Areca catechu L.) simplicia, class of compounds, and the antibacterial activity of the ethanol extract of areca nut (Areca catechu L.) against the growth of Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria. The method used is the ethanol extract of areca nut (Areca catechu L.) obtained from the maceration process with 96% ethanol. The results of phytochemical screening showed that the ethanolic extract of areca nut (Areca catechu L.) contains a group of alkaloid compounds, tannins, flavonoids, saponins, and triterpenoids. The effect of giving young betel nut ethanol extract to Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria was indicated by the formation of an inhibition zone of optimum concentration. The ethanol extract of old betel nut against Escherichia coli, Shigella dysentriae, and Salmonella typhi bacteria was characterized by the formation of an optimum concentration inhibition zone. Based on the results, it can be concluded that the ethanol extract of areca nut (Areca catechu L.) has antibacterial activity against Escherichia coli, Shigella dysentriae, and Salmonella typhi.

PENGARUH INFUSA KULIT BUAH MANGGIS (Garcinia mangostana) TERHADAP PROFIL FARMAKOKINETIKA PARASETAMOL PADA TIKUS PUTIH JANTAN (Rattus norvegicus L.) Kesaktian Manurung; Siti Nurbaya; Rezkita Raysyah
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Mangosteen rind is traditionally used by residents of Southeast Asia, especially Indonesia, to treat various diseases. Drug interactions can reduce or eliminate efficacy and cause serious health problems or problems. This study aims to determine the effect of mangosteen rind infusion on the pharmacokinetic profile of paracetamol administered orally to male white rats. Infusion of mangosteen rind was made in doses of 10% and 20%. The study was conducted by giving the solution successively for 7 days and on the 7th day after 4 hours, paracetamol solution was given orally. Furthermore, the blood of each male rat was taken with a time of 0 minutes, 10 minutes, 20 minutes, 30 minutes, 40 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes, and 360 minutes and measured by UV spectrophotometry. a wavelength of 257 nm. The results showed that there was an effect of mangosteen rind infusion on paracetamol in test animals.

FORMULASI DAN EVALUASI SEDIAAN LIP BALM DENGAN PEWARNA EKSTRAK UBI JALAR UNGU (Ipomoea batatas (L.) Lamk.) Supartiningsih Supartiningsih; Elly Nurita Sitorus; Yosy Cinthya Eriwaty Silalahi; Khairunnisa Khairunnisa
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Lip balm is a cosmetic preparation with the main components such as wax, fat, and oil from natural or synthesized extracts with the aim of preventing dryness of the lips by increasing lip moisture and protecting the adverse effects of the environment on the lips. The use of purple sweet potato as a dye is because purple sweet potato (Ipomoea batatas (L.) Lamk.) has an attractive color, the color of purple sweet potato is due to the presence of anthocyanin pigments which are derivatives of flavonoid compounds which are generally soluble in polar solvents. This study aims to formulate and evaluate lip balm preparations using purple sweet potato extract at concentrations of 3%, 6%, 9%, and without using purple sweet potato extract. This research is experimental research. Lip balm preparations were made by adding purple sweet potato extract with various concentrations (F1) 3%, (F2) 6%, (F3) 9%, and blank formula (F0) as the basis for lip balm preparations without purple sweet potato extract. Evaluation of the preparation includes homogeneity test, stability test, smear test, adhesion test, spreadability test, and pH test. The test results showed that purple sweet potato extract can be formulated in lip balm preparations that have a homogeneous composition, have good smearing power, good adhesion F0 (1 minute), F1 (1 minute 3 seconds), F2 (1 minute 8 seconds). seconds), F3 (1 minute 11 seconds), spreadability (5-5.7cm), pH test on all preparations showed a pH that was in accordance with the pH of the skin. And obtained formula 3 is the best formula.

PENETAPAN KADAR KALSIUM PADA BEDAK TABUR DARI BAHAN BAKU CANGKANG KERANG BULU (Anadaraantiquata) SECARA KOMPLEKSOMETRI Siti Nurbaya; Artha Yuliana Sianipar; Elly Nurita Sitorus; Winton F. Situmorang
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Until now, the utilization of clamshell waste has been limited to handicraft materials, whereas shellfish waste has a high calcium carbonate composition of about 98% which can be used as a source of calcium in the synthesis of compounds containing calcium metal. The purpose of this study was to determine the level of calcium contained in the shells of mussels and to determine the levels of calcium in the preparation of talcum powder which was added with powdered shells of feathers as an abrasive. Complexometric titration is also used to determine calcium levels in powder preparations formulated with feather shells powder. The results showed that the shells of feather shells contained calcium levels of 19.49% while the loose powder preparations contained calcium levels of 1.475%. The test results of the research on the formulation of loose powder preparations met the physical evaluation requirements. The pH test on loose powder, namely pH 7, meets the requirements of SNI 16-4399-1996, the pH value of cream cosmetic products is required to range from 4.5 to 8.0. The fine degree test is qualified because the loose powder can pass the sieving using a 100 mesh.

PENETAPAN KADAR VITAMIN C PADA DAUN JELATANG (Urtica dioica L.) DENGAN MENGGUNAKAN SPEKTROFOTOMETRI ULTRAVIOLET Zuhairiah Nasution; Siti Nurbaya; Supartiningsih Supartiningsih; Tiurma Sitompul
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Nettle leaf (Urtica dioica L) is the most widely known species in the genus Urtica and has many benefits for the community, one of which is to treat venereal diseases, kidney disorders, allergies, diabetes, anemia, and digestive tract diseases. Vitamins contained in nettle leaves that are useful for the body is vitamin C. Vitamin C has properties that are easily damaged by heat, and easily soluble in water. This study aims to determine the levels of vitamin C in young and old nettle leaves by an ultraviolet spectrophotometric method using Aquadest solvent and read a wavelength of 265 nm with a linear regression equation y= ax + b with a value of y= 0.0525 + 0.0618 with r = 0.9878 each treatment was replicated 6 times. Based on the results of the qualitative test experiment, it was stated that in nettle leaves there was vitamin C with iodine solution reagent, FeCl3, Fehling A&B, and obtained vitamin C levels in old nettle leaves 0.2526 mg/g and in young nettle leaves 0.2026 mg/g. So that the levels of vitamin C in old nettle leaves are higher than in young nettle leaves.

PENGARUH MINYAK SAWIT MERAH (RPO) DAN MINYAK ZAITUN MURNI (EVOO) TERHADAP PERTUMBUHAN RAMBUT PADA KELINCI Ahmad Gazali Sofwan; Adiansyah Adiansyah; Rika Rosalinda Tampubolon
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Haircare products are very important to prevent one of the problems of hair damage, both from synthetic and natural ingredients. One of the natural ingredients of hair care products is Red Palm Oil (RPO) and Extra Virgin Olive Oil (EVOO). This research is an experimental study that aims to see whether Red Palm Oil and Extra Virgin Olive Oil have effectiveness in growing hair. This research method used 4 groups of test animals, namely the red palm oil group, extra virgin olive oil, negative control (aqua dest), and positive control (minoxidil). The hair growth activity test was carried out by applying each formula to the marked rabbit's back and measuring the length of the hair using a caliper on the 5th, 10th, 15th, 20th, 25th, and 30th days. On the 31st day, the hair weight was tested by weighing the hair using an analytical balance. The results showed that each formula had hair growth activity, but the most effective oil preparation in accelerating hair growth was Red Palm Oil (RPO).

PENGGUNAAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereuscostaricensis (F.A.C. Weber) Britton & Rose.) DALAM FORMULASI PEWARNA RAMBUT Cut Masyithah; Siti Maimunah; Zuhairiah Zuhairiah; Cahaya Amalia Sitorus
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Hair is a symbol of beauty in humans which is one of the adnexa (parts) of the skin that grows from the skin. Hair grows from the root, hair that is in the dermis layer, and through the hair follicle channel out of the skin. There are some differences in each hair such as type, shape, amount, and color. Dragon fruit peel is an agricultural waste that contains high anthocyanin natural dyes. Anthocyanin is a dye that plays a role in giving red color which has the potential to be a natural colorant for food and can be used as an alternative to synthetic dyes that are safer for health. Anthocyanin was taken by the extraction method. The results showed that the higher the concentration of the adjuvant used, the darker the gray hair. The use of auxiliary materials in a concentration of 0.5% produces a brownish-black color, and a concentration of 1% produces a dark black color. The preparation of gray hair dye made with the formula of 2.5% dragon fruit peel extract and 1% adjuvant produces a deep black color, so pyrogallol, copper (II) sulfate, xanthan gum with a concentration of 0.5% are used in order to distinguish changes on white hair (grey), due to the EKBN formula or from added additives.

UJI AKTIVITAS EKSTRAK ETANOL BAWANG PUTIH (Alliumsativum L.)YANG DIHITAMKAN SEBAGAI ANTI INFLAMASI YANG DIINDUKSI OLEH KARAGENAN TERHADAP Mus musculus Dicky Yuswardi Wiratma; Kesaktian Manurung; Supartiningsih Supartiningsih; May Fransisca Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

One of the plants used as an alternative to traditional medicine is Garlic (Allium sativum L.). Garlic which is rich in organic organo sulfur compounds (amino acids and essential oils) in the form of allin has many benefits in treating various types of diseases. One of the processed forms of garlic is black garlic. Black garlic is a heating product from garlic that is heated at a temperature of 70oC with a relative humidity of 70-80%. This study aims to determine the use of black garlic as an anti-inflammatory, how to make black garlic and at what concentration black garlic has an anti-inflammatory effect. The method used in this research is a pure experimental method. The results of the %R measurement, the negative control group had the highest level of inflammation and the lowest was the black garlic extract group with a concentration of 60%. Meanwhile, in the %IR measurement, the black garlic extract group with a concentration of 60% had the greatest ability to block inflammation. From the tests that have been carried out, black garlic is obtained from heating results and the results of measuring the effectiveness of its anti-inflammatory activity, namely black garlic extract with a concentration of 60% have a better anti-inflammatory effect compared to other concentrations and diclofenac sodium.

UJI AKTIVITAS GETAH GAMBIR(Uncariagambir Roxb.) TERHADAP BAKTERI Escherichia coli DAN Salmonella typhi Adiansyah Adiansyah; Ahmad Gazali Sofwan; Siti Nurbaya; Lestari Simanjuntak
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Gambir is an extract of the leaf sap and twigs of the Gambir plant (Uncariagambir Roxb.) which has been dried. According to information, Gambir sap can be used as a mixture of drugs for burns, headache medicine, diarrhea medicine, mouthwash, thrush medicine. Because there is the main content of catechins and tannins. The purpose of this study was to determine the antibacterial activity of secondary metabolites and the concentration of Gambir sap (Uncariagambir Roxb.) against Escherichia coli and Salmonella typhi bacteria. The method used is agar diffusion using disc paper. The results showed that the diameter of the inhibition of Gambir sap on Escherichia coli bacteria at a concentration of 300 mg/ml in the bacterial test was 16.03 mm, at a concentration of 200 mg/ml there was a bacterial test of 15.00 mm and Salmonella typhi at a concentration of 300 mg/ml contained bacterial test 16.06 mm, at a concentration of 200 mg/ml bacterial test 16.03 mm.

ANALISA KADAR CEMARAN LOGAM MERKURI PADA IKAN SARDEN (Sardinella lemuru) KEMASAN KALENG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Yosy Cinthya Eriwaty Silalahi; Cut Masyithah Thaib; Siti Nurbaya
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Food packaging in cans is a food preservation technology using high-temperature sterilization. Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. This study aims to determine the levels of mercury contamination in canned sardines. The samples used in this study were 6 different brands of canned sardines. The method used to determine mercury (Hg) levels is qualitatively using color reagents and quantitatively using AAS (Atomic Absorption Spectrophotometry). The results obtained from 6 samples of canned sardines that were positive for heavy metal mercury (Hg) were indicated by the formation of orange color with KI reagent, yellow precipitate with NaOH, white precipitate with HCl. The wavelength used is 253.7 nm. The results showed that Brand A mercury 4.9814 ± 0.0301 mg/kg, Brand B 0.8757 ± 0.0308 mg/kg, Brand C 1.4899 ± 0 mg/kg, Brand D 1.4175 ± 0 mg/kg , Brand E 0.7527 ± 0 mg/kg, and Brand F 0.5270 ± 0 mg/kg. This study concludes that the mercury content in canned fish circulating in the Medan Brastagi Supermarket is above the maximum limit allowed by the National Standardization Agency (2016) in SNI 8222-2016, which is 0.5 mg/kg.

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Journal Mail Official ojs.usmindonesia19@gmail.com

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Location Kota medan, Sumatera utara INDONESIA

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Contact Name
HENNY SYAPITRI

Contact Email
heny_syahfitri86@yahoo.com

Phone
+6285359022627

Journal Mail Official
ojs.usmindonesia19@gmail.com

Editorial Address
http://e-journal.sari-mutiara.ac.id/index.php/2/Editorial-Team

Location
Kota medan,

Sumatera utara

INDONESIA