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Zahratul Aini
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INDONESIA
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 14 Documents
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Search results for , issue "JKKI, Vol 10, No 3, (2019)" : 14 Documents clear
COMPARISON OF PHYSICAL PROPERTIES AND RATE OF RIFAMPICIN DISSOLUTION IN FIXED DOSE COMBINATION 2FDC TABLET AGAINST TO RIFAMPICIN TABLET Normalitasari Ayu Damayanti; Widyasari Putranti; Deasy Vanda Pertiwi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art4

Abstract

Background: The World Health Organization (WHO) has recommended using fixed dose combination (FDC) for tuberculosis treatments as it can improve patient compliance and prevent drug resistance. A combination of rifampicin and isoniazid can cause reductions in concentration of each drug because the rifampicin is labile and can not be mixed with all three other TB drugsObjective: This study is aimed to understand effects of the combination of both physical properties and dissolutions of rifampin. Methods: This laboratory study observed rifampicin tablets and combination tablets of rifampicin and isoniazid (2 FDC) by testing physical properties of the tablets and dissolution tests. Friability test was conducted by using friability tester, hardness test was by hardness tester, disintegration test was by disintegration tester and dissolution test was by dissolution tester type 1 (basket). Its data were analysed by Mann Whitney test. The data had value if p<0.05 with CI 95%.Results: This study found that each tablet of rifampicin and 2 FDC tablets respectively had averages of 0.25% and 0.14% of brittleness, 11.07 kg and 10.19 kg of hardness, 2 minutes 1 second and 10 minutes 9 seconds of disintegration time. Consequently, the generic rifampicin tablets were more fragile but harder and faster to crumble than the 2 FDC tablets, in which their mean values were DE45 92.03% and 93.94%. Based on statistical test of Mann Whitney on the rifampicin tablets and 2 FDC, there were no significant differences of hardness test result and mean DE45 0.076(p>0.05 ), while there were significant difference of fragile test result and disintegration time 0.015(p<0.05).Conclusion: The combination of rifampicin and isoniazid in tablet 2 Fixed Dose Combination (2 FDC) had no effects on the dissolution rates of rifampicin, but they had effects on some parameters of physical property test of the tablets.
FRAKSI ETIL ASETAT SPONS Stylissa carteri MENURUNKAN VIABILITAS SEL KANKER PAYUDARA TIPE HER2+ RESISTEN TRASTUZUMAB Julia Nur Jannah; Pandji Irani Fianza; Tenny Putri; Muhammad Hasan Bashari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art6

Abstract

Background: HER2+ breast cancer is a very aggressive type of breast cancer. Although trastuzumab, specifically targeted for HER2, has been used for breast cancer treatments, some patients become resistant to trastuzumab. A marine sponge is one of the potential sources of anticancer agents. One of marine sponges commonly found in Indonesia is Stylissa carteri, but it has not been explored extensively.Objective: This study aimed to identify cytotoxic effects of the ethyl acetate fraction of Stylissa carteri on HCC-1954, HER2+ trastuzumab-resistant breast cancer cells, by assessing cell viability and determining IC50 value.Methods: This study was an experimental in vitro study conducted in The Cell Culture Laboratory, Faculty of Medicine Universitas Padjadjaran on February 2018 to June 2018. The Stylissa carteri was collected from Pramuka Island, Kepulauan Seribu National Park Jakarta. HCC-1954 cells were treated by serial concentration of fractions and were incubated for 72 hours. Cell viability were observed under a microscope and analysed with MTT assay. The IC50 value was also determined by using four parametric logistic regression (4PL) method by Sigmaplot version 12.0. Result: Data of this study showed descent of cell viability significantly when exposing the ethyl acetate fraction of Stylissa carteri. There was a decrease of 49% cell viability in 10 µg/ml of the ethyl acetate fraction of Stylissa carteri. The estimated IC50 value was 9.25 µg/ml.Conclusion: This result indicated that the ethyl acetate fraction of Stylissa carteri has cytotoxic effects on HER2+ trastuzumab-resistant breast cancer cells.
SUBCRONIC TOXICITY TEST COMBINATION OF Phyllanthus niruri AND Centella asiatica EXTRACT AT HEMATOLOGY IN RATS Siti Fatmawati Fatimah; Endang Darmawan; Iin Narwanti; Dzulhaifa Dzulhaifa; Ira Aprilia Wulandari; Ria Putri Salma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art8

Abstract

Background: Meniran (Phyllathus niruri) and pegagan (Centella asiatica) are well-known medicinal plants in Indonesia. Uses of meniran and pegagan as herbal medicines need to be examined for their subchronic activity to assure their safety. Objective: This study aimed to evaluate subchronic effects of a combination of extracted meniran and pegagan on Wistar rats through haematological parameters (erythrocytes, haemoglobin, haematocrit, MCV, MCH, and MCHC).Methods: Animal models used were 56 male and female Wistar rats and were divided randomly into 4 groups. Group 1 received CMC-Na 1% (control group). Group 2 received extracts of meniran and pegagan (50:50 mg/kgBW). Group 3 received extracts of meniran and pegagan (250:250 mg/kgBW). Group 4 received extracts of meniran and pegagan (1250:1250 mg/kgBW). Subchronic test of meniran and pegagan was conducted by providing treatments for the Wistar rats for 28 days. Their haematological substances were analysed statistically by using one way ANOVA and Kruskal-Wallis method with confidence interval of 95% and post-hoc. Results: This study found that the haematological substances in male Wistar rats were normal and did not significantly change (p>0,05). It also showed that haemoglobin and haematocrit substances in female rats were normal and did not significantly change (p>0,05). Erythrocytes, MCV, MCH, and MCHC in female rats indicated significant change (p<0,05), but they were still in normal ranges.Conclusion: It could be concluded that administration of the combination of extracted meniran and pegagan was not toxic to haematology of the rats in all doses.
HUBUNGAN PEMANFAATAN PELAYANAN KESEHATAN IBU HAMIL DENGAN PEMILIHAN FASILITAS PERSALINAN DI INDONESIA Hadi Ashar; Leny Latifah; Ina Kusrini; Dwi Hapsari Tjandrarini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art10

Abstract

Background: Maternal mortality rate (MMR) in Indonesia is still high, 359 per 100,000 born alive. One of the government's efforts to reduce MMR is by providing antenatal care (ANC) service, and holding pregnancy classes (KIH). KIH is a program to increase maternal knowledge and support the making pregnancy safer (MPS) program policy, which is an Obstetric service approach, that every pregnant woman must be assisted by health workers. Objective: The purpose of this study is to determine the relationship between ANC and KIH to the place and birth attendants.Methods: A cross-sectional study, national health indicator survey (SIRKESNAS) 2016, calculation of samples based on the 2010 population census (SP) data. Primary sampling unit (PSU) is a sub-district selected as probability proportional to size (PPS), households that have children aged 0-59 months (Eligible households), samples were selected by simple random sampling of eligible households, as many as 7,313 mothers. The collected variables were ANC, KIH, and the place and birth attendant. Data were analyzed by logistic regression testResults: Logistic regression test results showed that the ANC was positively related to the place of delivery (OR 4,054; p <0.000) and birth attendants (OR 2.659; p <0.000). There was a relationship between KIH and the place of delivery (OR 1,327; p <0.001), and birth attendants (OR 1,718; p <0,000).Conclusion: Mothers who performed at least 4 ANCs, and attended pregnancy classes, were more likely to choose to deliver in health care facilities and deliver with health workers.
Peran dokter puskesmas dalam menerapkan prinsip kedokteran keluarga untuk mencegah difteri di Kota Banda Aceh Zahratul Aini; Eti Poncorini Pamungkasari; Ari Probandari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art5

Abstract

Background: They are expected to be able to apply principles of family-based health treatments by prioritizing preventive, coordinative, and collaborative services. Based on the principles, identifying and managing diphtheria cases at some of health centres should be evaluated because there have been an increase of diphtheria cases, especially in Banda Aceh city.Objective: This study aimed to evaluate roles of doctors in the health centres to prevent the diphtheria. Furthermore, this research also aimed to determine obstacles of the diphtheria treatments encountered by the doctors.Methods: This study was a multiple case study. Its data were collected by in-depth interviews with doctors at five health centres in Banda Aceh. Data from the interviews were verified by using source and technical triangulation methods at the health offices and governmental hospitals in Banda Aceh.Result: Doctors’ efforts at the health centres in Banda Aceh to apply principles of family medicine for the immunization experienced some obstacles. For example, they had less understanding about developing problems in their societies, namely issues of illegitimate (haram) vaccines and KIPI (post-immunization follow-up events). They also did not make active efforts to identify diphtheria cases by making coordination with their colleagues in other health service units.Conclusion: The doctors at the health centres of Banda Aceh had not fully implemented the principles of family medicine.
Status resistensi vektor Aedes aegypti terhadap malation dan enzim esterase non spesifik di kecamatan Tembalang Irneta Bela Novita; Martini Martini; Retno Hestiningsih; Sri Yuliawati; Nissa Kusariana; Mochammad Hadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art3

Abstract

Background: Controlling of dengue vectors around dengue haemorrhagic fever cases is often conducted by using insecticides, including a malathion insecticide in the city of Semarang. A research on susceptibility status of Ae. aegypti to insecticides, used for fogging and based on a high number of hemorrhagic fever cases in Tembalang district, Semarang city, needs to be observed.Objective: This study aimed to determine resistance status of Ae. aegypti mosquitoes based on bioassay and biochemical tests of esterase non-specific enzyme activity in the Tembalang District. Methods: This study used a cross sectional design, it was conducted in June-September 2018 in a population of Aedes sp. from Tembalang District, Semarang City. Samples of F2 generations of female Ae. aegypti were obtained by ovitraps in the Tembalang District consisting of 12 urban villages, and their resistance status were tested by impregnated paper bioassay with malathion at a diagnostic dose of 0.8%. Esterase enzyme activity in the Ae. aegypti mosquito body of this population was tested biochemically to prove an increase in a non-specific esterase enzyme on the a-naphthyl acetate substrate.Results: The bioassay results showed that mortality rates of Ae. aegypti at the 12 villages in Tembalang district after 24 hourtest by impregnated paper indicated a range of 0-62%. Mechanism of resistance indicating an increase of non-specific enzyme esterase activity on a-naphthyl acetate at Rowosari, Kedungmundu, Sambiroto, and Meteseh could not be seen, It began to be seen in a low percentage (15%) at Sendang Mulyo, Tandang, Sendangguwo and Bubusan, and in a moderate percentage (45-75%) in Tembalang, Jangli and Mangunharjo. The mechanism of high esterase enzyme activity could be seen in the Ae. aegypti population at Kramas with AV=0,700-0,900 by a percentage of 20%, and AV=0,900 by a percentage of 80%.Conclusion: This study provided information about some Ae. aegypti mosquitoes from Tembalang District that showed resistance to the malathion insecticide with an elevation of non-specific esterase enzyme activity ona-naphthyl acetate substrate in several villages except Kelurahan Rowosari, Kedungmundu, Sambiroto, and Meteseh.
Evaluation of vector mediated gene therapy as a novel approach to mitigate cardiovascular diseases; A short review Saleh Muhammad Raqib; Syaefudin Ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art11

Abstract

Positioning in the top list of mortality and morbidity, cardiovascular disease (CVD) is required new approaches to mitigate the risk and prevalence. Recombinant DNA (rDNA) technology and genome sequencing explore the new horizon to treat CVD through modified therapy. Gene transfer mechanism eventually angiogenic gene therapy provides efficacy in early-stage heart failure. Targeted gene delivery system depicts the novel therapeutic pattern for both genetic disorder and pathophysiological deficit and opens the pathway of early diagnose and treatment. Despite  some limitations of a specific vector (viral vector) mediated gene transfer, these new approaches make  hope on CVD treatment rather than the surgery and other ways.  Furthermore, some vectors are less hazardous than viral vectors to suggest successful non-viral gene modulations to Cardiovascular tissues and perform in the clinical trial. However, plasmid-mediated gene transfer method along with genome editing technology might be the best possible approach for future CVD prognostics and diagnostics.
Effects of a support group to self efficacy of breast cancer patients that receiving chemotherapy Hanik Rohmah Irawati; Yati Afiyanti; Mondastri Korib Sudaryo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art7

Abstract

Background: The self-efficacy to cope with breast cancer patients can improve their adaptive coping skills, well-being and quality of life. Objective: This study aims to identify the effects of a support group to improve self-efficacy of breast cancer patients that receiving chemotherapy.Methods: This study used a quasy-experimental design with non-equivalent control pre-test post-test design. As much as 76 patients with breast cancer were assigned into either an experimental group or a control group (38 person each). All of them were selected through a consecutive sampling method. In addition, it used an instrument of cancer behavior inventory version 2. Results: Respondents who were supported by the support group had 1.4 times higher level of self-efficacy to cope with cancer than those who were not supported by a support group. No significant difference in the level of self-efficacy to cope with the cancer between the experimental group and the control group (RR 1.4 with 95% CI 1.0-1.8, a > 0.05).Conclusion: Supports provided by the support group had no effect on the level of self-efficacy to cope with the cancer.
Bullying of adolescent in Yogyakarta: Responses and impacts Ema Waliyanti; Farhah Kamilah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art9

Abstract

Background: Phenomena of bullying for adolescents in Indonesia require a serious concern from the government, schools and parents. A high number of bullying incidents on adolescents can have negative impact physically and psychologically for actors and victims. Adolescent responses on bullying can be indicated as self-defence of a victim when being bullied.Objective: This research aimed to identify adolescent responses on bullying and its impacts for the adolescents in Yogyakarta.Methods: This study used a qualitative method of phenomenology. Data in this study were collected through observation and in-depth interviews. Participants included in this study were 14 people who consists of parents, adolescents, and teachers, and they were determined by purposive sampling. Validating of the data was conducted by using methodological triangulation, data triangulation and peer debriefing. Thematic data analysis was conducted by using the open code software 4.02.Results: This study found that the responses of adolescents to the bullying included resistance, avoidance, silence, and fear. Then impacts of the bullying could make the victims have avoidant personality disorder or shift them as actors. For actors, they would feared by his friend at school and get punishment from the school.Conclusion: Prevention of bullying of adolescents is urgently needed to overcome the impacts for the adolescents. The results of this study could be used as basic data to deal with bullying of the adolescents.
Irritant contact dermatitis caused by sap of rengas Betty Ekawati Suryaningsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art14

Abstract

Irritant contact dermatitis (ICD) is an inflammation of skin caused by direct cytotoxic effects of chemical, physical or biological agents on epidermal cells without a presence of specific antibody production. It was reported that a 40-year-old man, complaining of itching and a burned sensation on his skins accompanied by pain after contaminated by sap of Rengas. Diagnosis of ICD was established by history taking and physical examination: there are erythematous, multiple, discrete papules, partly necrotic-erythematous skin base on his forearm and right lower abdomen. The patient was treated with mometasone furoate smeared and antihistamines once a night. A characteristic of the sap is black on its woods. Compounds of the sap contain ursiol, rengol, glutarengol, laccol and thitsiol that are irritants causing the ICD. 

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