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Bayu Brahma
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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 3 Documents
 1 
Search results for , issue "Vol 9, No 3 (2015): Jul - Sept 2015" : 3 Documents clear
Hubungan antara Ekspresi mRNA Gen Epidermal Growth Factor Receptor (EGFR) dengan Penurunan Kadar ?-hCG Serum Pasca-evakuasi Mola Hidatidosa Komplit LAURENS DAVID PAULUS; YUDI MULYANA HIDAYAT; SUPRIADI GANDAMIHARJA
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (654.467 KB) | DOI: 10.33371/ijoc.v9i3.385

Abstract

In 2008, the incidence of hydatidiform mole that occurred in West Java around 1:28. Malignant transformation of Complete Hydatidiform Mole (CHM) is influenced by many factors, among others, is the expression of the epidermal growth factor receptor (EGFR). This study uses Historical Cohort to retrieve CHM patients data and trophoblastic tissue paraffin block in 2007-2012, and perform examination of Polymerase chain reaction.Results of the study: 40 CHM patients, 24 with EGFR (-) and 16 with EGFR (+), at 12 weeks monitoring post evacuation using the Mochizuki regression curve was not obtained persistent mole in the group with EGFR (-), while the group of EGFR (+), all showed an increase in ?-hCG levels. Relative risk (RR) of 3.4 in the CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 6th week and RR of 13.0 in CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 8th week. The conclusion of this study demonstrate the suitability of the hypothesis that the higher mRNA gene expression of EGFR, the slower decrease in serum levels of ?-hCG after CHM evacuation and expression EGFR (+) may be a predictor of the occurrence of persistent mole.Pada 2008, insiden mola hidatidosa (MH) yang terjadi di Jawa Barat sekitar 1:28. Transformasi keganasan dari mola hidatidosa komplit (MHK) dipengaruhi oleh banyak faktor, antara lain ekspresi Epidermal Growth Factor Receptor (EGFR). Penelitian ini menggunakan metode historical cohort dengan mengambil data dan parafin block jaringan trofoblas pasien MHK tahun 2007?2012, dan dilakukan pemeriksaan POLYMERASE CHAIN REACTion. Hasil penelitian menunjukkan dari 40 pasien MHK, 24 di antaranya EGFR (-) dan 16 EGFR (+) pada 12 minggu pascaevakuasi menggunakan kurva regresi Mochizuki. Tidak didapatkan mola persisten pada kelompok EGFR (-), sedangkan kelompok EGFR (+) semuanya menunjukkan peningkatan ?-hCG (mola persisten). Risiko relatif (RR) sebesar 3,4 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-6 dan RR sebesar 13,0 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-8. Hasil penelitian ini menunjukkan kesesuaian dengan hipotesis bahwa semakin tinggi ekspresi EGFR maka semakin lambat penurunan kadar ?-hCG serum pasca-evakuasi MHK. Ekspresi EGFR dapat menjadi prediktor terjadinya mola persisten.
Profil Pasien Kanker Payudara di Rumah Sakit Onkologi Surabaya, 2014 LOELITA MARCELIA LUMINTANG; ADI SUSANTO; RAISSA GADRI; ARIO DJATMIKO
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.409 KB) | DOI: 10.33371/ijoc.v9i3.386

Abstract

The prevalence of breast cancer in developing countries as well as developed countries still occupies in high level. The awareness of breast cancer risk factors can enhance the early detection program. The objective of this research is to achieve a complete description concerning risk factors: social, economy and demography statuses that will be advantageous for integrated prevention program of breast cancer. This descriptive research used 485 datas out of 560 medical records that belonged to Rumah Sakit Onkologi Surabayas new breast cancer patients in 2014. The results of this research showed that 31.34% of breast cancer patients attained in the age of 41-50 years old and 51-60 years old; 41.65% acquired university education, 53.61% lived in Java; 69.69% did not have any history of cancer in their family; 85.36% did not have any history of breast cancer in their family; 57.31% were housewives; 42.27% obesity; 46.19% had been pregnant more than twice; 38.56% gave birth more than twice; 82.06% never used any contraception; 8.66% usedcontraception for 1-5 years; 63.71% breast-feeding; 27.84% breast-feeding to 3 or more children; and 21.03% breastfeeding for 0 to 6 months. There were some risk factors that are detectable and preventable.Prevalensi kanker payudara di negara berkembang dan negara maju masih sangat tinggi. Kesadaran akan faktor risiko kanker payudara dapat meningkatkan peluang untuk melakukan program deteksi dini. Penelitian ini bertujuan untuk mendapatkan gambaran yang lengkap perihal faktor risiko: status sosial, ekonomi, dan demografi yang akan bermanfaat untuk perencanaan program penanggulangan kanker terpadu. Penelitian deskriptif ini menggunakan 485 data dari 560 data rekam medis pasien kanker payudara baru 2014 di Rumah Sakit Onkologi, Surabaya. Hasil penelitian menunjukkan 31,34% pasien berusia 41?50 tahun dan 51?60 tahun; 41,65% berpendidikan universitas; 53,61% bertempat tinggal di Pulau Jawa; 69,69% tidak memiliki riwayat keluarga dengan kanker; 85,36% tidak memiliki riwayat keluarga dengankanker payudara; 57,31% ibu rumah tangga; 42,27% obesitas; 46,19% hamil lebih dari 2 kali; 38,56% melahirkan lebih dari 2 kali; 82,06% tidak pernah menggunakan kontrasepsi; 8,66% menggunakan kontrasepsi selama 1-5 tahun; 63,71% memiliki riwayat menyusui; 27,84% menyusui 3 anak atau lebih; dan 21,03% menyusui selama 0?6 bulan. Didapatkan sejumlah faktor risiko yang dapat diwaspadai serta dicegah.
Koagulasi Intravaskuler Diseminata pada Kanker ANDREE KURNIAWAN; NATA PRATAMA HARDJO LUGITO
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (920.543 KB) | DOI: 10.33371/ijoc.v9i3.388

Abstract

Disseminated Intravascular Coagulation is one of thrombosis manifestation other than venous thromboembolism, which onset is acute and has slight different clinical manifestation that tends to be chronic. Pathogenesis of the DIC in hematology malignancy is caused by the activation of fibrinolytic pathway by tumor cells. In solid tumor the pathogenesis is mainly because of the activation of cogulation factor by tissue factor expressed by tumor cells. Thediagnosis of DIC in cancer still needs further validation from the international society of thrombosis and hemostasisand Japanese society hematology criteria in cancer subjects. The principle of therapy for DIC in cancer patients is management of the cancer itself as the underlying etiology with the target is remission. The uses of anticoagulant therapy needs further clinical trial in the future. Coagulation factor and platelet transfusion can be given if there is significant bleeding.Koagulasi intravaskuler diseminata (KID) adalah manifestasi trombosis lain selain tromboemboli vena yang bersifat akut. Pada pasien kanker gambarannya sedikit berbeda, yaitu cenderung bersifat kronik, tergantung pada jenis kankernya. Patogenesis KID pada keganasan hematologi adalah akibat fibrinolisis yang meningkat. Sedangkan pada tumor solid terjadi akibat aktivasi faktor koagulasi oleh faktor jaringan yang diekspresikan oleh sel kanker. Diagnosis KID pada kanker masih memerlukan validasi kriteria dari perhimpunan trombosis hemostasis internasional dan Jepang pada kelompok pasien kanker. Prinsip terapi KID pada kanker adalah tata laksana kanker yang menjadi penyebab, dengan target remisi penyakit. Pemberian antikoagulan memerlukan uji klinis menggunakan populasi pasien kanker. Transfusi faktor koagulasi dan atau trombosit hanya diberikan apabila terdapat perdarahan yang bermakna.

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