International Journal of Health and Pharmaceutical (IJHP)
International Journal of Health and Pharmaceutical (IJHP) e- ISSN : 2808-845X is a communication media and scientific publication in the health and pharmaceutical fields published by Inara Publisher. International Journal of Health and Pharmaceutical (IJHP) contains articles from research focusing on basic medicine, clinical medicine, epidemiology, preventive medicine (social medicine), pharmacy, and other medical fields. International Journal of Health and Pharmaceutical (IJHP) is published periodically four times a year (February, May, August and November).
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<![CDATA[Anti-Inflammatory Effect Of Carica Papaya Leaves Extract In Male Wistar Rats Based On Variation Of Concentration ]]>
<![CDATA[Aulianshah, Vonna]]>;
<![CDATA[Ratu Thaharah, Yelda]]>;
<![CDATA[Zakiah, Noni]]>;
<![CDATA[Handayani, Rini]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v4i3.279
<![CDATA[Treatment of inflammation is currently dominated by using synthetic drugs, which if used in cases of chronic inflammation such as hyperuricemia and rheumatoid arthritis will carry the risk of increasing side effects for the user. Papaya leaves as a potential herb in some communities are also used as a treatment for inflammatory conditions. The aim of this research was to determine the anti-inflammatory effect of papaya leaf extract in vivo based on variations in concentration in Wistar white rats. This research is an in vivo study using 25 male Wistar Rats and divided into 5 groups. Group I was given as a negative control (P0), the group used Diclofenac Sodium as a positive control (P1), the Carica papaya leaf extract test group with varying concentrations of 40% (P2), 50% (P3), and 60% concentration (P4). Carrageenan 1% is used as an inflammation inducer. The inflammation observation parameter in this study was the volume of edema in the rats' feet at 30 minute intervals for 180 minutes. The average percentage reduction in edema during 180 minutes of observation in the P2, P3 and P4 extract test groups was 81.00%, 78.33% and 81.00%, respectively. The positive control group (P1) showed a reduction of 81.66%, while the negative control was only 26%. The results of statistical tests show that there is an effect of giving the extract on reducing edema in mice compared to the negative control group. From these results it can be concluded that the ethanol extract of Carica papaya leaves with concentrations of 40%, 50% and 60% showed an anti-inflammatory effect on male Wistar rats.]]>
<![CDATA[Analysis Of Iron (Fe) And Zinc Content (Zn) From Bay Leaves (Syzygium Polyanthum) ]]>
<![CDATA[Mutiara Devi, Rhisma]]>;
<![CDATA[Magna Patriadi Nuhriawangsa, Adi]]>;
<![CDATA[Sri Rahardjo, Setyo]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v3i4.307
<![CDATA[Background: Anemia is a nutritional problem in children, pregnant women, teenagers, and women of childbearing age. The prevalence of anemia in Indonesia in 2018 among young women was 48.9%. Bay leaves are widely known in various culinary and traditional medicine in Indonesia. Objective: This study analyzes the iron (Fe) and zinc (Zn) content in bay leaves (Syzygium polyanthum) growing in Karanganyar, Indonesia. Method: This research is an observational descriptive experiment with a laboratory approach carried out through a series of experiments. An Atomic Absorption Spectrophotometer (AAS) is used to analyze iron levels. Results: This research shows that the average concentration of Fe in bay leaves growing in Karanganyar is 294.28 mg/L per 100 grams of bay leaves. Meanwhile, the average concentration of Zn in bay leaves is 15.19 mg/L per 100 grams of bay leaves. According to TKPI 2017, bay leaves contain around 44.1 mg of iron per 100 g. Apart from that, the results of research conducted by Suharni 2021 show that 100 g of bay leaf extract contains around 30.09 mg of iron. Comparison with other plants shows that bay leaves contain much more iron and zinc. Higher than plants such as Moringa leaves. As an example of another plant that is often consumed, Moringa leaves have a lower iron and zinc content, namely 6 mg Fe/100 grams of Moringa leaves and 0.6mg/100 grams of zinc. In addition, this research opens up opportunities for application to experimental animals such as mice, which can be given bay leaf powder to understand its impact on iron and zinc levels in their bodies. Conclusion: The average test concentration of Fe in bay leaves is 294.28 mg/L. Meanwhile, the average concentration of Zn in bay leaves is 15.19 mg/L.]]>
<![CDATA[Test The Growth Process of Hair Follicles by Administering Coconut and Candlenut Oil to The Entire Back of White Rats (Rattus Norvegicus) Of the Wistar Strain ]]>
<![CDATA[Mulan, Mulan]]>;
<![CDATA[Hendrianto, Hendrianto]]>;
<![CDATA[Ferdinand, Sahna]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v3i4.309
<![CDATA[Hair serves a variety of purposes, including thermoregulation and protection. Hair regulates temperature in nonhuman animals, including primates, by holding heat or preventing cold. Hair can also be used for disguise and as a sexual attractant. Human hair is thinner and lighter than that of primates. The purpose of this study was to determine and test the efficacy of providing a coconut oil and candlenut oil mixture in the process of hair development in Wistar rats (Rattus norvegicus). The study's findings indicate that a combination containing 80% coconut oil and 20% candlenut oil is the most efficient in stimulating hair development in white rats (Rattus norvegicus) of the Wistar strain. This hair growth acceleration is possible because coconut oil contains a high concentration, precisely 80%. Because coconut has a high amount of lauric acid, it has numerous health benefits, including good hair.]]>
<![CDATA[Effectiveness of Dermapen Action Using Green Belt Leaf Extract Cream (Piper betle L) On Hair Growth on The Skin Surface of Female Wistar Strain Rats (Rattus Norvegicus) ]]>
<![CDATA[Hardianti, Novy]]>;
<![CDATA[Henny, Henny]]>;
<![CDATA[Delfian, Taufik]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v3i4.311
<![CDATA[Hair loss is a very prevalent hair issue. Hair loss is typical for all humans, but if it becomes severe, it can lead to baldness. Hair goes through a unique cycle of development and loss for each strand, and one herbal plant that has the activity of fertilizing hair growth and overcoming the problem of hair loss is green betel leaf (Piper betle L). The purpose of this study was to determine the efficacy of a derma pen utilizing green betel leaf extract cream (Piper betle L) on hair development on the skin surface of female Wistar rats (Rattus norvegicus). Betel leaves have been shown to help with issues such as hair loss. Using betel leaves regularly aids in It promotes hair growth, conditions hair, and makes it thick and long. Betel leaves can also assist with itching, dandruff, and broken ends. The polyphenol and flavonoid content in betel leaves is an antioxidant and anti-inflammatory, protecting hair from damage caused by inflammatory skin illnesses and free radicals that cause hair loss on the head.]]>
<![CDATA[Toxity Test Of Primary And Secondary Metabolite Extracts On Caulerpasp. Which Is Cultivated By The Community Of The District Takalar ]]>
<![CDATA[Sugrani, Andis]]>;
<![CDATA[Taufiq, Nuramaniyah]]>;
<![CDATA[Khusnul Khatimah, Qurrata]]>;
<![CDATA[Tiwa Patanduk, Valen]]>;
<![CDATA[Wahyuni Pakayya, Sri]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v3i4.312
<![CDATA[Lawi-lawi (Caulerpa sp) has economic value for some coastal communities who cultivate it. Apart from having the opportunity to be exported abroad as a complement to processed seafood, it turns out that lawi-lawi can also be used as an antidote to cancer or malignant diseases. This research is about the level of toxicity of the seaweed extract fraction (Caulerpa sp) on Artemia salina Leach larvae, method while for screening anticancer activity used the Brine Shrimp Lethality Test (BSLT) method. In methanol extract Caulerpa sp based on the results of toxicity test measurements using the BSLT method, it is included in the toxic category. Primary extract In Caulerpa sp based on the results of toxicity test measurements using the BSLT method, it is included in the very toxic category.]]>
<![CDATA[The Effect of Swimming Aerobic Physical Exercise On White Rats (Rattus Novergicus) Of the Wistar Strain That Are Obese ]]>
<![CDATA[Altamira, Vita]]>;
<![CDATA[Angie, Evelyn]]>;
<![CDATA[Kunardi, Sidharta]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v4i2.321
<![CDATA[Women are more likely to be obese and at risk of hypertension and coronary heart disease than men. Genetic factors influence it. Physical exercise can reduce obesity, especially on endothelial factors such as ET-1 and NO. This research explores the effect of swimming physical training on the expression of endothelin-1 and receptor-A in obese mouse models. This type of research is a true experiment carried out on 12 adult female Wistar rats (Rattus norvegicus) as research samples. The research procedures were carried out by caring for test animals, raising rats until they were obese, not giving treatment (control), physical training in the form of swimming exercises, and finally, examination of ET-1, ET-A, blood sugar levels, and total cholesterol levels. The data obtained was analyzed using SPSS. The research results of the normality test for the treatment group were more significant than 0.05 in the ET-1 examination of 0.315 and ET-A of 0.261. ET-1 levels were 92.5 pg/ml and ET-A levels were 62.5 pg/ml. Their blood sugar level was 167 mg/dL. The research concluded that in mouse tests, physical training was better for increasing ET-1 levels and reducing ET-A levels. Swimming and aerobics are better at lowering blood sugar levels.]]>
<![CDATA[The Influence Of Booklet On The Success Of Toilet Training In Children Aged 2-3 Years At Ra Bintang Zhafira Tulang Bawang Regency ]]>
<![CDATA[Wulandari M, Ranti]]>;
<![CDATA[Nur Assyaidah, Sonda]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v4i2.327
<![CDATA[Background: According to the Child Development Institute Toilet training, it is reported that 10 -20% of children aged 5 years, 5% of children aged 10 years, almost 2% of children aged 12-14 years, and 1% of children aged 18 years still wet the bed. Toilet training is an effort to train children to be able to control defecation (BAB) and urination (BAK) in their place (toilet). Education is one way to increase mothers' or parents' intellectual knowledge about toilet training. Education or health education can be provided using various methods and media, including: lectures, discussions, giving leaflets, booklets or direct practice related to the mother's needs. A booklet is a small book that contains writing, pictures or both. Research objective: to determine the effect of booklets on the success of toilet training in children aged 2-3 years at RA Bintang Zhafira, Tulang Bawang Regency. Research method: This research uses quantitative with a Quasy Experiment design with a one group pretest and posttest design. The population in this study was 32 mothers who had children aged 2-3 years and the sample taken was 32 respondents. The research was carried out at RA Bintang Zhafira, Tulang Bawang Regency in December 2023-January 2024. Data analysis was carried out univariate and bivariate (t test). Research results: it is known that the average success of toilet training before intervention was given to children aged 2-3 years was 8.0 and after intervention was given to children aged 2-3 years was 12.1. There is an influence of the booklet on the success of toilet training in children aged 2-3 years at RA Bintang Zhafira, Tulang Bawang Regency with p-value = 0.000 or p ≤ α (0.05). Conclusions and Suggestions: There is an influence of the booklet on the success of toilet training in children aged 2-3 years at RA Bintang Zhafira, Tulang Bawang Regency and suggestions for RA Bintang can provide health education to mothers who have toddler age children regarding the implementation of toilet training.]]>
<![CDATA[Comparison Of Buerger Allen Exercise With 3 Physical Therapy Modalities On The Value Of Ankle Brachial Index In Patients With Type Ii Diabetes Mellitus ]]>
<![CDATA[Aisyah, Nur]]>;
<![CDATA[Suaib, Suaib]]>;
<![CDATA[Ibrahim, Ikhsan]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v4i2.329
<![CDATA[Hyperglycemia is one of the problems of people with Diabetes Mellitus, poorly controlled hyperglycemia conditions can cause complications, one of which is impaired peripheral vascular flow which can cause diabetic wounds. Vascularization disorders can be prevented by Buerger Allen Exercise therapy and 3 Physical Therapy Modalities to increase Ankle Brachial Index (ABI) values. The purpose of this study was to compare the effect of Buerger Allen Exercise and 3 Physical Therapy Modalities on ABI values in people with type II Diabetes Mellitus. The design of this study was Quasi Experiment Pre and post test two groups with 15 respondents of group A given Buerger Allen Exercise intervention and 15 respondents of group B given 3 Physical Therapy Modalities intervention. The results showed that there was an increase in ABI values after intervention in both groups with the difference in the Buerger Allen Exercise group increase of 0.050 while the Modaliatas Physical Therapy group amounted to 0.113. In conclusion, there was an increase in ABI values in both groups after the intervention but group 3 Modaliatas Physical Therapy had a higher increase. Intervention 3 Modaliatas Physical Therapy can be recommended as one of the alternative therapies as a prevention of complications of peripheral arterial disease.]]>
<![CDATA[The Relationship Between Covid-19 Vaccination And The Incidence Of Covid-19 At The Hospital Putri Hijau Hospital, Medan ]]>
<![CDATA[Dasopang, Eva Sartika]]>;
<![CDATA[Natalia Siahaan , Desy]]>;
<![CDATA[Hasanah, Fenny]]>;
<![CDATA[Handayani Lubis , Salma]]>;
<![CDATA[Yuni M , Yohana]]>;
<![CDATA[Pane , Ramona]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v4i2.338
<![CDATA[Vaccination is the process of entering vaccines to stimulate the body's immune system, as a preventive effort in reducing morbidity and mortality caused by the coronavirus. Putri Hijau Hospital in Medan City, which participated in the second dose of Covid-19 vaccination, confirmed that the respondents who were still affected by Covid-19 needed to be developed, so in particular knowing the number of cases of Covid-19 that appeared in respondents who had been infected. received a second dose of vaccination. The purpose of this study was to see whether there was a relationship between vaccination and the incidence of Covid-19 at Putri Hijau Hospital in Medan.This type of research uses a quantitative approach method by using a questionnaire distributed through the Google Form platform on a smartphone to store all the answers that have been filled in by the respondent based on the questionnaire guidelines that have been made previously with the target of respondents who have vaccinated the second dose of Covid-19.The results showed that from 100 respondents there were 28 male patients (28%) and 72 female patients (72%). Judging from the age of most patients at the age of 15 to 25 years. There were 8 people and 92 people who were not exposed. With the symptoms of Covid-19, such as fever, cough, sore throat, and loss of sense of smell. This is because the respondents had antibodies that were formed slightly after vaccination, were active outside the home, did not apply health protocols and maintained their immune system so that they were exposed to Covid-19.]]>
<![CDATA[Effect of Celery (Apium graveolens L.) Extract Administration on Kidney Function of White Rats (Rattus norvegicus) Wistar Strains Exposed to Lead ]]>
<![CDATA[Selviana Barus, Shella]]>;
<![CDATA[Napiah Nasution, Ali]]>;
<![CDATA[Wienaldi, Wienaldi]]>
<![CDATA[ International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024 ]]>
Publisher : <![CDATA[CV. Inara ]]>
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DOI: 10.51601/ijhp.v4i3.339
<![CDATA[Lead significantly affects health because of its sensitivity to the central nervous system and rapid absorption rate. The phytochemicals included in celery, such as flavonoids, may mitigate lead-induced kidney damage. This research aimed to determine how administering celery extract affected the expression of the Caspase-3 gene and the kidney TNF-α gene in Rattus Norvegicus Wistar white rats exposed to lead. The research method true experiment examined the effects of 80 mg/day celery extract on Caspase-3 gene expression and renal TNF-α gene expression in rats exposed to lead. Each of the three groups will include six rats; there will be eighteen male Wistar rats in the study. The study used SPSS 26.0 and the Saphiro Wills test to analyze data on TNF-α and Caspase 3 expression in rats exposed to lead acetate (Pb). The results showed a normal distribution for the negative control group (K-) and the positive control group (K+) and a normal distribution for the treatment group (P). However, the paired t-test showed significant differences in all treatment groups (p <0.05), indicating a normal distribution in the data. The study concludes the impact of celery extract on kidney function in lead-exposed Wistar rats, revealing various active compounds like flavonoids. Despite insignificant caspase 3 reduction, flavonoids showed potential in mitigating lead-induced kidney damage.]]>
