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Ratna Kumalasari
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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
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Search results for , issue "Vol. 34 No. 2 (2021): MEDICINUS" : 8 Documents clear
Korelasi Kadar Serum Nitric Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.767 KB) | DOI: 10.56951/medicinus.v34i2.61

Abstract

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.
Analisis In Silico Potensi Minyak Kedelai (Glycine max) dalam Terapi Dermatitis Atopik Primadhanty. R. S. Bhadra; Mardiana; Ahmad Fiqri; Ummi Rinandari; Didik H. Utomo; Muhammad Eko Irawanto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.375 KB) | DOI: 10.56951/medicinus.v34i2.63

Abstract

Soybean oil contains various bioactive phytochemicals such as phenolic acids, flavonoids, isoflavones, saponins, phytosterols and sphingolipids which might give benefit in the treatment of atopic dermatitis (AD). This study aimed to evaluate the soybean oil compounds using computational in silico analysis for the treatment of atopic dermatitis. The active compounds of soybean oil were extracted from the KNApSAcK database. Results showed that soybean oil might possess some potential bioactivity such as immunosuppressant, antiinflammatory, improves skin barrier function, antieczema and histamine inhibitor. The highest potential bioactivity of soybean oil was as antiinflammatory, with an average value of probable to be active (Pa) 0.684; while the high potency active compound is alpha-tocopherol (Pa: 0.956).
Closing the Gap of Unmet Needs in Inflammatory Pain Management: Case Series of Predimenol for Pain Rizaldy Pinzon
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.21 KB) | DOI: 10.56951/medicinus.v34i2.65

Abstract

Chronic inflammatory pain is major medical problem worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors are commonly used medications to treat chronic pain. However, these agents have been associated with serious gastrointestinal, renal and cardiovascular adverse effects. This limitation indicates a clear unmet need in terms of safety of current treatment options for the management of chronic inflammatory pain. Those adverse effects may caused by overlapping roles of COX-1 and COX-2 in physiological and pathophysiological processes. Predimenol is a herbal medicine that can be used to treat pain. Recent findings showed that these phytochemicals may directly act upon several inflammatory processes and offer compelling evidence that predimenol could reduce pain and inflammation. We report two cases and short review of the use of predimenol for pain management. Our review showed that predimenol formulations could be a valuable alternative treatment to relieve symptoms of pain with good safety profile. Further researches through large, high quality RCTs to investigate the clinical benefit of predimenol for pain management are needed.
Ulkus Marjolin yang Berkembang dari Ulkus Trofik Kronis pada Pasien Kusta Adniana Nareswari; Harijono Kariosentono; Nugrohoaji Dharmawan; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.255 KB) | DOI: 10.56951/medicinus.v34i2.67

Abstract

Marjolin’s ulcer is a malignant complication of chronic ulcer. Changes in ulcer lesions to malignancy can be caused by chronic irritation, infection, decreased vascular variation, and increased expression of proto-oncogene. The most common histopathological form of Marjolin's ulcer is squamous cell carcinoma. A 55-year-old man, complaining of a protruding wound on his left hand that has not healed since three years ago. The patient was diagnosed with leprosy 30 years ago with a history of incomplete treatment. On physical examination, the left palmar region showed solitary ulcer, ±10x8x1.5 cm in size, nodular surface, reddish, hard consistency, with bulging and irregular edge. Slit-skin smear (SSS) examination with Ziehl-Neelsen staining found abundant acid-fast bacilli. Histopathological examination of the ulcer edge shows appearance of epithelial tumor, with differentiated epidermal cells invading the dermis, tumor cells arranged focally and concentrically with a mass of keratin appeared as horn pearl cells. Fite-Faraco staining found abundant M. leprae acid-fast bacilli. Based on the patient’s medical history and clinical examination, patient was diagnosed with Marjolin's ulcer in multibacillary (MB) leprosy. Patient was treated with MB multidrug therapy for 12 months and below-wrist amputation.
Studi Kasus Covid-19 Akibat Kerja Anna Suraya; Zulfikli Dharma; Putri Tresnasari; Putri Dwi Ginanti; Fani Syafani
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.154 KB) | DOI: 10.56951/medicinus.v34i2.69

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yang menjadi penyebab Coronavirus Disease 2019 (Covid-19) merupakan pajanan biologis di fasilitas kesehatan, di mana perawat, dokter, serta petugas medis maupun nonmedis lainnya menjadi kelompok pekerja yang rentan tertular Covid-19 saat bekerja. Studi kasus ini bertujuan untuk memberikan gambaran penerapan tujuh langkah diagnosis okupasi pada tiga kasus Covid-19 yang terjadi pada tenaga kesehatan. Kasus pertama adalah Covid-19 pada perawat ICCU yang terbukti mengalami kontak dengan pasien Covid-19 saat bertugas kurang dari 14 hari sebelumnya. Kasus kedua merupakan kasus Covid-19 pada dokter yang terjadi akibat penularan di rumah tangga, dan kasus ketiga adalah kasus Covid-19 pada dokter UGD yang merawat pasien Covid-19 beberapa hari sebelum munculnya gejala. Kasus ini merupakan kasus fatalitas yang mendapatkan kompensasi dari BPJS Ketenagakerjaan. Penegakkan diagnosis okupasi sangat penting karena dapat menjadi umpan balik atau evaluasi terhadap tindakan pencegahan yang sudah dilakukan di tempat kerja. Adanya penyakit akibat kerja (PAK) di kalangan pekerja merupakan sinyal diperlukannya peningkatan perlindungan bagi pekerja.
Granulomatosis Wegener dengan Antineutrophil Cytoplasmic Antibodies (ANCA) Negatif pada Laki-laki Usia 38 Tahun Achmad Satya Negara; Harijono Kariosentono; Endra Yustin Elistasari
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.981 KB) | DOI: 10.56951/medicinus.v34i2.72

Abstract

Background : Wegener’s granulomatosis or granulomatosis with polyangiitis is a systemic necrotizing vasculitis, which affects small- and medium-sized blood vessels. This disease is often associated with antineutrophil cytoplasmic antibodies (ANCA). Etiology of Wegener’s granulomatosis may originate from infectious, environmental, chemical, toxic or pharmacological triggers in people who are genetically predisposed to this autoimmune disease. The disease can present with nonspecific symptoms such as malaise, myalgia, arthralgia, anorexia, and weight loss. Skin manifestations of Wegener’s granulomatosis includes leukocytoclastic vasculitis, purpura, ulcer and subcutaneus nodul. It also known could affect different organs. Case: A 38-year-old man came with a chief complaint of erythematous patches and stiffness on his face, body, arms and legs. The dermatological status showed a saddle nose and discrete multiple purpura on the superior and inferior extremities. ANCA examination result was negative. Histopathological examination of the epidermal layer showed dense proliferation of lymphocyte cells, perivascular infiltrates and a few neutrophil cells. In the dermis layer, there were granulomas consisting of many epitheloid histiocytes and foamy macrophages also damaged blood vessels with neutrophil infiltration on the walls and erythrocyte extravasation. Discussion: Wegener’s granulomatosis is a rare autoimmune disease of localized granulomatous inflammation of the upper and lower respiratory tract and systemic vasculitis associated with ANCA. Symptoms that arise in Wegener’s granulomatosis are often mild at first, but may progress to a more severe clinical features. A negative ANCA examination cannot immediately rule out the diagnosis. Initial therapy for Wegener’s granulomatosis are cyclophosphamide and glucocorticoids for 3-6 months. Patient showed clinical improvement with the reduction of purpura throughout the body after five weeks treatment.
Faktor yang Berpengaruh Terhadap Kejadian Hipertensi pada Remaja di Indonesia Nina Widyasari
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.703 KB) | DOI: 10.56951/medicinus.v34i2.75

Abstract

Prevalensi penyakit tidak menular (PTM) semakin meningkat dalam beberapa tahun terakhir. Hipertensi merupakan salah satu penyakit tidak menular (PTM) yang menjadi masalah serius dan termasuk dalam sepuluh penyakit kronis dengan angka kejadian tertinggi di Amerika. Umumnya hipertensi terjadi pada orang dengan usia lanjut, namun data menunjukkan bahwa hipertensi juga dapat muncul sejak remaja. Sayangnya, remaja pada umumnya tidak menyadari bahwa mereka menderita hipertensi, sehingga berpeluang menjadi masalah serius di kemudian hari, serta dapat berlanjut hingga usia dewasa dan berdampak pada peningkatan risiko morbiditas dan mortalitas. Tujuan dari kajian literatur ini adalah menganalisis berbagai faktor yang memengaruhi kejadian hipertensi pada remaja di Indonesia. Artikel-artikel yang diperoleh melalui mesin pencari merupakan artikel penelitian cross-sectional dengan responden berusia antara 11–19 tahun dan area penelitian di Indonesia. Kriteria inklusi artikel yang dipilih adalah subjek remaja dengan hipertensi atau ancaman hipertensi. Hasil analisis menunjukkan bahwa terdapat beberapa faktor risiko yang berkaitan dengan kejadian hipertensi pada remaja di Indonesia, antara lain kualitas tidur, indeks massa tubuh terhadap usia (IMT/U), pola asupan gizi, merokok, aktifitas fisik, serta riwayat hipertensi dalam keluarga. Remaja dengan kualitas tidur buruk memiliki risiko hipertensi 4,1 kali lebih besar, IMT/U yang tinggi memiliki risiko hipertensi sebesar 4,85 kali, merokok memiliki potensi hipertensi di masa yang akan datang, sementara remaja dengan riwayat hipertensi dalam keluarga memiliki risiko hipertensi sebesar 3,9 kali. IMT/U merupakan faktor dominan terhadap risiko hipertensi pada remaja. Deteksi dini hipertensi pada remaja perlu diperhatikan guna mencegah risiko penyakit kardiovaskular yang tidak diinginkan.
Terapi Probiotik pada Akne Vulgaris Reti Anggraeni; Arie Kusumawardani
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.003 KB) | DOI: 10.56951/medicinus.v34i2.76

Abstract

Acne vulgaris (AV) is a skin chronic inflammatory disease that affects pilosebaceous unit and results in non-inflammatory abnormalities in the form of open comedones (blackhead) and closed comedones (whitehead) and also inflammatory lesions such as papules, pustules and nodules. Many factors contribute to the pathogenesis of AV including skin microbiomes like Propionibacterium acnes (P. acnes) and Malassezia spp. which is associated through its effect on sebum secretion, comedones formation and inflammatory response. Antibiotic therapy with the target of P. acnes has long been the mainstay of AV therapy where it can actually affect the composition of skin microbiomes. As antibiotic resistance increases, knowledge of skin microbiomes associated with AV becomes very relevant and important to be an alternative basis for AV alternative therapy.

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