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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol. 34 No. 3 (2021): MEDICINUS" : 5 Documents clear
Tata Laksana Terkini untuk Endometriosis Binarwan Halim; Timothy Adiwinata
MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.503 KB) | DOI: 10.56951/medicinus.v34i3.77

Abstract

Endometriosis is a benign gynecological disease that is often found among women in reproductive age with 10% of incidence. There are many theories regarding development of endometriosis, and to date the etiopathogenesis of this disease is still controversial. Understanding the various pathogenesis of endometriosis is important for the management of endometriosis. The current management of endometriosis is still focused on the main symptoms experienced by the patients, such as pain and infertility. A number of therapeutic approaches have been developed based on the pathogenesis of endometriosis, in terms of immunological, angiogenic, hormonal, genetic, local neurogenesis, and central sensitization aspects. However, the ideal and curative treatment for endometriosis has not been found.
Hubungan Lama Rawat Inap dengan Kejadian Depresi pada Anak Usia 10–18 Tahun yang Dirawat di RSUD Dr. Soetomo Surabaya Rika Hapsari; Mira Irmawati; Ahmad Suryawan; Irwanto
MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.655 KB) | DOI: 10.56951/medicinus.v34i3.78

Abstract

Background: Depression can occur in children with chronic disease who are hospitalized. Prolonged hospitalization correlates with higher prevalence of depression that may affect clinical outcome. The aim of this study is to determine the correlation between length of hospitalization and depression in children with chronic disease. Method: This cross-sectional study was conducted at Dr. Soetomo Hospital Surabaya, from January to March 2019. Children ages 10-18 years with chronic diseases such as oncology hematology, chronic kidney disease, and liver disease hospitalized for ≥7 days were screened for depression. Children with a history of previous depression or other mental illnesses were excluded. Depression was evaluated using the Children’s Depression Ratting Scale-Revised (CDRS-R) questionnaire. Statistical analysis using comparative test and correlation test with p value <0.05. Results: A total of 58 children were treated in the pediatric ward Dr. Soetomo Hospital Surabaya, 50 met the inclusion criteria and 8 were excluded. Subjects consist of 27(54%) boys and 23(46%) girls. The mean age was 11.8±0.39 years. The average duration of treatment was 16±1.6 days. Depression screening found 39(78%) children with varying degrees of depression, 17(34%) moderate depression and 22(44%) severe depression with an average CDRS-R score of 45.2±2.3. The results showed 65.5% of children who were hospitalized for 7-14 days and 95.2% of children who were hospitalized for more than 14 days had depression (OR value=10.52; 95% CI; 1.227-90.311; p = 0.016). Correlation test results between the length of stay and CDRS-R score (r=0.502, p<0.001). Conclusion: Children with chronic disease who are hospitalized more than 7 days have higher risk of depression.
Familial Erythema Annulare Centrifugum pada Anak Berusia 9 Tahun Achmad Satya Negara; Endra Yustin Elistasari
MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.845 KB) | DOI: 10.56951/medicinus.v34i3.80

Abstract

Background: Erythema annulare centrifugum (EAC) is a rare cutaneous disease characterized by erythematous papule which slowly migrates and peripherally enlarges into polycyclic lesion with central clearing that usually involves thigh and legs area. The etiology is unclear, but presumabley related with medication history, infection, malignancy, and stress. The diagnosis of EAC is based on clinical manifestations and histopathological examination. Histopathologically, EAC can be divided into superficial and deep type. Pathognomonic signs include coat sleeve and trailing scale. Symptomatic treatment of EAC may involve topical corticosteroid, topical vitamin D analog, and antihistamine. Case: A 9-year-old boy came with a complaint of erythematous patches on his face and body. Histopathological biopsy showed showed a mild appearance of hyperkeratosis and spongiosis at the epidermis, and perivascular lymphocytic infiltrate at the dermis. Based on these findings, patient was diagnosed with erythema annulare centrifugum. We gave antihistamine and topical corticosteroid to treat his condition. Discussion: Erythema annular centrifugum is a rare skin condition, with most cases is idiopathic. Histopathological biopsy can be used to help establish the diagnosis of EAC. Topical & systemic corticosteroid is the first-line therapy of idiopathic EAC, but administration of empirical therapy using antibiotics or antifungals may also be considered.
Terapi Oral dan Tetes Mata Topikal pada Green Nail Syndrome Putti Fatiharani Dewi; Ambar Aliwardani; Nugrohoaji Dharmawan
MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.156 KB) | DOI: 10.56951/medicinus.v34i3.81

Abstract

Background: Green nail syndrome is one of the chromonychia caused by infection of Pseudomonas aeruginosa, characterized by onycholysis and greenish-black discoloration of the nail. There were no reports regarding the incidence of green nail syndrome in Indonesia. Predisposing factors for the occurrence of green nail syndrome include onychomycosis, high activity in moist and wet conditions, diabetes mellitus, and immunosuppression. Case: A 51-year-old man complained about greenish-black discoloration on his fingernails. Dermatological examination in 1st and 3rd digit of the right hand, as well as 1st digit of the left hand, found multiple greenish-black discoloration with onychodystrophy. Dermoscopy examination of the affected nails showed greenish-black pigmentation in the distolateral nails with peripheral fading. Culture examination using MacConkey agar showed colonies of greenish-brown pigments. The patient was diagnosed with green nail syndrome and treated with ciprofloxacin 500 mg/day and topical polymixin B eye drops b.i.d. for 3 weeks, resulting in good outcome. Discussion: The diagnosis of green nail syndrome is made based on anamnesis, physical examination, and bacterial culture. showing a distinctive feature. The predisposition factor in this case, is the frequent washing hands habit of the patient up to more than ten times per day. Treatment using topical eye drops facilitates the absorption of active ingredients into the nails.
The Promising Therapeutic Effects of Nigella Sativa Rimenda Sitepu; Kirsten Putriani Hartman; Yessy Adhi Utami
MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.453 KB) | DOI: 10.56951/medicinus.v34i3.83

Abstract

Medicinal plants can be potential source to improve general health and perhaps for the treatment of various diseases. However, despite the fact that herbal medicine has been used among various civilizations worldwide, scientific research regarding many herbal medicines was still limited. Nigella sativa (N. sativa), commonly known as fennel flower, black caraway, black cumin, jintan hitam, or kalonji, is a widely used medicinal plant that has been used for the treatment of various health problems. N. sativa contains some compounds that are potentially beneficial for health and wellness, particularly thymoquinone (TQ). Studies have shown some therapeutic benefits of N. sativa, however most them require further investigations to evaluate its efficacy and safety profile. This paper provides summary of available studies and reviews of N. sativa, including findings and limitations of the studies.

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