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Ratna Kumalasari
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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol. 35 No. 2 (2022): MEDICINUS" : 7 Documents clear
Peran Vitamin D dalam Aktivitas Penyakit Lupus Eritematosus Sistemik (LES) Sukamto Koesnoe
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.131 KB) | DOI: 10.56951/medicinus.v35i2.87

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that leads to various immune system dysregulation. SLE has complex pathophysiology involving interaction between factors that will produce abnormal immune response. This abnormal immune response results in inflammatory reactions throughout various organs, and this chronic process will lead to tissue and organ damage. Vitamin D has been studied for its’ role as an immunomodulator, therefore it is potential to be part of SLE management.The potential benefits of vitamin D supplementation to improve clinical conditions of SLE patients has been investigated. Some studies showed that there were positive effects after supplementation with vitamin D in SLE patients. This can be explained considering vitamin D deficiency is associated with disease activity and frequency of exacerbations in SLE. Vitamin D’s active form, calcitriol, was found to have an important role in the pathogenesis of SLE. Study found that vitamin D supplementation could help to reduce disease activity and improve clinical condition in SLE patients.
Potensi Daun dan Bunga Telang (Clitoria ternatea L.) sebagai Antioksidan Florentinus Dika Octa Riswanto; Anastasia Melin Fitria Wulandari; Faustina Evania Ngai; Corina Febrianti Isabel; Agatha Kania Ugahari Dyatmika; Filisia Putri Rosari; Dewi Setyaningsih
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.205 KB) | DOI: 10.56951/medicinus.v35i2.92

Abstract

Indonesia has various traditional plants that are potential to be used as medicinal agents. The telang plant (Clitoria ternatea L.) has been studied regarding its’ potency as a traditional medicine. The parts of the telang plant that are often used are leaves and flowers. Telang leaves and flowers contain several compounds with antioxidant activity including phenolics, flavonoids, anthocyanins, and tannins. Antioxidant activity can be tested using several methods, e.g. DPPH, ORAC, and FRAP. Based on the results of the literature review, it is known that telang leaves and flowers have antioxidant activity and do not show any potential toxicity, therefore they can be considered as safe to be used.
Tuberkulosis Okular Fabiola Supit
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.874 KB) | DOI: 10.56951/medicinus.v35i2.93

Abstract

Ocular tuberculosis (OTB) is a chronic disease caused by infection of M. tuberculosis in the eye with various manifestations and can lead to blindness. Indonesia has the second highest tuberculosis burden worldwide, with 11% of the case is extrapulmonary TB, including OTB. The most common clinical presentation of OTB is posterior uveitis, but it could also involve all surrounding ocular tissue. OTB has a good prognosis if patients receive full course of antituberculosis therapy, but there are so many challenges in the diagnosis and treatment initiation. There is a new international concensus published by the Collaborative Ocular Tuberculosis Study (COTS) working group which could aid clinicians to manage the disease.
Koinfeksi Sifilis Sekunder, Condyloma Acuminata dan Human Immundeficiency Virus (HIV) pada Pria Homoseksual Ahmad Fiqri; Endra Yustin ES
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.563 KB) | DOI: 10.56951/medicinus.v35i2.94

Abstract

Introduction: Men who have sex with men (MSM) have higher risk of contracting sexually transmitted infections (STIs) such as syphilis, one of chronic and systemic STI. HIV and HPV infection can be risk factors for syphilis infection, while coinfection between syphilis and HIV facilitates the course of the two diseases. Case: A 22-year-old homosexual man complained of red scaly patches on both palms and feet, no itching, hair loss and lumps in the genital area. Examination revealed nonscarring alopecia on occipital region, bilateral patches with multiple erythematous plaques partly confluent hyperpigmentation and an overlying scale on palmar and plantar region, also multiple nodule papules with pale red smooth surface on perineal region. The acetowhite examination at the verrucous lesion was positive. The results of the CD4 examination was 112 cells/µl, VDRL/RPR was reactive 1:256; and TPHA was also reactive >1:5,120. Histopathological examination of the skin showed the features of skin syphilis and condyloma acuminata. Immunohistochemistry test revealed brownish Spirochaeta. The patient was diagnosed with secondary syphilis coinfection, condyloma acuminata, and HIV. Conclusion: We found a case of MSM patient that was coinfected with secondary syphilis, condyloma acuminata, and HIV. HPV and HIV infection are often coexisting because they both increase the risk of sexually transmitted infections.
Peran Balneoterapi pada Psoriasis Putri Oktriana Rachman; Budi Eko Prasetyorini; Nathania Amelinda; Fatimah Fitriani; Arie Kusumawardani
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.252 KB) | DOI: 10.56951/medicinus.v35i2.95

Abstract

Psoriasis is a chronic recurrent inflammatory disease influenced by several risk factors, including genetics, immune system, environment, and hormones. Skin lesions associated with psoriasis are well-defined erythematous plaques covered in thick, layered, white scales. Psoriasis treatment varies according to the severity of the condition and may include topical or systemic medications, light therapy, or natural elements such as minerals and balneotherapy. Balneotherapy may be used in conjunction with other treatments for psoriasis due to its efficacy in healing psoriasis lesions, particularly plaque forms. Balneotherapy is a traditional medicinal treatment that involves bathing, drinking, or inhaling mineral-containing water. Mineral sources include mineral water, mineral mud (peloids), and natural gas from natural springs. Balneotherapy can thin the stratum corneum and lucidum, decrease the number of lymphocytes, histiocytes, granulocytes, and eosinophils, increase skin permeability, decrease inflammation, improve microcirculation and the skin immune system, and decrease pro-inflammatory cytokines in psoriasis. This article aims to explore the efficacy of balneotherapy as adjuvant therapy for psoriasis to accelerate clinical improvement and reduce disease recurrence.
Laporan Kasus Terapi Kombinasi Kuretase dan Cimetidine Oral pada Pasien Moluskum Kontangiosium Annisa Fildza Hashfi; Nurrachmat Mulianto; Winda Wijayanti; Niluh Wijayanti
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.641 KB) | DOI: 10.56951/medicinus.v35i2.96

Abstract

Background: Molluscum contagiosum is an infectious disease of the skin caused by poxvirus. The virus may be transmitted through direct skin and mucous membrane contact, including sexual contact, and through contaminated fomites. The prevalence of sexually transmitted molluscum contagiosum has increased in recent years. This disease causes anxiety and discomfort for the patients. Diagnosis of molluscum contagiosum is made based on history taking, physical examination, dermoscopic examination, and histopathological examination. Proper diagnosis and management can help to reduce risk of recurrence. Case: A 26-year-old woman with main complaint of developing shiny white rashes on her thighs and buttocks since 3 months ago. The nodules felt itchy yet painless. At first, only 4 papules appeared on the buttocks. In the last month, the nodules multiplied and spread to the thighs. The patient had tried to squeeze the nodule and rice-like white mass came out. The patient had history of unprotected sexual intercourse. Dermatological examination on the right and left femoral regions and the gluteus, found that there were discrete, multiple shiny white pearl-like papules of 0.1-0.5 cm in size, smooth surface, well-defined, dome-shaped, umbilicated with caseous plug. Dermoscopic examination showed a white to yellow polylobular appearance with crown vessel. Histopathological examination showed an appearance of intracytoplasmic eosinophil inclusion bodies (molluscum bodies). Discussion: Clinical findings such as discrete multiple, pearl-colored, umbilicated dome-shaped papules, are characteristic features of molluscum contagiosum. Dermoscopic examination results and histopathological images also support the diagnosis of molluscum contagiosum. Treatment was carried out using curettage on the lesions and prescription of oral cimetidine 2x800 mg for 2 months. No recurrence was found after 5 months of follow-up
Profile of Candidiasis Patients in RSUD Dr. Moewardi Surakarta January 2016−December 2019 Nurrachmat Mulianto; Siti Efrida Fiqnasyani
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.977 KB) | DOI: 10.56951/medicinus.v35i2.97

Abstract

Background: Candidiasis is caused by Candida sp. infection, mainly Candida albicans. The skin, mucous membranes, nails, and digestive tract are organs that can be affected by this infection. The risk of infection is higher in immunocompromised individuals. Objective: To determine the profile of candidiasis patients in Dr. Moewardi Hospital Surakarta between January 2016-December 2019. Method: This is a retrospective, descriptive study that evaluate the distribution of sex, age, primary diagnosis, comorbidities, and candidiasis type among candidiasis patients in RSUD Dr. Moewardi. Results: During study period, there were 177 candidiasis patients (147 outpatients and 30 inpatients). Pseudohyphae was seen in all inpatients’ KOH test. Majority of the patients are women (77,97%), age distribution varies between outpatients and inpatients. Cutaneous candidiasis was found in 53,74% outpatients and 66,67% inpatients. Type 2 diabetes mellitus was the most frequent (20%) comorbidity among those patients. Topical miconazole 2% and systemic fluconazole 150 mg were given to 42,37% and 33,90% patients, respectively.

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