cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Ratna Kumalasari
Contact Email
medicinus@dexagroup.com
Phone
+6287808191388
Journal Mail Official
medicinus@dexagroup.com
Editorial Address
Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224
Location
Kota tangerang selatan,
Banten
INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol. 36 No. 2 (2023): MEDICINUS" : 6 Documents clear
Neuroprotection in the Treatment of Glaucoma Astrianda Nadya Suryono
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.119

Abstract

Glaucoma is a neurodegenerative disease with certain characteristics of progressive damage to the optic nerve, loss of retinal ganglion cells (RGC) and their axons, accompanied by typical visual defect. Increased intraocular pressure (IOP) is the main risk factor for glaucoma. Some study stated that RGC death is still progressing despite the use of IOP-lowering medications. The main aim of glaucoma treatment remains to lower IOP, however neuroprotective agents have increased interests due to its effects to prevent or slow down the rate of RGC death other than IOP-dependent mechanisms. Production of glutamate and nitric oxide is known as one of the contributing factors of RGC death, and neuroprotective agents that work by targeting the production of glutamate and nitric oxide can be a valuable option to prevent further RGC death.
Insidensi dan Profil Penyakit Psoriasis di RS Martha Friska Multatuli Medan Periode Januari−Desember 2022 Viktoria Thanita
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.120

Abstract

Background: Psoriasis is a chronic, recurrent, inherited immunologic disorder. Psoriasis is characterized by changes in epidermal cell growth and differentiation. The mechanism of skin inflammation involves the activation of cytokines, chemokines, and growth factors that results in impaired regulation of keratinocytes, inflammatory cells, and blood vessels. This study aimed to evaluate incidence and profile of psoriasis patients at Martha Friska Multatuli Hospital, Medan, in January-December 2022. Method: This is a descriptive study using retrospective, cross-sectional design, where data collection is carried out from the medical record data of Martha Friska Multatuli Hospital. Results: Most of psoriasis cases (42 cases; 65.63%) in Martha Friska Multatuli Hospital is existing patients. Psoriasis was reported to be more prevalent in women (33 cases; 51.57%). Based on body mass index (BMI), psoriasis was found the most in those whose BMI <24,9 (34 case; 53.14%). Based on age, psoriasis was found the most in elderly (>60 years) with 26 cases (40.64%).
Kasus Morfea Tipe Linier (En Coup de Sabre) pada Wanita Berusia 20 Tahun Achmad Satya Negara; Arie Kusumawardhani
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.121

Abstract

Background: Morphea is a chronic inflammatory disease characterized by sclerosis of the skin which belongs to the group of idiopathic sclerotic diseases. Frontoparietal linear morphea is a unilateral atrophy linear plaque on the forehead that can extend to the eyebrows, nose, lips, and scalps, causing alopecia. The aim of this case report is to establish the diagnosis of frontoparietal linear morphea. Case: A 20-year-old woman presented with a dark brown spot on her forehead. Histopathological examination showed a basket-weave hyperkeratosis and flattening of the rete ridges of epidermal layer, and pigmented cells in the basal cells of the dermal-epidermal junction. Based on the results of physical examination and histopathology, patient was diagnosed with linear morphea en coup de sabre. Patient was treated with topical and systemic corticosteroid. Discussion: Morphea is a rare fibrotic disease of the skin and underlying tissue, characterized with diffuse thickening, induration, or atrophy. Histopathological biopsy examination can be used to confirm the diagnosis and rule out differential diagnosis. Histopathological biopsy of early phase morphea can show inflammation, the dermis looks dense with thickened collagen fibers accompanied by inflammatory cells, especially perivascular lymphocytes between collagen fibers, flattening of the epidermal rete ridges, and atrophy. Topical therapy with corticosteroid as anti-inflammatory drug can be used in active lesions of early-stage linear morphea.
Potensi Tanaman Sukun (Artocarpus altilis) sebagai Agen Antiinflamasi dan Antidiabetes Ni Gusti Ayu Diantari; Debby Yunita; Maria Aurelia Afila Tutonugi; Theresia Helena Tokan; Teresia Kiki Oktavianti; Florentinus Dika Octa Riswanto; Dewi Setyaningsih
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.122

Abstract

Background: Artocarpus altilis is a plant whose every part is beneficial for health. In Indonesia, the distribution of this plant is only found in certain places and has not been cultivated. Breadfruit is basically rich in flavonoid, tannin, and saponin compounds that are known to be potential as antidiabetic and antiinflammatory. Diabetes is a group of metabolic disease characterized by hyperglycemia, due to lack of insulin production and/or sensitivity. Type 2 diabetes is a degenerative disease that is a global health problem. Type 2 diabetes is treated using antidiabetic agents and/or insulin. Inflammation is a local reaction of the body characterized by certain symptoms. Treatment of inflammation using synthetic drugs is associated with various side effects. Objective: This review is aimed to provide information about antidiabetic and anti-inflammatory activities in breadfruit plant. Results: Substance of breadfruit plant with antidiabetic efficacy was found in the stem, leaf, and fruit, showed by results of phytochemical test. Antidiabetic activity was proven by in vivo, in vitro, and AlCl calorimetry tests, while anti-inflammatory substance was found in the leaf and fruit, and the anti-inflammatory activity was showed by results of in vivo and in vitro tests. Conclusion: Breadfruit plants can be potentially developed as an alternative treatment for diabetes and inflammation.
Tinjauan Histopatologi pada Pyoderma Gangrenosum dengan Infeksi Sekunder Wibisono Nugraha; Danu Yuliarto; Eka Devinta Novi Diana; Alfina Rahma; Prasetyadi Mawardi; Frieda; Ambar Mudigdo
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.123

Abstract

Background: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis, characterized by sterile, painful, necrotic ulcer, and is associated with systemic conditions. PG manifests as papules and vesicles that evolve into painful ulcers. Incidence of PG is relatively rare in Dr. Moewardi Hospital, so it is important to identify and correctly diagnose PG based on its’ histopathological features. Case A 54-year-old man complained of painful scab on several body parts. Hematoxylin and eosin staining in the epidermal layer showed a basket-weave orthokeratosis with necrotic tissue, acanthosis, and basal cell hypermelanosis. In the dermis layer there is a lymphocyte and neutrophil cell infiltrate with slight appearance of leukocytoclastic. Discussion: Pyoderma gangrenosum is a reactive, non-infectious inflammatory dermatosis (neutrophilic dermatoses). In this case, PG occurs in 54-year-old man as painful scab on back and legs. Classical PG characterized by papules, pustules, crusted or necrotic plaque, which typically have undermined, overhanging, dusky purple edges with surrounding induration and erythema. In this patient, the epidermal layer showed ulceration and slight appearance of leukocytoclastic vasculitis in the dermis area and lymphocyte infiltrate with slight neutrophil in the perivascular accompanied by erythrocyte extravasation, which support the diagnosis of PG.
Modalitas Terapi Striae Ambar Aliwardani; Putti Fatiharani Dewi; Fiska Rosita; Indah Julianto
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.124

Abstract

Striae or strechmark is a form of benign skin lesion manifested as inflammatory streaks perpendicular to the direction of skin tension which has cosmetic morbidity and possesses risk of secondary infection in severe case. Various therapeutic modalities have been introduced, such as topical therapy, physical therapy using devices, lasers, and the latest is celullar therapy using platelet-rich plasma. Such varied treatment modalities are reported to have varied results.

Page 1 of 1 | Total Record : 6

 1 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol. 39 No. 1 (2026): MEDICINUS Vol. 39 No. 2: MEDICINUS Vol. 38 No. 12 (2025): MEDICINUS Vol. 38 No. 11 (2025): MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS Vol. 38 No. 5 (2025): MEDICINUS Vol. 38 No. 4 (2025): MEDICINUS Vol. 38 No. 3 (2025): MEDICINUS Vol. 38 No. 2 (2025): MEDICINUS Vol. 38 No. 1 (2025): MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS Vol. 37 No. 1 (2024): MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS Vol 34 No 1 (2021): MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS Vol. 33 No. 1 (2020): MEDICINUS More Issue