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Elmiawati Latifah
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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 15 Documents
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Search results for , issue "Vol 9 No 2 (May-August 2023)" : 15 Documents clear
MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS Setiyo Budi Santoso; Widarika Santi Hapsari; Renny Setyowati
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8463

Abstract

Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid reference for researchers. This investigation aimed to establish a sustained dyslipidemia induction that persists after several days of intervention with a hypolipidemic agent. Six groups of mice, each consisting of five primary test animals and one reserve test animal, were used. After a seven-day acclimatization period, we induced each group for 14 days using three different methods: (1) 5% body weight of quail egg yolks (5% QEY), (2) 10% body weight of used cooking oil (10% UCOs), and (3) a combination of 5% QEY and 10% UCOs. Once all mice reached their peak lipid levels, we evaluated lipid performance through a seven-day intervention with simvastatin (0.026 mg/20-gram body weight) in one of the paired groups. A 14-day combined induction of 5% QEY and 10% UCOs resulted in a 39% elevation in mouse lipids compared to baseline levels. Our findings offer an alternative to traditional dyslipidemia models. However, the development of an animal model for dyslipidemia still poses challenges. Therefore, the identification of novel biomarkers capable of targeting dyslipidemia in humans is crucial.
PHYSICAL CHARACTERIZATION AND SUNSCREEN ACTIVITY OF NUTMEG OIL NANOEMULSION WITH ISOPROPYL MYRISTATE VARIATIONS Siti Setianingsih; Rizky Adityo Saputro; Vironica Rizky Fauziah; Wahyu Setyo Wibowo; Ayu Shabrina
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8481

Abstract

The nutmeg seed oil contains myristicin which can absorb UV rays. Nanoemulsion with isopropyl myristate can be used to increase the activity of sunscreen. This study aimed to determine the physical characteristics and effectivity of nutmeg oil (NMO) nanoemulsion with isopropyl myristate as an enhancer. The nanoemulsion was made with 6.4% NMO and variations of isopropyl myristate 1% (FI), 3% (FII), and 5% (FIII). The nanoemulsions were evaluated for physical characteristics such as appearance, pH, viscosity, transmittance percentage, particle size, and polydispersity index (PI). The in vitro SPF value was tested using a spectrophotometer, and sunscreen effectivity was determined by the Minimum Erythemal Dose (MED) value. Data obtained were analyzed using one-way ANOVA. This study showed that the colour of the NMO nanoemulsion was light yellow and clear, with a transmittance percentage of 97.5-97.9%. The pH FI, FII, and FIII results were 6.79±0.03, 6.84±0.04, and 7.02±0.03. The viscosity was 1.63 ± 0.81 to 1.82 ± 0.85 d.Pas with Newtonian rheology. The particle size was 14.3 ± 1.41 nm to 16.0 ± 2.13 nm, with PI less than 0.5. SPF value were 16.34 ± 5.50 (FI); 16.70 ± 5.20 (FII) and 17.80 ± 3.20 (FIII). MED values were 220.5 ± 6.34 (FI), 225.4 ±5.41 (FII), and 240.2 ±3.45 (FIII) minutes. The MED value showed that FIII was significantly different from FI and FII. Isopropyl myristate at 5% in nanoemulsion increases the effectivity of sunscreen.
THE RELATIONSHIP BETWEEN THE LEVEL OF KNOWLEDGE AND PERCEPTION OF THE USE OF TRADITIONAL MEDICINE IN THE PEOPLE OF KLATEN CITY IN 2022 Tista Ayu Fortuna; Arifah Sri Wahyuni; Nadya Tiara Putri
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8647

Abstract

The use of traditional medicine in today's society is increasing with labels "back to nature" which is realized through the utilization of Indonesia's natural potential. Based on an incidental survey study in Klaten City, the affecting factor the use of traditional medicine in this region is knowledge and perception. Public knowledge related to the utilization of traditional medicine is assumed to be lacking because of the assumption that traditional medicine is much safer than chemical drugs. There is an assumption based on the side effects of traditional medicine being lower than chemical drugs. This study aims to assess the contribution of perception and knowledge to the use of traditional medicine. The research uses a cross-sectional study and the data collection instruments through questionnaires. The sampling technique used was purposive sampling with a total of 1089 respondents. Data collection used a questionnaire instrument whose results were analyzed using the Chi-Square statistical test. From these results can be concluded that types of knowledge involve definitions, type, efficacy, side effects, how to use, perceptions, convenience, currentness, and policy that can affect the use of traditional medicine. The results of data analysis show that the contribution of knowledge and perception to the use of traditional medicine has a coefficient of determination of 0.742
COST-EFFECTIVENESS ANALYSIS OF CEFTRIAXONE AND CEFIXIME IN TYPHOID FEVER PATIENTS HOSPITALIZED AT BERKAH PANDEGLANG REGIONAL HOSPITAL FOR THE PERIOD 2020-2021 Yusransyah Yusransyah; Yuni Rahmawati; Baha Udin; Nia Marlina Kurnia
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8648

Abstract

Typhoid fever is an infectious disease among humans caused by the bacterium Salmonella typhi. With the high Multi-Drug Resistance (MDR) of Salmonella typhi, selecting the right antibiotic is a factor that must be considered in addition to cost constraints. Therefore, cost-effectiveness is needed. This study aims to determine the cost-effectiveness of typhoid fever patients using ceftriaxone and cefixime antibiotics. The data used are retrospective, and the sampling was done by purposive sampling. This study was conducted at Berkah Pandeglang Regional Hospital. Sample in this study, namely typhoid fever patients of the period 2020-2021, who meet the inclusion and exclusion criteria. In this study, 16 samples were obtained. The results of this study showed that the total average direct medical costs for the ceftriaxone group were IDR 78.632.500 In contrast, the cefixime group was IDR 75.527.300. The ACER value of typhoid fever patients who used Ceftriaxone + cefixime was IDR 91,646.27, Ceftriaxone was IDR 77,463.89, and cefixime was IDR 88,027.15. The patients with typhoid fever who used Ceftriaxone were more cost-effective than those who used Cefixime
NON-ADHERENCE FACTORS TO TUBERCULOSIS TREATMENT IN PULMONARY TUBERCULOSIS PATIENTS IN SURAKARTA CENTRAL GENERAL HOSPITAL, INDONESIA Hidayah Karuniawati; Gayuh Ilham Rahmadi; Erindyah Retno Wikantyasning
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.9109

Abstract

Tuberculosis is an infectious disease that must be treated in the long term. One of the therapeutic efficacy factors in tuberculosis treatment is medication adherence by patients. Non-compliance to treatment leads to no achievement of treatment goals, increasing the risk of resistance, mortality, and morbidity. This study analyzed association factors that predicted the influence of the pulmonary tuberculosis patient’s non-adherence to anti-tuberculosis medicines in Surakarta Central General Hospital, Indonesia. The research was analytical research with a cross-sectional approach. The study samples were 80 respondents. The inclusion criteria were patients diagnosed with pulmonary tuberculosis in Surakarta Central General Hospital, aged >17 years old, and patients who received Anti-Tuberculosis Drugs for at least two months. This study used a questionnaire that has been validated. Data were analyzed by bivariate analysis (chi-square or Fisher) and continued by multivariate logistic analysis. Of 80 respondents, there were 30 respondents (37.5%) were non-adherence to taking Tuberculosis (TB) drugs. The predicted factors that influenced non-adherence in taking anti-tuberculosis drugs were beliefs about the medicine of the harm subscale (p = 0.001; OR = 8.167), suffering from drug side effects (p = 0.022; OR = 4.222), and beliefs about the medicine of overuse subscale (p = 0.038; OR = 3.504). The wrong beliefs of patients and side effects may influence patients’ adherence to TB medicines. Counseling and education are needed to improve patients’ beliefs and manage medicines’ side effects.

Page 2 of 2 | Total Record : 15

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