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Medical and Health Journal
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : 28073541     DOI : https://doi.org/10.20884/1.mhj.2023.2.2.8053
Core Subject : Health,
Medicine & Pharmacology
Medical and Health Journal (EISSN. 2807-3541) is containing various articles/ manuscripts in the forms of research article, systematic reviews, case reports in the field of medicine focusing on basic medicine, clinical medicine, biomedical sciences, medical biotechnology, and public health. This journal is published by Universitas Jenderal Soedirman, Purwokerto, Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 28 Documents
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Search results for , issue "Vol 5 No 2 (2026): February" : 28 Documents clear
Ileal Atresia in a Preterm Neonate Complicated by Necrotizing Enterocolitis: A Case Report Hapsari, Ariadne Tiara; Nugroho, Andika Eka; Yulyanti, Desi
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19475

Abstract

Background: Ileal atresia is a congenital intestinal obstruction that frequently affects premature neonates and is associated with high morbidity, particularly when complicated by necrotizing enterocolitis (NEC) and sepsis. Optimal outcomes depend not only on surgical intervention but also on comprehensive perioperative management by a multidisciplinary team, particularly neonatologists. Case Presentation: We report a male preterm neonate born at 32 weeks and 5 days of gestation with progressive abdominal distension, bilious gastric residue, and failure to pass meconium. Initial respiratory distress improved with non-invasive ventilation. However, gastrointestinal deterioration occurred on day four of life, with radiographic findings consistent with NEC stage III and pneumoperitoneum. Emergency laparotomy revealed ileal atresia, and staged surgical management was performed. Discussion: The pediatric or neonatal team played a crucial role in preoperative stabilization, including respiratory support, fluid and electrolyte correction, broad-spectrum antibiotics, and nutritional optimization. Postoperatively, close monitoring of respiratory status, infection control, gradual advancement of enteral nutrition, and growth assessment enabled recovery without major complications. Full oral feeding was achieved, and the patient was discharged in stable condition on day 27 of life. Conclusion: This case highlights the pivotal role of pediatricians or neonatologists in perioperative management of ileal atresia in premature neonates, emphasizing that meticulous supportive care significantly contributes to favorable surgical outcomes.
Characteristics of Presbycusis Patients at RSUD Prof. Dr. Margono Soekarjo Purwokerto Abdurrohman, Mukhammad Ilham; Kusdaryanto, Wahyu Dwi; Amalia, Ary Nahdiyani; Darmawan, Anton Budi; Nur Hestiyani, Rani Afifah
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19511

Abstract

Presbycusis is a progressive sensorineural hearing loss commonly affecting the elderly and significantly reducing quality of life. RSUD Prof. Dr. Margono Soekarjo Purwokerto, as a referral hospital, treats a large number of elderly patients, making characterization of presbycusis patients essential. This study aimed to describe the characteristics of presbycusis patients based on age, sex, occupation, comorbidities, and degree of hearing loss. A descriptive quantitative study with a retrospective approach was conducted using total sampling of presbycusis patients at the ENT outpatient clinic from 2022 to 2024. A total of 81 patients met the inclusion criteria. Most patients were male and aged 61–74 years. The most common occupation was farmer, and hypertension was the most frequent comorbidity. Hearing loss was generally bilateral with moderate to moderately severe degree.
In Silico Analysis of Moringa oleifera Leaf Phytochemicals as Potential DNA Gyrase Inhibitor in Salmonella typhi Kusuma, Meike Tiya; Umam, Muzid Syauqil; Birhi, Damiana Nofita
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19522

Abstract

Salmonella typhi is an infectious bacterium leading to typhoid fever, that is increasing in cases worldwide each year. Due to the resistance to antibiotics, the discovery of safer and efficacious drugs remains important. This study evaluates the potential interaction of M. oleifera phytochemical compounds against DNA gyrase of Salmonella typhi using an in silico molecular docking approach. Ligand’s phytochemicals were retrieved from the PubChem database, while the three-dimensional structure of DNA Gyrase subunit A and subunit B were obtained from the Protein Data Bank (PDB ID: 5ZJT and 6J90). Molecular docking was done using PyRx software and BIOVIA Discovery Studio as visualization software. Phytochemical compounds that had higher predictive binding affinity to DNA gyrase subunit A were Naringenin (∆G=-7.9 kcal/mol), 6-Prenylnaringenin (∆G=-8.1 kcal/mol), 6-Methoxypodophyllotoxin (∆G=-7.9 kcal/mol). Brefeldin A- DNA gyrase subunit A complex had the same binding affinity to ciprofloxacin (∆G=-7.7 kcal/mol). Phytochemical compounds that had higher predictive binding affinity to DNA gyrase subunit B were Naringenin (∆G=-8.9 kcal/mol), 6-Prenylnaringenin (∆G=-8.8 kcal/mol), 3',4'-Dimethoxy-7-hydroxyflavone (∆G=-8.6 kcal/mol), Sinapoyl malate (∆G=-7.8 kcal/mol), and Sinapoyl malate-4'-methyl ester (∆G=-8.3 kcal/mol). These findings suggest that phytochemical compounds from M. oleifera leaves may act as potential DNA gyrase inhibitors. However, further in vitro and in vivo validation is required to confirm its antibacterial activity.
Beyond Survival: Multisystem Life-Threatening Illness in an Infant with Congenital Heart Disease and Sepsis Oliviany, Windy; Pratidina, Rr. Wening Gelar; Kinanti, Luhung Sekar
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19603

Abstract

Introduction: Congenital malformations are a leading cause of infant disability and mortality. Congenital infections, particularly cytomegalovirus (CMV) and Toxoplasma gondii, are associated with structural abnormalities of multiple organ systems, including congenital heart disease (CHD). In utero infection may disrupt cardiac organogenesis, increasing the risk of heart failure. Infants with CHD are also highly susceptible to sepsis, frequently requiring pediatric intensive care. Managing life-threatening conditions in infants presents significant clinical challenges, including complex therapeutic decisions, drug dosing, and multidisciplinary care. Case Report: A 1-month-old male infant presented with poor feeding and lethargy. He had been previously diagnosed with failure to thrive and CHD consisting of atrial septal defect (ASD) and ventricular septal defect (VSD). Further evaluation revealed heart failure (Ross III), congenital CMV and toxoplasmosis infections, sepsis, bronchopneumonia, prolonged jaundice, and hydrocele dextra. The patient required PICU admission for 6 days followed by 7 days of inpatient care. Clinical improvement was achieved following comprehensive medical management, and the patient was discharged in stable condition. Conclusion: Congenital infections may play a critical role in the development and clinical severity of CHD, contributing to heart failure and increased susceptibility to sepsis. Early recognition and integrated multidisciplinary management are essential to improve outcomes in infants with multiple life-threatening conditions, emphasizing care that extends beyond survival toward functional recovery..
Indicators of Mothers’ Knowledge Regarding Completeness of Basic Imunization for Children Aged 0-24 Months in Kota Tengah Public Health Centre, Gorontalo Indrawati, Indrawati; Modjo, Dewi; Haruna, Ariel Syafrianto
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19605

Abstract

Immunization is a crucial preventive measure to protect children from infectious diseases. A significant decline in coverage is often influenced by the role of mothers as the primary decision-makers in children's health.This study aimed to describe maternal knowledge indicators and their relationship with the completeness of basic immunization for children aged 0-24 months. Utilizing a quantitative design with a cross-sectional approach, the study was conducted on 42 respondents in the Kota Tengah Public Health Center work area, selected through accidental sampling. Data were collected using knowledge questionnaires and Maternal and Child Health (MCH) books, and then analyzed descriptively and using the Chi-square test. The results show that while the majority of mothers understand the definition of immunization, approximately one-third of respondents still have misconceptions regarding the types, benefits, and schedules of vaccinations. Statistical tests reveal a significant relationship between the level of maternal knowledge and immunization completeness (p=0.001), where mothers with better knowledge tend to be more compliant in completing their children's immunization status. In conclusion, maternal knowledge is a vital determinant in the success of immunization programs. More comprehensive health education strategies and continuous guidance for parents are highly necessary to raise awareness and ensure optimal child health protection at the public health center level.
Molecular Mechanisms and Clinical Effects of Medicinal Plants in Modulating Oxidative Stress: A Systematic Review from Athletic Performance to Vital Organ Protection Azzizah, Isma Nur; Zahroh, Endah Wati; Dewi, Arifiana Wungu Kartika; Cahya, Dini Aulia
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19721

Abstract

Oxidative stress constitutes a major pathophysiological mechanism in conditions ranging from exercise-induced muscle fatigue to chronic organ damage including diabetic nephropathy and ischemic stroke. Medicinal plants offer therapeutic potential through bioactive compounds that modulate cellular defense pathways. This systematic review evaluated the molecular mechanisms and clinical efficacy of medicinal plants (Kaempferia galanga, Nigella sativa, Panax ginseng, and other herbal formulations) in managing oxidative stress across diverse health contexts. A comprehensive literature search was conducted using reputable databases. Studies measuring oxidative stress biomarkers (MDA, SOD) and cellular signaling pathways (Nrf2, NF-κB, PI3K/AKT) were included. Results showed that N. sativa and K. galanga supplementation in athletes significantly reduced MDA levels and inflammatory cytokines (IL-6), accelerating post-exercise recovery. Bioactive compounds including Ginsenoside Ro and Kaempferide demonstrated organ-protective effects through Nrf2/HO-1 activation, autophagy promotion, and mitochondrial protection in ocular and renal tissues. These findings indicate that medicinal plants exert cytoprotective effects by activating endogenous antioxidant systems. The therapeutic spectrum spanning athletic performance enhancement to chronic organ protection underscores the translational potential of herbal interventions as promising antioxidant agents.
Expectative Management of a Late-Diagnosis Twin Reversed Arterial Perfusion Sequences (TRAPS) - A Rare Case Report Devina, Velika; Sumawan, Herman; Aziz, Muhammad Alamsyah; Fakih, Mohamad
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19785

Abstract

Twin Reversed Arterial Perfusion Sequence (TRAPS) is a rare and severe complication unique to monochorionic twin pregnancies, characterized by retrograde perfusion of a nonviable acardiac twin by a structurally normal pump twin. Management of TRAPS diagnosed in late gestation remains controversial due to limited interventional options and an unpredictable clinical course. While early fetal intervention is generally recommended, evidence supporting expectant management in late-diagnosed cases, particularly in resource-limited settings, remains scarce. We report a 31-year-old gravida 2, para 1 woman with a monochorionic diamniotic twin pregnancy complicated by TRAPS, who was referred to a maternal–fetal medicine clinic at 29–30 weeks of gestation. Given stable pump twin hemodynamics, late gestational age, and unavailability of fetal therapy, expectant management with intensive ultrasound surveillance was pursued. At 32 weeks, signs of evolving cardiac compromise prompted delivery by cesarean section. The pump twin survived with prematurity-related complications and was discharged in stable condition. This case highlights that expectant management may be a reasonable option in carefully selected late-diagnosed TRAPS cases when fetal therapy is unavailable, provided that close surveillance and timely delivery are ensured.
The Role of Rumination in University Students’ Mental Health: A Mediation Analysis of Depression and Anxiety Maghfiroh, Nisaul; Oktavilia, Ernasiwi Astri; Hidayah, Arfi Nurul; Kamal, Isran; Mardihusodo, Hajid Rahmadianto; Syamsu Hidayat, Muhammad Zaenuri
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19800

Abstract

This study examined the relationship between rumination and mental health among university students by testing the mediating roles of depression and anxiety. Rumination refers to a repetitive and passive focus on negative experiences and emotions that may influence psychological functioning. A quantitative correlational design was employed. A total of 113 students completed the Ruminative Response Scale (RRS), Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and General Health Questionnaire (GHQ-12). Parallel mediation analysis indicated that rumination significantly predicted depression (β = .6197, p < .001) and anxiety (β = .5830, p < .001). Depression significantly predicted mental health (β = .2893, p = .025), whereas anxiety was not a significant predictor (β = .1186, p = .343). The direct effect of rumination on mental health was not significant (β = −.0940, p = .427), nor was the total effect (β = .1544, p = .098). However, the indirect effect through depression was significant (β = .1793, p = .031; 95% CI [.00464, .0957]), whereas the indirect path through anxiety was not significant (β = .0692, p = .347). These findings indicate that depression fully mediates the relationship between rumination and mental health. Thus, the influence of rumination on students’ mental health primarily operates through increased depressive symptoms.

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