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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 3 (2023)" : 60 Documents clear
Review: Perbandingan Validasi dan Kadar Amlodipin dalam Sampel Plasma Darah pada Kromatografi Cair Kinerja Tinggi dan Kromatografi Cair Spektrometri Massa Deborah Chennia Lau; Tiara Cinta Amelia; Diara Ravika Hadjami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.166

Abstract

Amlodipine has a high bioavailability, a large volume of distribution, and a sufficiently long elimination half-life of 35 to 50 hours so that low plasma concentrations of amlodipine are achieved after oral administration. One of the methods used to quantify amlodipine levels is High-Performance Liquid Chromatography and Liquid Chromatography Mass Spectrometry. This review aims to compare the validation of the two methods according to the parameters and determine the advantages and disadvantages of each process in terms of accuracy in identifying samples of amlodipine in blood plasma. An article review was conducted by collecting data from 2013 to 2023 using the Google Scholar and ScienceDirect databases filtered according to the inclusion and exclusion criteria. Seven journals could be compared according to the parameters of precision, accuracy, linearity, limit of detection and quantification. Better precision and accuracy are in the High-Performance Liquid Chromatography method, and good linearity is in the Mass Spectrometry Liquid Chromatography method. Liquid Chromatography Method Mass Spectrometry is easier to detect amlodipine levels because it can detect concentrations of more minor sample levels.  
Resistensi Obat Aspirin Terhadap Pasien Penyakit Jantung Koroner: Sebuah Literature Review Mally Ghinan Sholih; Munir Alinu Mulki; Ain Luthfiannisa; Esti Syahrin; Moza Aulia Syifni; Muhammad Naufal Nurhadi Hidayat; Safira Rosyidah; Salma Alviyah; Muhammad Raka Tresna
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.167

Abstract

In Indonesia, coronary heart disease is the largest contributor to mortality with a prevalence related to cardiovascular disease. Using drugs from a combination of fibrinolytics, anticoagulants, and antiplatelets can overcome acute coronary heart disease. The most commonly used therapy is the antiplatelet class in the form of aspirin as a treatment for the management of cardiovascular disease and its prevention. However, several studies have stated that aspirin is a conventional antiplatelet which sometimes has the potential to cause failure and is ineffective for the treatment of coronary heart disease, so that it can be said to be aspirin resistance. Article writing method review This study uses scientific literature. The steps taken begin with collecting various journal references through the database PubMed Identifier (PMID), google schoolar, and science direct within the last 10 years (2013-2023). The keyword in the literature search is aspirin resistance, aspirin resistance coronary disease, and aspirin coronary heart diseases. Based on the results of reviews that have been reviewed, it shows that there are resistance mechanisms and factors that influence aspirin resistance in coronary heart disease patients.
Review jurnal: pola perbandingan pengobatan farmakologi penderita dispepsia di beberapa rumah sakit Mally Ghinan Sholih; Munir Alinu Mulki; Sophy Wulandari; Putri Wahyu Primasti; Giga Anugerah Arsylrakhmatika; Nurlita Dwi Putri Prihasti; Amanda Maharani; Roudotul Jannah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.170

Abstract

Dyspepsia is a common complaint often found in the community and among patients who come to clinical practice. Symptoms of dyspepsia include abdominal discomfort, nausea, vomiting, burning, bloating in the upper digestive tract, early satiety, fullness after eating, and belching. This literature review compared prescription patterns in dyspepsia patients from several hospitals. The research method began with a literature search through the PubMed and Google Scholar databases within the specified year range and using the keywords dyspepsia, pattern, treatment, and drug. The conclusion is that there are many uses for generic drugs and different types of drugs in treating patients with dyspepsia. Factors influencing the management of dyspepsia in inpatients include gender, reported clinical symptoms, class of antiulcer therapy, differences in the number of drugs, and drug dosage forms.  
Review artikel: efektivitas penggunaan fototerapi terhadap rinitis alergi pada ibu hamil Mally Ghinan Sholih; Munir Alinu Mulki; Annisa Frastica Septi; Muhammad Ja'far Ash Shidiq; Nariyyah Fitriana; Shalum Putriyani; Yuni Lili Indriyani; Yuniar Fathil Ilmi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.171

Abstract

Rhinitis is an inflammation of the mucous membrane of the nose that affects millions of people worldwide. Although there has been much research and development related to the management of rhinitis, there are still challenges in achieving effective treatment and optimal symptom control. The purpose of writing this article is to achieve effective treatment and optimal control of rhinitis symptoms. The writing method used is literature review by collecting primary references from international journals published in the last 10 years (2013-2023). Referrals are selected through the pubMed database with relevant keywords.  The results and discussion of this study include information on allergic rhinitis, rhinitis of pregnancy, hormonal changes during pregnancy, and commonly used medications. In the treatment of gestational rhinitis, the use of phototherapy can be the right choice. Based on articles that have been reviewed, it shows that treatment with phototherapy is more effective in overcoming the symptoms of allergic rhinitis. Phototherapy has a good effect on immunosuppressants and immunomodulators that can suppress the body's immune activity and also relieve inflammation.  
Formulasi Dan Uji Stabilitas Sabun Padat Transparan Ekstrak Biji Pala (Myristica fragrans Houtt) Fauziah Fauziah; Nurmalia Zakaria; Azmalina Adriani; Nazirah Nazirah; Khamdiyah Indah Kurniasih
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.172

Abstract

Transparent solid soap is a solid texture soap. Solid soap formulated with the addition of nutmeg extract serves as a drug agent to treat infections of the skin that cause bacteria. This study aims to determine the formulation and stability of the solid soap from the nutmeg seed extract. The research method is an experimental method. The treatments used were concentrated in formula 1 (0.5%), formula 2 (1%) and formula 3 (1.5%). The research parameters were organoleptic test, pH test, foam stability test, moisture content test. The results showed that the form of transparent solid soap from nutmeg seed extract was very dense, varied in color, namely clear chocolate (Formula 1), brown (Formula 2) and dark chocolate (Formula 3) with a less nutmeg odor. This soap has a pH of 11 and has different levels of foam. Formula 1 with initial foam height of 6.7 cm and final foam height of 5.5 cm (moisture content 5.17%). Formula 2 has a foam height of 7.4 cm and a final foam height of 5.8 cm (water content 4.99%), while formula 3 has a foam height of 8 cm and a final foam height of 6.3 cm (moisture content is 4.96%). The conclusion is the transparent solid soap made from nutmeg extract has met the soap requirements as stipulated by the Indonesian National Standard for the soap stability test (SNI 3532-2016).
Uji Efektitivitas Sediaan Gel Ekstrak Daun Kemangi (Ocimum basilicum L) Terhadap Penyembuhan Luka Sayatan Tikus Putih (Rattus nornvegicus) Anastasia Walukow; Douglas N. Pareta; Silvana L. Tumbel; Joke L. Tombuku; Christel N. Sambou
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.173

Abstract

Natural wealth has a variety of herbal plants, plants that are included in it efficacious as medicine. Traditional medicine, is an ingredient or herb that is usually used as traditional medicine and is used to accelerate the healing of diseases, one of the plants used to accelerate wound healing is basil leaves (Ocimum basilicum L.). This study aimed to determine the effectiveness of basil leaf gel preparations against wound healing in white rats (Rattus norvegicus). The test animals used were 15 rats. A 1 cm cut wound is made on the back of the mouse using a scalpel. The method used in this study is in the form of laboratory experiments. This study used a Complete Randomized Design (CDR) consisting of 5 treatments, including 1 negative control, 1 positive control (bioplacenton), and 3 stratified concentrations, namely 5% concentration gel, 10% concentration gel and 15% concentration gel with 3 repetitions each. The treatment is carried out for 7 days. The results of measuring wound diameter in rats based on the results showed that basil leaf extract gel concentration of 15% provided a healing effect more effective than other extracts.
Uji Efektivitas Etanol Daun Pandan (Panandus amarylifolius Roxb) Sebagai Penyembuhan Luka Sayat pada Tikus Putih (Rattus norvegicus) Priska C. Londoran; Jabes W. Kanter; Christel N. Sambou; Hariyadi Hariyadi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.174

Abstract

An incision is a wound that splits the skin area due to being cut by a sharp object. Indonesian people use medicinal plants very much in traditional or modern medicine. One of the plants that can be used as a medicinal ingredient is fragrant pandan leaves which can accelerate the wound healing process. This study aims to determine the level of effectiveness of pandan leaf extract as a healer for cuts. This study used 15 white rats which were then slashed on their backs using a 1 cm long scalpel with a depth of ± 2 mm. This study used a laboratory experiment using a completely randomized design consisting of 5 treatment groups, including 1 negative control, positive control (10 percent povidone iodine) and 3 graded concentrations, namely pandan leaf extract concentrations of 5.10 to 15 percent with 2 each. repetition times. The results of measuring the length of the wound in rats showed that fragrant pandan leaf extract with a concentration of 10 percent and 15 percent had the same effectiveness.
Uji perbandingan efektivitas ekstrak daun kemangi (Ocimum sanctum ) dan daun mint (Mentha arvensis) sebagai insektisida larva nyamuk Aedes aegypti Ali Napiah Nasution; Mahwina Yusari Harahap; Erika Auria Sinaga; Salsabila Bizlany Harahap
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.175

Abstract

Mosquitoes are vectors of various parasitic and viral diseases, especially in tropical and subtropical regions. A mosquito is a type of small insect that belongs to the family Culicidae. They are known for their annoying nature and bite humans as well as other animals to obtain blood as a food source. Female mosquitoes need protein contained in the blood to develop and lay their eggs. This study is a laboratory experiment, with a true experimental post-test only control group design which aims to compare the effectiveness of basil leaf extract ocimum sanctum. and mint leaves of mentha arvensis. As an insecticide of mosquito larvae Aedes Aegepty. At a concentration of 5% basil extract of dead larvae is 40% and mint leaf extract is 24% of dead larvae. At a concentration of 10%, mint extract of dead larvae 32%, while basil leaf extract 56% of dead larvae. At a concentration of 15% mint leaf extract of larvae that died 60% while basil leaf extract 60% of larvae died, and at a concentration of 25% mint leaf extract of larvae that died 64% while basil leaf extract 72% of larvae died. The results showed that basil leaf extract was more effective as an insecticide for Aedes aegpyti mosquito larvae than basil leaf extract. The higher the concentration of mint leaf extarak and basil leaf extract, the higher it is effective as an insecticide of Aedes aegpyti mosquito larvae.
Skrining Fitokimia Dan Analisis Kadar Kafein Pada Kopi Bubuk Jenis Arabika Di Kota Takengon Menggunakan Spektrofotometri Ultraviolet Muhammad Andry; Fahma Shufyani; Muhammad Amin Nasution; M. Fariz Fadillah; Ika Julianti Tambunan; Firman Rezaldi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.176

Abstract

Background: Coffee is a type of plant that contains caffeine and can be made into a delicious drink. Currently, coffee is the world's most popular drink after water and tea. The stuay aimed was to determine the caffeine content in Arabica ground coffee circulating in the Takengon market according to Indonesian national standards (SNI 01-7152-2006). This research was experimental by taking samples purposively. The research method used was phytochemical screening, qualitative analysis, and ultraviolet spectrophotometry at a wavelength of 273nm. The specified validation parameters were precision, linearity, LOD and LOQ. The results of the phytochemical screening of sample A in the Meyer test treatment obtained negative results but the others were positive. And in sample B, all tests were positive. In the three qualitative analyses tests on samples A and B, the results were positive. The average yield of quantitative analysis in sample A was 11.632 mg once and the daily concentration was 34.897mg. while in sample B the level was 6.663 mg once and drank 19.989mg per day. Validation test results obtained linearity r2 = 0.998, LOD and LOQ namely 0.882µg/ml and 2.94µg/ml, RSD value of 1.11%. Based on the conclusion, sample A and sample B met the requirements according to SNI 2006 (50mg once and 150mg daily) and also met the requirements according to the Pharmacopoeia Edition III, namely a maximum dose of 500 mg once and 1.5g daily.
Formulasi sediaan krim lulur dari sari wortel (Daucus carota L.) sebagai anti aging Fahma Shufyani; Muhammad Andry; Rida Evalina Tarigan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.177

Abstract

Background; Carrots are famous for the high beta carotene content in the fruit along with other vitamins, namely vitamin B and vitamin E. Vitamin E's role in the skin includes antioxidant, maintaining skin moisture, sun protection, and wound healing process. As a natural antioxidant, vitamin E is able to counteract free radicals and oxygen molecules. Objective:  To find out carrot juice (Daucus carota L.) can be formulated as a scrub cream as anti-aging and to find out at what concentration is the most effective in the preparation of carrotle scrub cream (Daucus carota L.) as anti-aging. Methods: This type of research was conducted experimentally. This research includes collecting respondents, measuring moisture content, smoothness, pores, blemishes, and wrinkles on the skin of respondents, making carrot juice, making scrub preparations from carrotle and evaluating preparation tests. Results: The use of scrub cream preparations containing carrotle (Daucus carota L.) concentration of 15% for 4 weeks showed changes in skin condition for the better with increased water content of 19.3 to 40 (107.25%), smoother skin smoothness of 36.3 to 20.6 (43.25%), shrinking pores 64 to 20.6 (67.81%), many blemishes were reduced 51 to 11.3 (77.97%), wrinkles that were reduced on the respondent's skin showed better results obtained, namely changes in wrinkles 45 to 13.6 with a recovery percent of (69.77%). Conclusion: The conclusion of this study is that carrottle (Daucus carota L.) can be formulated as a scrub cream as anti-aging.

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