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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "JPS Volume 7 Nomor 4 (2024)" : 26 Documents clear
Skrining fitokimia dan uji aktivitas antiinflamasi ekstrak akar Sonneratia alba terhadap luka bakar pada tikus (Rattus norvegicus): Indonesia Mongi, Jeane; Karauwan, Ferdy A.; Tuda, Aletheia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.639

Abstract

Burns caused by inflammation can lead to severe and potentially fatal conditions, especially if the burn is located in a very sensitive area of the body or if the burn becomes infected. Untreated inflammation can cause very severe inflammation, which can damage cells, tissues, or organs. The roots of Sonneratia alba contain alkaloids, flavonoids, saponins, triterpenoids, and tannins that can help heal burns. The aim of this research is to determine the phytochemistry and the effects of the ethanolic extract of Sonneratia alba roots on the healing of burn wounds on rat skin. Research Method: The research uses an experimental method. The research includes the extraction stage, using 96% ethanol as a solvent in the maceration process, and the ethanol extract of S. alba roots is screened for its chemical content. Testing phase of the anti-inflammatory activity of Sonneratia alba mangrove root extract on burn wound healing. Experimental animals used were 15 Rattus norvegicus rats divided into 5 groups with different concentrations of 3 treatments, that is: the positive control group with Bioplacenton gel, the negative control group with Aquadest, the group with 15% ethanol extract of S. alba root, the group with 30% ethanol extract of S. alba root, and the group with 45% ethanol extract of S. alba root. During the observation phase, the measurement of burn healing diameter was conducted over 32 days using callipers. The research result show that the ethanol extract of Sonneratia alba roots contains alkaloids, flavonoids, saponins, tannins, triterpenoids, and phenolic compounds. The 15%, 30%, and 45% concentrations of the ethanol extract of Sonneratia alba roots have the potential to heal burns in rats. Ethanolic root extract showed an increase in healing power after the 20th day, faster than Biopalcenton gel.
Formulasi sediaan pelembab bibir mengandung ekstrak kulit buah pisang raja (Musa paradisiaca L) Siregar , Runisya Maugin Utami; Yuniarti, Rafita; Lubis, Minda Sari; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.674

Abstract

Lip balm is a care product that can keep your lips moist, which is a type of ointment used to treat dry and chapped lips. The benefit of using lip balm for lips is to regulate lip moisture. Lip balms are generally clear or colorless, although recently colored variants have also been created. To find out whether the extract of plantain peel (Musa paradisiaca L) can be formulated in the form of lip balm preparations. The purpose of this study was to determine whether lip balm preparations could be used as moisturizers. To find out lip balm preparations well made and of good physical quality. This research method is experimental. Collection of plants was carried out purposively, ie without comparison with other areas. The sample used was the skin of fresh ripe plantains obtained from the Simpang Limun market in Medan. This study included quality inspection preparations, moisture effectiveness test preparations, irritation tests on formulations and hedonic tests on variations in preparations made. The results of this study indicate that extracts of plantain peel (Musa paradisiaca L) with concentrations of 1%, 3%, 5%, 10%, and 15% can be formulated in the form of lip balm preparations. Formula 5 with a concentration of 15% showed the best lip balm preparation by fulfilling the requirements for physical quality, effectiveness and safety. With a preference value of 5 (like very much), has a melting point of 57'C and has a pH of 5.9 so it does not cause skin irritation and is stable at room temperature storage for 28 days. Lip balm preparations made using cocoa butter base are safe to use and meet the standards..
Review : Identifikasi senyawa bioaktif utama dalam daun leilem (Clerodendrum minahassae) dan potensi farmakologis Sambou , Christel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.696

Abstract

Clerodendrum minahassae leaves contain various bioactive compounds, including flavonoids, alkaloids, saponins, and phenolic acids, contributing to their pharmacological activity. This study aims to identify the main bioactive compounds in Leilem leaves (Clerodendrum minahassae) and their pharmacological potential through a literature review of various relevant scientific sources. The methodology employed includes systematic observation and meta-analysis. This review article describes the compounds present in Leilem leaves and evaluates their pharmacological activities, thereby enhancing the understanding of this underexplored medicinal plant. The findings indicate that Leilem leaves hold substantial potential as a source of bioactive molecules with diverse pharmacological properties. Based on a review of multiple scientific research articles, it can be concluded that Leilem leaves exhibit considerable efficacy in antimicrobial, anti-inflammatory, and antioxidant activities, as well as in reducing blood glucose levels.
Formulation of nanocream whitening preparation from a combination of yam starch (Pachyrhizus erosus L.) and rice starch (Oryza sativa L.) Nur, Hijrotun; Dalimunthe, Gabena Indrayani; Rani, Zulmai; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.698

Abstract

Whitening cosmetics have become a popular choice in modern society, with the perception that beauty is associated with white skin. The high market demand is an opportunity for cosmetic business actors but it also increases the risk of illegal cosmetic production containing hazardous materials such as hydroquinone. One of the cosmetic ingredients that is often found in whitening creams containing hydroquinone, which is effective in removing dark spots, has the risk of serious side effects. Therefore, it is advisable to find a safe, natural alternative for long-term skin whitening. Jicama starch and rice water starch are natural choices for whitening cosmetics. Nanoparticle-based cosmetics are superior to micro-scale cosmetics. The objective of the research was to determine whether a combination of jicama starch and rice water starch whitening cream can meet the characteristic requirements of a nano cream, to determine all concentrations of jicama starch and rice water starch whitening nano cream that meet the physical quality requirements and to determine all concentrations of jicama starch and rice water starch whitening nano cream have different effectiveness. This research method was True Experimental with Post Test Only Control Group Design research design. The independent variables are variations in the concentration of yam starch and rice water starch. The dependent variables were sample characteristics, characteristics of the whitening nano cream formulation and nano cream effectiveness test. The results showed that yam starch and rice water starch had effectiveness as whitener with a concentration of f3 (5:5) water content of 55.67%, sebum of 16% and pigment of 15.67%. The whitening cream met the characteristics of a nano cream with particle sizes of f0: 134.04, f1: 1849.20, f2: 147.64 and f3: 188.14 nm. Yam starch and rice water starch in the preparation of the whitening nano cream meet the physical quality requirements.
Uji penghambatan enzim α-glukosidase ekstrak etanol daun karas tulang (Chlorantus erectus) Arly Syahputri , Janies; Haryoto, Haryoto
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.642

Abstract

Karas tulang plant (Chloranthus erectus) is a medicinal plant that has been used in several areas such as China and Southeast Asia. There has been no research regarding the potential of bone karas leaves as an antidiabetic through inhibiting the α-glucosidase enzyme from the ethanol extract of bone karas leaves. Inhibition of the α-glucosidase enzyme can work due to the presence of phytochemical compounds, such as flavonoids, saponins, tannins and quinones. This is because the phytochemical compounds contained therein can act as antidiabetic agents to prevent hyperglycemia in diabetes sufferers. This research aims to identify chemical compounds and the activity of the α-glucosidase enzyme in the ethanol extract of leaves contained in karas bone leaves. The thin layer chromatography method was used to screen phytochemical chemicals for alkaloids, flavonoids, saponins and tannins. The ELISA reader 405 nm method was used to test the inhibition of the α-glucosidase enzyme. The substrate used was p-NPG while the comparison used was acarbose tablets. The results of this research were that the IC50 value for the extract was 30.541 ????g/mL while for acarbose it was 3.873 ????g/mL. From these results it can be concluded that the inhibitory power of the α-glucosidase enzyme is in the active category, while that of acarbose is in the very active category.
Formulasi eyeshadow kombinasi umbi bit (Beta vulgaris L.) dan rimpang kunyit (Curcuma longa L.) dalam perbandingan ekstrak dan nanoekstrak Sihotang, Laura Indah Restu; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.723

Abstract

Eyeshadow is an eye cosmetic that contains coloring agents to color effects and change the appearance. Some eyeshadow products use synthetic dyes that have a negative impact, so it is important to use safe dyes such as beetroot to produce a red color and turmeric rhizome to produce a yellow color. Turmeric rhizome yellow color. Nanoparticle-based cosmetics have advantages and can penetrate cell walls more effectively. This study aims to determine whether beetroot and turmeric rhizome extracts meet the requirements of nano extracts. Nano extracts determine the color difference at each concentration in the extracts and nano extracts as colorants for eyeshadow preparations, and choose the color of the extracts and nano extracts in eyeshadow preparations with certain concentrations that can meet the physical quality and favored by panels. This research method is True Experimental, and the research design used is a post-test-only control group design. The research design used was a post-test-only control group design. Independent variables are variations in the concentration of the combination of extracts and nano extracts of beetroot and turmeric rhizomes and eyeshadow formulations of various concentrations. Turmeric rhizome and eyeshadow formulations of multiple concentrations. The dependent variables are simplicity characteristics, phytochemical screening, particle uniformity characteristics, nano extract, and various tests. Nano extracts and various physical quality inspection tests of eyeshadow. The results showed that the beetroot and turmeric rhizome extracts met the requirements of nanoextracts with a particle size of beetroot 261 nm and turmeric rhizome 203 nm. Eyeshadow preparations containing a combination of beetroot and turmeric rhizomes in extracts and nano extracts have different colors: F1 is pink, F2 is light brown, F3 is Salem peach, F4 is peach pink, F5 is brown, and F6 is Salem pink. All eyeshadow preparation formulas meet the physical quality requirements, and F5 and F6 are the most preferred formulas for volunteers because they provide attractive colors.

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