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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 55 Documents
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Search results for , issue "JPS Volume 8 Nomor 1 (2025)" : 55 Documents clear
Perbandingan aktivitas antidiabetes ekstrak air dan etanol Muntingia calabura L Folium terhadap mencit jantan Pangondian, Aswan; PS, Nurunnisa; Husein, Saddam; Umaya, Chindy; Athaillah, Athaillah; Chandra, Putra
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.461

Abstract

Muntingia calabura L is an Indonesian herbal plant known as kersen which has the ability to reduce blood sugar levels. M. Calabura has secondary metabolites, namely flavonoids, tannins, triterpenoids, saponins and polyphenols. This study aimed to compare the antidiabetic activities of water and ethanol extracts of M. calabura in male mice. In this study, M. calabura was extracted using the maceration method with 70% ethanol solvent (EEMC) and decoction of Kersen leaves (EDMC). Blood glucose levels were measured at intervals of 15, 30, 45, and 60 minutes using a glucometer after being induced by alloxan induction. Animals were divided into eight groups (positive group, negative group and EEMC group, and EDMC group with doses of 125, 250 and 500 mg/kg BW. The results of the investigation showed that the activity to reduce blood glucose levels during the interval time was significantly different compared to the negative group, and positive control was not significantly different compared to the EEMC 250 mg/kg BW and EDMC 500 mg/kg BW groups. The conclusion of this study was that the EEMC and EDMC groups had decreased blood glucose levels. EEMC 250mg/kg BW and EDMC 500 mg/kg BW groups showed comparable activity to the positive control.
Formulasi hand cream antibakteri berbasis kitosan dan ekstrak daun putri malu (Mimosa pudica L.) Fendy, Fendy; Suryawan, Chinesia Prastialin; Fadila, Rina Fitriana; M.Saad, Nabilatul Rafi’ah; Mubayyinah, Hamidatul; Darmawan, Noviyan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.576

Abstract

CoronaVirus Disease 2019 is a respiratory disease caused by Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) which is transmitted through the air and droplets of fluid. One of the health protocols recommended by the World Health Organization (WHO) is washing hands. Hand-washing activities have limitations because not all places provide them, so the alternative that has been circulating in the community is hand sanitiser. However, the alcohol content and synthetic antibacterials cause dry and irritated skin. The purpose of this study was to create an antibacterial hand cream from putri malu leaf as a utilization of wild plants. Putri malu leaf extract and chitosan were made in the form of nanoparticles, and then an evaluation of the physical characteristics of the hand cream preparation was carried out in the form of pH, organoleptic, homogeneity, and stability observed for 14 days. The antibacterial activity of putri malu leaf extract and hand cream was tested against S. aureus and E. coli. The particle size obtained was 1529.5 ± 42.5 nm. The results of the physical characteristics obtained were pH 6.15; dark orange, odourless, stable at room temperature, and high homogeneity. Antibacterial testing of putri malu leaf extract against S. aureus produced an inhibition zone of 10.27 mm at a concentration of 25% and antibacterial hand cream produced inhibition zones of 23.18 mm and 12.22 mm with an extract concentration of 10% so both are classified as strong antibacterials that are effective against S. aureus and E. coli bacteria.
Efektivitas kinerja pengawasan obat dan makanan di wilayah kerja Balai Besar Pengawas Obat dan Makanan di Bandung Aristawidya, Levina; Zuhrotun , Ade
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.593

Abstract

The increasing demand for drugs and food will have an impact on the production and distribution of drugs and food which is increasingly widespread. The widespread distribution of drugs and food has caused public health problems related to quality and safety that do not meet standards, so that it is necessary to increase drug supervision both pre-market and post-market by the National Agency of Drug and Food Control (NADFC). Therefore, this article aims to determine the effectiveness of the monitoring performance of drug and food production and distribution facilities carried out by one of the Technical Implementation Units of Indonesia NADFC, namely Balai Besar POM in Bandung The method used in this article is descriptive qualitative using primary data from performance reports from the Balai Besar POM in Bandung from years 2020 to 2023. Based on the achievement of performance indicators, the implementation of supervision activities for drug and food production and distribution facilities by the POM Center in Bandung is considered quite effective as evidenced by the Performance Achievement Value which is always above 100% from year to year. The overall achievement value and performance efficiency from 2020 to 2023, respectively, include 104.66%; 101.38%; 107.60%; and 103.82%. However, if we look closely at the realization value per indicator each year, there are several indicators that have not reached the 2020-2024 strategic plan target so that further efforts are needed to improve and maximize the performance achievement value. These efforts can be successful if accompanied by collaboration and synergy of all stakeholders so that the public receives quality and safe drug and food products according to standards.
Karakteristik pasien dan rasionalitas penggunaan obat demam berdarah dengue pada pasien anak rawat inap Lubis, Salmah Handayani Lubis; Dasopang, Eva Sartika; Siahaan , Desy Natalia; Hasanah, Fenny; Ndruru, Mei Kasih Murni; Aisyah , Teti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.633

Abstract

Dengue hemorrhagic fever (DHF) is an infectious disease that can affect children. The main principles of DHF treatment are supportive therapy that can reduce mortality to less than 1%, and maintenance of circulating fluid volume.  This study aims to determine the distribution of the proportion of DHF patients in children based on age, gender, clinical symptoms and the rationality of the use of DHF drugs in pediatric patients treated at Dr. Pirngadi Medan Hospital. This study was a descriptive nonanalytic study with a case study design. The population data in this study were all medical records of pediatric patients diagnosed with DHF who were treated in the period of 2022 at RSUD Dr. Pirngadi Medan.  This study concluded that most pediatric DHF patients were female (47.6%), age 0-35 years (42.7%), clinical symptoms of fever (82%), fever duration of 4 days (82.9%). The most common complaints of pediatric DHF disease were fever (100%), vomiting (81%), nausea (75%). In evaluating the rationality of drug use in the correct dose of analgesic and antipyretic paracetamol administration was obtained 100% (correct dose) and the administration of lactated ringer fluid 85.36% (not correct dose).
Penilaian densitas kolagen pada luka bakar derajat II tikus putih (Rattus norvegicus) yang diterapi dengan krim ekstrak daun melinjo (Gnetum gnemon L.) Srimaryanto, Leonardo Reza; Hidajati , Nove; Triakoso , Nusdianto; Herupradoto, Eduardus Bimo Aksono; Lazuardi, Mochamad; Setiawan, Boedi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.680

Abstract

Second-degree burns are complex traumatic conditions requiring optimal tissue healing interventions. This experimental study investigated the impact of Gnetum gnemon L. leaf extract cream on collagen density in burn wounds. The research was conducted using 20 male Wistar rats (Rattus norvegicus), divided into five groups: negative control, positive control (silver sulfadiazine), and three treatment groups with varying leaf extract concentrations (2.5%, 5%, and 10%). Burn induction was performed on the right gluteal area using a thermostat at 85°C for 5 seconds. Collagen density was evaluated through histopathological analysis using ImageJ with density scores ranging from 0 to 4. Research results demonstrated significant collagen density increases in treatment groups, with the 10% concentration displaying the highest density (score +4). Significant differences between groups were confirmed by statistical analysis (p<0.05). Findings indicate the potential of Gnetum gnemon L. extract as an alternative therapy for improving burn wound healing through collagen density optimization.
Efektivitas krim ekstrak daun melinjo (Gnetum gnemon L.) terhadap jumlah sel fibroblas pada luka bakar derajat II dalam tikus putih (Rattus norvegicus) Sulaiman, Azhari Athaillah; Maslachah, Lilik; Utama, Suzanita; Yuniarti, Wiwik Misaco; Sukmanadi, Moh.; Hidajati, Nove
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.693

Abstract

Burn wound is an injury that causes tissue damage, typically due to contact with a heat source. Fibroblasts have an important role in wound healing, synthesizing collagen as the main constituent of the extracellular matrix which is important in wound integrity. The purpose of this study was to determine the effectiveness of cream of melinjo (Gnetum gnemon L.)  leaf extract on the number of fibroblast cells in deep partial thickness burn in white rats (Rattus novegicus). Twenty male white rats (Rattus norvegicus) were divided into five treatment groups, with four replications in each group, and were induced with in deep partial thickness burn. The negative control group (K-) was treated with cream base, the positive control group (K+) was treated with Silver Sulfadiazine, while P1, P2, and P3 group was treated with respectively 2.5, 5 and 10% melinjo (Gnetum gnemon L.) leaf extract cream. Therapy was given twice a day for 14 days. Oneway ANOVA showed significant differences between each treatment group (p <0.05) and continued with the Duncan test. The average number of fibroblasts in each treatment group showed that the K- were significantly different from the K+, P2, P3 groups but not P1. The lowest mean number of fibroblast cells was found in the K- group. The conclusion from the research that has been carried out was that melinjo (Gnetum gnemon L) leaf extract cream decrease the number of fibroblast cells in second-degree burns wounds in white rats (Rattus norvegicus).
Hubungan pengetahuan ibu dengan tindakan manajemen swamedikasi pada anak balita di Desa Ketapang Dua Aceh Timur. Shufyani, Fahma; Siregar, Syati Manaharawan; Dominica, Dwi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.727

Abstract

Introduction: Self-medication is something that is often practiced by the Indonesian community as a way to take care of themselves when they are sick. Taking and consuming medication without advice from a healthcare professional, whether for diagnosis, prescription, or health supervision, is called self-medication. Self-medication can provide significant benefits to the government in maintaining national health if done correctly. Self-medication can assist healthcare professionals, reduce the time spent waiting for a doctor's diagnosis, and save money, especially in developing countries, because healthcare professionals will be more focused on more serious and critical health conditions. Objective: This study aims to determine mothers' knowledge about self-medication for fever and to understand the self-medication actions taken by mothers, as well as to examine the relationship between mothers' knowledge and their self-medication actions for fever in toddlers in Ketapang Dua Village, East Aceh. Method: This study uses a quantitative method of a descriptive-analytical nature with a cross-sectional design. The sampling technique used purposive sampling. Data were analyzed using the Chi Square test. Data collection was conducted in July 2024. The research population is the knowledge of mothers regarding self-medication management for toddlers in Ketapang Dua Village, East Aceh. The sample of this study consists of 40 respondents. Results: from this study indicate that 35% of mothers have a fairly good level of knowledge about self-medication for fever. Self-medication for fever in toddlers shows that around 47.5% have taken appropriate actions. There is a significant relationship between maternal knowledge and self-medication actions for fever in toddlers in Ketapang Dua Village, East Aceh, with a p-value of 0.026 < 0.05. It can be concluded that the presence of maternal knowledge regarding self-medication for fever in toddlers in Ketapang Dua Village, East Aceh, is classified as quite good. The conclusion: of this study is that the frequency distribution of maternal knowledge shows that some have fairly good knowledge, with 14 respondents (35.0%) and respondents with less adequate knowledge amounting to 21 respondents (65.5%). The frequency distribution of fever self-medication actions shows that some mothers provided appropriate self-medication actions, with 19 respondents (47.5%) doing so, while 21 respondents (52.5%) provided less appropriate self-medication actions. There is a significant relationship between maternal knowledge and self-medication practices for fever in toddlers in Ketapang Dua village, East Aceh, with a p-value of 0.026 > 0.05.
Pengaruh penambahan ekstrak kental daun kelapa sawit (Elaeis Guineensis Jacq.) terhadap viskositas krim tabir surya antijerawat Dominica, Dwi; Putri , Yona Harianti; Versita , Riana; Shufyani , Fahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.729

Abstract

Introduction: ROS due to sun exposure can damage the skin. Skin structures that are damaged or thinned cause the risk of acne on the skin, one of which is that the skin can be infected with acne-causing bacteria. Palm leaf (Elaeis guineensis Jacq.) is one of the plants that has good antioxidants and antibacterial. The aim: This study aims to determine the effect of the addition of extracts on the viscosity of anti-acne sunscreen creams. Methods: This study was experimental by conducting a viscosity test of sunscreen preparations using a brokfield viscometer. The results of this study show that Formula F1 (1.5%) has the highest viscosity of 8,970 cPs, followed by F2 (3%) at 7890 cPs, and F3 (4.5%) at 7090 cPs which is included in the good viscosity range. Sunscreen creams have pseudoplastic flow properties. Conclusion: the higher the concentration of the extract, the greater the viscosity of the preparation.
Formulasi salep sari batang daun talas (Colocasia esculenta L. ) schoot pada penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Ardiani, Rani; Shufyani, Fahma; Siregar, Syati Manaharawan; Silalahi , Ali Affan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.730

Abstract

Introduction: Taro contains several compounds that can accelerate wound healing, such as flavonoids, phenols, and saponins. These compounds act as natural antibiotics, cleansing wounds with their antibacterial and antifungal properties. Therefore, this plant can aid in the wound healing process. Tannins, on the other hand, have the ability to constrict blood vessels and reduce bleeding in the wound area, decrease infection, and aid in wound healing during the inflammatory phase. One of the wound healing factors, vitamin C helps strengthen the walls of blood vessels, especially in the injured area, to maintain blood supply there and assist in accelerating collagen synthesis during the wound healing process. Lectin, a substance that can accelerate wound closure by aiding better cell regeneration. Arecaceae plants have many benefits for society, such as being used as a food source by harvesting their tubers, or being used as ornamental plants that beautify yards. Taro is also used as medicine both internally and externally. Almost all parts of the taro plant are processed into medicines, and the tubers, stem bark, and roots are crushed and then applied to the skin to heal wounds or bruises. Objective: This study aims to determine the wound healing effects of the sap from the taro stem (Colocasia esculenta L) Schott on male rats (Rattus norvegicus). Method: This study uses an experimental method, which includes sampling, preparation of taro leaf stem extract with concentrations of 2%, 4%, 6%, ointment evaluation test, and incision wound healing activity test on white rats grouped into 5 groups, each consisting of 3 rats. Statistical analysis includes one-way ANOVA to see if there is a significant difference between concentrations in the healing of incisional wounds in male white rats. Result: The research conducted shows that F1 (2% concentration) can heal the rats on the 10th day. F2 (4% concentration) the rats healed on the 8th day, F3 (6% concentration) the cut wounds healed on the 7th day, positive control (Betadine ointment) all rats healed on the 7th day. Conclusion: The extract of taro leaf stems (Colocasia esculenta L) Schoot can be formulated into an ointment preparation for the healing of incised wounds in male white rats (Rattus norvegicus), with the most effective concentration being 6% because it can heal incised wounds the fastest among the other concentrations.
Uji efektivitas ekstrak etanol daun bayam hijau (Amaranthus hybridus L.) sebagai imunostimulan pada mencit putih jantan (Mus musculus) Tarigan, Rida Evalina; Sinaga, Arinda Agnes; Shufyani, Fahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.735

Abstract

The immune system plays a critical role in defending the body against pathogens, and enhancing its activity through immunostimulants is essential for improving health. This study aims to evaluate the immunostimulatory potential of ethanol extract from green amaranth leaves (Amaranthus hybridus L.) in male white mice (Mus musculus). The ethanol extract green amaranth leaves was prepared from dried green amaranth leaves and tested for its effect on phagocytic activity using the carbon clearance method. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, and steroids. The animals were divided into five groups: negative control (0.5% Na CMC), positive control (Stimuno Forte®), and three experimental groups receiving varying doses of the ethanol extract (125 mg/kg, 250 mg/kg, and 500 mg/kg body weight). The results indicated that the ethanol extract significantly enhanced phagocytic activity, with the most optimal effect observed at 125 mg/kg body weight. The stimulation index increased with higher doses, demonstrating the dose-dependent immunostimulatory effect. The study concludes that the ethanol extract of green amaranth leaves can serve as an effective natural immunostimulant, with the 125 mg/kg body weight dose being the most effective in enhancing immune function in male white mice. These findings suggest the potential of green amaranth as a therapeutic agent for immune-related disorders.

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