cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
 1   2   3   4   5 
Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Uji Aktivitas Antibakteri Fraksinasi Alkaloid Ekstrak Kulit Kayu Raru (Cotylelobium melanoxylon Pierre) Terhadap Bakteri Escherichia coli dan Staphylococcus aureus Salwa, Shakhila; Daulay , Anny Sartika; Rahayu , Yayuk Putri; Ridwanto, Ridwanto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.951

Abstract

Background: Indonesia is rich in medicinal plants, including Cotylelobium melanoxylon Pierre (raru bark), traditionally used to treat diarrhea, malaria, and diabetes. However, scientific validation of its alkaloid compounds and antibacterial potential is still limited. Objective: This study aimed to (1) fractionate alkaloids from raru bark extract using chloroform liquid-liquid extraction, (2) identify alkaloid functional groups via FT-IR spectroscopy, (3) quantify alkaloid levels in ethanol and methanol extracts using UV spectrophotometry, and (4) evaluate their antibacterial activity against Escherichia coli and Staphylococcus aureus. Methods: The research stages included plant material processing, ethanol/methanol extraction, phytochemical screening, alkaloid fractionation with chloroform, FT-IR analysis, UV spectrophotometry for alkaloid quantification, and antibacterial testing via disc diffusion at 40%, 50%, and 60% concentrations. Results: Alkaloid fractions were successfully isolated, containing functional groups N-H, C-N, C=O, aromatic C=C, and sharp C=O. The methanol extract yielded higher alkaloid levels (21.03 ± 0.10%) than ethanol (18.95 ± 0.09%). The 50% alkaloid fraction showed the strongest antibacterial activity, with inhibition zones of 21.1 mm (E. coli) and 23.1 mm (S. aureus). Conclusion: Raru bark alkaloids exhibit significant antibacterial effects, with methanol extract demonstrating superior alkaloid content and efficacy.
Sunscreen Innovation: Development of a Water-Resistant Compact Powder Formula Based on Titanium Dioxide for Optimal UV Protection Muliadi, Rahmat; Aspadiah, Vica; Sahumena, Muhammad Handoyo; Aftira, Nidya
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.961

Abstract

Background: Ultraviolet (UV) radiation contributes to skin aging and damage, necessitating effective protection. Sunscreens offer a solution by absorbing, scattering, and reflecting UV radiation, especially those containing titanium dioxide, which has strong UV-blocking properties. Innovation in the form of compact powder sunscreen presents a practical and efficient daily protection approach due to its easy-to-apply formulation. Objective: This study aimed to evaluate the physical characteristics of compact powder sunscreen formulations, including organoleptic properties, pH, homogeneity, adhesion, hardness, and the effect of titanium dioxide on the Sun Protection Factor (SPF) value. Methods: Formulations were prepared and evaluated through physical tests, including organoleptic assessment, pH, homogeneity, adhesion, and hardness, as well as SPF measurement using a UV-Vis spectrophotometer. Results: Titanium dioxide contributed to the light brown color, smooth texture, and vanilla scent of the formulations. It also enhanced the SPF value. The most optimal formulation was Formula 4, containing 25% titanium dioxide, which met the desired physical criteria and achieved an SPF value of 15.06, categorized as ultra protection. Conclusion: The addition of titanium dioxide positively affected the physical characteristics and SPF value of compact powder sunscreen. Formula 4, with 25% titanium dioxide, demonstrated the best results and the highest SPF, making it the most optimal formulation for UV protection
Formulasi Gel dari Fraksi Etil Asetat Batang Jarak Cina (Jatropha multifida L.) Efektivitas Terhadap Luka Bakar Giovana Zola, Elpa; Hartesi, Barmi; Anggresani, Lia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.966

Abstract

Background: Burns represent a condition of damaged or lost skin tissue due to high-temperature exposure. Oral therapy has limitations in penetrating hardened skin tissue, necessitating topical preparations such as gels that offer advantages in comfort, absorption capability, and ease of application. The stem of physic nut (Jatropha multifida L.) contains bioactive compounds including alkaloids, flavonoids, saponins, and tannins that may accelerate burn wound healing, particularly in its ethyl acetate fraction. Objective: This study aimed to formulate the ethyl acetate fraction of physic nut stem into a gel preparation and evaluate the effect of concentration variations on burn wound healing efficacy. Methods: Physic nut stems were extracted with 96% ethanol, then fractionated using n-hexane, ethyl acetate, and ethanol solvents. The ethyl acetate fraction was formulated into a hydrophilic gel at concentrations of 0.140%, 0.281%, and 0.421%. The gel preparations were evaluated through organoleptic tests, homogeneity, pH, spreadability, stability, irritation, and burn healing efficacy tests in rabbits. Results: Phytochemical screening revealed that the ethyl acetate fraction contained alkaloids, flavonoids, saponins, and tannins. All gel formulations met physical preparation requirements with skin-compatible pH (5.95-6.37). Formula F1 (0.140%) demonstrated optimal burn healing efficacy, equivalent to positive control (p > 0.05), and was topically safe (non-irritating). Conclusion: The ethyl acetate fraction of physic nut stem was successfully formulated into a stable and effective gel preparation for burn wound healing, with 0.140% as the optimal concentration. Further studies are required to examine toxicity and the mechanism of action of active compounds.
Hubungan Tingkat Pendidikan, Pengetahuan, dan Dukungan Suami dengan Praktik Pemberian ASI Eksklusif pada Ibu Bekerja di Klinik Pratama Sunggal Bali , Florentina Aspienti Regnat Killianis; Laia , Firina; Gulo, Indah Mawati; Rangkuti, ⁠Ifrina; Nababan, Tiarnida; Duha, Yantriani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.973

Abstract

Background: The low rate of exclusive breastfeeding in Indonesia (52.5% in 2021), particularly in North Sumatra (57.83%), remains a pressing public health issue, especially among working mothers. Educational level, knowledge, and husband support are strongly suspected to influence the success of exclusive breastfeeding, yet these factors have been underexplored in the context of primary clinics in urban areas such as Sunggal. Objective: To analyze the relationship between educational level, knowledge, and husband support with exclusive breastfeeding practices among working mothers at the Sunggal Primary Clinic.Methods: This quantitative, cross-sectional study involved 30 working mothers selected through total sampling. Data were collected via questionnaires and interviews, then analyzed using Chi-Square tests and logistic regression to measure the strength of associations (OR). Results: Statistical analysis showed significant relationships between all three independent variables and exclusive breastfeeding practices (p<0.05). Husband support emerged as the most dominant factor with an odds ratio (OR) of 8.2 (95% CI: 2.1–32.4), followed by maternal knowledge (OR=5.6; 95% CI: 1.8–17.3) and educational level (OR=4.3; 95% CI: 1.5–12.4). Specifically, mothers who received strong support from their husbands were 8.2 times more likely to successfully provide exclusive breastfeeding compared to those who did not. Likewise, mothers with good knowledge were 5.6 times more likely to succeed, and highly educated mothers were 4.3 times more successful than those with limited knowledge and education. Multivariate analysis indicated interaction among these three factors, with husband support amplifying the positive effects of education and knowledge. Among respondents who possessed all three positive factors (higher education, good knowledge, and strong husband support), 86.7% successfully provided exclusive breastfeeding, while only 13.3% succeeded in the group lacking these factors. Conclusion: This study strengthens the evidence that family-based interventions focusing on enhancing the husband’s role, along with comprehensive education, can be an effective strategy to increase exclusive breastfeeding rates among working mothers. These findings highlight the need for clinic policies that integrate lactation counseling for couples.
Faktor yang Berhubungan Dengan Kerusakan Berkas Rekam Medis di Rumah Sakit Umum Bandung Sembiring, Rima Melinda; Tarigan, Andini Mentari; Rangkuti, Dyna Safitri Rakhelmi; Sianturi, Greisella A.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.992

Abstract

Background: Damage to medical record documents represents a serious challenge in hospital archive management, characterized by torn, faded, discolored, or illegible documents due to intrinsic (material quality) and extrinsic (environmental) factors. A preliminary survey at Bandung Medan General Hospital identified 47 damaged documents in September 2024, indicating the need for systematic intervention. Objective: To analyze the relationship between intrinsic and extrinsic factors and damage to medical record files at Bandung Medan General Hospital. Methods: This study employed a cross-sectional analytical design with a sample of 92 documents (purposive sampling). Data were analyzed using univariate and bivariate (Chi-Square test) methods. Results: The findings revealed that 51.1% of documents were damaged, with intrinsic factors (paper quality, ink, and adhesives) identified in 47 documents (51.1%) and extrinsic factors (physical, biological, and chemical environment) in 48 documents (52.2%). Statistical analysis demonstrated a highly significant association between intrinsic factors and document damage (p=0.000; OR=15.2), indicating documents with material quality issues had a 15 times higher risk of damage. Similarly, extrinsic factors showed a highly significant relationship (p=0.000; OR=12.8), with suboptimal storage conditions being the primary contributor. Environmental factors, particularly high humidity (78%) and dust accumulation (65%), were the most dominant causes of physical document damage. Conclusion: Medical record damage is influenced by both factors, with recommendations for storage system improvements, environmental control, and implementation of standard operating procedures (SOPs) for risk mitigation. The study findings should serve as valuable input for enhancing medical record document storage to ensure better safety and preservation.
Uji Aktivitas Antibakteri Formulasi Sediaan Obat Kumur Ekstrak Etanol Daun Senduduk (Melastoma malabathricum L.) Terhadap Pertumbuhan Streptococcus mutans Ayu , Tri Indah Pagar; Nasution , Haris Munandar; Rahayu, Yayuk Putri; Nasution , Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1002

Abstract

Background: Dental caries is a common oral health problem caused by Streptococcus mutans. Antiseptic mouthwash containing natural ingredients like senduduk leaves (Melastoma malabathricum L.) shows potential as an alternative, as it contains antimicrobial compounds (alkaloids, flavonoids, saponins, and tannins). Objective: To determine the antibacterial activity of senduduk leaf ethanol extract mouthwash against S. mutans and evaluate its physical characteristics. Methods: This experimental study included: (1) ethanol extraction of senduduk leaves using 96% ethanol maceration, (2) simplicia characterization and phytochemical screening, (3) formulation of three mouthwash concentrations (2.5%, 5%, 7.5%), (4) preparation evaluation (organoleptic properties, pH, viscosity), and (5) antibacterial activity testing using the well diffusion method. Results: The mouthwash preparation met physical criteria as a light-to-dark brown liquid with pH 6.33-6.43 and viscosity of 4.833-5.726 cps. Antibacterial tests showed dose-dependent effects, with the highest inhibition zone in the 7.5% formula (18.53 mm; strong category). Conclusion: Senduduk leaf extract shows potential as an antibacterial active ingredient in herbal mouthwash against S. mutans in vitro, though further testing (in vivo/clinical trials) is needed to validate therapeutic claims.
Penetapan Kadar Nikotin Tembakau Gayo (Nicotiana tabacum L) Menggunakan Metode Titrasi Asidimetri dan GC-MS. Rezky , Deswita Ina; Supiyani, Supiyani; Daulay, Anny Sartika; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.909

Abstract

Background: Gayo tobacco (Nicotiana tabacum L.) is known for its distinctive quality and is highly sought after, particularly among young adults. This tobacco contains nicotine, a compound that plays a significant role in influencing human behavior, acting both as a stimulant and as a raw material for cigarette production. Understanding the nicotine content in Gayo tobacco is crucial for assessing its potential industrial applications and its impact on health. Objective: This study aimed to determine the nicotine content in Gayo tobacco leaves and analyze it using acidimetric titration and GC-MS methods to obtain more accurate results. Methods: This research employed two analytical methods: acidimetric titration for quantitative nicotine determination and Gas Chromatography-Mass Spectrometry (GC-MS) for qualitative analysis of other chemical compounds in the Gayo tobacco leaf extract. The tobacco leaf samples were obtained from the Gayo region of Aceh and extracted using 96% ethanol. Results: The study revealed that the nicotine content in Gayo tobacco leaves was 1,3% based on acidimetric titration, while the ethanol extract showed a higher nicotine concentration of 2.5%. GC-MS analysis identified various other compounds, including piperidine derivatives, terpenoids, and aromatic compounds, which have potential pharmaceutical and industrial applications. Conclusion: This study successfully determined the nicotine content in Gayo tobacco leaves using acidimetric titration and GC-MS. The findings provide a comprehensive overview of the chemical composition of Gayo tobacco, serving as a foundation for further research into its applications in pharmaceuticals and other industries.
Hubungan Lingkungan, Petugas Kesehatan dan Pola Asuh Ibu yang Bekerja dengan Tumbuh Kembang Bayi di Klinik Pratama Sunggal Aulia , Marshanda Putri; Sephira, Intan Nadya; Sinaga , Jesika Kristin; Sembiring , Juni Kristiani Br; Sidabutar , Liontin; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.974

Abstract

Background: Infant growth and development during the first 0-12 months represents a crucial phase with long-term impacts on quality of life. Environmental factors, working mothers' childcare practices, and healthcare providers' roles serve as key determinants influencing this process. The risk of developmental delays significantly increases for infants in less supportive environments or those receiving inadequate stimulation. Objective: To analyze the influence of environmental conditions, working mothers' childcare practices, and healthcare providers' roles on the growth and development of infants aged 0-12 months at Sunggal Primary Clinic. Methods: This observational analytical study employed a cross-sectional design involving 35 subjects selected through total sampling. Data collection utilized structured questionnaires and was analyzed using chi-square tests. Results: Statistical analysis revealed significant relationships between environmental conditions and child development (p=0.000, with 62.9% supportive environments), between healthcare providers' roles and development (p=0.000, with 60% adequate services), and between working mothers' childcare practices and development (p=0.000, with 57.1% optimal practices). Conclusion: All three variables significantly influence infant growth and development, indicating the need for an integrated approach to optimize these contributing factors.
The Perbandingan Kualitas Hidup Peserta Prolanis Diabetes Melitus Tipe 2 yang Memperoleh Monoterapi dan Politerapi di Puskesmas Prambanan Sleman Umsipyat , Annis Syafitri; Ananda, Raden Ajeng Dewinta Sukma; Nurinda , Eva; Wulandari, Ari Susiana
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.588

Abstract

Diabetes mellitus (DM) cases in the Yogyakarta Special Region in 2022 reached 42,050 patients (53.9%), with Sleman Regency having the highest prevalence. The therapy received by patients affects their clinical condition and quality of life. This study aims to determine the difference in the average quality of life of Prolanis DMT2 participants receiving monotherapy and polytherapy at Prambanan Public Health Center in Sleman. This research used an observational analytic study with a cross-sectional approach. The sample consists of 34 Prolanis participants at Prambanan Health Center, selected through total sampling. The instrument used is a quality-of-life questionnaire with a reverse Likert scale. The data analysis to measure quality of life is the Mann-Whitney statistics, using independent variables of monotherapy and polytherapy, and the dependent variable of quality of life scores. The majority of respondents are female (22 people, 66.7%), aged 56–65 years (16 people, 47.1%), and have a high school education level (15 people, 44.1%). Most are unemployed (21 people, 61.8%), have had diabetes for ≤ 5 years (26 people, 76.5%), and do not have complications (26 people, 76.5%). The average quality of life score for monotherapy is 28.88, and for polytherapy, it was 41.70. The quality of life for monotherapy is higher than for polytherapy, with a p-value of 0.001 (<0.05). This study aims to determine the difference in the average quality of life between Prolanis DMT2 participants receiving monotherapy and polytherapy at Prambanan Health Center in Sleman. Based on the research results, it was concluded that there is a difference in the average quality of life between Prolanis DMT2 participants at Puskesmas Prambanan Sleman who received monotherapy and those who received polytherapy, with a p-value of 0.001 (<0.05)
Formulasi Dan Uji Aktivitas Antibakteri Sabun Kertas Virgin Coconut Oil (VCO) Dengan Variasi Gliserin Sebagai Plasticizer Terhadap Staphylococcus Aureus Apriani, Aida; Dewi, Resmila; Sidiq, Teuku Sultan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.688

Abstract

Background: Virgin Coconut Oil (VCO) contains medium-chain saturated fatty acids (MCFA), particularly lauric acid, which is known for its antibacterial properties. VCO has the potential to be formulated into a practical and hygienic paper soap dosage form. In paper soap formulation, glycerin acts as a plasticizer that affects the physical properties of the preparation, but its effect on antibacterial activity has not been widely explored. Objective: This study aimed to formulate VCO paper soap with variations in glycerin concentration and to analyze its antibacterial activity against Staphylococcus aureus. Methods: This experimental research formulated four paper soap formulas with variations in glycerin concentration: 0% (F1), 10% (F2), 15% (F3), and 20% (F4). The preparations were evaluated through organoleptic tests, pH tests, foam height tests, and free alkali tests. Antibacterial activity was tested against Staphylococcus aureus using the disk diffusion method (Kirby-Bauer) with a positive control (commercial paper soap) and a negative control (aquadest). Results: The evaluation results showed that all formulas met the physico-chemical quality standards for soap. Formula 3 (15% glycerin) was the best preparation based on overall evaluation. The antibacterial test showed that all four VCO paper soap formulas (F1-F4) had moderate antibacterial activity against Staphylococcus aureus with inhibition zone diameters that were not statistically significantly different. The negative control showed no activity, while the positive control showed strong antibacterial activity. Conclusion: It was concluded that VCO paper soap was successfully formulated and exhibited moderate antibacterial activity against Staphylococcus aureus. Variations in glycerin concentration (0-20%) did not significantly affect the antibacterial activity, which is presumed to be more influenced by the lauric acid content in VCO.

Page 2 of 8 | Total Record : 75

 1   2   3   4   5 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue