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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
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Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Eksplorasi Aktivitas Antimikroba Bakteri Endofit Daun Betadine (Jatropha multifida L.) terhadap Patogen Staphylococcus aureus Arfiandi, Arfiandi; Fadjria , Neri; Nofita, Dewi; Rahmadini, Mutia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.899

Abstract

Background: Antibiotic resistance has spurred the exploration of novel antibacterial agents, including endophytic bacteria from medicinal plants like Jatropha multifida L. (Betadine leaves), traditionally used as antiseptics. Objective: To assess the antibacterial activity of endophytic bacterial isolates from Betadine leaves against Staphylococcus aureus. Methods: A laboratory-based experimental study employing the paper disc diffusion method. Endophytic isolates were cultured in Nutrient Broth, and centrifuged supernatants were tested for inhibition zones compared to positive (chloramphenicol) and negative (Na.CMC) controls. Results: The endophytic isolate produced a 16.11 mm inhibition zone (moderate activity), while chloramphenicol showed 27.63 mm (strong activity). No inhibition was observed in the negative control. Conclusion: Endophytic bacteria from Betadine leaves exhibit potential as natural antibacterial agents, though their efficacy is lower than standard antibiotics. Further development requires active compound characterization and toxicity studies.
Aktivitas Antijamur Kitosan Dari Cangkang Kerang Bambu (Solen corneus) Pada Pembuatan Hidrogel Terhadap Trichophyton mentagrophytes Hasibuan , Nabila Hasim; Ridwanto, Ridwanto; Nasution , Haris Munandar; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.906

Abstract

Background: Hydrogels are topical preparations applied to the skin surface. Chitosan, a compound derived from the deacetylation of chitin, has various benefits, including antifungal activity. Utilizing waste from bamboo clam shells (Solen courneus) collected in Belawan waters as a source of chitosan could provide a sustainable solution for developing antifungal hydrogel formulations. Objective: This study aimed to produce chitosan from bamboo clam shells, formulate it into a stable hydrogel, and evaluate its antifungal activity against Trichophyton mentagrophytes. Methods: This experimental study involved isolating chitosan through deproteinization, demineralization, depigmentation, and deacetylation steps. The resulting chitosan was characterized by moisture content, ash content, yield, solubility, and functional group identification using FTIR spectroscopy. Subsequently, chitosan was formulated into four hydrogel variations (0%, 2%, 4%, and 6%). The hydrogel formulations were evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, and antifungal activity. Results: The produced chitosan exhibited functional groups similar to standard chitosan and a degree of deacetylation of 77.5%. Hydrogel evaluation over three weeks showed good stability, with pH values of 4–6.5, spreadability of 5–7 cm, adhesiveness greater than 1 second, and viscosity ranging from 3,000–50,000 cps, all meeting the required standards. The antifungal test demonstrated that the 6% chitosan hydrogel had the highest inhibition zone (11.5 mm) against Trichophyton mentagrophytes. Conclusion: Chitosan derived from bamboo clam shells was successfully formulated into a stable hydrogel with effective antifungal activity. The 6% concentration exhibited the strongest antifungal effect, indicating its potential as a topical preparation for treating skin fungal infections.
Pengaruh Konseling terhadap Kepatuhan pada Pasien Diabetes Melitus Tipe 2 di Poliklinik Penyakit Dalam Rumah Sakit Umum dr. Ferdinand Lumbantobing Sibolga Panjaitan , Riza Zul Syahri; Nasif , Hansen; Sari , Yelly Octavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.912

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a global health threat with a steadily increasing prevalence. Its treatment is lifelong and requires optimal patient adherence to achieve therapeutic success. Pharmacist counseling is one of the interventions believed to improve such adherence. Objective: This study aimed to analyze the effect of pharmacist counseling and patient characteristics (age, gender, education, occupation, and access to hospital care) on medication adherence among T2DM patients. Methods: This study employed a one-group pretest-posttest design conducted at the Internal Medicine Polyclinic of dr. Ferdinand Lumbantobing Regional Hospital, Sibolga. A total of 75 respondents meeting the inclusion criteria were recruited. Adherence was measured using the MARS-10 (Medication Adherence Rating Scale 10 items) questionnaire before and after the counseling intervention. The Mann-Whitney and Kruskal-Wallis tests were used to analyze the influence of patient characteristics, while the Wilcoxon test was used to analyze the effect of counseling. Results: Analysis of demographic variables such as age, gender, education, occupation, and hospital access showed no significant relationship with adherence either before or after counseling (p>0.05). However, pharmacist counseling was proven to significantly improve adherence. The mean adherence score increased from 6.49 (pretest) to 8.08 (posttest) (p<0.05). The proportion of adherent patients rose from 52% to 94.67% following counseling. Conclusion: Patient characteristics had no significant effect on adherence. Pharmacist counseling was shown to be effective in significantly improving medication adherence among Type 2 Diabetes Mellitus patients.
pill box Pengaruh Tingkat Kepatuhan Menggunakan Pill Box Terhadap Keberhasilan Terapi Pasien Hipertensi Di Puskesmas Alalak Tengah Wahyunita , Sari; Rosyadi , Muhammad Ihsan; Fakhrani , Erwin
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.962

Abstract

Background: Medication adherence is a crucial factor in the management of hypertension. Non-adherence is a common problem that can hinder therapeutic success. The use of a pill box as a reminder tool is considered to improve adherence; however, its impact on therapeutic outcomes requires further investigation, particularly at Alalak Tengah Primary Health Center, which has a high burden of hypertension cases. Objective: This study aimed to analyze the effect of pill box education on medication adherence and therapeutic success, as well as to examine the relationship between adherence and therapeutic outcomes among hypertensive patients at Alalak Tengah Primary Health Center. Methods: This experimental study with a cross-sectional design employed purposive sampling of 100 uncontrolled hypertensive patients. Data were collected from medical records and pill count observations to measure adherence. Therapeutic success was determined based on achieving target blood pressure. Data analysis was conducted using the Wilcoxon test to compare outcomes before and after the intervention, and the Spearman test to assess the correlation between adherence and therapeutic success. Results: The majority of respondents were female (76%), aged 51–60 years (36.5%), and housewives (71%). The pill box intervention significantly improved therapeutic success, with the proportion of patients achieving target blood pressure increasing from 0% to 79% (p-value = 0.001). Post-intervention medication adherence was very high (97%). However, statistically, there was no significant correlation between adherence and therapeutic success (p-value = 0.636 > 0.05). Conclusion: Education on pill box use was proven effective in significantly improving blood pressure control. However, high medication adherence was not directly correlated with therapeutic success. This indicates that hypertension treatment outcomes are influenced by other multifactorial factors beyond adherence, such as diet, physical activity, and individual responses to medication.
Unintended Medication Discrepancies (UMD) Pada Saat Rekonsiliasi Transfer dalam Konteks Negara Berpenghasilan Rendah dan Menengah : Tinjauan Naratif Husain, Aprilia; Khairinisa , Miski Aghnia; Insani , Widya Norma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.983

Abstract

Unintended medication discrepancies (UMD) frequently occur during transitions of care, particularly in low- and middle-income countries (LMICs), where the healthcare system often lacks standardized protocols, integrated information systems, and trained clinical pharmacists. This narrative review aims to explore the prevalence, characteristics, and contributing factors of UMD across LMICs based on analysis of 10 selected studies. Omission was the most frequently reported type of discrepancy, especially among elderly patients with complex therapy regimens. Factors influencing the occurrence of UMD include polypharmacy, inadequate documentation, absence of medication reconciliation protocols, limited pharmacist involvement, and poor inter-facility communication. Despite systemic limitations, studies demonstrate that pharmacist-led interventions can significantly reduce the incidence of UMD, even in resource-limited settings. Comparative analysis with studies from developed countries reveals that digital tools, standardized policies, and integrated pharmacist roles greatly enhance medication safety during transitions of care. The review concludes that addressing UMD in LMICs requires a multi-faceted approach, including national policy development, pharmacist integration into clinical teams, implementation of context-appropriate digital systems, and strengthening pharmacy education. These strategies are crucial for improving patient safety and reducing preventable adverse drug events related to medication discrepancies.
Interaksi Padatan dan Pembentukan Eutektik dalam Campuran Biner Gemfibrozil-Nikotinamida Prihandini , Khairinna; Wisudyaningsih , Budipratiwi; Wicaksono, Yudi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.986

Abstract

Background: Gemfibrozil is an antihyperlipidemic drug that effectively lowers cholesterol and triglyceride levels in the blood. However, it has limitations, primarily low solubility and compactibility. Objective: The objective of this study was to analyze the solid interactions in a binary mixture of gemfibrozil and nicotinamide, which is useful for modifying the physicochemical properties of gemfibrozil through the formation of multicomponent solids. Methods: The method employed for solid-state interaction analysis was differential scanning calorimetry (DSC), which involved constructing solid-liquid phase diagrams, accompanied by Fourier transform infrared spectroscopy (FTIR) analysis to identify any hydrogen bonding interactions between the components. Results: The results revealed that the gemfibrozil-nicotinamide binary mixture formed a solid-liquid phase diagram characterized by a V-type solid curve. A eutectic mixture was observed at a molar ratio of 8:2, with a eutectic melting point of 59.3 °C. FTIR analysis revealed no hydrogen bonding interactions between gemfibrozil and nicotinamide. Conclusion: It was concluded that gemfibrozil in the binary mixture system did not form a solid interaction with nicotinamide but was a eutectic mixture. These findings can be used to design strategies for improving the physicochemical properties of gemfibrozil through the formation of multicomponent solids.
Uji Aktivitas Antidiabetes In Vitro Ekstrak Etanol 96% Daun Karamunting (Melastoma malabathricum L.) dengan Metode Maserasi Muthia, Rahmi; Afra, Fairuz Yaumil; Nurmansyah, Dian; Fauzana, Erwin; Istiqamah, Qanita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.991

Abstract

Background: Diabetes mellitus remains a major global health issue, with rising prevalence due to population growth, aging, and lifestyle factors. Melastoma malabthricum L. has potential as an antidiabetic agent based on empirical data and in vivo study. Objective: To determine the content of secondary metabolite compounds contained in the extract of Karamunting leaves and to determine the activity and EC50 value of the extract for antidiabetes was evaluated using the Nelson-Somogyi method. Methods: This study used the phytochemical screening approach to identify the active chemicals. 96% ethanol was the solvent used in the maceration process to extract the leaves of M. malabathricum. The Nelson-Somogyi method was used to test the antidiabetic activity by calculated the sample's EC50 value on decreased glucose levels. The Nelson Somogyi method's antidiabetic activity was tested with a UV-Vis Spectrophotometer. It operated for 25 minutes at a wavelength of 740 nm. Results: Phenolic chemicals, flavonoids, saponins, steroids, and tannins all exhibited positive results from the phytochemical screening. After the addition of 96% ethanol extract of M. malabathricum leaves at gradually higher concentrations, the percentage decrease in glucose levels was 25.32%, 36.90%, 51.39%, 70.87, and 82.83% at concentrations of 1, 2, 3, 4, and 5 ppm. R2 = 0.9927 with y = 14.898x + 8.7747. Conclusion: 96% ethanol extract of M.malabathricum leaves contains several active substances, can reduce blood glucose levels and has an EC50 value of 2.76 ppm. Clinically, this implies a promising therapeutic potential with lower required dosages.
Konsentrasi Hambat Minimum dan Konsentrasi Bunuh Minimum Ekstrak dan Nanopartikel Ekstrak Etanol Daun Pepaya (Carica papaya L.) Terhadap Candida albicans Nurmala, Syandoval Triska Ananda; Rahayu , Yayuk Putri; Pulungan, Ainil Fithri; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.999

Abstract

Background: Fungal infections, particularly those caused by Candida albicans, are a significant health problem in tropical countries such as Indonesia. Humid environmental conditions, inadequate sanitation, high population density, and low socioeconomic levels contribute to the high prevalence of fungal infections. Papaya leaves (Carica papaya L.) are known to contain bioactive compounds with antifungal potential; however, their effectiveness can be enhanced through nanoparticle formulation. Objective: This study aimed to formulate nanoparticles of ethanol extract from papaya leaves and evaluate their antifungal activity against Candida albicans by comparing the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) values between the conventional extract and the nanoparticle extract. Methods: This experimental study utilized ethanol extract of papaya leaves and its nanoparticle formulation at varying concentrations. Particle size was characterized using a Particle Size Analyzer (PSA). Antifungal activity was tested against Candida albicans ATCC 10231 using broth and agar dilution methods as well as the disk diffusion method. Data were statistically analyzed using one-way ANOVA. Results: The nanoparticle extract exhibited a smaller particle size (330.27 nm) compared to the conventional extract (2203.45 nm). The MIC of the nanoparticle extract (1.25%) was lower than that of the conventional extract (12.5%), while the MFC of the nanoparticle extract (5%) was equivalent to that of the conventional extract (50%). The disk diffusion test showed that the 5% nanoparticle extract had an inhibition zone of 21.6 mm, classified as sensitive and comparable to the 50% conventional extract. Conclusion: The nanoparticle formulation of papaya leaf extract enhanced antifungal efficacy, enabling a tenfold dose reduction compared to the conventional extract. These findings highlight the potential of nanoparticles as a more efficient alternative therapy for fungal infections.
Pengaruh Pengambilan Keputusan Bersama terhadap Kadar Glukosa dan HbA1c pada Pasien Diabetes Mellitus: Tinjauan Literatur Hilmawati, Febriana; Karuniawati , Hidayah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1008

Abstract

Background: Diabetes mellitus (DM) is a chronic disease with a high global prevalence, requiring comprehensive and patient-centered care. Shared Decision Making (SDM) is a collaborative approach between patients and healthcare providers that has been associated with improved treatment adherence and clinical outcomes in chronic diseases. Objective: This literature review aimed to evaluate the impact of SDM on glycemic control, particularly blood glucose and HbA1c levels, in patients with diabetes mellitus. Methods: A systematic search was conducted on PubMed and Scopus databases using specific keywords, limited to randomized controlled trials (RCTs) published in English between 2015 and 2025. Inclusion criteria included adult patients with type 1 or type 2 DM, SDM as the primary intervention, and HbA1c or blood glucose levels as clinical outcomes. Results: Five RCTs met the eligibility criteria. Most studies reported a decrease in HbA1c in the intervention group, although only one study showed a statistically significant within-group reduction. No consistent significant differences were observed between the intervention and control groups. However, SDM was positively associated with improved patient engagement, satisfaction, and the quality of communication. Conclusion: While evidence regarding the direct impact of SDM on HbA1c remains inconclusive, SDM appears to enhance patient participation and therapeutic communication in diabetes care. Further standardized and long-term studies are needed to confirm its clinical effectiveness.
Formulasi, Evaluasi Sensori Dan Komposisi Gizi Food Bar Berbasis Pisang Dan Tepung Jagung Tinggi Mineral Sebagai Alternatif Pangan Darurat Ameliyah, Rantika Yesi; Hervidea, Radella; Puteri, Hidayatusy Syukrina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1012

Abstract

Background: As a disaster-prone country, Indonesia requires emergency food that meets the nutritional needs of disaster victims. This study develops a food bar based on local ingredients of kepok banana (Musa paradisiaca) and corn flour as a mineral-rich emergency food alternative. Objective: The research aims to analyze the optimal formulation, sensory evaluation, and nutritional composition of banana and corn flour-based food bars as emergency food products. Methods: This experimental study used a Completely Randomized Design (CRD) with three different formulations: F1 (80% banana + 20% corn flour), F2 (70% banana + 30% corn flour), and F3 (20% banana + 80% corn flour). Sensory testing involved 25 panelists evaluating color, aroma, taste, and texture. Data analysis used the Kruskal-Wallis test and Dunn's test, while nutritional composition was analyzed through proximate analysis and potassium testing using Atomic Absorption Spectrophotometry (AAS). Results: The results showed significant differences (p<0.05) in color, taste, and texture parameters, but not in aroma (p>0.05). Formulation F1 received the highest scores for taste (3.52) and texture (2.88). Proximate analysis revealed F1 had the highest water content (6.50%) and crude fiber (4.51%), while F3 had the highest carbohydrate content (72.62%). The potassium content of F1 reached 7.13 mg/g, meeting 10-11% of the daily RDI per 50g food bar. Conclusion: Formulation F1 (80% banana + 20% corn flour) is the best choice as emergency food due to its good sensory acceptance and complete nutritional content, particularly its potassium content which is crucial for emergency conditions.

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