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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
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Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Review Artikel: Evaluasi Efektivitas Perbandingan Preparasi Sampel Pada Instrumen Spektrofotometri Serapan Atom (SSA) Untuk Menganalisis Logam Timbal Putri, Indah Syah; Damara , Dandy Satria; Akifah , Muthia Nur; Utami , Marsah Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.672

Abstract

Lead (Pb) is a hazardous substance that has the potential to damage human health and the environment. This article evaluates the effectiveness of two sample preparation methods, namely wet digestion and dry digestion, in analyzing lead using Atomic Absorption Spectrophotometry (AAS) through a literature review, obtaining data using Google Scholar's “Publish or Perish” feature with the keywords lead, AAS, sample preparation, and method validation. Inclusion criteria are journals published within the last 10 years, while exclusion criteria are  journals that use methods other than AAS, focusing on other metals, or do not involving sample preparation methods involving destruction. The wet destruction method involves dissolving the sample in acid, while the dry destruction method uses high-temperature heating to form dry ash. The dry destruction method demonstrates better analytical performance than wet destruction, based on the parameters of recovery (98.5–104.2%), accuracy (absolute deviation <2%), and precision (%RSD <5%). These results indicate that dry destruction provides more accurate, precise, and consistent analysis, as well as more reliable quantification of elements such as heavy metals, compared to wet destruction, which tends to produce variations between replicates. Therefore, the dry destruction method is recommended for lead analysis using SSA because it is more effective and efficient.
Tinjauan Literatur: Analisis Sintesis dan Efektivitas Senyawa Kalkon serta Turunannya sebagai Agen Antibakteri Damara , Dandy Satria; Akifah , Muthia Nur; Putri , Indah Syah; Utami , Marsah Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.681

Abstract

Chalcones are flavonoid compounds that have attracted attention in the development of antibacterial agents. This literature review aims to examine the synthesis and effectiveness of chalcone compounds and their derivatives as antibacterials. Through descriptive analysis, chalcone synthesis was carried out using several methods, one of which was the condensation between benzaldehyde and acetophenone, followed by structural modification to produce various chalcone derivatives. The antibacterial activity of chalcone compounds and their derivatives was tested against bacteria such as S. aureus, E. coli, B. substillis, and other types of bacteria. The results of the review of several literatures obtained online through Google, Google Scholar, and Publish or Perish were carried out using the keywords "Synthesis", "Chalcone", and "Antibacterial" with publications from the last 10 years (2014-2024) with a total of 8 references used. The study showed that changes in the structure of chalcones, such as the addition of hydroxyl and methoxy groups, can affect antibacterial activity. Some chalcone derivatives also showed promising antibacterial activity, although their effectiveness varied depending on the type of bacteria tested.
Tinjauan Literatur: Pengaruh Parameter Metode Kromatografi Lapis Tipis untuk Identifikasi Kafein dalam Kopi Hariadi, Nayla Nur Azkia; Basmalah, Nur; Laprilski , Dewi Hanun; Azzahra , Khaerunisa; Mulki , Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.683

Abstract

Background: The rising consumption of coffee in Indonesia necessitates reliable methods for caffeine analysis to ensure product quality and safety. Thin Layer Chromatography (TLC) is a simple, effective, and polarity-based technique widely used for the qualitative identification of compounds like caffeine in coffee. However, the results of TLC analysis are highly dependent on several methodological parameters. Objectives: This literature review aims to identify and analyze the critical parameters of the TLC method—including the mobile phase, stationary phase, visualization techniques, and sample preparation—that influence the effectiveness of caffeine identification in coffee. Methods: A systematic literature review was conducted using online databases (Google Scholar, PubMed, Semantic Scholar, and Crossref). Articles from the last ten years were selected based on inclusion and exclusion criteria, resulting in nine primary studies for in-depth analysis. Results: The review confirms that silica gel 60 F254 is the most effective stationary phase. The composition of the mobile phase is crucial; a mixture of dichloromethane:methanol (9.5:0.5) was found to be optimal for separating caffeine, yielding Rf values within the ideal range of 0.3–0.7. Visualization under UV light at 254 nm successfully detected caffeine as dark spots. Sample preparation techniques, particularly reflux and ultrasonic extraction, significantly enhanced extraction efficiency and detection sensitivity. Factors such as mobile phase stability, spotting technique, and sample matrix were also identified as key influencers on the chromatographic results. Conclusion: TLC is an efficient and cost-effective method for the qualitative identification of caffeine in coffee. Its success is determined by the optimization of critical parameters, primarily the mobile phase composition. While excellent for initial screening, TLC requires complementary techniques for precise quantitative analysis. Future work should focus on standardizing these parameters to improve the reproducibility and reliability of caffeine analysis using TLC.
Formulasi dan Evaluasi Mutu Fisik Serta Uji Aktivitas Antiinflamasi Sediaan Balsem Stik Ekstrak Etanol Daun Bakung (Crinum asiaticum L.) Ramadhan , Yusril; Yuniarti , Rafita; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.892

Abstract

Background: Spider lily leaves (Crinum asiaticum L.) contain bioactive compounds, such as flavonoids, which are known for their anti-inflammatory properties. Developing a convenient topical formulation like a stick balm could provide an effective and practical alternative for treating inflammation. Objective: This study aimed to formulate a stick balm containing ethanol extract of spider lily leaves (EESL) and evaluate its physical quality and anti-inflammatory activity. Methods: The extract was obtained by macerating the leaves in 96% ethanol. Stick balm formulations were prepared with varying concentrations of EESL: F0 (base), F1 (1%), F2 (3%), and F3 (5%). The physical quality of the formulations (homogeneity, pH, spreadability, melting point) was evaluated. Anti-inflammatory activity was tested on 24 male white rats induced with carrageenan. The rats were divided into six groups: negative control (induced only), positive control (commercial Geliga balm), F0, F1, F2, and F3. Paw edema volume was measured every hour for 6 hours. Results: All stick balm formulations met the physical quality standards. The anti-inflammatory test showed that the F3 formulation (5% EESL) exhibited the highest activity, with an edema reduction of 0.007 mm, which was equivalent to the positive control group (0.007 mm). The anti-inflammatory effect was concentration-dependent, with lower efficacy observed in the F2 and F1 groups. Conclusion: The ethanol extract of Crinum asiaticum L. leaves can be successfully formulated into a stable stick balm. The 5% EESL stick balm demonstrated significant anti-inflammatory activity that was comparable to a commercial product, making it a promising natural alternative for topical anti-inflammatory therapy.
Interaksi Obat Potensial pada Sirosis Hati: Tinjauan Pola dan Faktor Sosiodemografi Amni , Hudiyah; Fitria, Najmiatul; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.910

Abstract

Liver cirrhosis is a chronic condition characterised by the formation of regenerative nodules and fibrotic tissue resulting from prolonged liver damage. This condition is frequently accompanied by comorbidities and complications, often leading to the use of multiple medications (polypharmacy). Polypharmacy increases the risk of potential drug interactions, which may worsen clinical outcomes. This study aimed to describe the patterns of possible drug interactions and the sociodemographic characteristics of hospitalised patients with cirrhosis at Dr M. Djamil Central General Hospital in Padang. A cross-sectional study was conducted using prospectively collected data from patient medical records. A total of 579 medications used by 50 patients were classified into three categories: cirrhosis-specific drugs (48.9%), symptomatic treatments (43.2%), and medications for comorbid conditions (7.95%). Analysis with drugs.com showed potential drug interactions in 96% of patients, most commonly moderate–to–minor combinations (48%), followed by major, moderate, and minor interactions (22%). In comparison, moderate interactions only and major moderate combinations occurred in 18% and 9% of patients, respectively.  In terms of sociodemographic characteristics, most patients were male (58%), under 65 years old (64%), had more than one comorbidity (52%), had a basic education level (32%), were still employed (56%), and did not engage in high-risk social behaviors such as smoking or alcohol consumption (48%).
Pengaruh Edukasi Booklet terhadap Kepatuhan Minum Obat pada Pasien Hipertensi Peserta Prolanis di Puskesmas Butang Baru Kabupaten Sarolangun Sari, Trisia Mayang; Sari, Yelly Oktavia; Wahyuni, Fatma Sri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.911

Abstract

Background: Hypertension is a global health problem with a high prevalence and is a significant risk factor for cardiovascular disease. Low medication adherence remains a challenge in the long-term management of hypertension. Health education is a key strategy to improve patients’ understanding and adherence. Booklets are considered a potential educational medium for delivering information in a structured manner. Objective: This study aims to analyse the effect of booklet media education on medication adherence among hypertensive patients participating in the Prolanis program at Butang Baru Public Health Centre, Sarolangun Regency. Methods: This research employed a pretest-posttest control group experimental design. Fifty-six respondents were evenly divided into the intervention group (received booklet-based education) and the control group (received no intervention). Medication adherence was measured using the MARS-5 questionnaire. Data were analysed using the Wilcoxon Signed Ranks test. Results: There was a significant improvement in adherence in the intervention group. The percentage of patients with high adherence increased from 7.14% to 53.57%, while the low adherence category decreased from 25% to 0%. Conversely, the control group showed no meaningful changes. Statistical analysis confirmed these findings, with a p-value = 0.000 (p < 0.05), indicating that the booklet intervention significantly improved adherence. Conclusion: Education through booklet media was proven effective in improving medication adherence among hypertensive patients. Therefore, booklets can be applied as a practical and beneficial intervention strategy to support the success of chronic disease management programs such as Prolanis in primary health care settings.
Pengaruh Edukasi Terhadap Pengetahuan Pada Pasien Lansia Hipertensi di Rumah Sakit Umum Daerah Padang Pariaman Naluri , Lisma; Nasif , Hansen; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.913

Abstract

Hypertension is a prevalent chronic condition among the elderly, and improving patients' knowledge is a crucial factor in achieving successful therapy. This study aimed to evaluate the effect of educational interventions on knowledge among elderly hypertensive patients at Padang Pariaman General Hospital. A one-group pre-test post-test design was used involving 97 elderly participants who received education through pharmacist-led counseling sessions. Knowledge levels were assessed using the Hypertension Knowledge-Level Scale (HKLS). The Wilcoxon signed-rank test showed a significant improvement in knowledge after the intervention (p < 0.05). Before counseling, most participants had low knowledge, but this improved significantly post-education. The study concludes that structured educational interventions effectively enhance the knowledge of elderly hypertensive patients, and should be incorporated into routine pharmaceutical care.
Uji Aktivitas Antibakteri Sediaan Mouthwash Dari Ekstrak Daun Peppermint ( Mentha piperita L.) dan Daun Jarak Cina ( Jatropha multifida L.) Terhadap Streptococcus mutans Putri , Adilla; Nasution, Muhammad Amin; Lubis , Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.917

Abstract

Background: Mouthwash is a liquid preparation that plays an important role in maintaining oral health. An ideal formulation should possess antibacterial effectiveness, physicochemical stability, and acceptable organoleptic properties. Streptococcus mutans is the primary pathogenic bacterium responsible for halitosis and dental caries. Peppermint (Mentha piperita L.) and physic nut (Jatropha multifida L.) leaves are known to contain bioactive compounds such as flavonoids, saponins, and tannins, which have potential antibacterial activity. Objective: This study aimed to formulate peppermint and physic nut leaf extracts into a stable mouthwash preparation and evaluate its antibacterial activity against Streptococcus mutans. Methods: The extracts were prepared using maceration with ethanol as a solvent. The mouthwash formulations were developed with three variations of extract concentrations (2%, 2.5%, and 3%). The preparations were then evaluated for their physical stability (organoleptic properties and pH) and tested for antibacterial activity against S. mutans using the Kirby-Bauer disc diffusion method. Inhibition zone data were statistically analyzed using ANOVA and Duncan’s test. Results: Physicochemical evaluation showed that all formulations remained stable over 28 days of observation, with a pH of 6, which is compatible with the oral cavity. Antibacterial testing demonstrated an increase in inhibition zone diameter with higher extract concentrations: 10.33 mm (2%), 11.1 mm (2.5%), and 11.9 mm (3%). These results were comparable to the positive control, Betadine gargle (11.95 mm). The negative control showed no inhibition zone. Statistical analysis revealed significant differences (p < 0.05) among the concentrations. Conclusion: The combination mouthwash containing peppermint and physic nut leaf extracts at a concentration of 3% was found to be the most stable formulation and exhibited the strongest antibacterial activity, comparable to the commercial reference product. Thus, this combination extract has potential to be developed as a natural antibacterial agent for oral health.
Penetapan Kadar Asam Klorogenat dan Aktivitas Antioksidan Ekstrak NADES dari Biji Kopi Hijau Robusta (Coffea canephora) Menggunakan Metode MAE dan UAE sebagai Bahan Baku Kosmetik Alishlah, Tanfidz; Nuri, Nuri; Dianasari, Dewi; Rahman Hakim, Arif
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.937

Abstract

Antioxidants are essential for protecting skin cells from free radicals, causing oxidative damage, and supporting human skin’s health. Natural antioxidants are abundant in plants, particularly in Robusta green coffee beans (Coffea canephora), which are rich in chlorogenic acid (CA), a key contributor to antioxidant properties. Efficient extraction methods are necessary to obtain these bioactives effectively. Advanced extraction technology, such as Ultrasound-Assisted Extraction (UAE) and Microwave-Assisted Extraction (MAE), enhances mass transfer and reduces processing time compared to conventional methods. This study quantified chlorogenic acid using Thin Layer Chromatography-Densitometry (TLC-densitometry) and evaluated the antioxidant activity using the DPPH method of NADES (betaine–triethylene glycol) liquid extracts from Robusta coffee green beans extracted via UAE and MAE. Chlorogenic acid concentration of MAE (3.64 mg CA/g extract ± 0.06) was higher than that of UAE (2.69 mg CA/g extract ± 0.04). The antioxidant activity (IC₅₀) values were 3266.66 μg/mL ± 67.97 (UAE) and 2598.05 μg/mL ± 29.42 (MAE), indicating higher efficiency for MAE. When expressed as chlorogenic acid equivalents in NADES extracts, IC₅₀ values were 9.04 μg/mL ± 0.13 (UAE) and 9.44 μg/mL ± 0.07 (MAE). NADES-MAE could be a promising method to acquire raw materials with high antioxidant activity, especially for cosmetic formulation.
Pengaruh Intervensi Apoteker terhadap Pengetahuan, Tingkat Kepuasan dan Outcome Terapi Pasien Swamedikasi Commond Cold di Apotek Kasih Agape Tarigan, Eunike Victorita; Wiryanto, Wiryanto; Dalimunthe, Aminah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.941

Abstract

Self-medication for minor illnesses such as the common cold is generally done by the community. In situations like this, the role of pharmacists is very important in providing education to improve patient safety. This study aims to analyze the effect of pharmacist intervention (pretest-posttest) on the level of knowledge and outcome of self-medication therapy for common cold patients at Kasih Agape Pharmacy Medan. This study used a quasi-experimental design with a one-group pretest-posttest design approach on the knowledge and outcome indicators, while the patient satisfaction indicator used a descriptive quantitative research design. The sample consisted of 50 patients who were in the intervention group (pretest-posttest), randomly selected using a purposive sampling technique. The intervention was given in the form of pharmacist education and counseling. Data were collected using a questionnaire that had been tested for validity and reliability. The results of the analysis showed that there was a significant increase in the level of knowledge (p <0.05) and outcome of therapy (p <0.05) in the intervention group compared to the pretest and posttest. These results can also be seen as increasing patient knowledge, and the outcome of therapy can have an impact on increasing patient satisfaction. This study shows that pharmacist intervention can effectively improve the quality of self-medication for the common cold in patients. This study emphasizes the importance of the active role of pharmacists in providing education to support safe, rational drug use and improve therapeutic outcomes.

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