Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
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<![CDATA[RAPD Profiles of Rhynchostylis gigantea (Lindl.) Ridl. Collected from Puspa Nirmala Orchids Banyumas, Central Java ]]>
<![CDATA[Agus Hery Susanto]]>;
<![CDATA[Ali Romadhoni]]>;
<![CDATA[Murni Dwiati]]>
<![CDATA[ Molekul Vol 17 No 2 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.2.6206
<![CDATA[Rhynchostylis gigantea (Lindl.) Ridl. is an orchid species spread over Southeast Asia countries. This species is very popular among ornamental plant collectors, especially due to its densely pack inflorescences. Hence, it is commercially found in many ornamental plant nursuries, such as Puspa Nirmala Orchids Banyumas, Central Java. Further development of the species should be supported by scientific data, particularly regarding the genetic variation. One of the molecular markers commonly used to study genetic variation is Random Amplified Polymorphic DNA (RAPD). This study aims to assess genetic variation of R. gigantea cultivars of Puspa Nirmala Orchids Banyumas collection by RAPD profiles. Genomic DNAs were extracted from leaf samples of eight R. gigantea individuals, while RAPD markers were amplified using five random primers (OPA-15, OPK-16, OPP-15, OPP-08 and OPO-08). Descriptive analysis was employed on the data obtained. It was revealed that all of the primers resulted in a 100% monomorphism. This indicates an extremely low genetic variation among R. gigantea population of Puspa Nirmala Orchids collection, which is probably due to the same origin from a selected hybrid of the same crosses.]]>
<![CDATA[Atomistic Simulation of La and Mn-Doped PbBi2Nb2O9 Aurivillius Phase ]]>
<![CDATA[Akram La Kilo]]>;
<![CDATA[Ramona Nintias R. Abas]]>;
<![CDATA[Alberto Costanzo]]>;
<![CDATA[Daniele Mazza]]>;
<![CDATA[Deasy N Botutihe]]>;
<![CDATA[Jafar La Kilo]]>
<![CDATA[ Molekul Vol 17 No 2 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.2.6346
<![CDATA[This study aims to determine the effect of Mn3+ and La3+ dopants on the structure of PbBi2Nb2O9 (PBN) using atomistic simulation. PBN phase geometry was optimized before the Mn3+ and La3+-doped phase. Mn3+ partially substituted octahedral Nb5+ in the perovskite layer. While La3+partially substituted Bi3+ in the bismuth layer and dodecahedral Pb2+in the perovskite layer. The concentration (x) of dopants that doped PBN was made in such a way that it produces a phase of Pb1-2xBi1.5 + 2xLa0.5Nb2-xMnxO9 (x = 0, 0.1, and 0.3) which was not charged. The simulation results showed that the optimized PBN cell parameters were in a good agreement with the experimental result. Increasing the concentration of dopants result in the Pb1-2xBi1.5+ 2xLa0.5Nb2-xMnxO9 phase (PBNM-Bi and PBNM-A) being less stable, as indicated by the increased lattice energy. PBNLM-Bi structures experiences an elongation which was showed by the cell parameters of c increase while a and b decrease. La3+prefers to occupy bismuth oxide layer rather than the dodecahedral A-site of the perovskite layer. The results of this simulation can explain the PBLNM structure of experimental results that do not pay attention to the multiplicity of doped PBN with certain dopant concentrations.]]>
<![CDATA[Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column ]]>
<![CDATA[Dadan Hermawan]]>;
<![CDATA[Cacu Cacu]]>;
<![CDATA[Khansa Salsabila]]>;
<![CDATA[Suwandri Suwandri]]>;
<![CDATA[Amin Fatoni]]>;
<![CDATA[Uyi Sulaeman]]>;
<![CDATA[Ponco Iswanto]]>;
<![CDATA[Mudasir Mudasir]]>;
<![CDATA[Hassan Y. Aboul-Enein]]>
<![CDATA[ Molekul Vol 17 No 2 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.2.6348
<![CDATA[The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6 mm × 5 μm), mobile phase composition of acetonitrile : water (0.2% HCOOH) (20:80, v/v), and UV detection of 220 nm.The optimized HPLC method has been applied for the quantitative determination of econazole in the pharmaceutical (liquid) sample withpercentage recovery of 100.75 % (RSD = 0,95%; n = 3). The effect of several HPLC parameters on the chiral separation of econazole was also evaluated and the method was successfully validated in terms of linearity, accuracy, precision, and selectivity. The present HPLC method was simple, short analysis time, and high resolution.]]>
<![CDATA[Co-Precipitation Synthesis of Clay-Magnetite Nanocomposite for Adsorptive Removal of Synthetic Dye in Wastewater of Benang Bintik Batik ]]>
<![CDATA[ Molekul Vol 17 No 2 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.2.6358
<![CDATA[Clay is a natural material that has been widely applied as a low-cost adsorbent for removing various contaminants from wastewater. To improve its characteristics and activity, natural clay from Central Kalimantan was activated by acid and calcination treatments, then synthesized with magnetite (Fe3O4) in nanocomposite by co-precipitation method. The obtained nanocomposite was further characterized by Fourier transform infrared spectroscopy, X-ray diffraction, nitrogen adsorption, vibrating sample magnetometry, and transmission electron microscopy methods. The results showed that co-precipitation method has been successfully produced clay-magnetite nanocomposite from activated clay with specific surface area, saturation magnetization, and particle size were 37.458 m2/g, 24.910 emu/g, and 50 nm, respectively. The obtained natural clay, activated clay, and clay-magnetite nanocomposite were then evaluated for adsorptive removal of naphthol blue black (NBB) synthetic dye from wastewater generated by an industry of Benang Bintik batik in Central Kalimantan using a batch system. The results showed that optimum pH for adsorptive removal process from these adsorbents were 2, while the optimum contact times of natural clay, activated clay, and clay-magnetite nanocomposite were 90, 60, and 60 minutes, respectively. The clay-magnetite nanocomposite also showed a much better removal efficiency (99.58%) than activated clay (86.28%) and natural clay (68.27%). The utilization of clay-magnetite nanocomposite as adsorbent not only can increase its removal efficiency against NBB dye, but also can facilitate the separation of the adsorbent solid phase from wastewater using an external magnetic field after the adsorptive removal process.]]>
<![CDATA[Application of Box-Behnken Design for the Extraction of Padina australis ]]>
<![CDATA[Muhammad Nursid]]>;
<![CDATA[Anissa Permatasari]]>;
<![CDATA[Utami Dyah Syafitri]]>;
<![CDATA[Irmanida Batubara]]>
<![CDATA[ Molekul Vol 17 No 2 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.2.6359
<![CDATA[Optimization extraction of the brown algae Padina australis using the Box-Behnken design has been carried out. Box-Behnken design in relation to Response Surface Methodology analysis was conducted with four experimental factors (i.e., solvent concentration, temperature, extraction time, and sample to solvents ratio) towards the responses of yield antioxidant, anti-tyrosinase, anti-glycation, total phenolic content, and fucoxanthin content, completing with 29 running experiments. P. australis extraction's optimum condition was acquired at 79.99% solvent concentration, 18.48 hours extraction time, 44.50ºC temperature, and 1:9 ratio powders and solvents. The optimum condition provided a 7.30% extraction yield, 43.94% antioxidant activity, 86.83% anti-tyrosinase, 98.06% anti-glycation, 9.53 mg GAE/g total phenolic content, and 347.55 µg/g fucoxanthin content. Respond Surface Methodology analysis with the Box-Behnken design succeeded in making the appropriate model for producing the optimum P. australis extract.]]>
<![CDATA[Effect of Addition Elephant Grass Cellulose and CaCO3 Oyster Shell Waste as Bioplastic Composites ]]>
<![CDATA[M Prayogie Aulia]]>;
<![CDATA[Reza Rizki]]>;
<![CDATA[Sri Aprilia]]>;
<![CDATA[Farid Mulana]]>
<![CDATA[ Molekul Vol 17 No 2 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.2.6410
<![CDATA[The effect of adding cellulose and CaCO3 as a bioplastic filler was studied. The source of cellulose is obtained from elephant grass plants, while CaCO3 is obtained from oyster shell waste. The primary raw material for bioplastics is tapioca starch with glycerol as a plasticizer using the solution casting method. The resulting bioplastics are thin and transparent but not very elastic, with a thickness is 1 mm. The mechanical properties test of bioplastics obtained tensile strength between 1-3 MPa and elongation between 1-4.4%. Physical properties test results obtained density between 0.313-0.33 g/mL and water absorption between 31.94-81.16%. The morphological test showed that the bioplastic surface was getting more uneven with more CaCO3 filler. The use of cellulose fillers without the combination obtained better results than cellulose and CaCO3 fillers.]]>
