Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
Articles
18 Documents
Search results for
, issue
"Vol 20 No 3 (2025)"
:
18 Documents
clear
<![CDATA[Solvent-Free Microwave Extraction: Phytochemistry and Bioactivities of Essential Oil from Stachytarpheta jamaicensis, L. in Banyuwangi ]]>
<![CDATA[Susanti, Yuni]]>;
<![CDATA[Pambudi, Setyo]]>;
<![CDATA[A'yun, Ayu Qurota]]>;
<![CDATA[Aprilia, Melinda]]>;
<![CDATA[Hanum, Nabila Salsabila]]>;
<![CDATA[Armadan, Dwi Danang]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.16009
<![CDATA[ABSTRACT. Stachytarpheta jamaicensis, L. is a member of the Verbenaceae family. It is a medicinal plant easily found on vacant land and in rice fields in Banyuwangi. The present study is the first detail reported to examine the phytochemical compound and bioactivities of essential oil from S. jamaicensis L., using solvent-free microwave extraction (SFME). Forty chemical compounds were identified in the inflorescence and thirty in the leaves. β-caryophyllene, fulvoipolamiide, hexahydrofarnesyl acetone, t-phytol, neophytadiene, and squalene were identified in inflorescence oil. In contrast to the inflorescence, where these compounds were present in minor amounts, fulvoipolamiide, t-phytol, and squalene were the predominant components in the leaf oil. The IC50 values of leaves and inflorescence essential oils were 30.566 mg/mL and 52.510 mg/mL, respectively. Based on IC50 values, leaf essential oils have stronger antioxidant potential than inflorescence. Antibacterial and antifungal tests indicated that the leaf essential oil possesses greater antimicrobial efficacy than that of the inflorescence. These findings suggest that the essential oil of S. jamaicensis is a promising source of antioxidant, antibacterial, and antifungal agents, and holds potential for future pharmaceutical applications. Keywords: antibacterial; antifungal; antioxidant; medicinal plant]]>
<![CDATA[DFT-Based Study of Phenolic-Derived From Nutmeg (Myristica fragrans): Promising Bioreductants for Green Synthesis Silver Nanoparticles ]]>
<![CDATA[Nabila, Siti]]>;
<![CDATA[Abdjan, Muhammad Ikhlas]]>;
<![CDATA[Rakhman, Khusna Arif]]>;
<![CDATA[Annisa, Dira Ayu]]>;
<![CDATA[Mauraji, Ilham SW]]>;
<![CDATA[Umar, Sudir]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.16203
<![CDATA[ABSTRACT. The manufacture of silver nanoparticles (AgNPs) can be synthesized by reducing silver ions Ag+ to Ag0 by a reductant. Nutmeg (Myristica fragrans) fruit extract has the potential as a natural reductant (bioreductant) that can donate electrons to reduce Ag+ as a ligand and capping agent. This study aims to identify the potential of the bioactive compounds in Myristica fragrans (Mf) extract for the green synthesis of AgNPs using several parameters, including total energy, HOMO-LUMO, Fukui function, molecular electrostatic potential (MEP), global reactivity, and UV/Vis theoretical spectral analysis. The method used is Density Functional Theory (DFT) with Becke-3-parameter Lee-Yang-Parr (B3LYP) hybrid functionals, using the 6-31G (d,p) basis set for hydrogen (H), carbon (C), oxygen (O) atoms, and the LanL2Dz for the silver (Ag) atom. The results of the study indicate that single bioactive compounds eugenol, chalcone, carvacrol, and terpineol, as well as eugenol-Ag, chalcone-Ag, carvacrol-Ag, and terpineol-Ag complexes, are good reducing agents in the process of reducing Ag+ ions to Ag0 as AgNPs. In addition, these phen-Ag complexes show electron excitation at UV/Vis spectrophotometric simulation in the 454-473 nm wavelength range. This study provides a theoretical understanding of Ag+ reduction by bioactive compounds in Mf extract for green synthesis of AgNPs, thereby providing a scientific basis for developing green methods for eco-friendly, sustainable AgNP synthesis. Keyword: Bioreductant, DFT, green synthesis, Myristica fragrans, silver nanoparticles. .]]>
<![CDATA[The Phenolic Compounds Isolated from Myristica fragrans and Their Cytotoxic Effects on B16-F10 Melanoma Cancer Cell Lines ]]>
<![CDATA[Hasbilla, Raihan Fathurrahman]]>;
<![CDATA[Riyadi, Sandra Amalia]]>;
<![CDATA[Safriansyah, Wahyu]]>;
<![CDATA[Hidayat, Ace Tatang]]>;
<![CDATA[Susianti, Susianti]]>;
<![CDATA[Salam, Supriyanto]]>;
<![CDATA[Lesmana, Ronny]]>;
<![CDATA[Retnowati, Rurini]]>;
<![CDATA[Supratman, Unang]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.16265
<![CDATA[Phenolic compounds are a major type of secondary metabolite found in plants. These compounds are synthesized through shikimic and phenylpropanoid pathways, resulting in the formation of numerous unique structures and bioactivities. In addition, a significant amount has been reported in nutmeg, an endemic plant of Indonesia, which has been widely used in traditional medicine. A previous study also revealed that ethyl acetate extract of the plant has notable cytotoxic effects against melanoma B16-F10. Therefore, the purpose of this study is to isolate and evaluate phenolic compounds in nutmeg for their potential to inhibit B16-F10 melanoma cancer cell growth. The seeds extract of nutmeg was separated by various chromatographic techniques to yield a total of five compounds, which were identified through spectroscopic analysis (HR-TOF-ESI-MS, IR, and NMR) as well as comparison with literature. The compounds 1-5 were identified as (+)-veraguensin (1), 3',4',5'-trimethoxycinnamyl alcohol (2), (+)-galbegin (3), (-)-polysphorin (4), and 7-methoxycoumarin (5). Cytotoxic effects were then assayed against B16-F10 melanoma cell lines using the Resazurin method. Furthermore, compound 1 displayed the highest cytotoxic activity, with an IC50 value of 112.71 µM.]]>
<![CDATA[Optimization of Silver Doping on Natural Dye Mixed Chlorophyll-Anthocyanin on The Efficiency of Dye Sensitized Solar Cells (DSSC) ]]>
<![CDATA[Pangesti, Desita Suci]]>;
<![CDATA[Nurosyid, Fahru]]>;
<![CDATA[Suryana, Risa]]>;
<![CDATA[Iriani, Yofentina]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.16687
<![CDATA[ABSTRACT. This study aimed to incorporate silver (Ag) in the mixture of chlorophyll-anthocyanin dyes to improve DSSC efficiency. This research evaluated the impacts of various natural dye modifications with different concentrations of Ag incorporation on the DSSC performance. Here, anthocyanin (A) was extracted from butterfly pea flowers, while chlorophyll (C) was extracted from spinach leaves. The two dyes were mixed with a volume ratio of (anthocyanin: chlorophyll) 1:3. From the ratio of anthocyanin: chlorophyll, the extraction of anthocyanin solution is 25% and chlorophyll is 75%. Ag was incorporated into the dye mixture (AC) with distinct concentrations of 0%, 3%, and 5%. The dyes were characterized using a UV-Vis spectrophotometer and Keithley I-V meter to investigate their optical and conductivity properties. The DSSC performance was assessed with a Keithley I-V meter. The yields exhibited that the Ag incorporation improved the absorbances and widened the absorption area of the AC dyes as compared to the single and mixed dyes without Ag addition. Further, the results demonstrated that Ag incorporation enhanced the conductivity of the AC dyes, showing that the values were 4.43×10⁻² (Ωm)⁻¹, 6.46×10⁻² (Ωm)⁻¹, and 8,21×10⁻² (Ωm)⁻¹ for 0%, 3%, and 5% Ag incorporation. Moreover, the conversion efficiency values obtained by DSSCs prepared with AC dyes, Ag-incorporated AC 3%, and Ag-incorporated AC 5% were 0.073%, 0.209%, and 0.111%, respectively that Ag incorporation could significantly advance the DSSC performance. This study found that the AC dyes incorporated with 3% Ag were he optimal composition to produce the optimal DSSC performance. Keywords: anthocyanin, chlorophyll, DSSC, dye, silver]]>
<![CDATA[Colletotrichum sp. from Nutmeg Leaves Shows Antiproliferative Activity Against MCF-7 Cancer Cells: In Vitro Evaluation, Metabolite Profiling, and Docking Analysis ]]>
<![CDATA[Aisyah, Siti]]>;
<![CDATA[Suryati, Suryati]]>;
<![CDATA[Putra, Agus Budiawan Naro]]>;
<![CDATA[Palupi, Kartika Dyah]]>;
<![CDATA[Rahmi, Dwinna]]>;
<![CDATA[Ilyas, Muhammad]]>;
<![CDATA[Agusta, Andria]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.16748
<![CDATA[ABSTRACT. Endophytic fungi are recognized as a valuable source of bioactive compounds with significant therapeutic potential, with species from the genus Colletotrichum being particularly noted for their prolific production of structurally diverse secondary metabolites. This study aimed to evaluate the antiproliferative activity of the endophytic fungus Colletotrichum sp., isolated from the leaves of Myristica fragrans Houtt., commonly known as nutmeg against MCF-7 human breast cancer cells using an integrated in vitro and in silico approach. Bioassay-guided fractionation of the fungal extract followed by LC-HRMS analysis led to the identification of three major compounds: 2-amino-1,3,4-octadecanetriol, L-α-palmitin, and muscone-like compound. The antiproliferative activity of each subfraction was assessed using the MTT assay, while molecular docking studies were conducted to evaluate their binding affinities and interaction profiles with estrogen receptor α (ERα). Among the tested subfractions, F2.3 demonstrated the strongest antiproliferative activity, reducing MCF-7 cell viability to 22.08% at a concentration of 50 µg mL-1. The identified compounds demonstrated notable antiproliferative potential, with L-α-Palmitin showing the moderate binding affinity to ERα as indicated by a binding energy of -6.406 kcal mol-1. Molecular docking analyses revealed key interactions, including hydrogen bonding and hydrophobic contacts, contributing to receptor-ligand stability. These findings highlight Colletotrichum sp. as a promising source of antiproliferative agents, thus warranting further investigation into the isolation, structural characterization, and in vivo validation of its active constituents for potential pharmaceutical development. Keywords: antiproliferative, Colletotrichum sp., endophytic fungi, LC-HRMS, Myristica fragrans Houtt., secondary metabolites.]]>
<![CDATA[Some Morphological and Physiological Characters of Vanda bensonii Bateman Seedlings under Colchicine Application ]]>
<![CDATA[Khairunissa, Furidian]]>;
<![CDATA[Dwiati, Murni]]>;
<![CDATA[Susanto, Agus Hery]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.17191
<![CDATA[ABSTRACT. Vanda bensonii is an orchid species of some potentials to develop, one of which is by means of induced mutation resulting in polyploid individuals. Such individuals usually exhibit better phenotypical performance than that of the normal diploids. This can be performed by the application of antimitotic chemicals such as colchicine. This study aims to know the effect of colchicine on some morphological and physiological characters of V. bensonii seedlings and to find out the effective concentration in producing the most promising ideal phenotypical performance of the orchid species. The study was conducted at the Plant Physiology Laboratory, the Faculty of Biology, Universitas Jenderal Soedirman by using an experimental method arranged in a Completely Randomized Design with treatments consisting of five colchicine concentrations, i.e. 0, 20, 40, 60, and 80 µM. Each treatment was subjected to five replications giving rise to a total of 25 experimental units. The data obtained were analyzed using ANOVA with an F test of 0.05 and 0.01. Further analysis using Tukey test of 0.05 was performed when significant differences among treatments were found. The results show that colchicine significantly reduces plant height of V. bensonii, in which control plant shows taller in comparison to all treatments. Similarly, it is also the case with chlorophyll a content, while there is no significant effect of colchicine on leaf width, leaf length, leaf number, shoot number, chlorophyll b and total chlorophyll contents. Nevertheless, colchicine concentration of 60 µM is found most effective in increasing shoot number. It can be concluded that colchicine has significant effects on chlorophyll a content of V. bensonii, implying its potential application to create mutants of better performance. Keywords: colchicine, morphological characters, physiological characters, polyploid, Vanda bensonii]]>
<![CDATA[Enhanced Microwave Absorbing Characteristics of Cerium Barium Ferrite Composite: Effect of Sintering Temperature Variation ]]>
<![CDATA[Widanarto, Wahyu]]>;
<![CDATA[Tamtowi, Tomy]]>;
<![CDATA[Effendi, Mukhtar]]>;
<![CDATA[Rahmawati, Dina]]>;
<![CDATA[Supriyanti, Retno]]>;
<![CDATA[Ghoshal, Sib Krishna]]>;
<![CDATA[Kurniawan, Candra]]>;
<![CDATA[Jatmika, Jumaeda]]>;
<![CDATA[Handoko, Erfan]]>;
<![CDATA[Umar, Lazuardi]]>;
<![CDATA[Alaydrus, Mudrik]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.17825
<![CDATA[ABSTRACT. Cerium barium ferrite composites (CeBFCs) with improved microwave absorbance in the X-band spectral region are advantageous for varied advanced applications. Thus, the influence of various sintering temperatures on the microwave-absorbing traits of CeBFCs was evaluated. The main objective was to enhance the selective microwave absorption of BFC by modifying its magnetic properties through the substitution of Fe³⁺ with Ce³⁺ in the lattice structures. Four composites of CeBF were synthesized via mechanical alloying and sintered at 600, 800, 1000, and 1100°C. The produced samples were analyzed using XRD, VSM, and VNA to determine their microstructures, magnetic properties, and microwave reflection loss at X-band frequencies. XRD results revealed a significant promotion in forming a more pure crystalline barium hexaferrite phase at sintering temperatures higher than 800°C. This structural enhancement could directly influence the magnetic properties of the specimens with a progressive increase in the saturation magnetization with rising sintering temperature. In addition, the sintering temperature variation effectively modulated the electromagnetic properties (complex relative permeability and permittivity) that are vital for impedance matching and optimal wave absorption. The composite sintered at 1000°C displayed an optimal microwave absorption, indicating the lowest reflection loss within the X-band. The obtained products were shown to attenuate and dissipate surplus electromagnetic energy within the 8-12 GHz frequency range. The observed superior performance of the composites was ascribed to a balanced interplay between the magnetic and dielectric losses, leading to efficient impedance matching. It was affirmed that careful tuning of the sintering temperature can improve the crystalline phases, magnetic, electromagnetic, and microwave absorption properties of the proposed CeBFCs. Keywords: Cerium barium ferrite, Microwave absorption, Reflection loss, Sintering temperature, X-band]]>
<![CDATA[Antibacterial Activity of Bioactive Peptides Kacang Goat Milk and African Dwarf Breed Milk Fermented with Lactobacillus acidophilus and Bifidobacterium longum ]]>
<![CDATA[Anwar, Fauzi]]>;
<![CDATA[Murti, Tridjoko Wisnu]]>
<![CDATA[ Molekul Vol 20 No 3 (2025) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.20884/1.jm.2025.20.3.17877
<![CDATA[ABSTRACT. This study evaluated the antibacterial activity of bioactive peptides derived from African Dwarf crossbreed and Kacang goat milk fermented with Lactobacillus acidophilus and Bifidobacterium longum. Bioactive peptide fractions were obtained using Sephadex G-25 column separation, and their antibacterial activity was assessed using the well diffusion assay. Inhibition zones were measured at different fermentation times to compare the activity profiles between the two probiotic strains. Fermentation with Lactobacillus acidophilus and Bifidobacterium longum produced bacteriostatic effects, with inhibition zones ranging from 1.10 mm to 1.77 mm and activity persisting up to 24–36 hours, depending on strain and fermentation condition. These findings show that goat milk fermented for 12–18 hours is capable of producing bacteriocin-rich peptide fractions with antibacterial potential. Keywords: Antibacterial, Bifidobacterium longum, Bioactive peptides, Goat milk, Lactobacillus acidophilus.]]>
