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AMPLITUDO: Journal of Science & Technology Innovation
Published by Balai Publikasi Indonesia
ISSN : 28306171     EISSN : 28306902     DOI : https://doi.org/10.56566/amplitudo
Core Subject : Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture
AMPLITUDO: Journal of Science & Technology Innovation is a scholarly, online international journal that aims to publish peer-reviewed original research result-oriented papers in the fields of science, technology, and Innovative Technology. Submitted papers will be reviewed by the technical committees of the Journal. All submitted articles should report original, previously unpublished research results, and will be peer-reviewed. Articles submitted to the journal should meet these criteria and must not be under consideration for publication elsewhere. Manuscripts should follow the style of the journal and are subject to both review and editing. AMPLITUDO is steered by a distinguished Board of Directors, Researchers, and Academicians and is supported by an international review board consisting of prominent individuals representing many well-known universities, colleges, and the corporate world.
Arjuna Subject : Umum - Umum
Articles 11 Documents
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Search results for , issue "Vol. 4 No. 1 (2025): February" : 11 Documents clear
Development of Microcapsules of Bioactive Compounds Extracted from Grape Pomace of Ciravas Agra Afzal, Muhammad Hamza; Nadtochii, Liudmila
AMPLITUDO : Journal of Science and Technology Innovation Vol. 4 No. 1 (2025): February
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/amplitudo.v4i1.311

Abstract

Grape pomace is a prominent byproduct of winemaking, which provides bioactive phytochemicals such as polyphenols, conferring health benefits to humans, including anticancer properties. Delivering bioactive compounds extracted from grape pomace as microcapsules offers a sustainable and effective solution for developing tailored leukemia therapies. This approach highlights integrating environmentally friendly practices with medical innovation, mainly through the valorization of grape pomace, a byproduct of winemaking. For this purpose, the study uses ultrasound-assisted extraction (UAE) to optimize the extraction of these bioactive compounds. It evaluates how temperature and time affect antioxidant activity and total phenolic content. The results indicated that 60 minutes was optimal for the extraction yield of UAE with appreciable antioxidants (73.2 ± 1.5%) and total phenolic content (75.3 ± 2.1 mg GAE/g) compared to other methods studied here. Molecular docking analysis further revealed strong interactions between anthocyanins, particularly delphinidin-3-O-glucoside, and proteins associated with Acute Promyelocytic Leukemia (APL) and Chronic Myeloid Leukemia (CML), suggesting potential therapeutic applications. The present study offers a new perspective on the importance of grape pomace as an eco-friendly source of bioactive molecules in line with green chemistry ethics that may find applications in pharmaceuticals or nutraceutical sectors

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