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Benzena Pharmaceutical Scientific Journal
Published by Universitas Pekalongan
ISSN : -     EISSN : 29617375     DOI : http://dx.doi.org/10.31941/benzena.v2i01.3065
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology Public Health
Benzena Pharmaceutical Scientific Journal adalah jurnal peer-review yang diterbitkan dua kali setahun (Juni dan Desember) oleh Fakultas Farmasi Universitas Pekalongan. Ini tersedia online sebagai sumber akses terbuka dan juga dalam bentuk cetak. Pernyataan ini memperjelas perilaku etis semua pihak yang terlibat dalam tindakan penerbitan artikel di jurnal ini, termasuk penulis, pemimpin redaksi, Dewan Editorial, reviewer, dan penerbit. Pernyataan ini didasarkan pada Pedoman Praktik Terbaik COPE untuk Editor Jurnal. Focus dan scope : Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL" : 7 Documents clear
ANALISIS KARAKTERISTIK NANOPARTIKEL PADA SEDIAAN SUSPENSI EKSTRAK ETANOL BUAH BAKAU MINYAK (RHIZOPHORA APICULATA) Dwi Bagus; Wirasti; Achmad Vandian Nur
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

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Abstract

The ethanol extract of Rhizophora apiculata fruit was utilized in this study with the aim of formulating it into active nanoparticles, which were then prepared in the form of a suspension dosage and evaluated for stability. The nanoparticles were produced using the ionic gelation method, followed by particle characterization using a Particle Size Analyzer (PSA) and zeta potential measurement. The characterization results showed a particle size of 126.7 ± 2.170 nm, a polydispersity index of 0.601 ± 0.1005, and a zeta potential of 34.38 ± 0.2850 mV. Overall, these findings indicate that the Rhizophora apiculata fruit extract nanoparticles are stable and suitable for further development as a suspension dosage form.
PENGARUH KONSENTRASI ETANOL TERHADAP AKTIVITAS ANTIBAKTERI EKSTRAK DAUN LILI PARIS (Chlorophytum comosum) Dany Hexa Grosny Ralphsody; Lindawati, Novena Yety
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6644

Abstract

Staphylococcus aureus is a pathogenic bacterium that frequently causes serious infections, such as skin infections, pneumonia, and sepsis. The increasing resistance to conventional antibiotics has prompted the search for alternative therapies derived from natural sources. Spider plant (Chlorophytum comosum) leaves are known to contain bioactive compounds such as flavonoids, saponins, and terpenoids, which have potential antibacterial properties. This study aims to determine the effect of varying ethanol concentrations (40%, 70%, and 96%) on the antibacterial activity of spider plant leaf extracts against Staphylococcus aureus. Extraction was carried out using the maceration method with ethanol solvents at concentrations of 40%, 70%, and 96%. Each extract underwent phytochemical screening. Antibacterial activity was tested using the well diffusion method against Staphylococcus aureus ATCC 25923. The inhibition zones were measured using a caliper. Data were analyzed using normality and homogeneity tests, one-way ANOVA, and Tukey’s post hoc test. Phytochemical screening results showed that the 40% ethanol extract contained only flavonoids and tannins, while the 70% and 96% ethanol extracts contained flavonoids, terpenoids, tannins, and saponins. Antibacterial testing showed that the 70% ethanol extract produced the largest inhibition zone (9.75 mm), followed by the 96% ethanol extract (7.25 mm), and the 40% ethanol extract (6.3 mm). ANOVA results indicated significant differences between groups (p < 0.05), and the post hoc test showed that the 70% ethanol extract differed significantly from the other two groups. Ethanol 70% was the most effective solvent for extracting antibacterial compounds from spider plant leaves, as it produced the highest antibacterial activity against Staphylococcus aureus. These results support the potential use of spider plant leaf extract as a natural antibacterial candidate.
POTENSI ANTIOKSIDAN REBUSAN DAN SEDUHAN TEMU MANGGA (Curcuma mangga) DENGAN METODE DPPH Halimah, Nur; Sa'ad, Muhammad
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6697

Abstract

Background : Free radicals are unstable molecules that cause oxidative stress and various chronic diseases. Antioxidant compounds can play a role in neutralizing free radicals. Plants as natural ingredients of traditional medicine contain secondary metabolite compounds that act as antioxidants. One of the plants used as an antioxidant is temu mangga (Curcuma mangga). The use of natural ingredients as medicine by the people in Indonesia mostly uses the boiling and steeping methods. Objective : This study aims to determine the antioxidant activity of boiled and brewed temu mangga rhizome (Curcuma mangga) compared to quercetin. And to determine the content of secondary metabolites that are responsible for antioxidant activity. Method : Phytochemical screening using color reagents to determine the content of secondary metabolites including: alkaloids, tannins, saponins, and flavonoids. Antioxidant activity was measured using the DPPH method using the parameter of the Inhibitory Concentration 50% (IC50) value with quercetin as a positive control. Result : The results showed that both methods have secondary metabolite compounds that are responsible for antioxidant activity, namely: alkaloids, tannins, saponins, and flavonoids. Both methods showed very strong antioxidant activity, with IC50 quercetin, boiling and brewing method respectively of 5.62 ppm; 5.75 ppm; and 5.53 ppm. The brewing method was slightly more effective, possibly because the temperature used was lower, thus maintaining the stability of thermolabile antioxidant compounds such as flavonoids. Conclusion : Extraction method has significant effect on antioxidant activity. The brewing method can be a more optimal traditional method to maintain antioxidant properties of Curcuma mangga.
ANALISIS FISIKO-KIMIA SIMPLISIA DAN PROFIL KROMATOGRAFI LAPIS TIPIS HERBA BANDOTAN (Ageratum conyzoides L.) Pratimasari, Diah; Disa Andriani
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6707

Abstract

Background: Bandotan plant (Ageratum conyzoides L.) is a plant of the Aceraceae family that grows wild. Bandotan is empirically used as an antiseptic and wound healer. In addition, bandotan plants are also reported to have activities as antipyretic, anti-inflammatory, and antioxidant. These various pharmacological activities make the bandotan plant potential to be developed as a medicinal and cosmetic raw material. So far, research related to bandotan standardization has been carried out on the leaves, even though all parts of the bandotan plant including the roots have the potential to be developed. In addition, the use of all parts of the plant supports green chemistry, namely minimizing residual production waste. Objective: This study aims to conduct chemical physicochemical characterization of simplisia of all parts of bandotan herb and its Thin Layer Chromatography (TLC) profile. Methods: This research begins with making simplisia from all parts of the bandotan plant. The obtained simplisia was then observed for its physicochemical aspects including drying shrinkage, total ash content, water soluble juice content, ethanol soluble juice content and TLC identification. In addition to making simplisia, all parts of bandotan were also extracted with 70% ethanol, to be analyzed KLT compared with simplisia and kaemferol standards. Conclusion: The use of all parts of the bandotan herb plant meets the quality standards of simplisia. In addition, the use of all parts of the plant shows a diversity of spots on KLT that have the potential to be developed as medicinal and cosmetic raw materials
HUBUNGAN TINGKAT PENGETAHUAN MAHASISWA TERHADAP RASIONALITAS PENGGUNAAN OBAT ANTIBIOTIK Andre; Irda Rizky Wiharti; Erin Efrilia
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v4i01.6762

Abstract

Antibiotics are among the most commonly used drugs to treat infections. However, their use is often accompanied by misunderstandings and a lack of knowledge regarding proper usage. Pharmacy students, as health science students who study medicines, are expected to have a good understanding in order to provide accurate information about drugs within their community. The purpose of this study is to determine the level of knowledge about antibiotics among pharmacy students at the University of Pekalongan. The method used in this study was a questionnaire distributed using random sampling, involving 108 student respondents. Based on the results, the level of respondents' knowledge was categorized as good in 77.6% of the participants. Keywords: Knowledge, Pharmacy Students, Medication Use, Antibiotic
PENGARUH VARIASI SUHU PENGERINGAN TERHADAP KADAR FLAVONOID TOTAL EKSTRAK UMBI BIT (Beta vulgaris L.) DENGAN METODE SPEKTROFOTOMETRI UV VISIBEL Susilowati
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

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Abstract

Beetroot (Beta vulgaris L.) is one of the plants in Indonesia that is often utilized by the community in a traditional way. Several studies have shown that consuming red beet can improve cardiovascular health and lower daily systolic blood pressure. One of the secondary metabolites that actively plays a role in beetroot is flavonoids. This study aims to determine the highest total flavonoid content in beetroot extract dried using an oven with different drying temperature variations of 60°C, 70°C, and 80°C. The extraction method in this study is maceration using 96% ethanol as the solvent. Qualitative testing was performed with a flavonoid color test using the Taubeck method and Thin Layer Chromatography (TLC) with ammonia vapor. The determination of flavonoid content was done using UV-Visible spectrophotometry. The results showed that beetroot contains flavonoid compounds. The flavonoid content obtained at a temperature of 60°C was 371,11 ± 0 μgQE/g sample, at 70°C it was 357,77 ± 0.0128 μgQE/g sample, and at 80°C it was 241,48 ± 0.0127 mgQE/g sample. It can be concluded that drying temperature affects the total flavonoid content found in beet tubers and the highest flavonoid content obtained is at a temperature of 60°C, which is 371,11 ± 0 μgQE/g sample.
UJI DISOLUSI DAN PENETAPAN KADAR TABLET AMLODIPIN 5 mg GENERIK DAN BERMEREK khasanah, kharismatul
BENZENA Pharmaceutical Scientific Journal Vol 4 No 01 (2025): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

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Abstract

Hypertension is a significant health issue with a prevalence of 34.1% in Indonesia, yet many individuals with hypertension do not consistently take medication. Amlodipine, an antihypertensive and antianginal drug belonging to the calcium channel blocker class, is widely used in both generic and branded forms. The differences between these two are often considered when choosing treatment, as generic drugs are more affordable, although their quality is frequently questioned. Generic drugs are often perceived as inferior to branded or innovator drugs. Therefore, research is needed to ensure that the quality of generic drugs is not lower than that of branded products. This study aims to compare the quality of generic and branded amlodipine tablets through weight uniformity testing, content determination, and dissolution testing. A descriptive research method was used. The weight uniformity test was performed by weighing 20 tablets from each sample. The dissolution test was conducted using a paddle-type apparatus (method 2). Content determination was performed using UV-Vis spectrophotometry at a wavelength of 237 nm to determine the amlodipine content in the tablets. Data obtained were analyzed using Microsoft Excel. The results showed that both generic and branded amlodipine tablets met the dissolution test requirements according to the Indonesian Pharmacopoeia (Edition VI), with at least 50% dissolution within 30 minutes as indicated on the label. The dissolution profiles of both generic and branded amlodipine tablets showed similar drug release patterns. However, the dissolution efficiency (DE) for both samples was relatively low, with DE values at the 5-minute mark being 9.52% for the generic tablet and 10.32% for the branded tablet. At the 30-minute mark, the dissolution efficiency for both samples reached approximately 33%.

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