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INDONESIA
Jurnal Tumbuhan Obat Indonesia
Published by Universitas Tidar
ISSN : 1979897X     EISSN : 23548797     DOI : https://doi.org/10.31002/jtoi
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health
Jurnal Tumbuhan Obat Indonesia is published periodically twice a year. Result or review written by researcher from university or research Institute. Journal TOI has had an ISSN print version since 2008 and has an online Volume 6 number 1 year 2013.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol. 18 No. 1 (2025): July 2025" : 7 Documents clear
Modifikasi Struktur Eugenol Menjadi Etil 2-(4-Alil-2-Metoksifenoksi) Asetat Melalui Reaksi Alkilasi dengan Etil Kloroasetat Agistya, Hamida Azza; Fadlan, Arif; Masitoh, Heni
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1045

Abstract

Eugenol, a natural product with broad and promising biological activity, possesses three reactive functional groups of hydroxyl, allyl, and methoxy, which can be transformed through chemical reactions into various derivatives. The reaction of eugenol and ethyl chloroacetate with a mole ratio of 1:1 has been reported to produce an alkylation product. However, the use of dry acetone as a solvent and the reflux condition for 12 hours were the drawbacks of this reaction. The structural modification of eugenol into ethyl 2-(4-allyl-2methoxyphenoxy) acetate as an alkylation product was further studied in this paper. The alkylation reaction of eugenol and ethyl chloroacetate was performed in dimethylformamide with a mole ratio of 6:10 (method A), 1:1 (method B), 1:4 (method C), and 1:4 (method D) at room temperature (methods A and D) and under reflux conditions (methods B and C). The results showed that the alkylation reaction with a mole ratio of 1:4 at room temperature (method D) produced ethyl 2-(4-allyl-2-methoxyphenoxy)acetate as a pure compound with a yield of 94%. The structure of the alkylation product was determined by FTIR, NMR spectroscopy, and mass analysis. Ethyl 2-(4-allyl-2-methoxyphenoxy)acetate is a key compound in the development of various eugenol-derived active compounds.
Pemanfaatan Gel Ekstrak Belimbing Wuluh sebagai Antibakteri Penyembuh Luka Diabetes Melitus Tipe II pada Tikus yang Terinduksi Stz-Na Muna, Laili; Unsa Izzati; Rafiastiana Capritasari; Febriana Astusi
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1805

Abstract

Diabetes is a degenerative disease with a reasonably high prevalence rate. This is due to the community's low lifestyle, so there is an uncontrolled increase in glucose levels in the blood. If this condition is not handled properly, increased blood glucose levels will cause complications in the form of wounds that are difficult to heal. Improper treatment can result in infection and damage, so the affected body part can be amputated. The treatment on the market is clindamycin, an antibiotic that can cause resistance if it is used in the long term. The use of the star fruit extract of Belimbing wuluh, which has a mechanism as antibacterial properties, is a treatment option to reduce the risk of using antibiotics. The purpose of this study was to determine the effectiveness of using star fruit water extract as a wound closure developed into a gel preparation. The group in this study was divided into 6 test groups, namely the non-diabetic group (1 group) and the STZ-Na-induced diabetes group (5 groups). The test treatment of Belimbing wuluh water extract was divided into three concentration range groups, which are 2.5%, 5%, and 10%, with a positive control ratio of clindamycin, and the observation of diabetes parameters was weight loss and percentage of wound closure. The results showed that the decrease in blood glucose levels (IBD) affected the wound closure rate, a macroscopically important parameter for accelerating the wound healing process (PL). Weight loss in test animals is also a parameter of type 1 DM due to STZ-Na induction. In the P3 group, the %PL result was 40%, which was better than the P1 of 9.33%. However, it was no better than the clindamycin-positive control group of 52.67%. In the wound healing process, the higher the concentration of Belimbing wuluh extract used, the faster the wound healing process. This is due to the content of secondary metabolites in Belimbing wuluh, which act as antibacterial agents.
Karakterisasi Senyawa Aktif Ekstrak Daun Buas-buas (Premna serratifolia) sebagai Anti Kanker Kolon pada Sel WiDr Hadiarti, Dini; Mukhlishin, Hamdil
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1416

Abstract

The leaves of Buas-buas or Premna serratifolia (P. serratifolia) have been used in Asian countries to treat inflammation, respiratory disorders, and postnatal recovery. Previous studies have demonstrated its anticancer activity against HT-29 and DLD-1 colon cancer cell lines; however, the isolation approach was selective and did not detect the range of active compounds or their functional groups. This study aims to identify functional groups and active compounds using Ultra High Performance Liquid Chromatography–High Resolution Mass Spectrometry (UHPLC-HRMS) and Fourier Transform Infrared Spectroscopy (FTIR) without isolation, and to evaluate cytotoxicity against WiDr cells. The research included ethanol extraction of P. serratifolia leaves, fractionation with n-hexane, ethyl acetate, and water, phytochemical, in vitro cytotoxicity assays, and FTIR and UHPLC-HRMS analyses. Phytochemical screening indicated the presence of flavonoids, tannins, saponins, and steroids. Aside from the ethanol extract, all three fractions showed moderate cytotoxic activity, with the ethyl acetate fraction (IC₅₀ = 49.12 μg/mL) selected for further analysis. FTIR spectra revealed functional groups including –OH, C–H, C=O, C=C, –CH₃, C–O, and =C–H. UHPLC-HRMS identified compounds such as luteolin, quercetin, apigenin, kaempferide, aurantioobtusin, isorhamnetin, scrofulein, and 5,7-dihydroxy-6-methoxy-3-phenyl-4H-chromen-4-one in the ethyl acetate fraction, with mass accuracy ranging from –0.53558 to 3.07641 ppm.
Pengaruh Emulgator Terhadap Stabilitas dan Aktivitas Tabir Surya Krim Ekstrak Mahkota Dewa dan Kencur Jalil, Nur Khairi; Maulita Indrisari; Ikbal; Nurul Hikma
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2633

Abstract

Paparan sinar ultraviolet (UV) yang berlebihan berpotensi menimbulkan kerusakan jaringan kulit, mempercepat penuaan, hingga meningkatkan risiko kanker kulit. Upaya pencegahan dilakukan melalui penggunaan tabir surya untuk membatasi penetrasi UV ke kulit. Dua sumber bahan aktif alami yang prospektif digunakan yaitu buah mahkota dewa dan rimpang kencur, buah mahkota dewa mengandung senyawa glukosida benzofenon yaitu phalerin dan rimpang kencur mengandung etil-parametoksisinamat yang merupakan senyawa turunan sinamat. Tujuan penelitian untuk menemukan konsentrasi emulgator yang optimal yang dapat meningkatkan stabilitas produk serta memperbaiki kinerja perlindungan terhadap sinar UV. Ekstrak diperoleh melalui proses maserasi menggunakan etanol96%, selanjutnya diformulasi dalam bentuk sediaan krim sebanyak 9 formula dengan variasi konsentrasi berbagai emulgator yaitu novemer, viscolam dan  tween 80-span 80 lalu dilakukan pengujian efektivitas tabir surya dari krim ekstrak dengan menghitung nilai %Te, %Tp, dan SPF. Hasil penelitian menunjukkan emulgator viscolam dengan konsentrasi 4% (formula VI) merupakan formula krim yang paling stabil berdasarkan parameter organoleptis, homogenitas, pH, tipe emulsi, viskositas, daya sebar serta daya lekat dan hasil pengujian tabir surya  dikategorikan sebagai proteksi ekstra dengan nilai %Te 3,83854 dan sunblock dengan nilai %Tp 2,703703 sedangkan nilai SPF 74,4323 yang memberikan efek proteksi ultra. Kata kunci: Ekstrak, Mahkota Dewa, Kencur, Emulgator, Tabir surya.
Characterization of Yellow Tabebuia Flower Extract (Tabebuia aurea) Nanoparticles and Bioactivity as Antioxidant: Karakterisasi Nanopartikel Ekstrak Bunga Tabebuya Kuning (Tabebuia aurea) dan Bioaktivitas sebagai Antioksidan Yunita, Yunita; Syarifah, Anisa Lailatusy; Rahayu, Lina Oktavia; Wijayanti, Ernanin Dyah
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2174

Abstract

Degenerative diseases can be prevented by natural antioxidants in plant. Yellow tabebuia flower is natural antioxidants. Plant extracts can develope into green synthesis nanoparticle to increase the effectiveness as medicinal materials. This research aims to determine the characteristics of yellow tabebuia flower extract nanoparticles and bioactivity as antioxidants. The methods included preparation and extraction of simplisia using ethanol solvent by maceration and sonication. The extract was determined flavonoid and phenol content by colorimetric method and antioxidant activity by DPPH method. The extract was also made into nano particles by ionic gelation method, with variations addition of tween 80 as much as 0.5, 0.75 and 1 ml. The results of this research are extract has a yield 13.09%, contains flavonoids, tannins, phenolics, alkaloids, saponins and terpenoids. The value of total flavonoid content is 0.59%, total phenolic content is 3.11% and antioxidant activity test has IC50 value of 165.26. The use ionic gelation method can reduce particle size. Three formulas that made the variation surfactant addition has a particle size of 47-283 nm, in addition tween80 1 ml has the smallest particle size of 47 nm with a zeta potential value of 39.3 mV. Keywords: yellow tabebuia flower extract, nanoparticles, antioxidant activity
Metabolite Profiling Famili Asteraceae (Kenikir, Bunga Matahari, Krisan) dengan Metode HPTLC dan Principal Component Analysis (PCA) Mutiah, Roihatul; Hayati, Elok Kamilah; Andiartama, Amanda Milano
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2315

Abstract

Tanaman dari famili Asteraceae di Indonesia memiliki berbagai potensi bioaktif yang tinggi karena kandungan senyawa seperti lakton, alkaloid, dan tanin. Penelitian ini bertujuan untuk menganalisis profil metabolit daun kenikir, bunga matahari, dan krisan yang berasal dari famili Asteraceae dengan pendekatan metabolomik. Ekstrak daun diperoleh melalui ekstraksi ultrasonik dengan etanol 96% dan dianalisis menggunakan High Performance Thin Layer Chromatography (HPTLC). Visualisasi dilakukan dengan menggunakan instrumen TLC Visualizer dan perangkat lunak ImageJ, sehingga menghasilkan densitogram. Profil metabolit dengan HPTLC dan analisis PCA berimplikasi pada penguatan kontrol kualitas dan standarisasi fitokimia melalui autentikasi spesies, identifikasi marker metabolit, serta penjaminan konsistensi mutu produk herbal berbasis Asteraceae. Hasil menunjukkan bahwa terdapat perbedaan jumlah noda dan intensitas warna antar sampel. Hasil PCA menunjukkan sebaran metabolit mengelompok pada area yang berbeda, dengan total variasi 72,5% (PC1 = 56,5% dan PC2 = 15,9%). Analisis Heatmap menunjukkan bahwa ekstrak daun bunga matahari memiliki intensitas senyawa aktif tertinggi, yang ditandai dengan area merah yang lebih pekat akibat nilai AUC tertinggi. Penelitian ini membuktikan bahwa terdeapat perbedaan profil metabolit pada ketiga tanaman yang berasal dari famili yang sama. Kata kunci: Profil Metabolit, Asteraceae, HPTLC, Principal Component Analysis
Sublingual Film Formulation of Tempuyung Leaf Extract (Sonchus Arvensis L.) as Anthyperuricemic Agent Subagja, Seina Lathifa; Nurdianti, Lusi; Agustiani, Dika Tri; Jayanty, Rizka Sri; Khaelani, Eka; Dwi Lestari, Oktaviana
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1406

Abstract

Tempuyung leaves (Sonchus arvensis L.) are known to contain flavonoid compounds with potential antihyperuricemic activity. This study aimed to prepare Sonchus arvensis leaf extract and formulate it into a sublingual thin film dosage form to develop a therapeutic formulation for the treatment of hyperuricemia. The study employed a Completely Randomized Design using 24 rats (Rattus norvegicus), divided into six groups: positive control (Allopurinol), negative control, blank, and three treatment groups receiving Sonchus arvensis extract at doses of 50 mg/70 kg BW, 100 mg/70 kg BW, and 200 mg/70 kg BW. The sublingual film formulation was prepared using the solvent casting method. Data were analyzed using ANOVA and LSD tests. The results indicated that Formula 3, with a dose of 200 mg, produced the most significant reduction in uric acid levels. Standardization parameters of the extract, including moisture content, ash content, water-soluble extract, ethanolsoluble extract, and loss on drying, complied with the applicable standards. Evaluation of the sublingual film demonstrated that the formulation met the required characteristics and quality standards for sublingual films. In conclusion, the sublingual film of Sonchus arvensis leaf extract shows potential as an effective antihyperuricemic agent. Keywords: Tempuyung Leaves, Antihyperuricemia, Thin Film

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