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Dharma Permana
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Departement of Pharmacology, Faculty of Medicine, YARSI University, Jakarta 10510, Indonesia
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INDONESIA
Yarsi Journal of Pharmacology
Published by Universitas Yarsi
ISSN : -     EISSN : 27164578     DOI : https://doi.org/10.33476/yjp
Core Subject : Health,
Medicine & Pharmacology
Yarsi Journal of Pharmacology (YJP) is an electronic open-access journal, focusing in the field of Pharmacology and Clinical Pharmacy, and it publishes two times yearly (January-June and July-December). YJP aims to improve scientific and knowledge of therapeutic uses of drugs and the journal accepts original research articles, review articles and case report.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 1 No. 1 (2020): January 2020" : 5 Documents clear
Analysis of rational prescribing in “X” Hospital, Jakarta Nurul Habibah; Lilian Batubara
Yarsi Journal of Pharmacology Vol. 1 No. 1 (2020): January 2020
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v1i1.1206

Abstract

Background: The irrational prescribing is one of the problems in health care in Indonesia. The irrational prescribing can cause medication errors, increase costs, the possibility of adverse drug side effects or drug interactions that may inhibit the quality of care. The purpose of this study is to know the rationality of drug prescribing in March 2016 in Hospital X, Jakarta.Methods: This study assessed a prescribing which admitted in March at X hospital with descriptive analysis design and samples taken by multistage sampling.Results:  384 prescription were used and the results of this study : 23,96 % (92) rational prescribing, 5,47 % (21) incomplete administrative prescription,  15.88% (61) overprescribing, 11.20% (43) underprescribing, 15,36 % (59) multiple prescribing, 4.95 % (19) extravagant prescribing and  23.18% (89) polypharmacy.Conclusion: Rational presription 23.96% and the most irrational prescription form is polypharmacy  23.18% .
Clinical description of dementia patients concerned by acetylcholinesterase inhibitor and other drugs in Dr. Soeharto Heerdjan Psychiatry Hospital Muhammad Fahmi Syah Putra; Nasruddin Noor
Yarsi Journal of Pharmacology Vol. 1 No. 1 (2020): January 2020
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v1i1.1207

Abstract

Background: Dementia is a syndrome of brain damage caused by cognitive changes due to brain trauma or degenerative, while clinical symptoms in dementia have a variety of both cognitive impairments and non cognitive disorders so that appropriate management in the form of pharmacological interventions is needed.Objective: To determine the clinical symptoms of dementia patients and use of drug Acetylcholinesterase Inhibitor and other drugs as a treatment in the Dr. Suharto Heerdjan Psychiatric Hospital.Methods: Quantitative non-experimental or analytical research, and the determination of samples by consecutive sampling method, that is, all medical records that meet established inclusion and exclusion criteria are included in the study until the number of samples is met.Results: Obtained inclusion criteria of 96 medical records belonging to Dr. Soeharto Heerdjan Psychiatric Hospital patients. with gender of female and male, age presenile dementia (<65 years) and senile dementia (> 65 years) were found. The classification is found in dementia patients including not classified dementia, Alzheimer's dementia, vascular dementia, ytt dementia, parkinson's dementia, and finally dementia ydk, for acetylcholinesterase drugs were founded using donepezil, rivastigmine, and galantamine. The symptoms are obtained with general symptoms of dementia, positive symptoms, and negative symptoms. Comorbid diseases include hypertension, paranoid schizophrenia, residual schizophrenia, tension type headache, anxiety disorders, recurrent depression, and depressive disorders. And other drugs include antipsychotics, antiparkinsonians, mood stabilizers, antidepressants, anxiolytics, anticonvulsants, analgesics, immunosuppressants, antihypertensive agents, vitamins, and N-Methyl-D-Aspartate.Conclusion: Dementia patients at Dr. Soeharto Heerdjan Psychiatric Hospital has the highest diagnosis of Alzheimer's dementia with the most clinical symptoms in sundowner symptoms and delusional symptoms with some of them having the most comorbid disease in the form of hypertension. As for management, drug use in the acetylcholinesterase group in the form of donepezil and other drugs such as antipsychotic drugs in the form of risperidone or olanzapin, and anti-hypertensive drugs in the form of captopril, amlodipine, and beta blockers are drugs that are often used in patients.
Use of Antibiotics for acute respiratory infection (ARI) in Puskesmas Karang Rejo, Tarakan Mirza Insani; Dharma Permana
Yarsi Journal of Pharmacology Vol. 1 No. 1 (2020): January 2020
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v1i1.1208

Abstract

Background: Acute respiratory infection (ARI) is a serious infection that prevents normal breathing function. It usually begins as a viral infection in the nose, trachea (windpipe), or lungs. If the infection is not treated, it can spread to the entire respiratory system. ARI prevents the body from getting oxygen and can result in death. ARI is the most common diagnosis for which antibiotics are prescribed and there are many reasons why primary care doctors prescribe antibiotics. The aim of this study was to know the use of antibiotic drugs in ARI patients at Puskesmas Karang Rejo, Tarakan.Methods: The research method is a descriptive with retrospective data collection by collecting secondary data obtained from medical records at Puskesmas Karang RejoTarakan in the period of January-April 2017. Results: A total of 595 medical records were selected, there were 58.66% (n = 349) female and 41.34 % (n = 246) male, and most occurred in children aged 1-5 years 31.60% (n=188) and aged 6 -10 years 20.84% (n=124). The most common types of ARI were acute tonsillitis 33.61% (n=200), nonspecific respiratory tract infection 32.77% (n=195) and pneumonia 13,94% (n=83. The antibiotic drugs used were amoxicillin 73.11% (n=435), cotrimoxazole 22.02% (n=131), ciprofloxacin 2.52% (n=15), cephadroxil 1.68% (n=10) and chloramphenicol  0.67% (n=4). Amoxicillin and cotrimoxazole were the most commonly used antibiotic for treatment of patients with all types of ARI. Amoxicillin use was highest in acute tonsillitis (94.00%, n=188) and nonspecific respiratory tract infection (85.13%, n=166), while cotrimoxazole use was highest in pneumonia (90.36%, n=75).Conclusion: Amoxicillin and cotrimoxazole were the mostly used antibiotics for treatment of patients with ARI in Puskesmas Karang Rejo, Tarakan.
The use of antihypertensive drugs in the treatment of essential hypertension at outpatient installations, Puskesmas Karang Rejo, Tarakan Salma Nara Fadhilla; Dharma Permana
Yarsi Journal of Pharmacology Vol. 1 No. 1 (2020): January 2020
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v1i1.1209

Abstract

Background: Essential hypertension is the most common type of hypertension, affecting 95% of hypertensive patients. Essential hypertension can be managed through a combination lifestyle changes and antihypertensive drugs. The aim of this study was to know the use of antihypertensive drugs in the treatment of essential hypertensive at outpatient installations, Puskesmas Karang Rejo, Tarakan.Methods: The research method is descriptive by using secondary data from complete patient medical records of the essential hypertension patients undergoing outpatient treatment at Puskesmas Karang Rejo, Tarakan in the period of January-April 2017.Results: A total of 557 medical records were selected, there were 72.53% (n = 404) female and 27.47 % (n = 153) male; age ranged from 20-80 years (mean = 50.32 years). The most common of essensial hypertension were 47.22 % (n = 263) grade II hypertension and 45.42 % (n = 253) grade I hypertension. The antihypertensive drugs were used single or in combination in the following order: Amlodipine (Calcium channel blockers), Captopril (ACE inhibitors), Hydrochlorothiazide/HCT (Diuretic), Methyldopa (alpha-2 adrenergic receptor agonist) and Isosorbid dinitrate (Vasodilator). Four hundred fifty four (81.51%) patients were treated with a single drug (monotherapy) and 103 (18.49%) patients were given combination therapy. Monotherapy and the combination of two antihypertensive drugs were used for prehypertension, grade I hypertension and grade II hypertension, with the most widely used drugs as monotherapy was amlodipine (67.86%, n =378 ) and the mostly used combination therapy of two antihypertensive drugs was Amlodipine-Hydrochlorothiazide (15.80%, n = 88).  The combination of antihypertensive Amlodipin-Hydrochlorothiazide-Captopril (0.35%, n=2) was used for hypertension grade II.Conclusion: Amlodipine was the most widely used drug as monotherapy or combination drugs therapy in the treatment of essensial hypertension at outpatient installations, Puskesmas Karang Rejo.
The differences of antibiotics effectiveness in therapy of thypoid fever without complications in children at Putra Bahagia Hospital, Cirebon Muhammad Nurhanif; Insan Sosiawan A Tunru
Yarsi Journal of Pharmacology Vol. 1 No. 1 (2020): January 2020
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v1i1.1210

Abstract

Background: Typhoid fever remains a health problem, particularly in Indonesia and other developing countries. There are few selection of antibiotics that used for the treatment of typhoid fever.Objective: The purpose of this research was to determine the antibiotic used in the treatment of typhoid fever without complications in children at Putera Bahagia Hospital Cirebon and to see the difference effectiveness.Methods: The research was conducted in retrospective, that is taking medical records of pediatric patients aged 1-15 years with a diagnosis of typhoid fever at Putera Bahagia Hospital, Cirebon, periode of 2011-2014. Statistical analysis was performed using Kruskal-Wallis test, with SPSS 23 program. Results: Found 117 cases that met the inclusion criteria and antibiotics used are chloramphenicol (23.08%), cefixime (11.97%), cefotaxime (11.11%), ceftriaxone (49.57%), and azitromisin (4.27%). The fastest fever’s free-time is ceftriaxone, 42.46 hours (average time) and the shortest treatment duration is azithromycin, which is 4.8 days.Conclusion: In this research, there was no significant difference between fever’s free-time and treatment duration of chloramphenicol, cefixime, cefotaxime, ceftriaxone, and azithromycin.

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