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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 2 Documents
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Search results for , issue "Vol 10 No 4 (2025): Forthcoming Issue" : 2 Documents clear
NETWORK PHARMACOLOGY ANALYSIS OF BIOACTIVE COMPOUNDS OF RED BETEL (Piper crocatum Ruiz dan Pav) STEM AS AN ANTI-INFLAMMATORY AGENT Sari, Putri Kharisma Novita; Febyaningrum, Vitasigi Dwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 4 (2025): Forthcoming Issue
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i4.1770

Abstract

Inflammation is a mechanism in the body's defense system that occurs through the release of pro-inflammatory mediators. However, inflammation needs to be controlled because it triggers excessive production of inflammatory mediators that cause tissue damage and disease progression. Various types of first-line anti-inflammatory therapy drugs have potential for adverse side effects such as anemia, hypertension, and immunosuppression, so alternative anti-inflammatory agents are needed that are considered safe and effective. The red betel plant (Piper crocatum Ruiz and Pav) is known to contain secondary metabolites such as sesquiterpenes, aldehydes, phytosterols, and sterols that are already known as anti-inflammatory agents. This study aims to determine the anti-inflammatory potential of the red betel plant based on pharmacological network analysis. The test compounds are secondary metabolites that were successfully detected in the red betel stem such as caryophyllene, octadecadienal, stigmasterol, and sitosterol. Proteins related to anti-inflammatory activity obtained from GeneCards, proteins interacting with test compounds predicted by SwissTargetPrediction, and the results of the intersection of both types of proteins were further analyzed using STRING with Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment methods. GO and KEGG enrichment analysis showed involvement in NF-?B, IL-17, PI3K/AKT, and TNF signaling pathways, with 16 key genes related to anti-inflammatory activity targets. The main target proteins of caryophyllene and stigmasterol being HSP90AA1 and STAT3, respectively, while octadecadienal and sitosterol showed NFKB1 as the same main target protein. The results provide a scientific data for the use of these secondary metabolites as anti-inflammatory agents.
FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF Camellia sinensis KOMBUCHA ETHYL ACETATE EXTRACT AND CREAM FORMULATION Bethasari, Maulidwina; Rahayu, Anis Puji; Safitri, Novis
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 4 (2025): Forthcoming Issue
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i4.1786

Abstract

Kombucha, a fermented tea beverage made using a symbiotic culture of bacteria and yeast (SCOBY), is gaining interest due to its bioactive compounds, particularly flavonoids, which are known for their antioxidant properties. These natural antioxidants, derived from the tea leaves of Camellia sinensis, may offer functional benefits when applied in topical formulations such as creams. This study aimed to determine the flavonoid concentration in kombucha extracts after fermentation for 7 and 14 days and to evaluate the antioxidant activity of a cream formulation containing kombucha extract. Kombucha extract was obtained using a liquid-liquid extraction method with ethyl acetate as the solvent. Antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, where a lower IC50 value indicates stronger antioxidant activity. The results showed that The total flavonoid content in the kombucha extract fermented for 7 days (H7) was 125.79 ± 0.192 mg QE/g, while the extract fermented for 14 days (H14) contained 35 ± 0.333 mg QE/g. Antioxidant activity testing revealed IC50 values of 6.84 for the H7 extract and 7.48 for the H14 extract, indicating that the 7-day fermented kombucha had a higher antioxidant potential. These findings suggest that fermentation duration significantly affects the flavonoid content and antioxidant capacity of kombucha extracts, which may influence their efficacy when incorporated into topical formulations, such as creams. This study highlights the potential of kombucha extracts as natural antioxidant agents for cosmetic and pharmaceutical applications. Keywords: antioxidant, Camellia sinensis, flavonoid, kombucha, SCOBY

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