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JOURNAL OF BIOMEDICAL SCINECES AND HEALTH
Published by Universitas Karya Husada Semarang
ISSN : 30477182     EISSN : 30626854     DOI : https://doi.org/10.34310/
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
SCOPE 1. Biochemistry (medical) This scope includes biochemical mechanisms behind the pathogenesis, diagnosis, and management of human diseases and research concerning the subjects of Medical Biochemistry. 2. Medical Sciences and Pharmacology : This scope includes applications in the health sector (principles, procedures, care, treatment) carried out and developed by health workers. 3. Traditional Herb This scope focus on the cultivation and extraction of raw materials, or the analysis of these materials’ phytochemical or pharmacological effects and toxicity, as well as their potential applications of natural extracts, fractions, or compounds in the formulation of traditional medicine. 4. Biology and Life Science Scientific articles in the scope of biology including: botany, zoology, microbiology, genetics, physiology and conservation. 5. Genetics and Molecular Biology This scope is exploration and conservation of genetic diversity, analysis of gene and protein function, genetic engineering, synthetic biology, multimics (genomics). , transcriptomics, nutrigenomics, etc.) and supported by bioinformatics and big data analysis. 6. Immunology 7. Anatomy and Physiology 8. Tropical infection and parasitology 9. Clinic health sciences.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Penuaan
Articles 5 Documents
 1 
Search results for , issue "Volume 1 No. 2 Agustus 2024" : 5 Documents clear
Antibacterial Affectiveness of Green Tea Extract (Camellia Sinensis L.) Liquid Soap Against Staphylococcus aureus and Streptococcus pyogenes: ANTIBACTERIAL  AFFECTIVENESS  OF  GREEN  TEA  EXTRACT (CAMELLIA  SINENSIS  L.)  LIQUID  SOAP  AGAINST STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PYOGENES Meutia Rizki Wibowo; Heni Wijayanti; Isy Royhanaty
Journal Of Biomedical Sciences and Health Volume 1 No. 2 Agustus 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/

Abstract

Aureius dan S. pyogeineis meirupakan bakteiri gram positif peinyeibab dari peinyakit impeitigo. Impeitigo adalah infeiksi ulit yang meinyeirang hidung, mulut, dan tangan seirta ditandai deingan ruam meirah. Peingobatan impeitigo umumnya meinggunakan antibiotik, namun peinggunakan antibiotik dalam jangka waktu panjang akan meinimbulkan eifeik samping pada tubuh. Oleih kareina itu, peineiliti ingin meingeiksplorasi bahan alami yaitu daun teih hijau untuk teirapi kompleimeinteir peinyakit impeitigo. Tujuan peineilitian untuk meingeitahui peingaruh liquid soap eikstrak daun teih hijau (C. sineinsis) konseintrasi 7%, 10%, dan 13% teirhadap zona hambat bakteiri S. aureius dan S. pyogeineis. Jeinis peineilitian yang digunakan truei eikspeirimeintal deingan deisain postteist-only with control group. Instrumein yang digunakan adalah hard instrumein dan soft instrumein (SOP), deingan analisis data meinggunakan Onei Way Anova untuk peingukuran zona hambat dan Mann-Whitneiy untuk meimbandingkan diameiteir zona hambat. Hasil peineilitian meinunjukkan bahwa konseintrasi optimum liquid soap pada bakteiri S. aureius dan S. pyogeineis adalah dikonseintrasi 10% yang meinghasilkan zona hambat 2,7 mm dan 3,1 mm. Pada peirbandingan zona hambat S. aureius dan S. pyogeineis meinunjukkan nilai signifikansi 0,345 (p>0,05) yang beirarti tidak ada peirbeidaan nyata antara aktivitas antibakteiri liquid soap eikstrak teih hijau teirhadap S. aureius dan S. pyogeineis Kata kunci: Cameillia sineinsis; liquid soap; Staphylococcus aureius; Streiptococcus pyogeineis. ABSTRACT Aureius and S. pyogeineis arei gram-positivei bacteiria that causei impeitigo. Impeitigo is a skin infeiction that attacks thei nosei, mouth and hands and is characteirizeid by a reid rash. Treiatmeint for impeitigo geineirally useis antibiotics, but long-teirm usei of antibiotics will causei sidei eiffeicts on thei body. Theireiforei, reiseiarcheirs want to eixplorei natural ingreidieints, nameily greiein teia leiaveis, for compleimeintary theirapy for impeitigo. Thei aim of thei reiseiarch was to deiteirminei thei eiffeict of liquid soap with greiein teia leiaf eixtract (C. sineinsis) conceintrations of 7%, 10% and 13% on thei inhibition zonei of S. aureius and S. pyogeineis bacteiria. Thei typei of reiseiarch useid was truei eixpeirimeintal with a postteist-only deisign with control group. Thei instrumeints useid weirei hard instrumeints and soft instrumeints (SOP), with data analysis using Onei Way Anova to meiasurei thei inhibition zonei and Mann-Whitneiy to comparei thei diameiteir of thei inhibition zonei. Thei reiseiarch reisults showeid that thei optimum conceintration of liquid soap for S. aureius and S. pyogeineis bacteiria was 10%, which produceid an inhibition zonei of 2.7 mm and 3.1 mm. A comparison of thei inhibition zoneis of S. aureius and S. pyogeineis shows a significancei valuei of 0.345 (p>0.05), which meians theirei is no reial diffeireincei beitweiein thei antibacteirial activity of greiein teia eixtract liquid soap against S. aureius and S. pyogeineis Keiywords: Cameillia sineinsis; liquid soap; Staphylococcus aureius; Streiptococcus pyogeineis
COMPARISON OF ANTIOXIDANT COMPOUNDS OF GREEN BETEL (Piper betle) AND RED BETEL (Piper crocatum) EXTRACTS USING DIFFERENT SOLVENTS WITH THE DPPH METHOD Septahani; Poppy Fransisca A; Heni Wijayanti
Journal Of Biomedical Sciences and Health Volume 1 No. 2 Agustus 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/

Abstract

Latar belakang : Ekstrak  daun sirih hijau mempunyai sifat antibakteri dan ekstrak ini mempunyai banyak manfaat, salah satunya dapat digunakan untuk mengatasi beberapa masalah kesehatan. Daun sirih hijau dimanfaatkan sebagai ekspektoran, obat cacing, antiseptik luka, obat sakit gigi, penyegar dll. Kandungan kimia  daun sirih hijau (Piper betle) antara lain minyak atsiri, terpenoid, tanin, polifenol dan steroid. Tujuan : Untuk mengetahui perbandingan senyawa antioksidan dari ekstrak daun sirih hijau (Piper betle) dan ekstrak daun sirih merah (Piper crocatum) dengan pelarut etanol 70% dan methanol 70%. Metode : Penelitian ini termasuk penelitian Eksperimental Laboratoris. Desain penelitian yang digunakan adalah perbandingan uji senyawa antioksidan dan uji aktivitas antioksidan pada ekstrak daun sirih dengan metode DPPH. Data yang diperoleh dalam penelitian ini diolah secara deskriptif kuantitatif dengan metode kurva regresi linier y= ax+b. Penelitian ini dilakukan setelah mendapatkan Ethical clearance dengan Nomor: 003/KEP/UNKAHA/SLE/2024, berasal dari Komisi Etik Peneltian (KEP) Kesehatan Universitas Karya Husada Semarang. Hasil : Hasil penelitian menunjukkan dengan menggunakan pelarut etanol 70% dapat disimpulkan bahwa, ‘ada perbandingan fitokimia dari ekstrak daun sirih hijau (Piper betle) dan ekstrak daun sirih merah (Piper crocatum) dengan pelarut etanol 70% dan methanol 70%. Kesimpulan : ada perbandingan senyawa antioksidan dari ekstrak daun sirih hijau dan daun sirih merah. Hasil penelitian ini dapat digunakan sebagai pengujian bahan alam untuk melakukan eksperimen penelitian selanjutnya. Kata Kunci: Daun Sirih Hijau (Piper betle), Daun Sirih Merah (Piper crocatum), Etanol 70% dan Metanol 70%. ABSTRACT Background : Green betel leaf extract has antibacterial properties and this extract has many benefits, one of which can be used to treat several health problems. Green betel leaves are used as an expectorant, worm medicine, wound antiseptic, toothache medicine, freshener, etc. The chemical contents of green betel leaves (Piper betel) include essential oils, terpenoids, tannins, polyphenols and steroids. Objective : To determine the phytochemical comparison of green betel leaf extract (Piper betle) and red betel leaf extract (Piper crocatum) with 70% ethanol and 70% methanol solvents. Metods : This a research included laboratory experimental. data obtained in this study were processed descriptively quantitatively with the linear regression standard curve method. Research result : The results showed that by using 70% ethanol solvent it can be concluded that, 'there is a phytochemical comparison of green betel leaf extract (Piper betle) and red betel leaf extract (Piper crocatum) with 70% ethanol solvent and 70% methanol. Conclusion : There is a phytochemical comparison of green betel leaf extract and red betel leaf extract. The results of this study can be used as a test of natural materials to conduct further research experiments. Keywords : of green betel leaf extract (Piper betle), red betel leaf extract (Piper crocatum), 70% ethanol solvent and 70% methanol.
ANTIBACTERIAL ACTIVITY OF RED GINGER (Zingiber officinale var. rubrum) EXTRACTS AS GROWTH INHIBITORS OF Klebsiella pneumoniae Anwar Rovik
Journal Of Biomedical Sciences and Health Volume 1 No. 2 Agustus 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/

Abstract

Pneumonia, a significant global health concern, is caused by Klebsiella pneumoniae infection. Antibiotic use is the primary treatment for K. pneumoniae infection; however, inappropriate use of antibiotics can result in bacterial resistance. Antimicrobial resistance poses a significant challenge in treating K. pneumoniae infections, as it can render existing antibiotics ineffective against infections. Natural products derived from plants have received considerable attention as potential sources of new antimicrobial agents, including red ginger (Zingiber officinale var rubrum). This study aims to determine red ginger extracts' effectiveness in inhibiting the growth of Klebsiella pneumoniae in vitro and silico. The research stages included compound extraction from red ginger rhizomes, antimicrobial activity testing against K. pneumoniae, and in silico analysis of target genes. The red ginger extract inhibited the growth of K. pneumoniae. The 25% extract concentration gave the most minor inhibition, with an inhibition zone of 6.7 mm. The 100% extract concentration gave the most significant inhibition, with an inhibition zone of 8 mm. The bioactive compound of red ginger may target various proteins and act in multiple sites in K. pneumoniae cells. This study showed that red ginger targets the acrR gene, a multidrug efflux pump AcrAB operon transcription repressor essential in the resistance of K. pneumoniae to antibiotics. Keywords: antimicrobial resistance; efflux pump; Klebsiella pneumoniae; red ginger Pneumonia masih menjadi masalah kesehatan global yang signifikan, disebabkan oleh infeksi Klebsiella pneumoniae. Penggunaan antibiotik adalah pengobatan utama untuk infeksi K. pneumoniae; namun, penggunaan antibiotik yang tidak tepat dapat menyebabkan resistensi bakteri. Resistensi antimikroba merupakan tantangan yang signifikan dalam mengobati infeksi K. pneumoniae, karena dapat membuat antibiotik yang ada menjadi tidak efektif melawan infeksi. Produk alami yang berasal dari tanaman telah mendapat perhatian yang cukup besar sebagai sumber potensial agen antimikroba baru, termasuk jahe merah (Zingiber officinale var rubrum). Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak jahe merah dalam menghambat pertumbuhan Klebsiella pneumoniae in vitro dan in silico. Tahapan penelitian meliputi ekstraksi senyawa dari rimpang jahe merah, pengujian aktivitas antimikroba terhadap K. pneumoniae, dan analisis in silico gen target. Ekstrak jahe merah menghambat pertumbuhan K. pneumoniae. Konsentrasi ekstrak 25% memberikan daya hambat yang paling kecil, dengan zona hambat sebesar 6,7 mm. Konsentrasi ekstrak 100% memberikan daya hambat yang paling besar, dengan zona hambat sebesar 8 mm. Senyawa bioaktif jahe merah dapat menargetkan berbagai protein dan bekerja di berbagai tempat dalam sel K. pneumoniae. Hasil penelitian menunjukkan bahwa ekstrak jahe merah menargetkan gen acR, sebuah multidrug efflux pump AcrAB operon transcription repressor yang berperan penting dalam resistensi K. pneumoniae terhadap antibiotik. Kata kunci: jahe merah; Klebsiella pneumoniae; pompa eflux; resistensi antimikroba
PETRISSAGE MASSAGE AND LAVENDER AROMATHERAPY TO REDUCE LOW BACK PAIN IN THIRD TRIMESTER PREGNANT WOMEN Dyah Ayu Wulandari; Widi Isnaeni Zubaedah; Meika Jaya Rochkmana; Mei Lia Nindya Zulis
Journal Of Biomedical Sciences and Health Volume 1 No. 2 Agustus 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/

Abstract

Kehamilan merupakan proses alami yang akan membawa ketidaknyamanan bagi ibu hamil secara fisik maupun psikis. Ketidaknyamanan pada kehamilan trimester III salah satunya nyeri punggung bawah. Nyeri punggung pada kehamilan muncul karena adanya produksi hormone relaksin yang meningkat. Hormon ini yang menyebabkan persendian tulang panggul mengalami peregangan yang berfungsi mempermudah persalinan. Terapi untuk mengurangi nyeri dengan diberikan pijat petrissage dan aromaterapi lavender pada ibu hamil trimester III. Tujuan Penelitian adalah untuk mengetahui pengaruh kombinasi pijat petrissage dan aromaterapi lavender terhadap nyeri punggung bawah pada ibu hamil trimester III. Jenis penelitian kuantitatif berupa Quasy eksperimen. Desain penelitian one group pretest-posttest design without control  dengan 15 sampel. Responden dipijat kemudian diukur nyeri. Instrumen yang digunakan NRS untuk mengukur nyeri punggung bawah. Hasil uji Wilcoxon diperoleh nilai p 0,000 artinya kombinasi pijat petrissage dan aromaterapi lavender dapat mengurangi nyeri punggung bawah Ibu hamil trimester III. Kesimpulan : Ada pengaruh kombinasi pijat petrissage dan aromaterapi lavender terjadap nyeri punggung bawah ibu hamil trimester III. Saran: Ibu hamil dapat menerapkan kombinasi pijat petrissage dan aromaterapi lavender untuk mengurangi nyeri punggung bawah   Kata Kunci : pijat petrissage, aromaterapi lavender, ibu hamil trimester III, nyeri punggung bawah   ABSTRACT Pregnancy is a natural process that will bring discomfort to pregnant women physically and psychologically. One of the discomforts in the third trimester of pregnancy is lower back pain. Back pain in pregnancy occurs due to increased production of the hormone relaxin. This hormone causes the pelvic bone joints to stretch, which functions to facilitate childbirth. Therapy to reduce pain by giving petrissage massage and lavender aromatherapy to third trimester pregnant women. The aim of the study was to determine the effect of a combination of petrissage massage and lavender aromatherapy on lower back pain in third trimester pregnant women. The research design is one group pretest-posttest design without control with 15 samples. Respondents were massaged and then measured for pain. The instrument used by the NRS to measure low back pain. The Wilcoxon test results obtained a p value of 0.000, meaning that the combination of petrissage massage and lavender aromatherapy can reduce lower back pain for pregnant women in the third trimester. Conclusion: There is an effect of a combination of petrissage massage and lavender aromatherapy on lower back pain in third trimester pregnant women. Suggestion: Pregnant women can apply a combination of petrissage massage and lavender aromatherapy to reduce lower back pain.   Key word: petrissage massage, lavender aromatherapy, third trimester pregnant women, low back pain
THE EFFECT OF OXYTOCIN MASSAGE EDUCATION ON POSTPARTUM MOTHER BREASTFEEDING BEHAVIOR AT MUHAMMADIYAH RODLIYAH ACHID MOGA HOSPITALODLIYAH ACHID MOGA HOSPITAL anita afriani; Moch Jamaluddin; Sujanti P
Journal Of Biomedical Sciences and Health Volume 1 No. 2 Agustus 2024
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/

Abstract

Di Rumah Sakit Rodliyah Achid Moga ibu nifas yang baru melahirkan tiap bulannya sekitar 110 orang hanya 60% ibu menyusui bayinya dan 40% belum menyusui bayinya. Tindakan yang dilakukan  untuk menangani hal tersebut hanya di berikan edukasi cara menyusui dan perawatan payudara tetapi untuk edukasi tentang pijat oksitosin belum pernah dilakukan.  Tujuan : Tujuan dari penelitian ini adalah untuk mengetahui apakah ada pengaruh edukasi pijat oksitosin terhadap perilaku ibu menyusui di Rumah Sakit Muhammadiyah Rodliyah Achid Moga.  Jenis penelitian kuantitatif menggunakan desain pra eksperimen dengan pendekatan “one group pretest-postest design”.  Penelitian ini menggunakan  uji normalitas Kolmogorov Smirnov karena jumlah data  86 responden dan hasil uji menunjukkan sig < 0,01 artinya data tidak terdistribusi normal. Data yang diperoleh menunjukkan setelah dilakukan edukasi terdapat kenaikan nilai rata-rata dan nilai minimum. Berdasarkan uji Wilcoxon diperoleh nilai asymp Sig < 0,05. Artinya edukasi pijat oksitosin berpengaruh terhadap perilaku menyusui ibu postpartum di Rumah Sakit Muhammadiyah Rodliyah Achid Moga. Hasil penelitian ini dapat memberikan gambaran bahwa Edukasi pijat oksitosin dapat memperbaiki perilaku menyusui pada ibu postpartum Kata kunci : edukasi, pijat oksitosin, perilaku menyusui, ibu postpartum.     ABSTRACT At the Rodliyah Achid Moga Hospital, around 110 postpartum mothers give birth each month, only 60% of the mothers breastfeed their babies and 40% have not breastfed their babies. The only action taken to deal with this was education on how to breastfeed and breast care, but education on oxytocin massage had never been carried out.  Objective: The aim of this research is to determine whether there is an effect of oxytocin massage education on the behavior of breastfeeding mothers at the Muhammadiyah Rodliyah Achid Moga Hospital.  This type of quantitative research uses a pre-experimental design with a "one group pretest-posttest design" approach.  This research uses the Kolmogorov Smirnov normality test because the total data is 86 respondents and the test results show sig < 0.01, meaning the data is not normally distributed. The data obtained shows that after education there was an increase in the average and minimum scores. Based on the Wilcoxon test, the Sig asymp value <0.05 was obtained. This means that oxytocin massage education influences the breastfeeding behavior of postpartum mothers at the Muhammadiyah Rodliyah Achid Moga Hospital. The results of this study can provide an illustration that oxytocin massage education can improve breastfeeding behavior in postpartum mothers   Keywords: education, oxytocin massage, breastfeeding behavior, postpartum mother

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