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Meilinah Hidayat
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Journal of Medicine and Health
Published by Universitas Kristen Maranatha
ISSN : -     EISSN : 24425257     DOI : 10.28932/jmh
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Medicine and Health (JMH) focuses on contributing towards science and research development that can be accessed by researchers and academic practitioners. Journal of Medicine and Health (JMH) is an open access journal, published biannually on every February and August. JMH receives original research articles, case report, and review articles related to biomedical sciences, clinical medicine, public health sciences, nutritional sciences, and medical herbs sciences. Articles should be written in good English or Indonesian language. All articles will be processed through peer review process.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 11 Documents
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Search results for , issue "Vol 4 No 1 (2022)" : 11 Documents clear
Perbedaan Penangkapan 99mTc-Pyrophosphate vs 99mTc- Methylenediphosphate dalam Mendeteksi Amyloidosis Jantung; Pengalaman Pertama di RSUP Hasan Sadikin Hadi Marzuki; Erwin A Soeriadi; Astri Astuti; Hendra Budiawan; Achmad Hussein S Kartamihardja
Journal of Medicine and Health Vol 4 No 1 (2022)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v4i1.3640

Abstract

Cardiac amyloidosis (CA) is a disorder caused by deposits of insoluble fibrils in the myocardium and an underdiagnosed cause of heart failure. Immunoglobulin Light Chain-Associated Amyloid (AL) and Amyloidosis Transthyretin-related (ATTR) are the two protein precursors that most commonly cause cardiac amyloidosis. It is important to distinguish between these two types of amyloidosis because the treatment and prognosis of each types is different. Recent advances in cardiac radionuclide imaging, in particular using bone-seeking agents such as 99mTc-Pyrophosphate (PYP) and 99mTc-Methylenediphosphate (MDP), can differentiate AL from ATTR. This study aimed was to investigate the uptake characteristic of both tracers in CA. Three patients with suspected of having cardiac amyloidosis underwent two cardiac radionuclide imaging examinations using those two different radiopharmaceuticals. The cardiac images were analyzed quantitatively and semi-quantitatively based on ASNC (American Society of Nuclear Medicine) criteria. Cardiac radioactivity uptake of 99mTc-PYP was better from those of 99mTc-MDP based on quantitative as well as semi-quantitative (visual assessment). Keywords: cardiac amyloidosis; cardiac imaging; 99mTc-PYP; 99mTc-MDP

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