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Green and Tropical Laboratory for Sustainability
Published by Universitas Muhammadiyah Malang
ISSN : -     EISSN : 30645069     DOI : https://doi.org/10.22219/gtlabs.vxiy.xxxxx
Core Subject : Science, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Environmental Science Social Sciences
Green And Tropical Laboratory For Sustainability encompasses a broad range of research areas related to the Sustainable Development Goals (SDGs), including but not limited to: Laboratory-Based Studies on Tropical Ecosystems: Research on biodiversity, climate change, ecosystem restoration, and natural resource management within tropical regions. Development and Application of Laboratory Technologies for Sustainable Energy: Investigations into renewable energy sources, energy efficiency, and clean energy technologies that contribute to sustainable development. Laboratory Research on Waste Management and Pollution Control: Studies focused on waste treatment, recycling, circular economy practices, and pollution mitigation strategies. Laboratory Investigations into Food Security and Sustainable Agriculture: Research on organic farming, agroforestry, food safety, nutritional value, and sustainable agricultural practices. Laboratory Studies on Human Health and Environmental Interactions: Exploration of environmental health risks, infectious diseases, toxicology, and public health interventions. Research on Digital Governance for Sustainable Development: Studies examining the role of digital governance in enhancing sustainability efforts, including the application of digital tools and technologies in managing environmental resources, monitoring ecological impacts, and supporting policy-making processes. Social and Educational Research in the Context of Sustainability: Investigations into social dynamics, educational initiatives, and community engagement strategies that align with sustainability goals, particularly in tropical regions. This includes the integration of sustainability concepts into educational curricula and the promotion of social practices that support green and sustainable development.
Arjuna Subject : Umum - Umum
Articles 5 Documents
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Search results for , issue "Vol. 2 No. 1 (2025): August" : 5 Documents clear
In silico test of cytotoxic activity and toxicity of guava leaf compounds (Psidium guajava) as a drug for diabetes mellitus Aisha Azaria Nisa’ul Khoiro; Moh. Mirza Nuryady
Green and Tropical Laboratory for Sustainability Vol. 2 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/gtlabs.v2i1.38845

Abstract

Background: Diabetes mellitus is a metabolic disorder caused by a lack of the hormone insulin. Diabetes mellitus is characterized by elevated blood glucose levels due to the inactivity of the GLP-1 protein, which leads to decreased insulin function. Guava leaves (Psidium guajava) are suspected to have antidiabetic effects, but the active compound responsible for lowering blood glucose levels is unknown. Objectives: The aim of this study was to determine the physicochemical properties and toxicity as well as the mechanism of active compounds of guava leaves using In Silico studies. Methods: The method in this research is a computer-based experiment in the form of Molecular docking, by comparing the active compounds in guava leaves with the target protein GLP-1. Results: The results of the In Silico test show that the Caryophyllene and Cadala compounds have binding affinities of -7.8 and -6.9 and the toxicity class for caryophyllene is class 6, which indicates that the compound is not toxic, while for cadala the toxicity class is included in class 5, which indicates that it may be harmful if swallowed. Conclusion: The compounds Cadala and Caryophyllene demonstrated that further testing is warranted to determine the proportions required to maintain their safety. Meanwhile, benzene was not considered a drug candidate because its carcinogenicity was shown to be active in toxicity tests, suggesting it cannot be used as a drug candidate for diabetes mellitus.
Information technology-based waste management at the Sukoharjo Pati landfill with an importance performance analysis approach Metadelphi Werdianto; Nany Yuliastuti; Mochamad Arief Budihardjo
Green and Tropical Laboratory for Sustainability Vol. 2 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/gtlabs.v2i1.38857

Abstract

Background: Waste management is a crucial issue in achieving a clean and sustainable environment, necessitating the use of environmental information technology to improve its effectiveness. However, the effectiveness of this technology in waste management at final disposal sites still requires further analysis to meet public expectations and satisfaction. Objectives: This study aims to analyze environmental information technology-based waste management at the Sukoharjo Landfill, Pati Regency, using the Importance Performance Analysis (IPA) approach. Methods: The evaluation method is used to measure the effectiveness of waste management with data collected through surveys, interviews, observations, and literature studies. Data analysis was carried out quantitatively using the IPA method and qualitatively using descriptive-interactive techniques based on the stages of Miles and Huberman. Results: The results of the study show: (1) waste management includes all stages of management, namely planning, organizing, implementing, monitoring, evaluating, and following up; (2) environmental information technology is effective and satisfies the community, with 86.27% of respondents rating its performance as very good and 92.85% feeling satisfied; and (3) the IPA approach shows very high management performance (80.03%) and community expectations are met (87.13%). Conclusion: The results of the study show that the use of environmental information technology in waste management at the Sukoharjo Landfill has proven effective and is able to meet expectations and increase community satisfaction.
In silico test of cytotoxic activity and toxicity of bioactive compounds of Aloe vera extract as a candidate drug for diabetes mellitus Eva Ayuntya; Moh. Mirza Nuryady
Green and Tropical Laboratory for Sustainability Vol. 2 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/gtlabs.v2i1.38873

Abstract

Background: Diabetes mellitus is a disease characterized by hyperglycemia and metabolic disorders associated with absolute or relative deficiency in insulin action and/or secretion. Aloe vera contains several compounds with antihyperglycemic effects, and Aloe vera can mimic insulin and lower blood glucose levels. Objectives: The aim of this research is to determine the predicted physicochemical properties, toxicity and mechanisms of active compounds in Aloe vera. Methods: The method used is a computer-based experimental Molecular Docking, by predicting physicochemical, toxicity tests, bioactivity tests, protein and ligand preparation, score analysis, validation of molecular docking results, and 3D molecular visualization analysis by comparing three active Aloe vera compounds with the target protein GLP-1. Results: In silico results showed that sinapic acid, catechin, and quercitrin have good physicochemical, pharmacokinetic, and toxicity properties. In silico testing of the active Aloe vera compounds showed binding values of less than 10 with the same amino acid residues in the catechin and quercitrin compounds that bind to the active site of the GLP-1 protein. Conclusion: The active compounds contained in Aloe vera, sinapic acid, catechin, and quercitrin, can be predicted to be used as candidates for diabetes medication.
In silico study: Candidate compounds of Jatropha curcas L. plant as breast cancer inhibitors Desti Amalia Ramadhayanti; Moh Mirza Nuryady
Green and Tropical Laboratory for Sustainability Vol. 2 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/gtlabs.v2i1.38880

Abstract

Background: Cancer is a disease caused by the growth of abnormal cells in the body, which can grow and attack any part of the body. When someone has cancer, the microRNAs in the body play a role in preventing cancer from multiplying. Therefore, inhibiting microRNAs could be a solution for developing cancer drugs. One plant that can be used as a natural chemotherapy agent is Jatropha curcas L., also known as the castor oil plant. Objectives: Jatropha curcas plants can be used as an alternative to petroleum, namely in the manufacture of biodiesel and as a raw material for treating diseases including cancer, skin diseases, respiratory diseases, and infectious diseases. Methods: The research method is the 3D structure of Sirtulin1 protein (pdb id: 4I5I), β-sitosterol and 2-(Hydroxymethyl)-2 nitro-1,3-propanediol prepared with the PyRx program. Molecular docking was analyzed by the interaction of β-sitosterol and 2-(Hydroxymethyl)-2 nitro-1,3-propanediol with Sirtulin1 protein using Autodock 4.2 software. and visualized with discovery studio version 4.1. Data analysis used descriptively. Results: The results of the study of β-sitosterol and 2-(Hydroxymethyl)-2 nitro-1,3-propanediol with sirtulin1 protein produced 12 amino acid residues in the form of SER275, ASN465, SER442, ASP272, GLU467, PHE321, CYS380, ARG384, ILE387, PHE321, PHE366, PHE388. The presence of this bond indicates that the test ligand can bind to the amino acids present in the Sirtulin1 protein. Conclusion: Based on the docking results, it is known that the bonds that occur in the 2-(Hydroxymethyl)-2 nitro-1,3-propanediol ligand and the Sirtulin1 protein are Conventional Hydrogen Bond and Carbon Hydrogen Bond bonds. Hydrogen bonds are the strongest bonds among covalent bonds so they are more widely distributed and produce pharmacological activity. Thus, compounds that have amino acid residues in the form of hydrogen bonds are stronger and produce high inhibitory activity. The presence of these bonds indicates that the test ligand can bind to the amino acids in the Sirtulin1 protein.
In silico study of beta citronellol compound in lime plant (Citrus aurantifolia) as a drug candidate for enterovirus disease Early Maulina; Tanto Situmorang
Green and Tropical Laboratory for Sustainability Vol. 2 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/gtlabs.v2i1.41033

Abstract

Background: Human Enterovirus is an RNA virus affecting millions globally, particularly children, causing a range of symptoms from mild to severe, including serious conditions like meningitis and AFP. Current synthetic treatments have side effects, necessitating the exploration of natural alternatives. Lime (Citrus aurantifolia) is a potential candidate. Objectives: To determine the potential of the beta citronellol compound found in lime (Citrus aurantifolia) as an inhibitor of enterovirus activity in in-silico study. Methods: This research employed an in-silico method. This involved analyzing the bioactivity potential of beta citronellol, assessing its bioavailability and toxicity, and performing molecular docking. Data was sourced from PubChem and RSCB PDB. Bioactivity probability was predicted using PASS Online. Virtual screening was conducted via molecular docking with PyRx. Visualization was performed using PyMol and Discovery Studio. Results: The toxicity prediction and molecular docking analysis of beta citronellol against the 3J3Z protein indicated that this compound has a high and specific potential as a receptor candidate for the enterovirus target. Conclusion: The findings of this in silico study suggest that the beta citronellol compound possesses good antiviral activity against enteroviruses.

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