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INDONESIA
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology)
Published by Badan Tenaga Nuklir Nasional
ISSN : 14113481     EISSN : 25031287     DOI : https://search.crossref.org/?q=%22jurnal+sains+dan
Core Subject : Health, Science, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Energy Environmental Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics
Focus of Publication in Indonesian Journal of Nuclear Science and Technology : Result of experiment in the field of nuclear science and technology and its applications in various fields. Acceptable topics include: Radioisotope, Radiopharmacy, Nuclear Medicine, Nuclear Radiation and its Measurement, Nuclear Physics and Reactors, Nuclear Instrumentation and Radioactive Waste including its applications in the fields of health, biology, industry, agriculture, metallurgy and environment
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 22, No 1 (2021): February 2021" : 5 Documents clear
Analytical Capabilities of EDXRF for Determination of Rare Earth Elements Syukria Kurniawati; Muhayatun Santoso; Diah Dwiana Lestiani; Natalia Adventini; Woro Yatu Niken Syahfitri
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 22, No 1 (2021): February 2021
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2021.22.1.5815

Abstract

Rare earth elements (REE) are present in the lanthanide range and are widely used in high-tech and clean technology applications that are predicted to grow significantly in the coming decades. Therefore, there will be a high demand for REE in the future that will impact the needs for development of sensitive and selective methods for determination of REEs such as X-Ray Fluorescence (XRF). Reliability of REEs analysis results depend on analytical capability of XRF instrument’s performance. Analytical capability shows the ability of the instrument to perform sample analysis with high accuracy and precision and proven by validation so that the results obtained are reliable. The aim of this study is to assess the analytical capability of XRF for REEs analysis in samples particularly Lanthanum (La), Cerium (Ce), Neodymium (Nd), Samarium (Sm) and Yttrium (Y), by performing method validation of energy dispersive x-ray spectrometers (ED-XRF). Four measurement conditions that covered the selected elements were defined. Accuracy, precision and detection limits determination were performed by measuring the CRM In House Monazite Sand. The yield of the selected element corresponds to its certified value, with a %recovery between 95.99 to 103.1%. The %RSD values ranging from 0.59 to 5.19%. The detection limits (LLD) of ED-XRF ranged from 8.78 to 67.4 ppm. The results showed the good analytical capability of ED-XRF method for REEs analysis.
The Effect of Gamma Irradiation on Ethanolic Extract of Temulawak (Curcuma xanthorrhiza Roxb.) Against Human Cancer Cell Lines Susanto Susanto; Ermin Katrin Winarno; Hendig Winarno
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 22, No 1 (2021): February 2021
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2021.22.1.6221

Abstract

The Effect of Gamma Irradiation on Ethanolic Extract of Temulawak (Curcuma xanthorrhiza Roxb.) Against Human Cancer Cell Lines. One of the medicinal plants that are widely used by the people of Indonesia is temulawak (Curcuma xanthorrhiza Roxb.) with the active ingredient is curcuminoid. The curcuminoid is a yellow compound that is believed to have anti-cancer properties, therefore its properties must be maintained in the post-harvest process. This research aimed to study the effect of gamma irradiation on the simplicia of C. xanthorrhiza rhizomes in inhibiting the proliferative activity against human cancer cell lines. The dry powder of C. xanthorrhiza rhizome was irradiated with gamma at a dose of 10 kGy in 2 replications, then extracted using ethanol solvent, evaporated, to obtain an ethanol extract. As a control, an un-irradiated sample was prepared and extracted in the same manner. Each ethanol extract from irradiated and control samples was then tested for their antioxidant activity by DPPH method and antiproliferative activity against human cancer cell lines (HUT78, A549, HeLa, and THP1). The results showed that the ethanol extract of irradiated C. xanthorrhiza rhizome with a dose of 10 kGy still had antioxidant activity and anticancer properties based on the bioassay against four those human cancer cell lines, although the antiproliferative activity decreased between 8-30% compared to the control sample. The highest antiproliferative activity was shown by the ethanol extract against HUT78 cancer cell line with IC50 values of 5.4 and 10.7 µg/ml for control and irradiated samples respectively. Based on the silica gel TLC plate, the ethanolic extracts of C. xanthorrhiza rhizome both unirradiated- and irradiated samples contained curcumin (Rf = 0.58) and demethoxycurcumin (Rf = 0.38).
Morfologi dan Tingkat Ekspresi Molekuler Mamosfir Asal Sel Kelenjar Susu Macaca fascicularis yang Diiradiasi Sinar Gamma Sebagai Model Onkogenesis Iin Indriawati; Fitriya Nur Annisa Dewi; Silmi Mariya; Iin Kurnia Hasan Basri; Teja Kisnanto; Dwi Ramadhani; Irma Herawati Suparto
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 22, No 1 (2021): February 2021
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2021.22.1.6141

Abstract

Sel punca memiliki peran penting dalam perkembangan jaringan normal maupun onkogenesis, termasuk pada kejadian kanker payudara. Keterkaitan sel punca dan pembentukan kanker payudara perlu diteliti agar dapat ditemukan metode pencegahan dan terapi baru yang efektif. Teknik kultur mamosfir telah terbukti memperkaya populasi sel punca pada sel kelenjar susu manusia dan satwa primata. Penelitian ini bertujuan untuk mengembangkan model onkogenesis kelenjar susu secara in-vitro dengan induksi sinar gamma pada kultur mamosfir yang berasal dari kelenjar susu monyet ekor panjang (Macaca fascicularis). Analisis morfologi sfir dan uji imunofluoresensi untuk γH2AX dilakukan setelah pajanan iradiasi 4 Gy selama 62 detik pada kultur mamosfir. Penanda molekuler sel punca dewasa dan sel punca kanker dievaluasi menggunakan qRT-PCR. Hasil penelitian menunjukkan bahwa iradiasi sinar gamma menimbulkan kerusakan DNA (double strand break) di dalam sel-sel penyusun mamosfir. Pajanan radiasi juga mengubah morfologi sfir. Ekspresi penanda untuk sel punca dewasa kelenjar susu (CD49f atau Integrin Alpha 6; ITGA6) dan sel punca kanker (CD133 atau Prominin-1; PROM1 dan CD44) lebih tinggi pasca iradiasi dibandingkan dengan kontrol. Temuan ini menunjukkan bahwa kultur mamosfir iradiasi yang berasal dari kelenjar susu monyet berpotensi dikembangkan sebagai model in-vitro untuk studi onkogenesis, terutama yang berkaitan dengan deregulasi sel punca dan risiko kanker payudara. 
Physicochemical Properties Of 131I-Rutin Under Acidic Labeling Condition As A Radiolabeled Compound For The Diagnosis Of Cancer Maula Eka Sriyani; Maudy Shintia; endah rosyidiah; Witri Nuraeni; Adinda Saraswati; Eva Maria Widyasari
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 22, No 1 (2021): February 2021
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2021.22.1.6286

Abstract

Radiolabeled rutin (131I-rutin) has potential use in future diagnosis of cancer. The physicochemical characteristics of 131I-rutin are essential in regard to its distribution and accumulation in the body. Therefore, to ensure successful delivery of a labeled compound, it is necessary to evaluate its physicochemical properties. The labeling of 131I-rutin was accomplished using the oxidation method assisted by Chloramine-T under acidic conditions. Radiochemical purity value was measured by thin-layer chromatography (TLC-SG F254) using 100% methanol as the mobile phase. The electrical charge of 131I-rutin was determined by the paper electrophoresis. Moreover, the lipophilicity (P) was evaluated by the partition coefficient in the organic-water liquid. Plasma protein binding was determined in vitro by precipitation method using a 5% trichloroacetic acid (TCA) solution. The results showed that 131I-rutin has a neutral charge and a lipophilicity value (Log P) of 0.395 ± 0.203 (hydrophilic), and was bound to human blood plasma proteins with a percentage of 69.36% ± 1.88%.
Performance of 113Sn/113mIn Generator Prototype based on Zirconium Oxide for Radiotracer Applications in Industry Duyeh Setiawan; Ade Suherman; Titin Sri Mulyati
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 22, No 1 (2021): February 2021
Publisher : BATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jstni.2021.22.1.6486

Abstract

This paper describes the results of the research of 113Sn/113m radioisotope generator at the Centre for Applied Nuclear Science and Technology - National Nuclear Energy Agency with the aim of making radioisotope generator for radiotracer applications in industry. This research discussed the need of short half-life radiotracer for several material phases such as oil, water, gas and solid. Based on desired physical properties of half life, radiation type and energy, 113mIn radioisotope was selected. Thus, the performance of 113Sn/113mIn generator prototype based on zirconium oxide was determined for this purpose. The final product specification in the form of 113mInCl3 is clear solution, pH 2 with obtained yield of 95 %, radionuclide purity of 95 % and radiochemical purity of 95 %.

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