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The Journal of Experimental Life Sciences (JELS)
Published by Universitas Brawijaya
ISSN : 20872852     EISSN : 23381655     DOI : 10.21776/ub.jels
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience
The Journal of Experimental Life Science (JELS) is a scientific journal published by Postgraduate School, University of Brawijaya as distribution media of Indonesian researcher’s results in life science to the wider community. JELS is published in every four months. JELS published scientific papers in review, short report, and articles in Life Sciences especially biology, biotechnology, nanobiology, molecular biology, botany, microbiology, genetics, neuroscience, pharmacology, toxicology, and Applied Life Science including fermentation technology, food science, immunotherapy, proteomics and other fields related to life matter. JELS is a scientific journal that published compatible qualified articles to the academic standard, scientific and all articles reviewed by the expert in their field. The Journal of Experimental Life Science (JELS) have a vision to become qualified reference media to publish the best and original research results and become the foundation of science development through invention and innovation on cellular, molecular, nanobiology, and simulation work related to life matter rapidly to the community. The Journal of Experimental Life Science (JELS) has objectives to published qualified articles on research’s results of Indonesian researchers in life science scope. JELS encompasses articles which discuss basic principles on natural phenomenon with cellular, molecular, and nanobiology approach.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 11 Documents
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Search results for , issue "Vol. 10 No. 2 (2020)" : 11 Documents clear
Effects of Bitter Melon (Momordica charantia L.) and Starfruit (Averrhoa bilimbi L.) on Proinflammatory Cytokines Produced by Hyperglycemic Mice Model Bella Pradina Novinda Wardani; Sri Rahayu; Muhaimin Rifa'i
The Journal of Experimental Life Science Vol. 10 No. 2 (2020)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2020.010.02.03

Abstract

Hyperglycemia is a condition of excessive blood glucose in blood plasma caused by damage to the pancreatic beta-cell structure that causes impaired insulin secretion. This study aimed to investigate the combination of Bitter Melon and Star Fruit ethanol extract (SBME) on pro-inflammatory cytokines production in hyperglycemic albino mice models. This study was treated in 25 female albino mice weighing 25-30 and 9 weeks old. STZ was given in a dose of 145 mg.kg-1 BW intraperitoneally. Hyperglycemic mice were given orally with SBME ethanol extract at doses 10, 40, and 160 mg.kg-1 BW for two weeks. After treatment, pro-inflammatory molecules were analyzed by flow cytometry from the splenic cell. This study showed that SBME treatment can reduce the production of pro-inflammatory cytokines especially IL-1b, but increases IL-6 in hyperglycemic mice. After treatment with SBME at a dose of 40, the IL-1b pro-inflammation molecule decreased significantly (p>0,05). It reached a normal physiological level, but the dose has not been able to reduce the IL-6 pro-inflammation molecule significantly. The conclusion of this study was Bitter Melon and Star Fruit ethanol extract (SBME) with a treatment of 40 mg.kg-1 BW can suppress IL-1b pro-inflammatory cytokines in hyperglycemic mice models, but has not been able to reduce the expression of IL-6 pro-inflammatory cytokines. Suggesting this medicinal herb might be a useful strategy for future therapeutic interventions in degenerative diseases or diseases involving cell activation, but a study of doses is needed.Keywords: Averrhoa bilimbi L., Hyperglycemia, Inflammation, Momordica charantia L.

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