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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 25, No 03 (1993)" : 14 Documents clear
Role of insulin resistance and hyperinsulinemia in cardiovascular disease Ahmad H. Asdie Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Resi,stance to insulin-stimulated glucose uptake is present in the great majority of patients with impaired glucose tolerance or type 2 diabetes mellitus, in first degree relatives of patients with type 2 diabetes mellitus, as well as in approximately 25% of non-obese individuals with normal oral glucose tolerance. Deterioration of glucose tolerance can be prevented if beta cell is able to produce more insulin resulting hyperinsulinemia.The association between hypertension and diabetes mellitus is well recognized. Several reasons for the coexistence of these disorders have been postulated, i.e. as part of aging process, diabetes causes macrovascular and microvascular disease, renovascular stenosis which is enhanced by the development of hypertension. Insulin causes renal sodium reabsorption, stimulates the sympathetic nervous system, increases intracellular calcium, and is a vascular growth factor.Insulin resistance, hyperinsulinemia, impaired glucose tolerance, increased plasma triglyceride, and decreased HDL-cholesterol concentration have been shown to be associated with increased risk of coronary heart disease. Based upon these considerations, it raised the possibility that insulin resistance and hyperinsulinemia are involved in the etiology and clinical course of three major related disease; the type 2 diabetes mellitus, hypertension, and coronary heart disease.Key Words: hyperinsulinemia insulin resistance cardiovascular disease glucose homeostasis aging
Hepatitis-C virus (HCV) Suwarso Suwarso
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A new problem on hepatitis for Indonesian is hepatitis-C virus (HCV). This infection is endemic, majority sub-clinic and progressive in chronic. Viral transmission is primarily via a parenteral route, while other routes are still in debate.Diagnostic approach should be focused on how this virus developed.KeyWords: hepatitis-C virus molecular biology Westem-blot-HCV blood transfusion epidemiology
Usia Lanjut Anonim Anonim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Key Words: Ageing
The Use of Monoclonal Antibody in the Detection of Circulating Antigen in Malayan Filariasis Cases: a Preliminary Report Soeyoko Soeyoko
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Filariasis (penyakit kaki gajah) di Indonesia disebabkan oleh cacing filaria. Wuchereria bancrofti, Brugia malayi dan Brugia tintori. Dan ketiga spesies tersebut, B. malayi merupakan penyebab utama filariasis terutama di daerah endemik di luar Jawa. Diagnosis filariasis sampai saat ini masih didasarkan atas hasil pemeriksaan klinis, parasitologis dan imunologis konvensional, namun ketiga cara tersebut banyak kelemahannya.Dalam era bioteknologi, dengan diternukannya teknik hibridoma; dapat dihasilkan antibodi monoklonal yang spesifik terhadap filaria B. malayi dan mampu mengikat circulating antigen dalam senim penderita filariasis.Dengan teknik pemeriksaan dot-blot didapatkan serum yang mengandung circulating antigen sebagai berikut: 75% pada serum kelompok penderita simtomatik-rnikrofilarernia; 40% serum kelompok penderita shntomatik-amikrofilaremia; 88,8% serum kelompok penderita asimtomatik-mikrofilarernia; dan 19,6% serum kelompok penderita asimtomatik-amikrofdarentia.Antibodi monoklonal dapat membantu diagnosis filariasis terutama pada yang asimtomat ik-amikrofilarem ia.Key Words: Brugia malayi- filariasis-filarial circulating antigen-antifilarial monoclonal antibodies-dot-blot assay

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