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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol 26, No 02 (1994)" : 12 Documents clear
The Role of Lipids in Atherogenesis Ahmad H. Asdie Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Hiperkolesterolemia, hipertensi, diabetes dan merokok telah lama diakui sebagai faktor risiko utama penyakit jantung koroner. Komponen utama bercak aterosklerotik adalah timbunan lipid, terutama ester kolesterol dan kolesterol, proliferasi dan perubahan sel otot polos intima arteri. Timbunan lipid dalam intima arteri terutama berasal dari low-density lipoprotein (LDL) yang telah termodifikasi dalam darah. Hal ini terjadi sebelum proliferasi otot polos intima timbul. Walaupun hubungan kausal antara hiperkolesterolemia dan penyakit jantung koroner sudah lama diterima para pakar, namun mengenai peran trigliserida dan jenis lipoprotein lainnya (high density lipoprotein, HDL) masih belum didapatkan kesepakatan. Dalam makalah ini dibahas pecan lipid dalam proses aterogenesis.Disimpulkan bahwa kelainan lipid yang berupa peninggian kolesterol (dan LDL) dan trigliserida (VLDL, terutama VLDL-sisa), dan.penurunan HDL merupakan faktor risiko bebas aterogenesis. Faktor hormonal ikut berperan dalam proses aterogenesis, dan diduga melalui efek hormon terhadap metabolisme lipid.Key Words : atherosclerosis - lipid - lipoprotein - apolipoprotein - coronary heart disease
Liver Function Test in Chronic Hemodialyzed Patients with Anti Hepatitis C Virus Antibody Mochammad Sja'bani Mochammad Sja'bani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.099 KB)

Abstract

Untuk mengetahui fungsi hepar pada penderita gagal ginjal terminal dengan antibodi terhadap virus hepatitis C (anti HCV) positif yang menjalani hemodialisis, suatu penelitian potohOlintang telah dilakukan di Unit Hemodialisis. Rurnah Sakit Umum Pusat Dr: Sardjito, Yogyakarta.Selama penelitian ditemukan 58 penderita (42 laki-laki. 16 perempuan) dengan 32 (55%).anti HCV positif. Tidak ditemukan perbedaan yang bermakna antara kelompok dengan anti HCV positif dan kelompok dengan anti HCV negatif dalam kadar aspartate amino transferase (AST) (46,22 ± 20,85 UI/1 vs 40,15 ± 20,37 U1/1, p > 0,05), kadar alanine amino transferase (ALT) (45,44 ± 26,26 IU/1 vs 37,04 ± 23,03 U1/1, p > 0,05), kadar alkaline phosphatase (ALP) (156, 31 ± 141,141U/1 vs 144,57 ± 82,15.1y/l, p > 0,05),. dan jumlah hemodialisis (8 sampai dengan 733 kali). Kadar AST yang rneningkat di afas 1,5 kali nilai normal cenderung ditemukan lebih besar tapi secara statistik tidak signifikan pada kelompok dengan anti HCV positif dibanding dengan kelompok dengan anti HCV negatif (56.0% vs 30,7%, p > 0,05) yang mungkin akibat jumlah sampel yang kecil. Frekuensi transfusi ditemukan lebih tinggi secara bermakna pada kelompok dengan anti HCV positif dibanding kelompok dengan anti HCV negatif (3,53 ± 3,47 vs 2,23 ± 1,47 kali, p < 0,05).Key Words : hepatitis C virus-anti HCV antibodies -end stage renal disease-blood transfusion- hemodialysis

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