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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 36, No 1 (2004)" : 14 Documents clear
Glycosilation reaction models and the role of Madagascar periwinkle (Catharanthus roseus CU G. Don)' S leaves infusion as protein damage inhibitor Rizky Taufan Firdaus Rizky Taufan Firdaus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background : Glycosilation is a reaction between protein and glucose in high concentration. The basic of this reaction is the continuous increase of glucose concentration, followed by a hooking between glucose with the amin primary structure of the protein. Beside form the AGEs, glycosilation reaction forms free radicals as the side product. The free radical reaction with the protein forms a crosslinking of the protein and then change the structure of the protein.Objectives : This research was carried out to know glycosilation reaction model and the role of madagascar periwinkle ICatharanthus roseus ELI G. Don)' s leaves infusion as protein damage inhibitor. Method : This research is an experimental and explorative research. This research was carried out in two steps, the making of infusion and the test for protein damage inhibition by using the infusion of madagascar periwinkle' s leaves and glyclazide.Result : The activity of madagascar periwinkle's leaves infusion to inhibit the protein damage is 21,29% while the activity of glyclazide is 96,77%.Conclusion : The infusion of madagascar periwinkle (Caiharanihus roseus EL.] G. Don)'s leaves can inhibit the protein damage because of the glycosilation reaction but lower than the glyclazide's.Key words : Madagascar periwinkle - glycosilation - free radical - protein damage
Epidemiology of cervical-root caries on teeth: High prevalence in the coca leaf chewing in the Andean people. Etty Indriati Etty Indriati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Cervical-root caries on teeth often called rampant caries or circular caries often suffered by children who consumed bottled sweet milk. In adult, cervical-root caries occurs in unique cases such as cancer patients who undertake chemotherapy, and narcotic addicts.Objective: The research was aimed to study the dental and oral health of Andean people who have traditionally been chewing coca-leaves as a part of their cultural and integral lives.Materials and Method: The subject of study was 210 Aymara people from highland Chile and Bolivia, Andes. They were given questionnaire whether they chew coca leaves or not. Without knowing whether one chewed coca leaves or not, each individual was examined for: the carious teeth, the caries location, the periodontal stage, the oral pH, the molar radices, the molar loss, and the total number of teeth preserved.Result: The result showed that people who chewed coca-leaves every day suffered cervical-root caries on their molar teeth, only radices of molars preserved, or even lost their molar teeth. They also suffered tongue desquamation and periodontal damage at the buccal area of molar teeth. In contrast, those who did not chew coca-leaves were relatively free from these dental disadvantages. Statistical analysis showed significantly high correlation between duration and intensity of chewing coca leaves with dental disadvantages (R=0,62 for molar loss; R=0,63 for bad periodontal status; and R =0,54 for cervical-root caries).Conclusion: It is concluded that habitual chewing of coca leaves damaged the periodontal region of the molar area, caused the root of the molar teeth to expose and led to cervical-root caries, then, only roots of molar preserved, and last, the lost of molar teeth. The high prevalence of cervical-root caries in coca-leaves chewers is in accord with other conditions such as cancer patients who undertake chemotherapy, and narcotic addicts. The alkaloid in the coca leaves are associated with the drying out the mouth leading to less self-cleansing and damaging the cervical-root area. Understanding the cultural tradition in a society is important if we were to understand the disease processes.Key words: coca leaves - Andes - epidemiology - cervical-root caries - molar
Effect of autovaccine on bacterial infection in mice Ning Rintiswati Ning Rintiswati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: In the present time therapy with antibiotics does not always solve the problem of infectious disease. Many factors influence infectious disease including immun mechanism, disease, resistant strain of microorganism, etc. Immunotherapy using autovaccine could be an alternative therapy, especially on chronic ulcer.Objective:The study observed the effect of autovaccine on ulcer of mice infected by various single bacteria and mix of bacteria.Methods :One hundred and eighty female mice were divided into 3 groups, group 1 was infected by Stapylococcus aureus, group 2 by E.coli, group 3 by mix bacteria (P. aeruginosa, Stapylococcus aureus, E. cob), and ten mice served as control. Half of each group of infected mice then was given autovaccine subcutaneously once a day for seven days. Development of skin lession was observed daily until recovery occured. Titer antibody against bacterial was evaluated using agglutination test.Results: Autovaccine group recovered faster than untreatment group. Number of death in infected group was higher than control group. Autovaccine increase antibody titer in mix bacterial infected group, and group infected by S.aureus, but had no effect on antibody production on group infected by E.coli. Conclusion: Autovaccine has no effect on recovery of skin lession of single infected mice, but effective to heal in mix infected mice.Key words: autovaccine - immunostimulator - bacterial infection - antibody - ulcer healing
The effect of the administration of vitamin K2 to the pregnant women on the activities of prothrombin group in cord blood. Rahajuningsih D. Setiabudy Rahajuningsih D. Setiabudy
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 1 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Hemorrhagic disease of the newborn (HDN) is a hemorrhage at the neonatal period. The most dangerous form of HDN is intracranial bleeding which may be fatal. The most frequent cause of HDN is deficiency of vitamin K dependent factors or prothrombin group.Objective: The aim of the study is to know the effect of the administration of vitamin K2 to the pregnant women on the activities of prothrombin gourp in cord blood.Methods: This was experimental design. Forty pregnant women were enrolled in this study. Vitamin K2 was given orally at the dosage of 10 mg twice daily. At delivery the cord blood was collected for the measurement of prothrombin group activities.Results: In the treatment group the median activities of prothrombin were 37.3%, F VII were 62.4%, F IX were 29.5%, and F X were 34.9%, while in the control group the median activities of prothrombin were 33.5%, F VII were 47.3%, F IX were 23.7%, and F X were 29.0%. The difference of the activities of vitamin K dependent factors between treatment group and control group was statistically significant. Conclusion: The administration of vitamin K2 to the pregnant women increases the activities of vitamin K dependent factors in the cord blood.Key words: hemorrhagic disease of the newborn - oral vitamin K2 - cord blood - vitamin K dependent factor activity

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