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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
 1   2 
Search results for , issue "Vol 37, No 02 (2005)" : 14 Documents clear
Amniotic membrane transplantation and trabeculectomy in a patient with pseudophakic bullous keratopathy Imam Tiharyo Imam Tiharyo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 02 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Objective: To report the success of amniotic membrane transplantation combined with trabekulectomy ina patient with Pseudophakic bullous keratopaty.Case Report: Amniotic membrane transplantation and trabeculectomy followed by tarsoraphy had been successfully performed in an eye of male patient 67 years old with pseudophakic bullous keratopathy, with increased intraocular pressure, the visual acuity for both eyes was hand movement, intraocular pressure in the right eye was 25 mmHg and 18 mmHg in the left eye. Patient felt painful in both eyes also. Pre surgical and post surgical medication with oral and eye drop antibiotic, oral and eye drop steroid, and oral vitamin was given.Result: The painful of both eyes disappeared on the            111 day after amniotic membrane transplantation and no recurrence in 2 week observation. In the right eye amniotic membrane dissolves on the 41n day after surgery, an epithelization occurred on the 51" day after surgery. On the 7th day the visual acuity was 2/60. Amniotic membrane dissolves on the 31d day in the left eye, epithelization occurred on the 4th day. On the 71h day the visual acuity reached 3/60 and remained constant until the 2"tl week of observation.Conclusion: Amniotic membrane transplantation followed by tarsoraphy is effective for pseudophacic bullous keratopathy treatmentKey words: Pseudophacic - bullous keratopathy - amniotic membrane transplantation- trabeculectomy-intraocular pressure- visual acuity-
The role vitamin-C on phagocytosis of macrophage on C. albicans. Melok Tin Melok Tin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 02 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Several studies reported that vitamin-C can enhance immune response, including phagocytosis response on bacteria and virus. However at present there are only a few studies about the role of vitamin-C in phagocytosis response on fungi.Objectives: To determine the role of vitamin-C on macrophage phagocytosis on C. albicans.Methods: Ten ml blood was taken from healthy subject. Buffy coat containing monocytes was separated from the red-blood cells. After plating the mononuclear cells on the coverslip glass, the cells other than monocytes were washed out by tripsinization. The monocytes were treated with several doses of vitaminC i.e. 200 mg/mL, 100 mg/mL, 50 mg/mL, and 0 mg/mL as placebo. And then Candida suspension was added to the cells, stained PAS and HE counterstain. The result of macrophage phagocytosis activity was interpreted by counting intracellular Candida spores and was analyzed using one way ANOVA.Result: There is a high significant difference in the. number of intracellular candida spores, between vitamin-C 200 mg/mL compared to placebo (p<0.000); and there wasn't significant difference between 100mg/mL (p=0.064) and 50 mg/mL (p=0.709) compared to placebo.Conclusion: The dose of 200 mg/mL vitamin-C could increased macrophage phagocytosis activity on C.a/bicans significantly (p<0.01) compared to other doses. Key word: phagocytosis - macrophage - vitamin-C - C. a/bicans
Paradigm in the recent management of chronic myocard ischaemia. Bambang Irawan Bambang Irawan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 02 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Until now coronary heart disease is the number one killer in the world. Angina pectoris is one of the clinical manifestations of coronary heart disease. If there is an insufficient oxygen supply to meet the need ischaemic myocard will happen.Life style changing, drug treatment and operative procedure are applied for the management of pain caused by myocardial ischaemia. According to many big anti-thrombotic trials statin, ACE inhibitor, calcium inhibitor, beta blocker and nitrate are very helpful in the management of chronic coronary artery disease. Myocardial laser revascularization, enhanced external counter pulsation and spinal cord stimulation are alternative procedures in which we can handle it with common management. While conventional therapies are continued to be improved, strategies to increase myocardial circulation by stimulating formation of collateral vessels around the obstructed coronary arteries are also in development. These approaches include angiogenesis, protein transfer, gene therapy and cell therapy. It is hoped that those approaches will safely and effectively applied in the management of chronic coronary artery disease. Key words: Coronary heart disease - chronic stable angina - myocardial ischaemia - new approaches
Correlation between immediated pigmentation with oxydative DNA repair. A study among elementary school children under sun exposured sport activity Retno Mustikaningsih Retno Mustikaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 02 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Oxydative DNA damage, namely 8-OHdG, may occurred due to DNA oxydation by reactive oxygen species (ROS). Unrepaired 8-OHdG may initiate a carsinogenesis due to G to T transversion of gene point mutations. The 8-OHdG repair can be measured by determination of urinary 8-OHdG level. It is well known that ROS reaction with preexisting melanin may perform an immediate pigmentation darken-ing (IPD) and it can be measured by mexameter. The correlation between IPD and 8-OHdG repair capacity is still not known.Aim of Study: To know the correlation between IPD and 8-OHdG repair ability in order to predict the oxydative DNA repair capacity.Methods: Using of a quasi experimental design, 8-OHdG urine level alteration correlated with skin color alteration after oxydative stress among 30 healthy elementary-school children during sport activity pro-gram under sun exposure. 24 hours of skin color alterations as a IPD were measured by mexameter, and urinary-8- HdG- level were measured based on ELISA with 8-OHdG-Kit antibody. The correlation be-tween IPD and     8-OHdG urine level alteration was analyzed with Spearman test.Results: There was a very significant correlation between immediate pigmented darkening and urinary                      8- OHdG level alteration (r=0.8562; p<0.01).Conclusion: IPD represents 8-OHdG repair capacity after oxydative stressed under sun exposure Keyword: immediate pigmention darkening -  8-OHdG -mexameter - sun exposure 

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