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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 41, No 01 (2009)" : 14 Documents clear
The influence of stigma and depression on quality of life of leprosy patients Jenny MC Siagian, Carla R Marchira Agnes S. Siswati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Stigma attached to leprosy-affected individuals is one of the strongest stigma of diseases. Depression is often occurred to many lepers. Stigma and depression are two factors which affect the quality of life of the lepers. Objective: To determine whether stigma and depression affect the quality of life of leprosy patients in Dermatovenereology outpatient clinic at RSUP Dr Sardjito Hospital. Methods: It was a quantitative and cross-sectional research. The quantitative analysis was conducted with chi-square and multiple regression methods. Result: There was no significant correlation between stigma and quality of life of leprosy patients. The factors which significantly correlated with quality of life were gender, income, and depression score (p < 0.051. Depression score significantly affected the quality of life (B 1.876; P < 0.05; CI 1.166-36.5661. Conclusion: Depression affected the quality of life more than deformity and demographic factors among leprosy patients in Dermatovenereology outpatient clinic at RSUP Dr Sardjito Yogyakarta. Key words: stigma - depression - lepro
The influence of endometriosis peritoneal fluid on the development of mouse embryo in in vitro pre-implantation O. Wahyu, Djaswadi Dasuki Hasto Wardoyo, Ita Fauziah
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Endometriosis was associated with various immunologic changes detected both in the endometrial eutopic and blood edge sample. Some researchers reported that women with endometriosis have an increased amount of peritoneum fluid. Endometrial environment and peritoneal fluid diffusing to the ovarial tube may affect sperm-ovum interaction, initial phase of embryonic development and reduce endometrial receptability. The correlation between endometriosis and early in vitro embryonic development has been reported in some studies showing controversial results; therefore it is necessary to carry out researches to clarify the influence of endometriosis on the early embryonic development. Objective: to identify the influence of peritoneal fluid of infertile women with endometriosis and normal peritoneum fluid of fertile women on the development of mouse embryo in in-vitro pre-implantation. Methods: Prospective, randomized controlled trial subjects are 2 cells of the Swiss albino strain embryos super-ovulating procedure on mouse, 2 embryonic cells resulted from in-vivo fertilization were taken out and in-vitro culture was done with the exposure of 10% or 2.5% cell-free supernatant peritoneum fluid of infertile women with endometriosis and 10% or 2.5% cell-free supernatant peritoneum fluid of normal fertile women as the control. The blastocyst growth was observed in the 72 hour culture and hatching blastocyst culture in 96 hours. Results: An amount of 231 embryos of 2 cells was obtained. After 72 hours, there were 103 blastocyst cultures in both groups. Blastocyst development rate (BDR) culture with to endometriosis peritoneum fluid exposure was lower compared with the normal peritoneum fluid exposure (32.2% vs 56.9%, RR 0.5, 95% CI: 0.42-0.77). Hatching rate (HRI of blastocyst culture with endometriosis peritoneum fluid was lower than that of normal peritoneum fluid (35.1 % vs 92.4%, RR 0.38, 95%CI: 0.24-0.59). The exposure to 10% endometriosis peritoneum fluid lowered BDR significantly compared with the normal peritoneum fluid, 7.7% vs 43.9% (RR 0.18,95% CI: 0.07-0.42); while the exposure to 2.5 % BDR was significantly different, (64% vs 74%, RR 0.87,95% CI: 0.66-1.13). Exposure to 10% compared to 2.5% normal endometriosis peritoneum fluid showed significantly decreased BDR (p 0.05). There was a significant interaction between type of peritoneum fluid (endometriosis vs normal) and the concentration of peritoneum fluid (10% vs 2.5%1 in decreasing BDR (RR 0.17,95% CI: 0.04-0.65). Conclusion: Exposure to endometriosis peritoneum fluid lowered the blastocyst development rate and hatching rate as compared with that to normal peritoneum fluid on the development of the in- vitro mouse embryo model. Key words: embryonic development - peritoneum fluid - endometriosis
Giant fetus in fetu in a female 'child with fever: A case report Hanggoro Tri Rinonce Pieri Kumaladewi, Siti Iqbalwati Rochadi, Mei Neni Sitaresmi, Soeripto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Fetus in fetu is a form of monozygotic diamniotic twin pregnancy where the parasitic twin installs and grows in the body of its partner. It is a rare condition, with a reported incidence of 1 in 500.000 live births. The majority of these cases occur in children younger than 18 months with the chief complaint of an intraabdominal mass, and have a 2:1 male predominance. The size and weight of the fetus vary, from 4 cm to 24.5 cm and from 1.2 g to 1.8 kg. Whether this entity represents a highly differentiated teratoma versus a parasitic twin remains controversial. The objective of this paper was to report a rare condition of giant fetus in fetu in female child with fever, especially to emphasize the importance of proper examination. Although fetus in fetu is very rare, it should remembered as a possibility in an intraabdominal. In some cases further detailed examinations should be done to confirm the diagnosis. A rare case of giant fetus in fetu in a 20th month female patient with fever was reported. Intrabdominal mass was found as the first sign related to fetus in fetu but was neglected by the parents. USG, plain abdominal photo and CT-scan had revealed the diagnosis preoperatively. Proper examination of the fetus in fetu was done including grossly by doing extensive dissection, and detailed histological tissue examination from several sites to make diagnosis completely. Key words: giant fetus in fetu - fetiform teratoma - congenital abnormality - retroperitoneal, fever
The effect of Pandanus conoideus Lam. oil on pancreatic (i-cells and glibenclamide hypoglycemic effect of diabetic Wistar rats Winarto Maliyah Madiyan, Nur Anisah
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Oxidative stress has been implicated in pathogenesis and progression of many degenerative disorders including naturally occuring and chemically-induced diabetes mellitus. In addition to the increased production of free radicals, antioxidant defense systems are disturbed in diabetes mellitus. As a result, oxidative stress may cause oxidative damage of cellular, including Ii-cells of pancreas. Objective: This study was aimed at investigating the effect of P. eonoideus Lam. on hypoglycemic activity of glibenclamide and histochemical changes in pancreatic islets. Methods: Thirty male Rattus norvegicus rats were used in the study, and randomly selected. The animals were divided into two groups, each group consisted of 15 rats. Each group was devided into 3 subgroups, the first subgroups were subgroup 1; 2, 3 and the second was subgroup 4, 5, 6. Streptozotocin was injected intraperitoneally at a single dose of 60 mg/kg for induction of diabetes in the second group. Subgroup 1 and 4 did not receive anything, subgroup 2 and 5 received glibenclamide 0.09 g/kgBW/day and subgroup 3 and 6 received P. eonoideus Lam. 0.3 mLlkgBW/day and glibenclamide 0.09 g/kgBW/day. Rats were given P. eonoideus Lam. and glibenclamide everyday for 14 days. Hypoglycemic activity was evaluated in overnight fasted at day 1, 7 and 14, and the acute hypoglycemic activity was evaluated at time 0, 1, 2, 4, and 6 hour aher treatment at day 14. Blood was collected from orbital sinuses. Blood glucose level was determined using GOD-PAP method. At 15 day rat were killed, the pancreas was removed. The data was compared statistically using one-way analysis of variance (AN OVA) followed by post-hoc test and student unpaired t-test. For the analysis of immunohistochemical data, a non parametric test (Kruskal-Wallis) was used. Results: The combination of P. eonoideus Lam. and glibenclamide produced significant reduction in blood glucose in the serial study at day 1, 7 and 14 and comparable with that of standard drug, glibenclamide also control groups in normal and diabetic rats. It also produced significant reduction of blood glucose in the serial study at time 0, 1, 2, 4, and 6 hour after treatment at day 14. Significant increasing histoscore, number and diameter of Langerhans islets were observed in P. eonoideus Lam. treated rats. Conclusion: P. eonoideus Lam. could increase hypoglycemic effect of glibenclamide and histoscore, number, and diameter of Langerhans islets in diabetic rats. Key words: minyak buah merah - pancreas B-cells - glibenclamide hypoglycemic effect - diabetes

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