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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 34 Documents
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Search results for , issue "Vol 44, No 01 (2012)" : 34 Documents clear
Non-ST elevation of acute myocardial infarction caused by probable acute stent thrombosis after drug eluting stent implantation: a case report Budi Yuli Setianto Bagus Andi Pramono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Nowadays, one of the modalities in performing reperfusion in coronary artery disease ispercutaneous coronary intervention. Before drug eluting stent era, the problem that occurs themost among interventional cardiologists is restenosis. After drug eluting stent era, restenosiscan be reduced significantly. Unfortunately, it further develops another problem, that is calledstent thrombosis. Mechanism of stent thrombosis is related to vascular response, thrombosis,coagulation, and clinical factors. Based on our experience, non-ST elevation acute myocardialinfarction is caused by probable acute stent thrombosis after drug eluting stent implantation.Therefore, the prevention and therapeutic approaches should be put first in our priority becauseit can provide a serious complication.
Correlation between overt hyperthyroid and subclinical hyperthyroid and cognitive impairment in Dr. Sardjito General Hospital, Yogyakarta, Indonesia Berkat Hia Pernodjo Dahlan Abdul Ghofir
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Hyperthyroidism is a metabolic imbalance resulting from excessive production of thyroid hormones.Overt or subclinical hyperthyroid prevalence has reached 20%. The differences in thyroid statusinduce apoptosis in adult cerebral cortex. Triiodothyroxine (T3) acts directly on the cerebralcortex mitochondria and induces the release of cytochrome-c which leads to apoptosis. Theincrease of hormone levels encountered in hyperthyroidism which is associated with an increasein necrotic death of neurons and oxidative stress has a negative effect on cognition. Severalstudies demonstrated the significant association of hyperthyroidism with cognitive impairment,despite remaining as controversial results. The study aimed to evaluate the correlation betweenovert hyperthyroid and subclinical hyperthyroid and cognitive impairment in hyperthyroidismpatients. This was a cross-sectional study involving 68 patients of hyperthyroidism who weretreated in Endocrine Clinic of Dr. Sardjito General Hospital, Yogyakarta. The inclusion criteriawere hyperthyroidism based on anamnesis, clinical examination and laboratory tests, age of 20-60 years, symptoms of hyperthyroidism, and minimum education of elementary school. Therelationship of hyperthyroidism and cognitive impairment, and multivariate analysis was analyzedby Chi-square and logistic regression tests, respectively. The results were considered as statisticallysignificant if the value of p was <0.05. The results showed that overt hyperthyroidism hadsignificantly associated with cognitive impairment (p = 0.021). Another variable associatedwith cognitive impairment was female gender (p = 0.019). In a multivariate analysis, the variablesof overt hyperthyroidism (p = 0.024) and sex (p = 0.025) had independent association withcognitive impairment. In conclusion, this study found that overt hyperthyroidism had a significantassociation with incidence of cognitive impairment compared to subclinical hyperthyroidism.Keywords: hyperthyroidism - overt - subclinical - cognitive - mini-mental state examination
Serum testosterone level and active caspase-3 of Leydig cells of diabetic Sprague-Dawley male rats after administration of soybean (Glycin max) powder suspension Wiyadi Dicky Moch. Rizal Sri Kadarsih Soejono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Diabetes mellitus (DM) is known as the main death cause in the world. This disease causes acuteand chronic complication. The common chronic complication on male reproduction system isthe decrease of testosterone level. This hormone is produced in the Leydig cells. Soybeans(Glycin max) has been used in the management of DM to maintain blood glucose level. However,the effect of soybean on serum testosterone level is still unclear. The aim of this study was toevaluate serum testosterone level and caspase-3 active of Leydig cells of diabetic Sprague-Dawley (SD) male rats model induced by streptozotocine (STZ) after oral ingestion of soybeanpowder suspension. This was an experimental study with pre and post test control group design.Thirty SD male rats, aged 11-12 weeks with body weight (BW) of 200-250 g were divided into 5groups with 6 rats in each group. The first group (G1) was normal rat control and the secondgroup (G2) was diabetic rat control. The third to fifth group (G3, G4 and G5) were diabetic rattreatment with oral ingestion of soybean powder suspension that was given once a day during 4weeks with dose of 400; 800 and 1600 mg/kg BW, respectively. The serum testosterone levelwas measured by an ELISA and active caspase-3 of Leydig cells were measured by animmunohistochemistry method. The result showed that the serum testosterone level and activecasapse-3 Leydig cells of diabetic rats model induced by STZ were not significantly differentafter oral ingestion of soybean powder suspension with dose of 400, 800 and 1600 mg/kg BW(p>0.05). In conclusion, soybean powder suspension did not affect the serum testosteronelevel and active caspase-3 Leydig cells in diabetic rats.Keywords: diabetes - soybean - phytoestrogen - testosterone - active caspase-3
Antenatal and postnatal risk factors of obesity in children age 2-5 years old in Yogyakarta District, Indonesia I Ketut Rutin Pastadita Sunartini Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Obesity and overweight have become a health issue throughout the world, with a dramaticincrease in prevalence each year. An obese child is thought to be adorable, but parents are notaware of the health risk it holds. Preventive measures by decreasing the risk factors for obesityare more effective than treating the problem. The aim of this study was to identify the riskfactors of obesity in antenatal and postnatal period in children in Yogyakarta District. This wasan observational study with a case control design. Criteria of obesity were defined according toWHO 2006 growth chart. Subjects were children age 2 to 5 years old that were enrolled inplaygroups in the Yogyakarta Distric with a targeted sample size of 41 children. Parents ofchildren that met the inclusion and exclusion criteria were given questionnaires to fill out. Theresults were analyzed using bivariate analysis and multivariate logistic regression. Thirty fourobese children and 34 non obese children (as control) were explored for the obesity risk factors.Prematurity/gestational age (OR=16; 95%CI=3.27-78.28; p=0.001), passive smoking (OR=5.50;95%CI=1.90-15.96; p=0.001), low birth weight (OR=7.27; 95%CI=1.45-36.47; p=0.008),eating more than 3 times daily (OR=2.19; 95%CI=1.66-2.89; p=0.007), meals that are high inlipid (OR=4.18; 95%CI=1.45-12.02; p=0.007) were shown to be risk factors for obesity inchildren. Factors such as picky eaters (OR=0.16; 95%CI=1.45-12.02; p=0.002), early introductionto solid food (OR=0.29; 95%CI=0.10-0.79; p=0.01), exercise (OR=0.25; 95%CI=0.06-0.32;p=0.04), and watching TV or playing video game under 2 hours daily (OR=0.30; 95%CI=0.09-0.95; p=0.04) were identified as protective factors against obesity. By using the multivariateanalysis, there were only 2 risk factors for obesity i.e. eating more than 3 times daily andprematurity/gestational age and there were only 2 protective factors i.e. exercise and introductionto solid food that remained statistically significant as independent factors influencing obesity inchildren aged 2 to 5 years old in the Yogyakarta District.Keywords: obesity - children age 2 to 5 years old - antenatal - postnatal - risk factors

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