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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
 1   2 
Search results for , issue "Vol 45, No 02 (2013)" : 14 Documents clear
Systemic provocation in doxycycline induced fixed drug eruption: a case report Anik Murwaningsih; Rosmarini Estri Sih Hananti; Niken Indrastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 02 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2872.668 KB) | DOI: 10.19106/JMedScie004502201306

Abstract

Fixed drug eruption (FDE) is recurrent lesions that upon repeated uptake of causative drug, always appears at the same skin and mucosal site. Determination of causal relationship in drug allergy is very important. In this case report, cases of doxycycline-induced FDE was reported. The subject of the research was a 29-year-old male, referred by dermatologist, with history of reccurent FDE. Physical examination revealed an oval well demarcated patch hyperpigmentation. Patch test was perfomed on previous involved and uninvolved site. The result of the patch test was irrelevant. Retesting patch test gave similar result. Systemic provocation test or drug provocation test (DPT)  with doxcycline were done with suspected drug under ambulatory survelance and gave positive result. In this case, the DPT succeeded to identify doxycycline as the causal agent of FDE. The work-up of a suspected drug hypersensitivity includes a detailed clinical history, physical examination, skin tests, and provocation tests. The DPT is recommended to confirm drug’s hypersensitivity reactions. Systemic provocation test is considered as the gold standard for diagnosing FDE.
The acceleration of garlic (Allium sativum L) ethanolic extract on gingival wound healing process in Wistar rats Indra Bramanti; . Ngatidjan; Setyo Purwono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 02 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5016.517 KB) | DOI: 10.19106/JMedScie004502201301

Abstract

Garlic (Allium sativum L) is a medicinal plant traditionally used to relieve pain. Garlic’s active constituents, allicin and triacremonone, have been proven to have antibacterial and antiinflammatory activity. The aim of this study was to investigate the effect of garlic ethanolic extract gel in gingival wound healing process of rats. Thirty male Wistar rats aged 10 weeks with with body weight 200-250 g were subjected in this study. Rats were divided randomly into five groups with six rats in each group. Group I as negative control was given sodium carboxymethyl cellulose (Na CMC) base gel. Group II as positive control was given Benzydamine® gel and Group IV-V were given garlic ethanolic extract gel at dose of 20, 40 and 80%, respectively. Each group was subdivided into two sub groups of three rats according to the decapitation period which were 5th (D-5) and 7th (D-7) day after the garlic extract gel application. Excisional wounds using punch biopsy, 2.5 mm in diameter, were created at the mandibular labial gingiva between right and left incisor teeth of the rats. The garlic extract gel of each preparation dose was then applied on the wound three times a day, starting at 0 day until 7th day. The decapitation was conducted on the D-5 and D-7. Histological slides of wounded tissue were prepared. Epithelial thickness, new blood vessel, and number of fibroblast were examined. The results showed that the epithelial thickness of garlic ethanolic extract gel groups was significantly higher than control group (p<0.05), especially after 5thday application. However, the number of new blood vessels and the amount of fibroblast of those groups were not significantly higher than control group (p>0.05). In conclusion, topical application of garlic ethanolic extract gel accelerates the gingival wound healing process in rats by increasing epithelial thickness.   
Negative Correlation between cross-linked fibrin degradation products (d-dimer) and glasgow coma scale (GCS) scores in patients with head injury Andriani Tri Susilowati; Usi Sukorini; . Setyawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 02 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (893.511 KB) | DOI: 10.19106/JMedScie004502201303

Abstract

Traumatic Brain Injury (TBI) is damage in the brain caused by a traumatically injuring external force. To observe its severity, the Glasgow Coma Scale (GCS) and Computed Tomography (CT) scan are used. In addition, D-dimer as an end product of fibrinolytic activity is proposed as the predictor of TBI outcome. The increase of D-dimer value is correlated with severity. CT-scan is too expensive and requires patients’ mobility that can cause worse incidents. The aim of this study was to correlate between D-dimer and GCS in patients with traumatic brain injury. The cross sectional observational analytic design was carried out in the study. The TBI patients with 24 hours onset admitted to Emergency Room Dr. Sardjito Hospital Yogyakarta will be included with inclusion and exclusion criteria consecutively. Glasgow coma scale was measured and plasma D-Dimer was examined using Nycocard with immunofiltration method. Correlation between plasma D-Dimer and Glasgow Coma Scale was tested using Pearson Correlation when the population distribution was normal and Spearman when it was not normally distributed. There was a strong negative correlation between D-dimer and Glasgow Coma Scale (r=-0.622; p<0.001) and Prothrombin Time with D-dimer value (r=0527; p<0.001). Moreover, it was found that haemoglobin had a correlation with D-dimer (r=-0.517; p=0.001). Haemoglobin and PT had a correlation with Glasgow Coma Scale (r=0.419 vs -0.591; p<0.001) and neutrophil had poor correlation with Glasgow Coma Scale (r=-0.336; p=0.034). In conclusion, there was a strong negative correlation between degradation product of cross-linked fibrin (D-dimer) and Glasgow Coma Scale in patients with traumatic brain injury. Keywords: D-Dimer - Glasgow Coma Scale - Traumatic Brain Injury - CT scan - correlation
The effects of regular exercise on hippocampal estradiol levels and spatial memory of ovariectomized Sprague Dawley rats Sri Kadarsih Soejono, Siti Kaidah Ginus Partadiredja
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 02 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.551 KB)

Abstract

The decrease of estrogen levels leads to dysfunction of hippocampus, including spatial learning and memory. Previous studies have shown that physical exercise improved spatial memory of ovariectomized rats. Physical exercise was observed to be associated with increased extragonadal aromatization and neurotrophin synthesis. This study aimed to evaluate the effect of regular exercise on serum and hippocampal estrogens levels and the spatial memory of ovariectomized rats. The present study used 10 ovariectomized Sprague Dawley rats aged 12 weeks. The rats were randomly assigned into two groups with five rats in each group. Group I was exercise group and Group II was control group without exercise. During the exercise period, the rats were required to keep running constantly on the treadmill at a speed of 18 m/min and at the slope of 5% for a total duration of 60 minutes per day. The exercise was performed five times per week for 12 weeks. The spatial memory of rats was measured using Morris water maze. After the exercise program was completed, the blood and hippocampus samples were collected to determine the estrogen levels. This study revealed that the mean levels of hippocampal estrogen of exercise group (33.794 ± 4.760 pg/mL/100mg tissue weight) were significantly higher than that ofcontrol group (20.552 ± 2.057 pg/mL/100 mg tissue weight) (p<0.05). However, there was no significant difference in serum estrogen levels between the exercise group (26.070 ± 4.064 pg/mL/100mg tissue weight) and control group (24.530 ± 8.661 pg/mL/100mg tissue weight) (p>0.05). In the Morris water maze tests, there was no difference in the spatial learning between both groups (p>0.05). The spatial memory retention of the exercise group was significantly better than control group (p<0.05). In conclusion, regular exercise increases hippocampal estrogen levels and improves spatial memory of ovariectomized rats. Keywords: exercise - hippocampus - spatial memory - estrogen - ERβ

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